GB1038730A - Piperazine derivatives and processes for the production thereof - Google Patents

Piperazine derivatives and processes for the production thereof

Info

Publication number
GB1038730A
GB1038730A GB2513164A GB2513164A GB1038730A GB 1038730 A GB1038730 A GB 1038730A GB 2513164 A GB2513164 A GB 2513164A GB 2513164 A GB2513164 A GB 2513164A GB 1038730 A GB1038730 A GB 1038730A
Authority
GB
United Kingdom
Prior art keywords
radical
alkyl
formula
prepared
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2513164A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US333686A external-priority patent/US3157658A/en
Priority to US333686A priority Critical patent/US3157658A/en
Priority to US361538A priority patent/US3252984A/en
Priority to US368366A priority patent/US3256505A/en
Application filed by GD Searle LLC filed Critical GD Searle LLC
Priority to BR160589/64A priority patent/BR6460589D0/en
Priority to FR980397A priority patent/FR4063M/fr
Priority to FR1599666D priority patent/FR1599666A/fr
Priority to DES91838A priority patent/DE1237574B/en
Priority to BR160588/64A priority patent/BR6460588D0/en
Priority to BE650047D priority patent/BE650047A/xx
Priority to NL6407581A priority patent/NL6407581A/xx
Priority to US405616A priority patent/US3262934A/en
Priority to GB48139/64A priority patent/GB1029920A/en
Priority to BE657534D priority patent/BE657534A/xx
Priority to FR999704A priority patent/FR4292M/fr
Priority to FR14067A priority patent/FR4382M/fr
Priority to US463929A priority patent/US3374231A/en
Priority to US525353A priority patent/US3318901A/en
Priority to US567041A priority patent/US3356681A/en
Publication of GB1038730A publication Critical patent/GB1038730A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/88—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C07D335/14—Thioxanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D335/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C07D335/20—Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds of the Formula I wherein n represents 0, 1 or 2, R represents a hydrogen atom or an alkyl radical, X represents an oxygen or a sulphur atom, Y represents a hydrogen or chlorine atom or a methyl radical, R1 represents a hydrogen atom or an alkyl, phenyl, tolyl, halophenyl, methoxyphenyl, dimethoxyphenyl, methylenedioxyphenyl, hydroxyphenyl, dimethylaminophenyl, diethylaminoethoxyphenyl, acetamidophenyl, cyanophenyl, styryl, phenylalkyl, naphthyl, pyridyl, methylpyridyl, quinolyl or ferrocenyl (see Example 4) radical, R11 represents a hydrogen atom or an alkyl or phenyl radical or wherein R1 and R11 may together represent a cycloalkylidene radical containing 5 to 12 carbon atoms inclusive or a fluoren - 9 - ylidene, indanylidene, benzocylohexylidene, phenylcyclohexylidene, or 1-alkyl - 4 - piperidylidene radical and wherein the term "alkyl" means alkyl radicals containing from 1 to 6 carbon atoms inclusive, are prepare by contacting an amine of the Formula II with a compound of the Formula R1R11C = Z wherein > C = Z represents a carbonyl radical or a radical equivalent thereto for reaction with hydrazine to form a hydrazone thereof, and where n represents 1 or 2, if desired converting into an acid addition salt. <FORM:1038730/C2/1> <FORM:1038730/C2/2> Amines of the Formula II may be prepared by reducing the corresponding 4-nitrosopiperazino-compounds, which may be prepared by reacting a xanthen-9-ol or a thioxanthen-9-ol with 1-nitrosopiperazine in an inert solvent. Amines of the Formula II where n represents 1 or 2 may be prepared by reacting 1-nitrosopiperazine with the appropriate xanthen-9-yl or thioxanthen-9-yl substituted acid chloride and reducing the resulting 4-nitrosopiperazinocarbonyl derivative.
GB2513164A 1963-07-05 1964-06-17 Piperazine derivatives and processes for the production thereof Expired GB1038730A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
US333686A US3157658A (en) 1963-07-05 1963-12-26 1-carbalkoxy-4-(9-xanthenyl) piperazines and related compounds
US361538A US3252984A (en) 1963-07-05 1964-04-21 Esters of xanthenylpiperidinecarboxylic acid and related compounds
US368366A US3256505A (en) 1963-07-05 1964-05-18 1-xanthenyl-4-phenylpiperidine-4-carboxylic acid esters
BR160589/64A BR6460589D0 (en) 1963-07-05 1964-07-02 PROCESS FOR THE PREPARATION OF 1-AMINO-4- HYDRAZONES (XANTHENYL AND THIOXANTHENIL) PIPERAZINES
FR980397A FR4063M (en) 1963-07-05 1964-07-02
FR1599666D FR1599666A (en) 1963-07-05 1964-07-02
DES91838A DE1237574B (en) 1963-07-05 1964-07-02 Process for the preparation of piperazine derivatives
BR160588/64A BR6460588D0 (en) 1963-07-05 1964-07-02 -1-AMINO 4 HYDRAZONE PREPARATION PROCESS (XANTHENYL AND THIOXANTHENIL) PIPERAZINES
BE650047D BE650047A (en) 1963-07-05 1964-07-02
NL6407581A NL6407581A (en) 1963-07-05 1964-07-03
US405616A US3262934A (en) 1963-07-05 1964-10-21 Amino-substituted xanthenes and thioxanthenes
GB48139/64A GB1029920A (en) 1963-07-05 1964-11-26 Piperazine and piperidine compounds
BE657534D BE657534A (en) 1963-07-05 1964-12-23
FR999704A FR4292M (en) 1963-07-05 1964-12-23
FR14067A FR4382M (en) 1963-07-05 1965-04-21
US463929A US3374231A (en) 1963-07-05 1965-06-14 Hydrazones of 1-amino-4-(xanthenyl and thioxanthenyl)piperazines
US525353A US3318901A (en) 1963-07-05 1966-02-07 N-dialkylaminoalkyl-1-xanthenylpiper-idinecarboxamides and related compounds
US567041A US3356681A (en) 1963-07-05 1966-07-22 Xanthenylpiperazine anti-depressants

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US29313763A 1963-07-05 1963-07-05
US333686A US3157658A (en) 1963-07-05 1963-12-26 1-carbalkoxy-4-(9-xanthenyl) piperazines and related compounds
US361538A US3252984A (en) 1963-07-05 1964-04-21 Esters of xanthenylpiperidinecarboxylic acid and related compounds
US368366A US3256505A (en) 1963-07-05 1964-05-18 1-xanthenyl-4-phenylpiperidine-4-carboxylic acid esters
US405616A US3262934A (en) 1963-07-05 1964-10-21 Amino-substituted xanthenes and thioxanthenes
US525353A US3318901A (en) 1963-07-05 1966-02-07 N-dialkylaminoalkyl-1-xanthenylpiper-idinecarboxamides and related compounds

Publications (1)

Publication Number Publication Date
GB1038730A true GB1038730A (en) 1966-08-10

Family

ID=27559616

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2513164A Expired GB1038730A (en) 1963-07-05 1964-06-17 Piperazine derivatives and processes for the production thereof

Country Status (1)

Country Link
GB (1) GB1038730A (en)

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