FR3094636B1 - Composition pharmaceutique à usage topique comprenant au moins une substance antifongique locale azolée - Google Patents

Composition pharmaceutique à usage topique comprenant au moins une substance antifongique locale azolée Download PDF

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Publication number
FR3094636B1
FR3094636B1 FR1903677A FR1903677A FR3094636B1 FR 3094636 B1 FR3094636 B1 FR 3094636B1 FR 1903677 A FR1903677 A FR 1903677A FR 1903677 A FR1903677 A FR 1903677A FR 3094636 B1 FR3094636 B1 FR 3094636B1
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FR
France
Prior art keywords
mass
local
pharmaceutical composition
topical use
azole antifungal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1903677A
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English (en)
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FR3094636A1 (fr
Inventor
Catherine Bulcourt
Alice Denis
Séverine Sigurani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
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Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
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Application filed by Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA filed Critical Societe dExploitation de Produits pour les Industries Chimiques SEPPIC SA
Priority to FR1903677A priority Critical patent/FR3094636B1/fr
Priority to PCT/EP2020/059300 priority patent/WO2020201378A1/fr
Priority to JP2021557523A priority patent/JP2022527463A/ja
Priority to US17/601,325 priority patent/US20220193037A1/en
Priority to EP20713933.8A priority patent/EP3946323A1/fr
Priority to CN202080029799.0A priority patent/CN113727709A/zh
Publication of FR3094636A1 publication Critical patent/FR3094636A1/fr
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Publication of FR3094636B1 publication Critical patent/FR3094636B1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Abstract

Composition pharmaceutique à usage topique se présentant sous la forme d’une émulsion de type eau dans huile comprenant pour 100% de sa masse : de 0,3% à 5% massique d’au moins une substance antifongique locale azolée; de 60 à 90% massique d’une phase aqueuse gélifiée (A1) de 9,7 % à 35% massique d’une phase grasse (A2) comprenant au moins une huile et un système émulsionnant comprenant une combinaison d’au moins un agent tensioactif émulsionnant (S1) sélectionné parmi les éléments du groupe constitué par les compositions d’alkylpolyglycosides, les compositions d’alkylpolyglycosides et d’alcools gras, et d’au moins un agent tensioactif émulsionnant (S2) sélectionné parmi les éléments du groupe constitué par les esters de polyglycérols, les esters de polyglycérols alcoxylés, les polyhydroxystéarates de polyglycols, les polyhydroxystéarates de polyglycérols, les polyhydroxystéarates de polyglycérols alcoxylés.
FR1903677A 2019-04-05 2019-04-05 Composition pharmaceutique à usage topique comprenant au moins une substance antifongique locale azolée Active FR3094636B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR1903677A FR3094636B1 (fr) 2019-04-05 2019-04-05 Composition pharmaceutique à usage topique comprenant au moins une substance antifongique locale azolée
PCT/EP2020/059300 WO2020201378A1 (fr) 2019-04-05 2020-04-01 Composition pharmaceutique a usage topique comprenant au moins une substance antifongique locale azolee
JP2021557523A JP2022527463A (ja) 2019-04-05 2020-04-01 少なくとも１種のアゾール化局所用抗真菌物質を含む局所使用のための医薬組成物
US17/601,325 US20220193037A1 (en) 2019-04-05 2020-04-01 Pharmaceutical composition for topical use comprising at least one azolated local antifungal substance
EP20713933.8A EP3946323A1 (fr) 2019-04-05 2020-04-01 Composition pharmaceutique a usage topique comprenant au moins une substance antifongique locale azolee
CN202080029799.0A CN113727709A (zh) 2019-04-05 2020-04-01 包含至少一种局部唑抗真菌物质的用于局部使用的药物组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1903677A FR3094636B1 (fr) 2019-04-05 2019-04-05 Composition pharmaceutique à usage topique comprenant au moins une substance antifongique locale azolée
FR1903677 2019-04-05

Publications (2)

Publication Number Publication Date
FR3094636A1 FR3094636A1 (fr) 2020-10-09
FR3094636B1 true FR3094636B1 (fr) 2022-07-29

Family

ID=67384065

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1903677A Active FR3094636B1 (fr) 2019-04-05 2019-04-05 Composition pharmaceutique à usage topique comprenant au moins une substance antifongique locale azolée

Country Status (6)

Country Link
US (1) US20220193037A1 (fr)
EP (1) EP3946323A1 (fr)
JP (1) JP2022527463A (fr)
CN (1) CN113727709A (fr)
FR (1) FR3094636B1 (fr)
WO (1) WO2020201378A1 (fr)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2721607B1 (fr) 1994-06-28 1996-10-31 Seppic Sa Nouveaux dérivés d'ammoniums quaternaires, leur procédé de préparation et leur utilisation comme agents de surface.
US20070292355A1 (en) * 2002-10-25 2007-12-20 Foamix Ltd. Anti-infection augmentation foamable compositions and kit and uses thereof
CN101267804A (zh) * 2003-12-16 2008-09-17 弗米克斯有限公司 含油的药物和化妆品泡沫
US9616011B2 (en) * 2005-04-27 2017-04-11 The Procter & Gamble Company Personal care compositions
EA200870153A1 (ru) * 2006-01-05 2008-12-30 Драгтек Корпорейшн Композиция и способ ее использования
FR2912651A1 (fr) 2007-02-21 2008-08-22 Oreal Emulsion e/h pour le soin de la peau.
FR3004454B1 (fr) * 2013-04-12 2015-03-27 Seppic Sa Nouvelles emulsions eau-dans-huile a forte teneur en phase aqueuse, de consistances liquides et stables au stockage
FR3034988B1 (fr) * 2015-04-20 2017-03-31 Soc D'exploitation De Produits Pour Les Ind Chimiques Seppic Nouvelles emulsions cosmetiques se presentant sous la forme de mousse, procede pour leur obtention et leur utilisation en cosmetique
BR112018075998A2 (pt) * 2016-06-13 2019-04-02 Vyome Therapeutics Limited. composições antifúngicas sinérgicas e métodos das mesmas
WO2017216722A2 (fr) * 2016-06-13 2017-12-21 Vyome Biosciences Pvt. Ltd. Compositions antifongiques synergiques et leurs procédés

Also Published As

Publication number Publication date
FR3094636A1 (fr) 2020-10-09
JP2022527463A (ja) 2022-06-02
WO2020201378A1 (fr) 2020-10-08
US20220193037A1 (en) 2022-06-23
EP3946323A1 (fr) 2022-02-09
CN113727709A (zh) 2021-11-30

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