GB1025907A - New amino-steroid compounds and processes for their preparation - Google Patents
New amino-steroid compounds and processes for their preparationInfo
- Publication number
- GB1025907A GB1025907A GB3393763A GB3393763A GB1025907A GB 1025907 A GB1025907 A GB 1025907A GB 3393763 A GB3393763 A GB 3393763A GB 3393763 A GB3393763 A GB 3393763A GB 1025907 A GB1025907 A GB 1025907A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- preparation
- pregnanes
- carbons
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- NDDAQHROMJDMKS-XFYXLWKMSA-N [(2s,3s,5s,8r,9s,10s,13s,14s)-2-hydroxy-10,13-dimethyl-17-oxo-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-3-yl]azanium;chloride Chemical class Cl.C1[C@H](N)[C@@H](O)C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC[C@H]21 NDDAQHROMJDMKS-XFYXLWKMSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- TTWHFRCROZMNKN-PZTDUGPGSA-N (3R,5R,8S,9S,10S,11S,13S,14S,17S)-17-(1-aminoethyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,11-diol Chemical class O[C@H]1C[C@H]2CC[C@H]3[C@@H]4CC[C@H](C(C)N)[C@]4(C[C@@H]([C@@H]3[C@]2(CC1)C)O)C TTWHFRCROZMNKN-PZTDUGPGSA-N 0.000 abstract 1
- GPGPPYIWYMEUGA-SRJHXTLLSA-N 1-[(8r,9s,10s,13s,14s,17s)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanamine Chemical class C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(N)C)[C@@]1(C)CC2 GPGPPYIWYMEUGA-SRJHXTLLSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000007269 dehydrobromination reaction Methods 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000012457 nonaqueous media Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR907856A FR1421231A (fr) | 1962-08-27 | 1962-08-27 | Nouveaux amino-stéroïdes et procédé de préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1025907A true GB1025907A (en) | 1966-04-14 |
Family
ID=8785774
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3393763A Expired GB1025907A (en) | 1962-08-27 | 1963-08-27 | New amino-steroid compounds and processes for their preparation |
| GB3393663A Expired GB1025906A (en) | 1962-08-27 | 1963-08-27 | New amino-steroid compounds and processes for their preparation |
| GB3393863A Expired GB1025908A (en) | 1962-08-27 | 1963-08-27 | New amino-steroid compounds and processes for their preparation |
| GB1601065A Expired GB1045644A (en) | 1962-08-27 | 1965-04-14 | New amino-steroid compounds and processes for their preparation |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3393663A Expired GB1025906A (en) | 1962-08-27 | 1963-08-27 | New amino-steroid compounds and processes for their preparation |
| GB3393863A Expired GB1025908A (en) | 1962-08-27 | 1963-08-27 | New amino-steroid compounds and processes for their preparation |
| GB1601065A Expired GB1045644A (en) | 1962-08-27 | 1965-04-14 | New amino-steroid compounds and processes for their preparation |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE636641A (enExample) |
| DE (4) | DE1212080B (enExample) |
| ES (1) | ES290991A1 (enExample) |
| FR (3) | FR1421231A (enExample) |
| GB (4) | GB1025907A (enExample) |
| NL (4) | NL297135A (enExample) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3013008A (en) * | 1961-01-09 | 1961-12-12 | Searle & Co | N-substituted 20-aminopregnan-3-ols, esters thereof, and deta-derivatives corresponding |
-
0
- NL NL297131D patent/NL297131A/xx unknown
- BE BE636641D patent/BE636641A/xx unknown
- NL NL123751D patent/NL123751C/xx active
- NL NL297133D patent/NL297133A/xx unknown
- NL NL297135D patent/NL297135A/xx unknown
-
1962
- 1962-08-27 FR FR907856A patent/FR1421231A/fr not_active Expired
- 1962-11-27 FR FR916749A patent/FR2374M/fr not_active Expired
-
1963
- 1963-05-03 FR FR933624A patent/FR56F/fr not_active Expired
- 1963-08-22 ES ES290991A patent/ES290991A1/es not_active Expired
- 1963-08-27 GB GB3393763A patent/GB1025907A/en not_active Expired
- 1963-08-27 DE DER35990A patent/DE1212080B/de active Pending
- 1963-08-27 DE DER35992A patent/DE1212082B/de active Pending
- 1963-08-27 GB GB3393663A patent/GB1025906A/en not_active Expired
- 1963-08-27 GB GB3393863A patent/GB1025908A/en not_active Expired
- 1963-08-27 DE DER35991A patent/DE1212081B/de active Pending
- 1963-08-27 DE DER35993A patent/DE1212083B/de active Pending
-
1965
- 1965-04-14 GB GB1601065A patent/GB1045644A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1212083B (de) | 1966-03-10 |
| FR1421231A (fr) | 1965-12-17 |
| NL297133A (enExample) | |
| ES290991A1 (es) | 1963-12-01 |
| GB1025906A (en) | 1966-04-14 |
| DE1212081B (de) | 1966-03-10 |
| FR2374M (fr) | 1964-04-03 |
| DE1212080B (de) | 1966-03-10 |
| DE1212082B (de) | 1966-03-10 |
| GB1025908A (en) | 1966-04-14 |
| GB1045644A (en) | 1966-10-12 |
| NL123751C (enExample) | |
| FR56F (fr) | 1964-10-16 |
| BE636641A (enExample) | |
| NL297135A (enExample) | |
| NL297131A (enExample) |
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