GB1042930A - Improvements in or relating to tropane derivatives - Google Patents

Improvements in or relating to tropane derivatives

Info

Publication number
GB1042930A
GB1042930A GB2819263A GB2819263A GB1042930A GB 1042930 A GB1042930 A GB 1042930A GB 2819263 A GB2819263 A GB 2819263A GB 2819263 A GB2819263 A GB 2819263A GB 1042930 A GB1042930 A GB 1042930A
Authority
GB
United Kingdom
Prior art keywords
compounds
methoxy
nortropane
nitroso
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2819263A
Inventor
Ernst Jucker
Adolf Johann Lindenmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Patent Ltd
Sandoz AG
Original Assignee
Sandoz Patent Ltd
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Patent Ltd, Sandoz AG filed Critical Sandoz Patent Ltd
Publication of GB1042930A publication Critical patent/GB1042930A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises compounds of formula <FORM:1042930/C2/1> wherein R is a hydrogen atom or a methoxy group, acid addition salts thereof, and their preparation by reduction of the corresponding N-nitroso-compounds. 6 - Methoxy - N - nitroso - nortropane is prepared by reacting 6-methoxy-nortropinone with hydrazine hydrate and an alkali metal hydroxide to form 6-methoxy-nortropane, and reacting this with cold sodium nitrite solution. Compounds of formula <FORM:1042930/C2/2> wherein Hal is a chlorine or fluorine atom are prepared from the compounds of the invention by reaction with a 3-sulphamyl-4-chloro- or -fluoro-benzoyl halide.
GB2819263A 1962-07-31 1963-07-16 Improvements in or relating to tropane derivatives Expired GB1042930A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH914662A CH411896A (en) 1962-07-31 1962-07-31 Process for the preparation of new heterocyclic compounds

Publications (1)

Publication Number Publication Date
GB1042930A true GB1042930A (en) 1966-09-21

Family

ID=4348833

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2819263A Expired GB1042930A (en) 1962-07-31 1963-07-16 Improvements in or relating to tropane derivatives

Country Status (4)

Country Link
CH (1) CH411896A (en)
ES (2) ES290404A1 (en)
GB (1) GB1042930A (en)
NL (1) NL6512664A (en)

Also Published As

Publication number Publication date
ES290404A1 (en) 1964-02-16
CH411896A (en) 1966-04-30
NL6512664A (en) 1966-04-25
ES318028A2 (en) 1966-04-16

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