GB1016961A - New high yielding methods for producing oxytetracycline - Google Patents

New high yielding methods for producing oxytetracycline

Info

Publication number
GB1016961A
GB1016961A GB526363A GB526363A GB1016961A GB 1016961 A GB1016961 A GB 1016961A GB 526363 A GB526363 A GB 526363A GB 526363 A GB526363 A GB 526363A GB 1016961 A GB1016961 A GB 1016961A
Authority
GB
United Kingdom
Prior art keywords
oxytetracycline
sulphate
nutrient medium
new high
ammonium sulphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB526363A
Inventor
Gerardo Fabrizio
Eleuterio Isidori
Giovanni Aurigemma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Priority to GB526363A priority Critical patent/GB1016961A/en
Priority to DK51264A priority patent/DK114893B/en
Priority to ES0296142A priority patent/ES296142A1/en
Priority to NO15186964A priority patent/NO121389B/no
Priority to NL6400925A priority patent/NL6400925A/xx
Priority to DE1964P0033540 priority patent/DE1301004B/en
Priority to LU45372D priority patent/LU45372A1/xx
Priority to FR963073A priority patent/FR1384312A/en
Priority to CH146764A priority patent/CH430053A/en
Priority to AT99564A priority patent/AT256337B/en
Publication of GB1016961A publication Critical patent/GB1016961A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P29/00—Preparation of compounds containing a naphthacene ring system, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Laminated Bodies (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Oxytetracycline is produced by cultivating an oxytetracycline-producing strain of Streptomyces capuensis n.sp., especially strain C.B.S. 113.63, under submerged aerobic conditions in an aqueous nutrient medium containing assimilable sources of carbohydrate, nitrogen and inorganic salts including ammonium sulphate. Preferably, the inoculant is an 8 to 10-hour subculture of the micro-organism. A typical nutrient medium contains starch, corn steep, ammoium sulphate, calcium carbonate, ammonium chloride, cobalt chloride, lard oil and water. Maximum yields are obtained by initially using two-thirds of the total quantity of ammonium sulphate to be used in the culture medium and adding the remaining one-third after 40 to 80 hours of fermentation. The fermented broth is acidified to pH 2.0 and filtered. An alkaline solution such as aqueous sodium hydroxide or ammonia is added to pH 6 to 9 and the precipitated oxytetracycline is separated and may be further purified.
GB526363A 1963-02-08 1963-02-08 New high yielding methods for producing oxytetracycline Expired GB1016961A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GB526363A GB1016961A (en) 1963-02-08 1963-02-08 New high yielding methods for producing oxytetracycline
DK51264A DK114893B (en) 1963-02-08 1964-02-03 Process for the preparation of oxytetracycline or salts thereof.
ES0296142A ES296142A1 (en) 1963-02-08 1964-02-05 New high yielding methods for producing oxytetracycline
NO15186964A NO121389B (en) 1963-02-08 1964-02-05
NL6400925A NL6400925A (en) 1963-02-08 1964-02-05
DE1964P0033540 DE1301004B (en) 1963-02-08 1964-02-06 Process for obtaining high yields of oxytetracycline by means of oxytetracycline-forming streptomycetes
LU45372D LU45372A1 (en) 1963-02-08 1964-02-06
FR963073A FR1384312A (en) 1963-02-08 1964-02-07 Process for the production and recovery of oxytetracycline
CH146764A CH430053A (en) 1963-02-08 1964-02-07 Process for preparing oxytetracycline
AT99564A AT256337B (en) 1963-02-08 1964-02-07 Process for the biological production of oxytetracycline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB526363A GB1016961A (en) 1963-02-08 1963-02-08 New high yielding methods for producing oxytetracycline

Publications (1)

Publication Number Publication Date
GB1016961A true GB1016961A (en) 1966-01-12

Family

ID=9792802

Family Applications (1)

Application Number Title Priority Date Filing Date
GB526363A Expired GB1016961A (en) 1963-02-08 1963-02-08 New high yielding methods for producing oxytetracycline

Country Status (9)

Country Link
AT (1) AT256337B (en)
CH (1) CH430053A (en)
DE (1) DE1301004B (en)
DK (1) DK114893B (en)
ES (1) ES296142A1 (en)
GB (1) GB1016961A (en)
LU (1) LU45372A1 (en)
NL (1) NL6400925A (en)
NO (1) NO121389B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE533886A (en) * 1953-12-04
GB787368A (en) * 1954-12-07 1957-12-04 Bristol Lab Inc Production of tetracycline by fermentation
FR1279456A (en) * 1960-11-10 1961-12-22 Oxytetracycline production process

Also Published As

Publication number Publication date
DE1301004B (en) 1969-08-14
NO121389B (en) 1971-02-22
ES296142A1 (en) 1964-08-16
NL6400925A (en) 1964-08-10
LU45372A1 (en) 1964-04-06
AT256337B (en) 1967-08-10
DK114893B (en) 1969-08-18
DK114893C (en) 1975-04-07
CH430053A (en) 1967-02-15

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