GB1284486A - Process for preparing nucleoside 5'-polyphosphates - Google Patents

Process for preparing nucleoside 5'-polyphosphates

Info

Publication number
GB1284486A
GB1284486A GB823870A GB823870A GB1284486A GB 1284486 A GB1284486 A GB 1284486A GB 823870 A GB823870 A GB 823870A GB 823870 A GB823870 A GB 823870A GB 1284486 A GB1284486 A GB 1284486A
Authority
GB
United Kingdom
Prior art keywords
nucleoside
polyphosphates
prepared
organic amine
phosphoric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB823870A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Publication of GB1284486A publication Critical patent/GB1284486A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

1284486 Nucleoside-5<SP>1</SP>-polyphosphates ASAHI KASEI KOGYO KK 20 Feb 1970 [17 May 1969] 8238/70 Heading C2P A nucleoside-5<SP>1</SP>-polyphosphate is prepared by reacting the corresponding nucleoside-5<SP>1</SP>- phosphorodihalide with phosphoric acid or pyrophosphoric acid or an organic amine salt of one of these acids, in an organic solvent, and hydrolysing the resulting reaction mixture by contacting with water. When phosphoric or pyrophosphoric acid is used, the reaction is preferably carried out in the presence of an organic amine. The nucleoside- 5<SP>1</SP> -phosphoro - dihalide starting materials may be prepared by phosphorylating the corresponding nucleoside in which the 2<SP>1</SP> and 3<SP>1</SP> hydroxy groups are unprotected with a halogenated phosphorus compound. Specified nucleosides are cytidine, adenosine, uridine, guanosine and inosine.
GB823870A 1969-05-17 1970-02-20 Process for preparing nucleoside 5'-polyphosphates Expired GB1284486A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3769569 1969-05-17

Publications (1)

Publication Number Publication Date
GB1284486A true GB1284486A (en) 1972-08-09

Family

ID=12504674

Family Applications (1)

Application Number Title Priority Date Filing Date
GB823870A Expired GB1284486A (en) 1969-05-17 1970-02-20 Process for preparing nucleoside 5'-polyphosphates

Country Status (5)

Country Link
CH (1) CH525909A (en)
DE (1) DE2014440C3 (en)
FR (1) FR2046168A5 (en)
GB (1) GB1284486A (en)
NL (1) NL7002736A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114057813A (en) * 2021-11-30 2022-02-18 新乡拓新药业股份有限公司 Method for synthesizing sodium citicoline

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2909368A1 (en) * 1979-03-09 1980-09-18 Chinoin Gyogyszer Es Vegyeszet Adenosine tri:phosphate metallic complexes - which influence cell metabolism and are used to treat cerebrovascular and cerebroscelerotic troubles, fractures, osteoporosis etc.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114057813A (en) * 2021-11-30 2022-02-18 新乡拓新药业股份有限公司 Method for synthesizing sodium citicoline

Also Published As

Publication number Publication date
NL7002736A (en) 1970-11-19
CH525909A (en) 1972-07-31
FR2046168A5 (en) 1971-03-05
DE2014440A1 (en) 1970-11-26
DE2014440C3 (en) 1975-05-28
DE2014440B2 (en) 1974-09-05

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees