GB1002693A - Modification of coli bacilli antibiotic producing micro-organisms - Google Patents

Modification of coli bacilli antibiotic producing micro-organisms

Info

Publication number
GB1002693A
GB1002693A GB7816/62A GB781662A GB1002693A GB 1002693 A GB1002693 A GB 1002693A GB 7816/62 A GB7816/62 A GB 7816/62A GB 781662 A GB781662 A GB 781662A GB 1002693 A GB1002693 A GB 1002693A
Authority
GB
United Kingdom
Prior art keywords
coli
colonies
medium
species
micro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7816/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ILE DE RECH S SCIENT ET IND SO
Original Assignee
ILE DE RECH S SCIENT ET IND SO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR854461A external-priority patent/FR1185M/en
Priority claimed from FR854462A external-priority patent/FR1368714A/en
Priority claimed from FR889204A external-priority patent/FR1852M/en
Application filed by ILE DE RECH S SCIENT ET IND SO filed Critical ILE DE RECH S SCIENT ET IND SO
Priority to FR925517A priority Critical patent/FR3493M/en
Publication of GB1002693A publication Critical patent/GB1002693A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A strain of living non-pathogenic Bacillus soli, particularly suitable for oral administration in the treatment of intestinal disturbances following the administration of antibiotics, is prepared by cultivating Bacillus coli in a liquid nutrient medium in the presence of one or more species of pathogenic micro-organisms consisting of staphylococci, streptococci, Klebsellia, Shigella or Candida albicans (B), incubating a portion of the diluted mixed culture on solid nutrient agar, isolating B. coli from the colonies so formed and separately culturing it in a liquid nutrient medium for a desired period, adding thereto a culture of micro-organism (B) in a liquid nutrient medium, incubating and again transferring a portion of the liquid diluted mixed culture to solid agar, isolating the B. coli from the colonies so formed and repeating the aforesaid steps until the inhibitive power of B. coli is such that the colonies of (B) on nutrient agar do not exceed 10% of the colonies of B. coli. The initial strain of B. coli is a non-pathogenic strain obtained from the stools of a healthy human. The prepared medium for culturing the B. coli is an aqueous medium of pH 7.5 containing serum, vitamin A, vitamin D2, tocopherol, thiamine hydrochloride, vitamin B2, nicotinic amide, sodium pentothenate, pyridoxine, ascorbic acid, sodium monophosphate, sorbitan polyoxyalkylene monolaurate. This medium may be used in conjunction with a medium containing meat extract, pancreatic peptone and sodium chloride in water. The invention may also be used to modify antibiotic-producing streptomyces and antibiotic-producing penicillin (see Division C2). B. coli may be modified by Staphylococcus aureus, Candida albicans or mixtures of Klebsellia and Shigella.ALSO:Strains of living non-pathogenic microorganisms (A) consisting of antibiotic-producing streptomyses or antibiotic producing penicillin which have an adapted and developed antimicrobial activity against one or more strains of pathogenic micro-organisms (B) consisting of staphylococci, streptococci, Klebsellia, Shigella or Candida albicans, are produced by culturing the selected species (A) in a liquid nutrient medium in the presence of the preselected micro-organism(s) (B), incubating a portion of the diluted mixed culture on solid nutrient agar, isolating the species (A) from the colonies so-formed and separately culturing it in a liquid nutrient medium for a desired period, adding thereto a culture of micro-organism(s) (B) in a liquid nutrient medium, incubating and again transferring a portion of the liquid mixed culture to solid nutrient agar, isolating species (A) of the colonies so formed and repeating the aforesaid steps until the inhibitive power of species (A) is such that the colonies of (B) on nutrient agar do not exceed 10% of the colonies of species (A). An example relates to the modification of Streptomyces griseus by culturing in the presence of Staphylococcus aureus.
GB7816/62A 1961-03-03 1962-02-28 Modification of coli bacilli antibiotic producing micro-organisms Expired GB1002693A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR925517A FR3493M (en) 1962-02-28 1963-01-21 Curative medicine for ailments of the digestive system.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR854461A FR1185M (en) 1961-03-03 1961-03-03 Medicinal product based on live non-pathogenic colibacilli.
FR854462A FR1368714A (en) 1961-03-03 1961-03-03 Process for obtaining a culture of live non-pathogenic colibacilli
FR889204A FR1852M (en) 1962-02-26 1962-02-26 Specific antibiotic drug based on live non-pathogenic colibacilli.
FR889179 1962-02-26

Publications (1)

Publication Number Publication Date
GB1002693A true GB1002693A (en) 1965-08-25

Family

ID=27445282

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7816/62A Expired GB1002693A (en) 1961-03-03 1962-02-28 Modification of coli bacilli antibiotic producing micro-organisms

Country Status (3)

Country Link
BE (1) BE614583A (en)
DE (1) DE1442150A1 (en)
GB (1) GB1002693A (en)

Also Published As

Publication number Publication date
DE1442150A1 (en) 1969-05-08
BE614583A (en) 1962-07-02

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