GB1024645A - Chromone compounds - Google Patents

Chromone compounds

Info

Publication number
GB1024645A
GB1024645A GB2640362A GB2640362A GB1024645A GB 1024645 A GB1024645 A GB 1024645A GB 2640362 A GB2640362 A GB 2640362A GB 2640362 A GB2640362 A GB 2640362A GB 1024645 A GB1024645 A GB 1024645A
Authority
GB
United Kingdom
Prior art keywords
chroman
hydroxy
acid
contacting
propionic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2640362A
Inventor
Alan Ogden Fitton
George Rowntree Ramage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BENGER LAB Ltd
Original Assignee
BENGER LAB Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BENGER LAB Ltd filed Critical BENGER LAB Ltd
Priority to GB2640362A priority Critical patent/GB1024645A/en
Publication of GB1024645A publication Critical patent/GB1024645A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises 6-oxa-cyclohexano-[g] - chromone - 2 - carboxylic acid, salts and esters thereof and a process for the preparation thereof by condensing 7-acetyl-6-hydroxy-chroman with ethyl oxalate and cyclising the resultant diketone by heating with ethanolic HCl, H2SO4 or boron trifluoride to obtain the ethyl ester, or with glacial acetic acid and HCl to obtain the free acid. The 7-acetyl-6-hydroxy-chroman may be obtained by contacting b -(p-methoxyphenoxy) propionic acid with a strong acid catalyst to yield 6-methoxy-chromanone, reducing the chromanone to 6-methoxy chroman and contacting this with boron trifluoride acetic acid complex, or by acetylating b -(p-hydroxy-phenoxy) propionic acid with acetic anhydride, contacting the resulting (p-acetoxyphenoxy) propionic acid with a strong acid catalyst to yield 6-hydroxy chroman, acetylating to form 6-acetoxy chroman which is contacted with aluminium chloride. Pharmaceutical compositions having activity as inhibitors of the antigen-antibody reaction and containing the above compounds are administered orally in tablets, in solutions for injection or topically as creams, lotions and pastes or in an aerosol.
GB2640362A 1962-07-10 1962-07-10 Chromone compounds Expired GB1024645A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2640362A GB1024645A (en) 1962-07-10 1962-07-10 Chromone compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2640362A GB1024645A (en) 1962-07-10 1962-07-10 Chromone compounds

Publications (1)

Publication Number Publication Date
GB1024645A true GB1024645A (en) 1966-03-30

Family

ID=10243098

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2640362A Expired GB1024645A (en) 1962-07-10 1962-07-10 Chromone compounds

Country Status (1)

Country Link
GB (1) GB1024645A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238606A (en) * 1974-11-30 1980-12-09 Fisons Limited Tricyclic mono-chromone-2-carboxylic acids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238606A (en) * 1974-11-30 1980-12-09 Fisons Limited Tricyclic mono-chromone-2-carboxylic acids

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