GB1018288A - Artificial blood vessels and method of preparing the same - Google Patents

Artificial blood vessels and method of preparing the same

Info

Publication number
GB1018288A
GB1018288A GB49509/63A GB4950963A GB1018288A GB 1018288 A GB1018288 A GB 1018288A GB 49509/63 A GB49509/63 A GB 49509/63A GB 4950963 A GB4950963 A GB 4950963A GB 1018288 A GB1018288 A GB 1018288A
Authority
GB
United Kingdom
Prior art keywords
collagen
tube
anticoagulant
drying
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB49509/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spofa Vereinigte Pharma Werke
Original Assignee
Spofa Vereinigte Pharma Werke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spofa Vereinigte Pharma Werke filed Critical Spofa Vereinigte Pharma Werke
Publication of GB1018288A publication Critical patent/GB1018288A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/062—Apparatus for the production of blood vessels made from natural tissue or with layers of living cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Laminated Bodies (AREA)

Abstract

An artificial blood vessel comprises an outer tubular layer of a porous fabric resistant to resorption by body fluids and an inner tubular layer of collagen, the collagen tube being at least partially tanned and containing an anticoagulant. The collagen tube may contain, as anticoagulant, a mucopolysaccharide (e.g. chondroitin sulphate, hyaluronic acid, heparin, and heparin sulphate), as antibiotic, chlorotetracycline, neomycin and bacitracin, and glycerin. The fabric may be polytetrafluoroethylene or polyethylene glycol terephthalate. The blood vessel may be prepared by extruding a homogeneous gel comprising collagen and aqueous alkaline medium into a tube, drying or partially drying the collagen tube by passing air therethrough, covering the collagen tube with a porous fabric tube, contacting the inner wall of the collagen tube with tanning solution, washing to remove the residual tanning agent, contacting the inner wall of the collagen tube with anticoagulant solution, washing the inner wall and drying. The homogeneous gel may comprise an anticoagulant, an antibiotic and glycerin. A coating of collagen may be applied to the collagen tube before applying the fabric tube thereto. The tanning agents specified include extracts of Chinese gallnuts, oak, pine quebracho, sumach, mimosa and valonia, and Depremol, Bilton, Svitan TK, Kortan A30, degras, elain, chlorolignin, clay mixture and 2, 4, 6-trimethoxytriazine.
GB49509/63A 1963-06-15 1963-12-16 Artificial blood vessels and method of preparing the same Expired GB1018288A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS564463 1963-06-15

Publications (1)

Publication Number Publication Date
GB1018288A true GB1018288A (en) 1966-01-26

Family

ID=5401669

Family Applications (1)

Application Number Title Priority Date Filing Date
GB49509/63A Expired GB1018288A (en) 1963-06-15 1963-12-16 Artificial blood vessels and method of preparing the same

Country Status (6)

Country Link
US (1) US3425418A (en)
BE (1) BE649183A (en)
BR (1) BR6355428D0 (en)
CH (1) CH472219A (en)
DE (1) DE1491218C3 (en)
GB (1) GB1018288A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069156A1 (en) * 1981-07-02 1983-01-12 Intermedicat GmbH Method for the preparation of transplants with higher biological stability
US4416028A (en) * 1981-01-22 1983-11-22 Ingvar Eriksson Blood vessel prosthesis
WO1985004324A1 (en) * 1984-03-31 1985-10-10 Wessex Medical Group Limited Bioprosthetic conduits
EP0169259A1 (en) * 1984-07-25 1986-01-29 Surgical Patent Products Inc. Ltd. Vascular prostheses for dry preservation, method of conditioning and their use in surgery
EP0323144A2 (en) * 1987-12-28 1989-07-05 Vyzkumny Ustav Potravinarskeho Prumyslu Method of manufacturing at least single-layer tubular blood vessel endoprosthesis, especially of a small internal diameter, and extruding nozzle for carrying out this method

Families Citing this family (81)

* Cited by examiner, † Cited by third party
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US3526005A (en) * 1967-06-29 1970-09-01 Gulf General Atomic Inc Method of preparing an intravascular defect by implanting a pyrolytic carbon coated prosthesis
US3688317A (en) * 1970-08-25 1972-09-05 Sutures Inc Vascular prosthetic
US3710777A (en) * 1970-12-23 1973-01-16 C Sparks Method and apparatus for growing graft tubes in place
US3710400A (en) * 1971-08-30 1973-01-16 C Sparks Graft member grown in a living body
US3908657A (en) * 1973-01-15 1975-09-30 Univ Johns Hopkins System for continuous withdrawal of blood
US3974526A (en) * 1973-07-06 1976-08-17 Dardik Irving I Vascular prostheses and process for producing the same
US6436135B1 (en) 1974-10-24 2002-08-20 David Goldfarb Prosthetic vascular graft
US4101984A (en) * 1975-05-09 1978-07-25 Macgregor David C Cardiovascular prosthetic devices and implants with porous systems
US4280954A (en) 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
GB1515963A (en) * 1975-07-15 1978-06-28 Massachusetts Inst Technology Crosslinked collagen-mucopolysaccharide composite materials
JPS5413694A (en) * 1977-07-01 1979-02-01 Sumitomo Electric Industries Composite blood vessel prosthesis and method of producing same
DE2853614A1 (en) * 1978-01-25 1979-07-26 Bentley Lab IMPLANT
AU516741B2 (en) * 1978-05-23 1981-06-18 Bio Nova Neo Technics Pty. Ltd. Vascular prostheses
JPS6037735B2 (en) * 1978-10-18 1985-08-28 住友電気工業株式会社 Artificial blood vessel
SE424401B (en) * 1979-06-06 1982-07-19 Bowald S BLODKERLSPROTES
US4539716A (en) * 1981-03-19 1985-09-10 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4546500A (en) * 1981-05-08 1985-10-15 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
IT1154510B (en) * 1981-08-14 1987-01-21 Bentley Lab CONNECTOR DEVICE IMPLANTABLE IN THE BODY AND DEVICE OF VASCULAR IMPLANTATION ASSOCIATED WITH IT
US4442133A (en) * 1982-02-22 1984-04-10 Greco Ralph S Antibiotic bonding of vascular prostheses and other implants
NL8202894A (en) * 1982-07-16 1984-02-16 Rijksuniversiteit POLYESTER FILAMENT MATERIAL.
US5110852A (en) * 1982-07-16 1992-05-05 Rijksuniversiteit Te Groningen Filament material polylactide mixtures
JPH0631316B2 (en) * 1982-08-04 1994-04-27 ラ ジヨラ キヤンサ− リサ−チ フアンデイシヨン Polypeptide
US4695281A (en) * 1983-03-25 1987-09-22 Koken Co., Ltd. Medical material
EP0128501B1 (en) * 1983-06-06 1989-03-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Artificial vessel and process for preparing the same
US4670286A (en) * 1983-09-20 1987-06-02 Allied Corporation Method of forming prosthetic devices
FR2556210B1 (en) * 1983-12-08 1988-04-15 Barra Jean Aubert VENOUS PROSTHESIS AND PROCESS FOR PRODUCING THE SAME
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US4629458A (en) * 1985-02-26 1986-12-16 Cordis Corporation Reinforcing structure for cardiovascular graft
US4997440A (en) * 1985-04-25 1991-03-05 American Cyanamid Company Vascular graft with absorbable and nonabsorbable components
GB8516421D0 (en) * 1985-06-28 1985-07-31 Biotechnology Interface Ltd Fibronectins
CA1292597C (en) * 1985-12-24 1991-12-03 Koichi Okita Tubular prothesis having a composite structure
DE3608158A1 (en) * 1986-03-12 1987-09-17 Braun Melsungen Ag VESSELED PROSTHESIS IMPREGNATED WITH CROSSLINED GELATINE AND METHOD FOR THE PRODUCTION THEREOF
US5192311A (en) * 1988-04-25 1993-03-09 Angeion Corporation Medical implant and method of making
US4927410A (en) * 1988-11-18 1990-05-22 University Of South Florida Method for fabricating prosthesis material
US5256418A (en) * 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
CS277367B6 (en) * 1990-12-29 1993-01-13 Krajicek Milan Three-layered vascular prosthesis
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US20020055710A1 (en) * 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
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US6129757A (en) 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
US7244272B2 (en) 2000-12-19 2007-07-17 Nicast Ltd. Vascular prosthesis and method for production thereof
US20020084178A1 (en) 2000-12-19 2002-07-04 Nicast Corporation Ltd. Method and apparatus for manufacturing polymer fiber shells via electrospinning
US20070031607A1 (en) * 2000-12-19 2007-02-08 Alexander Dubson Method and apparatus for coating medical implants
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EP3003413B1 (en) * 2013-06-07 2017-12-13 Baxter International Inc. Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups
US9814560B2 (en) 2013-12-05 2017-11-14 W. L. Gore & Associates, Inc. Tapered implantable device and methods for making such devices
CN104027844A (en) * 2014-04-04 2014-09-10 张志辉 Novel method for coating artificial blood vessel with Astragalus polysaccharide
JP6673942B2 (en) 2015-06-05 2020-04-01 ダブリュ．エル．ゴア アンド アソシエイツ，インコーポレイティドＷ．Ｌ． Ｇｏｒｅ ＆ Ａｓｓｏｃｉａｔｅｓ， Ｉｎｃｏｒｐｏｒａｔｅｄ Tapered hypobleeding implantable prosthesis
WO2018007849A1 (en) 2016-07-05 2018-01-11 Carlos Alvarado Serous membrane for ocular surface disorders
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EP3658073A1 (en) 2017-07-28 2020-06-03 Stratasys Ltd. Method and system for fabricating object featuring properties of a blood vessel
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CN110141681B (en) * 2019-05-24 2021-09-10 深圳齐康医疗器械有限公司 Wound repair material for cell suspension transplantation and preparation method thereof

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US3106483A (en) * 1961-07-27 1963-10-08 Us Catheter & Instr Corp Synthetic blood vessel grafts
US3108357A (en) * 1962-06-20 1963-10-29 William J Liebig Compound absorbable prosthetic implants, fabrics and yarns therefor
US3272204A (en) * 1965-09-22 1966-09-13 Ethicon Inc Absorbable collagen prosthetic implant with non-absorbable reinforcing strands

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416028A (en) * 1981-01-22 1983-11-22 Ingvar Eriksson Blood vessel prosthesis
EP0069156A1 (en) * 1981-07-02 1983-01-12 Intermedicat GmbH Method for the preparation of transplants with higher biological stability
WO1985004324A1 (en) * 1984-03-31 1985-10-10 Wessex Medical Group Limited Bioprosthetic conduits
EP0169259A1 (en) * 1984-07-25 1986-01-29 Surgical Patent Products Inc. Ltd. Vascular prostheses for dry preservation, method of conditioning and their use in surgery
EP0323144A2 (en) * 1987-12-28 1989-07-05 Vyzkumny Ustav Potravinarskeho Prumyslu Method of manufacturing at least single-layer tubular blood vessel endoprosthesis, especially of a small internal diameter, and extruding nozzle for carrying out this method
EP0323144A3 (en) * 1987-12-28 1990-05-16 Vyzkumny Ustav Potravinarskeho Prumyslu Method of manufacturing at least single-layer tubular blood vessel endoprosthesis, especially of a small internal diameter, and extruding nozzle for carrying out this method

Also Published As

Publication number Publication date
CH472219A (en) 1969-05-15
DE1491218A1 (en) 1969-04-03
DE1491218B2 (en) 1972-06-08
BE649183A (en) 1964-10-01
DE1491218C3 (en) 1973-01-04
BR6355428D0 (en) 1973-07-19
US3425418A (en) 1969-02-04

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