GB1037642A - Pharmaceutical compositions containing 3,5-disubstituted isoxazoles - Google Patents
Pharmaceutical compositions containing 3,5-disubstituted isoxazolesInfo
- Publication number
- GB1037642A GB1037642A GB519/63A GB51963A GB1037642A GB 1037642 A GB1037642 A GB 1037642A GB 519/63 A GB519/63 A GB 519/63A GB 51963 A GB51963 A GB 51963A GB 1037642 A GB1037642 A GB 1037642A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- methyl
- isoxazole
- reaction
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises complexes of formula <FORM:1037642/C2/1> wherein n is 1 or 2 and MS is a metal salt, and their preparation by reaction of the complex components. 5 - Carboxy - 3 - methyl - isoxazole is prepared by reaction of acetopyruvic acid and hydroxylamine hydrochloride. 3 - Carboxy - 5 - methyl - isoxazole is prepared by reaction of acetonylacetone and nitric acid. 5 - Carbamoyl - 3 - methyl - isoxazole is prepared by reaction of 5-carboxy-3-methyl isoxazole with thionyl chloride and concentrated ammonium hydroxide.ALSO:Pharmaceutical compositions having hypoglycemic activity comprise (a) a compound of formula <FORM:1037642/A5-A6/1> wherein n is 1 or 2 and MS is a metal salt, in combination with a pharmaceutical carrier, or (b) a compound of formula <FORM:1037642/A5-A6/2> wherein R1 and R2 are C1-4 alkyl, carboxyl, C1-4 alkyl carboxylate, carbamoyl or C1-4 alkyl substituted carbamoyl groups, dispersed in a solid carrier or in a liquid carrier in which the active ingredient is insoluble. Dosage forms specified one for oral or parenteral commistration, e.g. tablets, pills, capsules, powders, wafers, cachets, elixirs, granules, suspensions or emulsions. Other pharmaceutically active compounds may be present, for example other hypoglycemic agents, such as tolbutamide, chlorpropamide, plenformin hydrochloride, mesoxalic and, insulin, nicotinic acid, triparanol, the D. isomer of 3, 5, 31-tri-codothyronine, triodothyropropionic acid, sodium L-thyroxine, and sodium D-thyroxine, glucocorticoids, such as hydrocortisone, prednisolone and 6a -methyl-prednisolone, anti-coagulants such as heparin, 2-diphenylacetyl-1, 3-indandione, polyethylene sulphonate and dicoumarol or its derivatives, vitamins such as nicotinic acid, vitamin B12, ascorbic acid or pyridoxine hydrochloride, esterogens, such as estradiol, androgens, such as testosterone, unsaturated fatty acids such as corn oil and linoleic acid or esters, antibiotics such as neomycin, analgesics such as aspirin, compounds associated with cholesteral synthesis or metabolism such as a -phenyl-butyric acid and a -p-biphenylylbutyric acid, lipotrophic agents such as choline and inosital, amino-acids such as taurine and glycine, sterols such as sitosterol, diuretics such as acetazolamide and chlorothiazide, anorexigenic agents such as amphetamine, and cardiovascular agents such as chlorisodamine chloride, hexamethonium chloride and pentaerythritol tetranitrate.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16791162A | 1962-01-22 | 1962-01-22 | |
US23732962A | 1962-11-13 | 1962-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1037642A true GB1037642A (en) | 1966-08-03 |
Family
ID=26863590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB519/63A Expired GB1037642A (en) | 1962-01-22 | 1963-01-22 | Pharmaceutical compositions containing 3,5-disubstituted isoxazoles |
Country Status (2)
Country | Link |
---|---|
BE (1) | BE627420A (en) |
GB (1) | GB1037642A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2373283A1 (en) * | 1976-12-10 | 1978-07-07 | Wuelfing Johann A | Methyl-isoxazole-carboxylate salts of theophylline derivs. - with antilipolytic and hypolipaemic activity |
WO2008043263A1 (en) * | 2006-10-06 | 2008-04-17 | Dou, Dexian | Isoxazole derivatives and methods of treating diseases |
-
1963
- 1963-01-22 BE BE627420A patent/BE627420A/en unknown
- 1963-01-22 GB GB519/63A patent/GB1037642A/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2373283A1 (en) * | 1976-12-10 | 1978-07-07 | Wuelfing Johann A | Methyl-isoxazole-carboxylate salts of theophylline derivs. - with antilipolytic and hypolipaemic activity |
WO2008043263A1 (en) * | 2006-10-06 | 2008-04-17 | Dou, Dexian | Isoxazole derivatives and methods of treating diseases |
Also Published As
Publication number | Publication date |
---|---|
BE627420A (en) | 1963-07-23 |
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