GB1002665A - Improvements in or relating to muscle relaxant and analgesic compositions - Google Patents

Improvements in or relating to muscle relaxant and analgesic compositions

Info

Publication number
GB1002665A
GB1002665A GB2920063A GB2920063A GB1002665A GB 1002665 A GB1002665 A GB 1002665A GB 2920063 A GB2920063 A GB 2920063A GB 2920063 A GB2920063 A GB 2920063A GB 1002665 A GB1002665 A GB 1002665A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
lower alkyl
amino
halogen
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2920063A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of GB1002665A publication Critical patent/GB1002665A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises carbostyril compounds of the general formula <FORM:1002665/C2/1> wherein Y is -CH=CH- or -CH2-CH2-; X is oxygen or sulphur and R2 is lower alkyl, or, when Y is -CH2-CH2-, hydrogen. Compounds of the above general formula, may be prepared by the reaction schemes outlined below <FORM:1002665/C2/2> R represents trifluoromethyl, R1 is hydrogen, and X is an anion. The term "lower" refers to groups having 1 to 4 carbon atoms. The N-oxide of 6-trifluoromethylquinoline is prepared by action of hydrogen peroxide on quinoline and then treated with acetic anhydride before hydrogenation to give 3,4-dihydro-6-trifluoromethylcarbostyril.ALSO:Pharmaceutical compositions having muscle relaxant and analgesic activity comprise a pharmaceutical carrier in association with a carbostyril compound <FORM:1002665/A5-A6/1> wherein Y is -CH = CH- or -CH2-CH2-; X is O or S; R is hydrogen, halogen, hydroxy, nitro, amino, mono-lower alkyl amino, di-lower alkyl amino, acetamido, trifluoromethyl, lower alkyl, lower alkoxy or ethoxycarbonyl; R1 is hydrogen or, together with R, dihalogen, dihydroxy, diloweralkoxy or methylene-dioxy; and R2 is lower alkyl or, when R is -CH2-CH2-, hydrogen. "Lower" refers to groups having 1 to 4 carbon atoms and "halogen" denotes chlorine, bromine or fluorine. Conventional solid or liquid carriers may be used, together with a sustained release material. The compositions may be used in the forms of a tablet, capsule, troche or lozenge, and their administration may be effected parenterally or orally.
GB2920063A 1962-08-08 1963-07-23 Improvements in or relating to muscle relaxant and analgesic compositions Expired GB1002665A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21552362A 1962-08-08 1962-08-08

Publications (1)

Publication Number Publication Date
GB1002665A true GB1002665A (en) 1965-08-25

Family

ID=22803314

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2920063A Expired GB1002665A (en) 1962-08-08 1963-07-23 Improvements in or relating to muscle relaxant and analgesic compositions

Country Status (5)

Country Link
BE (1) BE634894A (en)
CH (1) CH411885A (en)
DE (1) DE1470250A1 (en)
DK (1) DK105646C (en)
GB (1) GB1002665A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462438A (en) * 1967-10-16 1969-08-19 Smithkline Corp 1,2,2alpha,8beta-tetrahydrocyclobuta(c) quinolines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462438A (en) * 1967-10-16 1969-08-19 Smithkline Corp 1,2,2alpha,8beta-tetrahydrocyclobuta(c) quinolines

Also Published As

Publication number Publication date
DK105646C (en) 1966-10-24
BE634894A (en) 1964-01-13
DE1470250A1 (en) 1969-05-29
CH411885A (en) 1966-04-30

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