GB1030846A - Diagnostic apparatus - Google Patents

Diagnostic apparatus

Info

Publication number
GB1030846A
GB1030846A GB32651/64A GB3265164A GB1030846A GB 1030846 A GB1030846 A GB 1030846A GB 32651/64 A GB32651/64 A GB 32651/64A GB 3265164 A GB3265164 A GB 3265164A GB 1030846 A GB1030846 A GB 1030846A
Authority
GB
United Kingdom
Prior art keywords
cell
wavelength
photomultiplier
slide
cancerous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32651/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Business Machines Corp
Original Assignee
International Business Machines Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Business Machines Corp filed Critical International Business Machines Corp
Publication of GB1030846A publication Critical patent/GB1030846A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

1,030,846. Diagnostic apparatus utilizing photo-electric cytology. INTERNATIONAL BUSINESS MACHINES CORPORATION. Aug. 11, 1964 [Aug. 12, 1963], No. 32651/64. Heading A5K. [Also in Division G1] Cancerous animal cells are identified by scanning the cell with a beam of electromagnetic energy of a wavelength within the absorption band of nucleic acid in the cell, detecting the energy reflected or transmitted and indicating when the variations of energy intensity differ from a predetermined pattern of variation. Light from a source 7 is focussed on the cell under test on a slide 1 and the transmitted light is split by a prism 15 so that light of a wavelength absorbed by nucleic acids (2652 Š) falls on a photomultiplier 25 and a wavelength absorbed by cell proteins or a stain falls on a photomultiplier 31. The slide is moved in a rectangular raster pattern and the respective outputs S 1 , S 2 from 25, 31 are differentiated, and if the difference between the derivatives R1, R2 is greater than a preset valve a signal from circuit 39 indicates that the cell is cancerous. The prism may be replaced by filters or dichroic mirrors and the slide may be fixed, and scanned by a flying spot scanner. In a modification only wavelength 2652 Š is used, the presence of high frequency components in the output from the photomultiplier, detected by a high pass filter indicates that the cell is normal. Their absence indicates a cancerous cell.
GB32651/64A 1963-08-12 1964-08-11 Diagnostic apparatus Expired GB1030846A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US301265A US3327117A (en) 1963-08-12 1963-08-12 Cancer cell detector using two wavelengths for comparison

Publications (1)

Publication Number Publication Date
GB1030846A true GB1030846A (en) 1966-05-25

Family

ID=23162638

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32651/64A Expired GB1030846A (en) 1963-08-12 1964-08-11 Diagnostic apparatus

Country Status (6)

Country Link
US (1) US3327117A (en)
BE (1) BE651714A (en)
CH (1) CH424078A (en)
DE (1) DE1498824C3 (en)
GB (1) GB1030846A (en)
SE (1) SE321540B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1105413A (en) * 1964-10-16 1968-03-06 Barringer Research Ltd Method and apparatus for detecting traces of substances
US3443089A (en) * 1966-06-20 1969-05-06 Beckman Instruments Inc Radiant energy analyzer for directly measuring the polarization ratio of fluorescent radiation
US3497690A (en) * 1967-09-21 1970-02-24 Bausch & Lomb Method and apparatus for classifying biological cells by measuring the size and fluorescent response thereof
US3770349A (en) * 1969-03-17 1973-11-06 Sanchez G Legorreta Method and apparatus for automatically classifying complex, microscopic particles such as human cells
US3641344A (en) * 1969-04-01 1972-02-08 Perkin Elmer Corp Solar-stimulated fluorescent radiation detection method and apparatus
US3571589A (en) * 1969-06-04 1971-03-23 Barringer Research Ltd Method for absorption analysis using a source having a broadened emission line
GB1302865A (en) * 1969-07-14 1973-01-10
US3657537A (en) * 1970-04-03 1972-04-18 Bausch & Lomb Computerized slit-scan cyto-fluorometer for automated cell recognition
US3822095A (en) * 1972-08-14 1974-07-02 Block Engineering System for differentiating particles
US3851156A (en) * 1972-09-05 1974-11-26 Green James E Analysis method and apparatus utilizing color algebra and image processing techniques
US3999047A (en) * 1972-09-05 1976-12-21 Green James E Method and apparatus utilizing color algebra for analyzing scene regions
US4017192A (en) * 1975-02-06 1977-04-12 Neotec Corporation Optical analysis of biomedical specimens
US4328809A (en) * 1976-09-24 1982-05-11 Barry Herbert Hirschowitz Device and method for detecting the potential level of the electromagnetic field of a living organism
US4293221A (en) * 1979-04-17 1981-10-06 Research Corporation Multidimensional slit-scan flow system
US4263508A (en) * 1979-04-20 1981-04-21 Research Corporation Pulse edge measurement for determining particle dimensional characteristics
GB2068537B (en) * 1980-02-04 1984-11-14 Energy Conversion Devices Inc Examining biological materials
US4350892A (en) * 1980-07-31 1982-09-21 Research Corporation X'-, Y'-, Z'- axis multidimensional slit-scan flow system
US5104392A (en) * 1985-03-22 1992-04-14 Massachusetts Institute Of Technology Laser spectro-optic imaging for diagnosis and treatment of diseased tissue
US5318024A (en) * 1985-03-22 1994-06-07 Massachusetts Institute Of Technology Laser endoscope for spectroscopic imaging
US5199431A (en) * 1985-03-22 1993-04-06 Massachusetts Institute Of Technology Optical needle for spectroscopic diagnosis
DE3650688T2 (en) * 1985-03-22 1999-03-25 Massachusetts Inst Technology Fiber optic probe system for the spectral diagnosis of tissue
US4913142A (en) * 1985-03-22 1990-04-03 Massachusetts Institute Of Technology Catheter for laser angiosurgery
US5125404A (en) * 1985-03-22 1992-06-30 Massachusetts Institute Of Technology Apparatus and method for obtaining spectrally resolved spatial images of tissue
US4718417A (en) * 1985-03-22 1988-01-12 Massachusetts Institute Of Technology Visible fluorescence spectral diagnostic for laser angiosurgery
US4767717A (en) * 1985-05-02 1988-08-30 Baisden C Robert Method of detecting and quantitating cell malignancy in biological tissue
AT387860B (en) * 1985-09-16 1989-03-28 Optical Sensing Technology METHOD AND DEVICE FOR TUMOR DIAGNOSIS BY MEANS OF SERA
US5261405A (en) * 1986-02-26 1993-11-16 The Beth Israel Hospital Association Apparatus and method for detecting cancer using nuclear magnetic resonance
US6690966B1 (en) 1991-02-26 2004-02-10 Massachusetts Institute Of Technology Methods of molecular spectroscopy to provide for the diagnosis of tissue
BRPI0714697A2 (en) * 2006-08-04 2013-03-12 Koninkl Philips Electronics Nv Method for the determination in vivo of the amount of nuclear nucleic acids in at least one cell of an animal or human subject, and use of a device
WO2010103440A1 (en) * 2009-03-11 2010-09-16 Koninklijke Philips Electronics N.V. Irradiating an absorption contrast agent contained in a turbid medium
JP6767981B2 (en) * 2015-08-26 2020-10-14 倉敷紡績株式会社 Cell measurement method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2395489A (en) * 1942-05-20 1946-02-26 Du Pont Photometric process for gas analysis
US2790438A (en) * 1956-01-13 1957-04-30 Taplin Ronald Harold Earpieces for oximeters
US3210546A (en) * 1962-06-18 1965-10-05 Little Inc A Infrared scanning apparatus for flow detection using duplicate parallel detectors

Also Published As

Publication number Publication date
DE1498824A1 (en) 1969-05-14
US3327117A (en) 1967-06-20
DE1498824C3 (en) 1975-04-17
CH424078A (en) 1966-11-15
SE321540B (en) 1970-03-09
BE651714A (en) 1964-12-01
DE1498824B2 (en) 1974-08-15

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