FR2373283A1 - Methyl-isoxazole-carboxylate salts of theophylline derivs. - with antilipolytic and hypolipaemic activity - Google Patents

Methyl-isoxazole-carboxylate salts of theophylline derivs. - with antilipolytic and hypolipaemic activity

Info

Publication number
FR2373283A1
FR2373283A1 FR7637268A FR7637268A FR2373283A1 FR 2373283 A1 FR2373283 A1 FR 2373283A1 FR 7637268 A FR7637268 A FR 7637268A FR 7637268 A FR7637268 A FR 7637268A FR 2373283 A1 FR2373283 A1 FR 2373283A1
Authority
FR
France
Prior art keywords
antilipolytic
theophylline
methyl
derivs
isoxazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7637268A
Other languages
French (fr)
Other versions
FR2373283B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7637268A priority Critical patent/FR2373283A1/en
Publication of FR2373283A1 publication Critical patent/FR2373283A1/en
Application granted granted Critical
Publication of FR2373283B1 publication Critical patent/FR2373283B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Abstract

New 5-methylisoxazole-3-carboxylate salts of formula (I): (where R1 and R2 are H, 1-6C alkyl, hydroxyalkyl or alkoxyalkyl or cyclohexyl). (I) have antilipolytic and hypolipaemic activity. The prefd. cpd. is (I; R1=Me, R2 = CH2CH2OH). In an example, this is prepd. by reacting 7- 3-(N-methyl-N-hydroxyethylamino)-2-hydroxyethylamino)-2-hydrox- ypropyl -theophylline with 5-methylisoxazole-3-carboxylic acid.
FR7637268A 1976-12-10 1976-12-10 Methyl-isoxazole-carboxylate salts of theophylline derivs. - with antilipolytic and hypolipaemic activity Granted FR2373283A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7637268A FR2373283A1 (en) 1976-12-10 1976-12-10 Methyl-isoxazole-carboxylate salts of theophylline derivs. - with antilipolytic and hypolipaemic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7637268A FR2373283A1 (en) 1976-12-10 1976-12-10 Methyl-isoxazole-carboxylate salts of theophylline derivs. - with antilipolytic and hypolipaemic activity

Publications (2)

Publication Number Publication Date
FR2373283A1 true FR2373283A1 (en) 1978-07-07
FR2373283B1 FR2373283B1 (en) 1979-03-30

Family

ID=9180907

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7637268A Granted FR2373283A1 (en) 1976-12-10 1976-12-10 Methyl-isoxazole-carboxylate salts of theophylline derivs. - with antilipolytic and hypolipaemic activity

Country Status (1)

Country Link
FR (1) FR2373283A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1037642A (en) * 1962-01-22 1966-08-03 Upjohn Co Pharmaceutical compositions containing 3,5-disubstituted isoxazoles
FR2281758A1 (en) * 1974-08-14 1976-03-12 Wuelfing Johann A 3-METHYL-PYRAZOLE-5-CARBOXYLATES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1037642A (en) * 1962-01-22 1966-08-03 Upjohn Co Pharmaceutical compositions containing 3,5-disubstituted isoxazoles
FR2281758A1 (en) * 1974-08-14 1976-03-12 Wuelfing Johann A 3-METHYL-PYRAZOLE-5-CARBOXYLATES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS

Also Published As

Publication number Publication date
FR2373283B1 (en) 1979-03-30

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