GB0127140D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
GB0127140D0
GB0127140D0 GBGB0127140.2A GB0127140A GB0127140D0 GB 0127140 D0 GB0127140 D0 GB 0127140D0 GB 0127140 A GB0127140 A GB 0127140A GB 0127140 D0 GB0127140 D0 GB 0127140D0
Authority
GB
United Kingdom
Prior art keywords
novel compounds
novel
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0127140.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to GBGB0127140.2A priority Critical patent/GB0127140D0/en
Publication of GB0127140D0 publication Critical patent/GB0127140D0/en
Priority to JP2003544054A priority patent/JP2005513020A/ja
Priority to PCT/EP2002/012506 priority patent/WO2003042218A1/en
Priority to EP02787608A priority patent/EP1442043A1/en
Priority to US10/495,025 priority patent/US20050033052A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
GBGB0127140.2A 2001-11-10 2001-11-10 Novel compounds Ceased GB0127140D0 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GBGB0127140.2A GB0127140D0 (en) 2001-11-10 2001-11-10 Novel compounds
JP2003544054A JP2005513020A (ja) 2001-11-10 2002-11-08 新規化合物
PCT/EP2002/012506 WO2003042218A1 (en) 2001-11-10 2002-11-08 Novel compounds
EP02787608A EP1442043A1 (en) 2001-11-10 2002-11-08 Condensed pyrimidone derivatives as lp-pla2 inhibitors for the treatment of atherosclerosis
US10/495,025 US20050033052A1 (en) 2001-11-10 2002-11-08 Novel compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0127140.2A GB0127140D0 (en) 2001-11-10 2001-11-10 Novel compounds

Publications (1)

Publication Number Publication Date
GB0127140D0 true GB0127140D0 (en) 2002-01-02

Family

ID=9925626

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0127140.2A Ceased GB0127140D0 (en) 2001-11-10 2001-11-10 Novel compounds

Country Status (5)

Country Link
US (1) US20050033052A1 (enExample)
EP (1) EP1442043A1 (enExample)
JP (1) JP2005513020A (enExample)
GB (1) GB0127140D0 (enExample)
WO (1) WO2003042218A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8962633B2 (en) 2007-05-11 2015-02-24 Thomas Jefferson University Methods of treatment and prevention of metabolic bone diseases and disorders
AU2014200542B2 (en) * 2007-05-11 2016-08-25 Rowan University Methods of treatment and prevention of neurodegenerative diseases and disorders
JP5277243B2 (ja) * 2007-05-11 2013-08-28 トーマス・ジェファーソン・ユニバーシティ 神経変性疾患および障害を治療および阻止する方法
JP5437996B2 (ja) 2007-05-11 2014-03-12 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 皮膚潰瘍の治療方法
EA025527B1 (ru) * 2007-05-11 2017-01-30 Томас Джефферсон Юниверсити Способы лечения и предупреждения нейродегенеративных заболеваний и нарушений
US9011821B2 (en) 2010-06-18 2015-04-21 Whitehead Institute For Biomedical Research PLA2G16 as a target for antiviral compounds
CN103347864B (zh) 2010-12-06 2016-08-10 葛兰素集团有限公司 用于治疗由Lp-PLA2介导的疾病或病症的嘧啶酮化合物
ES2847883T3 (es) 2010-12-17 2021-08-04 Glaxo Group Ltd Uso de inhibidores de LP-PLA2 en el tratamiento y prevención de enfermedades oculares
US20130030012A1 (en) 2011-07-27 2013-01-31 Glaxo Group Limited Compounds
JP2014521611A (ja) 2011-07-27 2014-08-28 グラクソ グループ リミテッド Ｌｐ−ＰＬＡ２阻害剤としての２，３−ジヒドロイミダゾ［１，２−ｃ］ピリミジン−５（１Ｈ）−オン化合物の使用
US9296755B2 (en) 2013-01-25 2016-03-29 Glaxosmithkline Intellectual Property Development Limited 3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one compounds and their therapeutic applications
KR20150108896A (ko) 2013-01-25 2015-09-30 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Lp-pla2의 억제제로서의 비시클릭 피리미돈 화합물
MX2015009633A (es) 2013-01-25 2015-11-30 Glaxosmithkline Ip Dev Ltd Inhibidores de fosfolipasa a2 asociada con lipoproteinas basados en 2,3-dihidroimidazol[1,2-c] pirimidin-5(1h)-ona.
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN111825695B (zh) * 2019-04-15 2022-04-12 中国科学院上海药物研究所 噁唑烷酮类化合物、其制备方法、用途及其药物组合物
CN112778331B (zh) 2019-11-09 2022-07-05 上海赛默罗生物科技有限公司 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0108396B1 (pt) * 2000-02-16 2015-05-19 Smithkline Beecham Plc Derivados de pirimidina-4-ona como inibidores de ldl-pla2
GB0024807D0 (en) * 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
GB0024808D0 (en) * 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
US20050033052A1 (en) 2005-02-10
JP2005513020A (ja) 2005-05-12
WO2003042218A1 (en) 2003-05-22
EP1442043A1 (en) 2004-08-04

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)