GB1046429A - New 2-(1-naphthyl)-carboxylic acids and pharmaceutical compositions containing them - Google Patents
New 2-(1-naphthyl)-carboxylic acids and pharmaceutical compositions containing themInfo
- Publication number
- GB1046429A GB1046429A GB2937663A GB2937663A GB1046429A GB 1046429 A GB1046429 A GB 1046429A GB 2937663 A GB2937663 A GB 2937663A GB 2937663 A GB2937663 A GB 2937663A GB 1046429 A GB1046429 A GB 1046429A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- acetonitrile
- salts
- naphthyl
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 150000002825 nitriles Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- OQRMWUNUKVUHQO-UHFFFAOYSA-N 2-naphthalen-1-ylacetonitrile Chemical compound C1=CC=C2C(CC#N)=CC=CC2=C1 OQRMWUNUKVUHQO-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 150000002366 halogen compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000000871 hypocholesterolemic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR905361A FR1342159A (fr) | 1962-07-27 | 1962-07-27 | Nouveaux acides carboxyliques alpha-substitués par au moins un radical cyclique et leurs procédés de préparation |
| FR917497A FR82715E (fr) | 1962-12-04 | 1962-12-04 | Nouveaux acides carboxyliques alpha-substitués par au moins un radical cyclique et leurs procédés de préparation |
| FR932076A FR83531E (fr) | 1963-04-19 | 1963-04-19 | Nouveaux acides carboxyliques alpha-substitués par au moins un radical cyclique et leurs procédés de préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1046429A true GB1046429A (en) | 1966-10-26 |
Family
ID=27246712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2937663A Expired GB1046429A (en) | 1962-07-27 | 1963-07-24 | New 2-(1-naphthyl)-carboxylic acids and pharmaceutical compositions containing them |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | AT248430B (enrdf_load_stackoverflow) |
| CH (1) | CH430678A (enrdf_load_stackoverflow) |
| DE (1) | DE1468179A1 (enrdf_load_stackoverflow) |
| DK (1) | DK113773B (enrdf_load_stackoverflow) |
| GB (1) | GB1046429A (enrdf_load_stackoverflow) |
| SE (1) | SE311896B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4933339A (en) * | 1985-08-21 | 1990-06-12 | Rohm And Haas Company | (2-cyano-2-arylethyl)pyridine compounds useful in controlling fungicidal activity |
-
1963
- 1963-07-08 CH CH844663A patent/CH430678A/fr unknown
- 1963-07-18 SE SE797963A patent/SE311896B/xx unknown
- 1963-07-23 DE DE19631468179 patent/DE1468179A1/de active Pending
- 1963-07-24 GB GB2937663A patent/GB1046429A/en not_active Expired
- 1963-07-25 DK DK354263A patent/DK113773B/da unknown
- 1963-07-26 AT AT601963A patent/AT248430B/de active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4933339A (en) * | 1985-08-21 | 1990-06-12 | Rohm And Haas Company | (2-cyano-2-arylethyl)pyridine compounds useful in controlling fungicidal activity |
Also Published As
| Publication number | Publication date |
|---|---|
| SE311896B (enrdf_load_stackoverflow) | 1969-06-30 |
| DK113773B (da) | 1969-04-28 |
| AT248430B (de) | 1966-07-25 |
| CH430678A (fr) | 1967-02-28 |
| DE1468179A1 (de) | 1968-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1412130A (en) | 3-substituted-morphinan derivatives | |
| GB1040735A (en) | 4-aryl-3-hydroxybutyric acid and esters, amides and salts thereof | |
| ES413639A1 (es) | Un procedimiento para la preparacion de un compuesto deri- vado de dopamina. | |
| GB1062714A (en) | -ß-(4'-acyloxy-4'-piperidyl)-ketones | |
| HUT46895A (en) | Process for production of new 5-lipoxigenase bicyclic compounds with inhibiation effect | |
| CH610582A5 (en) | Process for the preparation of a stilbene derivative having analgesic and anti-inflammatory properties | |
| GB1228736A (enrdf_load_stackoverflow) | ||
| GB1046429A (en) | New 2-(1-naphthyl)-carboxylic acids and pharmaceutical compositions containing them | |
| ES8304971A1 (es) | Un procedimiento para la preparacion de derivados de tiocarbapenem 3-sustituidos. | |
| GB1118867A (en) | Phenoxazine derivatives | |
| GB1186495A (en) | 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation | |
| ES306802A1 (es) | Procedimiento de preparaciën de sustancias antibacterianas | |
| GB1242096A (en) | Benzobenzofuranooxepine compounds and process for preparing the same | |
| DE2964850D1 (en) | Thienylbenzoic-acid derivatives, process for their production, and pharmaceutical preparations containing these compounds | |
| DE3265110D1 (en) | New compound having antiinflammatory, analgesic and mucoregulating activity, process for its production and relative pharmaceutical compositions | |
| ES416311A1 (es) | Un procedimiento de preparacion de esteres dialquilaminoal-quilicos del acido 2-(6-metoxi-2-naftil) propionico. | |
| SE8301785L (sv) | Sett att framstella 2-tiofen-ettiksyraderivat och mellanprodukter erforderliga for deras framstellning | |
| GB959704A (en) | New indene derivatives and method of preparing the same | |
| GB1044309A (en) | Substituted 1-aralklyl-piperidines | |
| GB1114018A (en) | Process for producing 4-hydroxycyclohexanecarboxylic acid and derivatives thereof | |
| GB999590A (en) | ª‡-substituted carboxylic acid derivatives and their production | |
| GB1025564A (en) | Benzofuran derivatives and process for their production | |
| GB1000803A (en) | New uracil derivatives and process for their production | |
| GB843908A (en) | Novel morphinan derivatives and the manufacture thereof | |
| GB926624A (en) | New amines and process for their manufacture |