GB1013164A - Processes for the production of 5-ribonucleotides and 2,3-o-alkylidene ribonucleosides - Google Patents
Processes for the production of 5-ribonucleotides and 2,3-o-alkylidene ribonucleosidesInfo
- Publication number
- GB1013164A GB1013164A GB1512263A GB1512263A GB1013164A GB 1013164 A GB1013164 A GB 1013164A GB 1512263 A GB1512263 A GB 1512263A GB 1512263 A GB1512263 A GB 1512263A GB 1013164 A GB1013164 A GB 1013164A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phosphoryl chloride
- hydrolysed
- ketone
- ribonucleosides
- alkylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Ribonucleosides are reacted with phosphoryl chloride or "hydrolysed phosphoryl chloride" in the presence of a ketone. If the mole ratio of ketone to phosphoryl chloride is less than 5, a 21,31 - alkylideneribonucleoside - 51 - phosphorochloridate is formed and this is hydrolysed with water to form the 21,31-O-alkylidene-51-ribonucleotide which is in turn hydrolysed to the 51-ribonucleotide in aqueous acid medium. If the mole ratio of ketone to phosphoryl chloride is greater than 5, a 21,31-O-alkylideneribonucleoside is obtained; if the excess ketone is then removed and further phosphoryl chloride added and optionally a proton acceptor, the product may be phosphorylated and then hydrolysed as in the first embodiment. The "hydrolysed phosphoryl chloride" consists predominantly of orthophosphorodichloridic acid HOPOCl2 and may be obtained by treating POCl3 with water or a lower aliphatic alcohol, e.g. in situ, or by hydrogenation of esters. Excess HCl may be removed during the phosphorylation reaction by passing air or inert gas or by partial neutralization with an organic or inorganic base or a molecular sieve, or a proton acceptor such as an ether may be added. Examples describe the preparation of the sodium salts of 51-inosinic and a guanylic acids and of 21,31 - O - isopropylidene guanosine, inosine, adenosine, cytidine and uridine and 21,31-O-cyclohexylideneinosine. Specification 1,011,994 is referred to.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1537262 | 1962-04-20 | ||
| JP3847462 | 1962-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1013164A true GB1013164A (en) | 1965-12-15 |
Family
ID=26351495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1512263A Expired GB1013164A (en) | 1962-04-20 | 1963-04-17 | Processes for the production of 5-ribonucleotides and 2,3-o-alkylidene ribonucleosides |
Country Status (2)
| Country | Link |
|---|---|
| CH (1) | CH420170A (en) |
| GB (1) | GB1013164A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD384366S (en) | 1996-08-08 | 1997-09-30 | Myron Manufacturing Corporation | Combination ruler and calculator |
-
1963
- 1963-04-17 CH CH480363A patent/CH420170A/en unknown
- 1963-04-17 GB GB1512263A patent/GB1013164A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD384366S (en) | 1996-08-08 | 1997-09-30 | Myron Manufacturing Corporation | Combination ruler and calculator |
Also Published As
| Publication number | Publication date |
|---|---|
| CH420170A (en) | 1966-09-15 |
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