GB1012493A - New methyl-oestrenes and process for their manufacture - Google Patents
New methyl-oestrenes and process for their manufactureInfo
- Publication number
- GB1012493A GB1012493A GB4349263A GB4349263A GB1012493A GB 1012493 A GB1012493 A GB 1012493A GB 4349263 A GB4349263 A GB 4349263A GB 4349263 A GB4349263 A GB 4349263A GB 1012493 A GB1012493 A GB 1012493A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- oxo
- oestrene
- hydroxy
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises compounds of the formula <FORM:1012493/C2/1> where R1 represents a free or esterified hydroxyl group and R2 represents a hydrogen atom or a saturated or unsaturated aliphatic hydrocarbon group of up to 7 carbon atoms, or R1 and R2 together represent an oxo group, and a process for the preparation thereof wherein in a compound of the formula <FORM:1012493/C2/2> when R3 represents a thioketal group, the thioketal group is eliminated by a known method and, if desired, a resulting 17a -unsubstituted 17b -hydroxy compound is oxidized to a 17-oxo compound, a 17-oxo compound is reduced by a complex light metal hydride or reacted with a metal derivative of a lower saturated or unsaturated aliphatic hydrocarbon to form a 17b -hydroxy compound, in a resulting compound any unsaturated hydrocarbon radical in the 17a -position is hydrogenated and/or at any stage a resulting 17b -hydroxy compound is converted into an ester or vice-versa. D 4 - 3,3 - Ethylenedithio - 7a - methyl - 17b -acetoxy-oestrene is prepared by reacting ethylene dithiol with D 4 - 3 - oxo - 7a - methyl - 17b -acetoxy-oestrene in the presence of boron trifluoride etherate. D 4 - 3,3 - Ethylenedithio - 7a ,17a - dimethyl-17b -hydroxy-oestrene is prepared by reacting ethylene dithiol with D 4-3-oxo-7a ,17a -dimethyl -17b -hydroxy-oestrene in the presence of boron trifluoride etherate. Therapeutic compositions with anabolic, anti-hypercholesterolenic and ovulation-inhibiting properties, in the form of tablets, dragees, capsules, solutions, suspensions or emulsions for enteral or parenteral application, comprise compounds of the Formula (I) together with a suitable pharmaceutical carrier.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1377562A CH451930A (en) | 1962-11-23 | 1962-11-23 | Process for the preparation of new methylostrenes |
CH172663 | 1963-02-12 | ||
CH695663 | 1963-06-04 | ||
CH792363 | 1963-06-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1012493A true GB1012493A (en) | 1965-12-08 |
Family
ID=27428267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4349263A Expired GB1012493A (en) | 1962-11-23 | 1963-11-04 | New methyl-oestrenes and process for their manufacture |
Country Status (5)
Country | Link |
---|---|
AT (1) | AT271744B (en) |
DE (1) | DE1443619A1 (en) |
DK (1) | DK109866C (en) |
GB (1) | GB1012493A (en) |
SE (1) | SE320662B (en) |
-
1963
- 1963-10-31 DK DK513063A patent/DK109866C/en active
- 1963-11-04 GB GB4349263A patent/GB1012493A/en not_active Expired
- 1963-11-16 DE DE19631443619 patent/DE1443619A1/en active Pending
- 1963-11-21 SE SE1287863A patent/SE320662B/xx unknown
- 1963-11-22 AT AT938163A patent/AT271744B/en active
Also Published As
Publication number | Publication date |
---|---|
DE1443619A1 (en) | 1969-10-23 |
DK109866C (en) | 1968-07-22 |
AT271744B (en) | 1969-06-10 |
SE320662B (en) | 1970-02-16 |
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