GB1388312A - Antiviral nucleoside 3,5,-cyclic monophosphates - Google Patents

Antiviral nucleoside 3,5,-cyclic monophosphates

Info

Publication number
GB1388312A
GB1388312A GB5055772A GB5055772A GB1388312A GB 1388312 A GB1388312 A GB 1388312A GB 5055772 A GB5055772 A GB 5055772A GB 5055772 A GB5055772 A GB 5055772A GB 1388312 A GB1388312 A GB 1388312A
Authority
GB
United Kingdom
Prior art keywords
reacting
produce
cyclic
beta
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5055772A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeant Pharmaceuticals International Inc USA
Original Assignee
ICN Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICN Pharmaceuticals Inc filed Critical ICN Pharmaceuticals Inc
Priority to GB5055772A priority Critical patent/GB1388312A/en
Publication of GB1388312A publication Critical patent/GB1388312A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1388312 Arabinofuranosyl adenine-3<SP>1</SP>,5<SP>1</SP>- cyclic monophosphate ICN PHARMACEUTICALS Inc 2 Nov 1972 50557/72 Heading C2P The invention comprises 9-beta-D-arabinofuranosyl adenine-3<SP>1</SP>,5<SP>1</SP>-cyclic monophosphate and pharmaceutically acceptable salts thereof which may be prepared by reacting 8-halo- 3<SP>1</SP>,5<SP>1</SP>-cyclic adenosine monophosphate in a basic solution with an appropriate leaving group acid chloride to replace the H in the 2<SP>1</SP>-OH group with a leaving group (LG), either (a) reacting the compound obtained with an acetic acid/sodium acetate solution to produce Z<SP>1</SP>-OLG - 8 - hydroxy - adenosine - 3<SP>1</SP>,5<SP>1</SP> - cyclophosphate and subjecting this to a base catalysed cyclization reaction to produce 8-2<SP>1</SP>-anhydro- 8 - oxy - 9 - beta - D - arabinofuranosyladenine - 3<SP>1</SP>,5<SP>1</SP> - cyclic monophosphate or (b) reacting the compound containing the 2<SP>1</SP>-OLG group with methanolic ammonia to produce the above 8-2<SP>1</SP>-anhydro compound, reacting this with liquid H 2 S to produce 8-mercapto-9-beta- D - arabinofuranosyladenine - 3<SP>1</SP>,5<SP>1</SP> - cyclic monophosphate and finally subjecting this to catalytic reductive desulphurization. The compound of the invention and its pharmaceutically acceptable salts may be used as the active ingredients in conventional antiviral compositions.
GB5055772A 1972-11-02 1972-11-02 Antiviral nucleoside 3,5,-cyclic monophosphates Expired GB1388312A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB5055772A GB1388312A (en) 1972-11-02 1972-11-02 Antiviral nucleoside 3,5,-cyclic monophosphates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5055772A GB1388312A (en) 1972-11-02 1972-11-02 Antiviral nucleoside 3,5,-cyclic monophosphates

Publications (1)

Publication Number Publication Date
GB1388312A true GB1388312A (en) 1975-03-26

Family

ID=10456348

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5055772A Expired GB1388312A (en) 1972-11-02 1972-11-02 Antiviral nucleoside 3,5,-cyclic monophosphates

Country Status (1)

Country Link
GB (1) GB1388312A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107880087A (en) * 2017-12-19 2018-04-06 兰州奥凯化工公司 A kind of synthetic method of purine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107880087A (en) * 2017-12-19 2018-04-06 兰州奥凯化工公司 A kind of synthetic method of purine

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Legal Events

Date Code Title Description
CSNS Application of which complete specification have been accepted and published, but patent is not sealed