FR3087793B1 - Utilisation d'un oeuf greffe avec des cellules tumorales pour etudier l'efficacite anti-cancereuse d'immunotherapies, en l'absence de cellules effectrices immunitaires autres que celles de l'oeuf greffe - Google Patents

Utilisation d'un oeuf greffe avec des cellules tumorales pour etudier l'efficacite anti-cancereuse d'immunotherapies, en l'absence de cellules effectrices immunitaires autres que celles de l'oeuf greffe Download PDF

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Publication number
FR3087793B1
FR3087793B1 FR1860000A FR1860000A FR3087793B1 FR 3087793 B1 FR3087793 B1 FR 3087793B1 FR 1860000 A FR1860000 A FR 1860000A FR 1860000 A FR1860000 A FR 1860000A FR 3087793 B1 FR3087793 B1 FR 3087793B1
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transplated
egg
cells
immunotherapies
study
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FR1860000A
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English (en)
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FR3087793A1 (fr
Inventor
Xavier Rousset
Emilien Dosda
Jean Viallet
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Inovotion
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Inovotion
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Priority to FR1860000A priority Critical patent/FR3087793B1/fr
Application filed by Inovotion filed Critical Inovotion
Priority to PCT/FR2019/052572 priority patent/WO2020089561A1/fr
Priority to CA3118201A priority patent/CA3118201A1/fr
Priority to EP19816378.4A priority patent/EP3874028A1/fr
Priority to US17/289,198 priority patent/US20210337775A1/en
Priority to KR1020217016226A priority patent/KR20210104681A/ko
Priority to CN201980083375.XA priority patent/CN113195708A/zh
Publication of FR3087793A1 publication Critical patent/FR3087793A1/fr
Priority to ZA2021/03634A priority patent/ZA202103634B/en
Application granted granted Critical
Publication of FR3087793B1 publication Critical patent/FR3087793B1/fr
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/465—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from birds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
FR1860000A 2018-10-29 2018-10-29 Utilisation d'un oeuf greffe avec des cellules tumorales pour etudier l'efficacite anti-cancereuse d'immunotherapies, en l'absence de cellules effectrices immunitaires autres que celles de l'oeuf greffe Active FR3087793B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR1860000A FR3087793B1 (fr) 2018-10-29 2018-10-29 Utilisation d'un oeuf greffe avec des cellules tumorales pour etudier l'efficacite anti-cancereuse d'immunotherapies, en l'absence de cellules effectrices immunitaires autres que celles de l'oeuf greffe
CA3118201A CA3118201A1 (fr) 2018-10-29 2019-10-29 Utilisation d'un oeuf greffe avec des cellules tumorales pour etudier l'efficacite anti-cancereuse d'immunotherapies, en l'absence de cellules effectrices immunitaires autres que celles de l'oeuf greffe
EP19816378.4A EP3874028A1 (fr) 2018-10-29 2019-10-29 Utilisation d'un oeuf greffe avec des cellules tumorales pour etudier l'efficacite anti-cancereuse d'immunotherapies, en l'absence de cellules effectrices immunitaires autres que celles de l'oeuf greffe
US17/289,198 US20210337775A1 (en) 2018-10-29 2019-10-29 Use of an egg grafted with tumor cells in order to study the anti-cancer effectiveness of immune therapies in the absence of immune effector cells other than those in the grafted egg
PCT/FR2019/052572 WO2020089561A1 (fr) 2018-10-29 2019-10-29 Utilisation d'un oeuf greffe avec des cellules tumorales pour etudier l'efficacite anti-cancereuse d'immunotherapies, en l'absence de cellules effectrices immunitaires autres que celles de l'oeuf greffe
KR1020217016226A KR20210104681A (ko) 2018-10-29 2019-10-29 그래프트된 알의 면역 효과기 세포 이외의 면역 효과기 세포의 부재 하에 면역요법의 항암 유효성을 연구하기 위해 종양 세포로 그래프트된 알의 용도
CN201980083375.XA CN113195708A (zh) 2018-10-29 2019-10-29 移植了肿瘤细胞的卵用于不存在除移植卵中的免疫效应细胞以外的免疫效应细胞时研究免疫疗法的抗癌有效性的用途
ZA2021/03634A ZA202103634B (en) 2018-10-29 2021-05-27 Use of an egg grafted with tumor cells in order to study the anti-cancer effectiveness of immune therapies in the absence of immune effector cells other than those in the grafted egg

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1860000A FR3087793B1 (fr) 2018-10-29 2018-10-29 Utilisation d'un oeuf greffe avec des cellules tumorales pour etudier l'efficacite anti-cancereuse d'immunotherapies, en l'absence de cellules effectrices immunitaires autres que celles de l'oeuf greffe

Publications (2)

Publication Number Publication Date
FR3087793A1 FR3087793A1 (fr) 2020-05-01
FR3087793B1 true FR3087793B1 (fr) 2022-10-07

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ID=65494384

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1860000A Active FR3087793B1 (fr) 2018-10-29 2018-10-29 Utilisation d'un oeuf greffe avec des cellules tumorales pour etudier l'efficacite anti-cancereuse d'immunotherapies, en l'absence de cellules effectrices immunitaires autres que celles de l'oeuf greffe

Country Status (8)

Country Link
US (1) US20210337775A1 (fr)
EP (1) EP3874028A1 (fr)
KR (1) KR20210104681A (fr)
CN (1) CN113195708A (fr)
CA (1) CA3118201A1 (fr)
FR (1) FR3087793B1 (fr)
WO (1) WO2020089561A1 (fr)
ZA (1) ZA202103634B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021176455A1 (fr) * 2020-03-05 2021-09-10 Ichilov Tech Ltd. Méthodes de criblage in ovo de thérapies anticancéreuses
CN111593018A (zh) * 2020-05-20 2020-08-28 任宏政 基于鸡胚绒毛膜尿膜囊的肿瘤适时药物精确治疗模型

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006001021A2 (fr) * 2004-06-28 2006-01-05 Bar-Ilan University Systeme de criblage fonctionnant sur la base d'elements aviaires chimeres contenant des greffes mammiferes
CN101073578A (zh) * 2006-05-20 2007-11-21 于廷曦 用于制备抗血管生成、抗肿瘤侵袭和转移药物的土贝母苷乙
WO2017079646A1 (fr) * 2015-11-05 2017-05-11 Baylor College Of Medicine Système de xénogreffe efficace, modulable dérivé du patient basé sur une • membrane chorioallantoïque de poussin (cam) dans un modèle in vivo

Also Published As

Publication number Publication date
FR3087793A1 (fr) 2020-05-01
CN113195708A (zh) 2021-07-30
EP3874028A1 (fr) 2021-09-08
ZA202103634B (en) 2022-10-26
KR20210104681A (ko) 2021-08-25
WO2020089561A1 (fr) 2020-05-07
CA3118201A1 (fr) 2020-05-07
US20210337775A1 (en) 2021-11-04

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