ES453507A1 - N-acetyl thienamycin - Google Patents
N-acetyl thienamycinInfo
- Publication number
- ES453507A1 ES453507A1 ES453507A ES453507A ES453507A1 ES 453507 A1 ES453507 A1 ES 453507A1 ES 453507 A ES453507 A ES 453507A ES 453507 A ES453507 A ES 453507A ES 453507 A1 ES453507 A1 ES 453507A1
- Authority
- ES
- Spain
- Prior art keywords
- acetylthienamycin
- well
- salts
- inorganic
- active against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The microorganism Streptomyces cattleya, preferably the strain NRRL 8057, is cultivated under submerged aerobic conditions in an aqueous nutrient medium containing assimilable C and N sources as well as inorganic salts. N-Acetylthienamycin is obtained. Non-toxic, pharmaceutically acceptable salts of N-acetylthienamycin can be obtained by reaction with inorganic or organic bases. N-acetylthienamycin and its salts show remarkable antibiotic properties and are active against a wide range of pathogens as well as against resistant strains of particular microorganisms. The antibiotic is active against Gram-positive and -negative bacteria and is suitable for use in human and veterinary medicine and as antibacterial agent for commercial and industrial purposes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63430175A | 1975-11-21 | 1975-11-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES453507A1 true ES453507A1 (en) | 1977-11-16 |
Family
ID=24543237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES453507A Expired ES453507A1 (en) | 1975-11-21 | 1976-11-19 | N-acetyl thienamycin |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5265294A (en) |
| AR (1) | AR214305A1 (en) |
| AU (1) | AU514309B2 (en) |
| BE (1) | BE848346A (en) |
| CH (1) | CH630118A5 (en) |
| DE (1) | DE2652681C2 (en) |
| DK (1) | DK143713C (en) |
| ES (1) | ES453507A1 (en) |
| FR (1) | FR2332018A1 (en) |
| GB (1) | GB1561107A (en) |
| GR (1) | GR60782B (en) |
| HU (1) | HU175265B (en) |
| NL (1) | NL186867C (en) |
| PT (1) | PT65844B (en) |
| SE (1) | SE432780B (en) |
| ZA (1) | ZA766940B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2808563A1 (en) * | 1977-03-05 | 1978-09-07 | Beecham Group Ltd | DERIVATIVES OF 3-THIO-6- (1-HYDROXYAETHYL) -7-OXO-1-AZA-BICYCLO SQUARE CLAMP ON 3.2.0 SQUARE CLAMP FOR HEPT-2-EN-2-CARBONIC ACID, PROCESS FOR THEIR PRODUCTION AND CONTAINING THESE COMPOUNDS DRUG |
| US4162323A (en) * | 1977-04-18 | 1979-07-24 | Merck & Co., Inc. | Antibiotic N-acetyl-dehydro-thienamycin |
| NZ190994A (en) | 1978-07-24 | 1981-10-19 | Merck & Co Inc | Z-2-acylamino-3-monosubstituted propenoates |
-
1976
- 1976-11-03 DK DK497276A patent/DK143713C/en not_active IP Right Cessation
- 1976-11-04 SE SE7612294A patent/SE432780B/en not_active IP Right Cessation
- 1976-11-15 AU AU19646/76A patent/AU514309B2/en not_active Expired
- 1976-11-16 PT PT65844A patent/PT65844B/en unknown
- 1976-11-16 BE BE172360A patent/BE848346A/en not_active IP Right Cessation
- 1976-11-18 HU HU76ME2030A patent/HU175265B/en unknown
- 1976-11-18 AR AR265525A patent/AR214305A1/en active
- 1976-11-19 NL NLAANVRAGE7612931,A patent/NL186867C/en not_active IP Right Cessation
- 1976-11-19 CH CH1459876A patent/CH630118A5/en not_active IP Right Cessation
- 1976-11-19 FR FR7634888A patent/FR2332018A1/en active Granted
- 1976-11-19 GB GB48232/76A patent/GB1561107A/en not_active Expired
- 1976-11-19 ZA ZA00766940A patent/ZA766940B/en unknown
- 1976-11-19 DE DE2652681A patent/DE2652681C2/en not_active Expired
- 1976-11-19 ES ES453507A patent/ES453507A1/en not_active Expired
- 1976-11-20 GR GR52222A patent/GR60782B/en unknown
- 1976-11-22 JP JP51139655A patent/JPS5265294A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| AU514309B2 (en) | 1981-02-05 |
| ZA766940B (en) | 1978-06-28 |
| DK143713C (en) | 1982-03-08 |
| DK143713B (en) | 1981-09-28 |
| SE432780B (en) | 1984-04-16 |
| DK497276A (en) | 1977-05-22 |
| HU175265B (en) | 1980-06-28 |
| AU1964676A (en) | 1978-05-25 |
| CH630118A5 (en) | 1982-05-28 |
| DE2652681A1 (en) | 1977-06-02 |
| PT65844B (en) | 1978-10-10 |
| NL186867B (en) | 1990-10-16 |
| NL7612931A (en) | 1977-05-24 |
| GB1561107A (en) | 1980-02-13 |
| AR214305A1 (en) | 1979-05-31 |
| SE7612294L (en) | 1977-05-22 |
| NL186867C (en) | 1991-03-18 |
| BE848346A (en) | 1977-05-16 |
| JPS6210640B2 (en) | 1987-03-07 |
| GR60782B (en) | 1978-08-28 |
| FR2332018B1 (en) | 1979-09-28 |
| FR2332018A1 (en) | 1977-06-17 |
| PT65844A (en) | 1976-12-01 |
| DE2652681C2 (en) | 1985-04-25 |
| JPS5265294A (en) | 1977-05-30 |
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