GB1024495A - N-substituted n-arylsulphonyl ureas and processes for their production - Google Patents

N-substituted n-arylsulphonyl ureas and processes for their production

Info

Publication number
GB1024495A
GB1024495A GB29179/64A GB2917964A GB1024495A GB 1024495 A GB1024495 A GB 1024495A GB 29179/64 A GB29179/64 A GB 29179/64A GB 2917964 A GB2917964 A GB 2917964A GB 1024495 A GB1024495 A GB 1024495A
Authority
GB
United Kingdom
Prior art keywords
amino
substituted
aminoadamantane
adamantyl
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29179/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of GB1024495A publication Critical patent/GB1024495A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:1024495/C2/1> and their salts with inorganic or organic bases, wherein R1 is an amino group and R2 is hydrogen, halogen, CF3 or a C1- 3 alkyl or alkoxy group, and their preparation by reacting a corresponding nitrobenzenesulphonyl isocyanate with 1-aminoadamantane and reducing the N-nitrophenylsulphonyl-N1-adamantyl-urea obtained as product, to form the corresponding amino-derivative, or reacting a reactive functional derivative of a corresponding benzesulphonyl carbamic acid, substituted by an amino, nitro, alkanoylamino or alkoxycarbonylamino radical with 1-aminoadamantane and, if necessary, hydrolysing or reducing the product to convert the substituent to an amino group and, if an N-arylsulphonyl-N1-(1-adamantyl)-guanidine is first obtained, partially hydrolysing to the corresponding urea. Pharmaceutical preparations having hypoglycaemic activity comprise the above compounds of the invention and a carrier.
GB29179/64A 1963-07-16 1964-07-15 N-substituted n-arylsulphonyl ureas and processes for their production Expired GB1024495A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH886163A CH421088A (en) 1963-07-16 1963-07-16 Process for the preparation of new N'-substituted N-arylsulfonylureas

Publications (1)

Publication Number Publication Date
GB1024495A true GB1024495A (en) 1966-03-30

Family

ID=4345580

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29179/64A Expired GB1024495A (en) 1963-07-16 1964-07-15 N-substituted n-arylsulphonyl ureas and processes for their production

Country Status (12)

Country Link
AT (1) AT246741B (en)
BE (1) BE650563A (en)
BR (1) BR6460887D0 (en)
CH (1) CH421088A (en)
DE (1) DE1203764B (en)
DK (1) DK111522B (en)
ES (1) ES302128A1 (en)
FI (1) FI40898B (en)
FR (2) FR1415578A (en)
GB (1) GB1024495A (en)
NL (2) NL6408093A (en)
SE (2) SE301144B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010112946A1 (en) 2009-03-31 2010-10-07 Rudjer Boskovic Institute Adamantane bisurea derivatives, method of preparation and application in anion sensing

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4288454A (en) * 1978-07-24 1981-09-08 Hoffman-La Roche Inc. Antiviral 1-adamantyl-3-(phenylsulfonyl)thioureas

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010112946A1 (en) 2009-03-31 2010-10-07 Rudjer Boskovic Institute Adamantane bisurea derivatives, method of preparation and application in anion sensing

Also Published As

Publication number Publication date
AT246741B (en) 1966-05-10
DE1203764B (en) 1965-10-28
NL125670C (en)
FR4001M (en) 1966-03-14
NL6408093A (en) 1965-01-18
FR1415578A (en) 1965-10-29
SE317371B (en) 1969-11-17
BR6460887D0 (en) 1973-08-02
DK111522B (en) 1968-09-09
CH421088A (en) 1966-09-30
FI40898B (en) 1969-03-31
ES302128A1 (en) 1965-01-16
SE301144B (en) 1968-05-27
BE650563A (en) 1965-01-15

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