FR3085679B1 - Composes analogues de la squalamine et leur utilisation medicale - Google Patents

Composes analogues de la squalamine et leur utilisation medicale Download PDF

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Publication number
FR3085679B1
FR3085679B1 FR1858080A FR1858080A FR3085679B1 FR 3085679 B1 FR3085679 B1 FR 3085679B1 FR 1858080 A FR1858080 A FR 1858080A FR 1858080 A FR1858080 A FR 1858080A FR 3085679 B1 FR3085679 B1 FR 3085679B1
Authority
FR
France
Prior art keywords
squalamine
treatment
medical use
similar compounds
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1858080A
Other languages
English (en)
Other versions
FR3085679A1 (fr
Inventor
Olivier Blin
Jean Louis Kraus
Didier Raoult
Jean Michel Brunel
Jean-Marc Rolain
Adele Sakr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Assistance Publique Hopitaux de Marseille APHM
Institut Jean Paoli and Irene Calmettes
Original Assignee
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Institut National de la Sante et de la Recherche Medicale INSERM
Assistance Publique Hopitaux de Marseille APHM
Institut Jean Paoli and Irene Calmettes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aix Marseille Universite, Centre National de la Recherche Scientifique CNRS, Institut National de la Sante et de la Recherche Medicale INSERM, Assistance Publique Hopitaux de Marseille APHM, Institut Jean Paoli and Irene Calmettes filed Critical Aix Marseille Universite
Priority to FR1858080A priority Critical patent/FR3085679B1/fr
Priority to PCT/FR2019/052064 priority patent/WO2020053509A1/fr
Publication of FR3085679A1 publication Critical patent/FR3085679A1/fr
Application granted granted Critical
Publication of FR3085679B1 publication Critical patent/FR3085679B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne une famille de composés analogues de la squalamine pour leur utilisation comme médicament, en particulier pour le traitement ou la prévention d'infections mycobactériennes, notamment de la tuberculose. La présente invention a également pour objet de nouveaux composés analogues de la squalamine et leur utilisation comme médicament, notamment pour le traitement ou la prévention d'infections bactériennes, fongiques, virales, parasitaires ou dans le traitement du cancer chez l'homme ou l'animal, ainsi que des compositions pharmaceutiques ou vétérinaires les comprenant. L'invention concerne enfin l'utilisation de ces nouveaux composés comme agents désinfectant et/ou décontaminant.
FR1858080A 2018-09-10 2018-09-10 Composes analogues de la squalamine et leur utilisation medicale Expired - Fee Related FR3085679B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR1858080A FR3085679B1 (fr) 2018-09-10 2018-09-10 Composes analogues de la squalamine et leur utilisation medicale
PCT/FR2019/052064 WO2020053509A1 (fr) 2018-09-10 2019-09-09 Composes analogues de la squalamine et leur utilisation medicale

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1858080A FR3085679B1 (fr) 2018-09-10 2018-09-10 Composes analogues de la squalamine et leur utilisation medicale
FR1858080 2018-09-10

Publications (2)

Publication Number Publication Date
FR3085679A1 FR3085679A1 (fr) 2020-03-13
FR3085679B1 true FR3085679B1 (fr) 2020-09-11

Family

ID=65201336

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1858080A Expired - Fee Related FR3085679B1 (fr) 2018-09-10 2018-09-10 Composes analogues de la squalamine et leur utilisation medicale

Country Status (2)

Country Link
FR (1) FR3085679B1 (fr)
WO (1) WO2020053509A1 (fr)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2953138B1 (fr) 2009-12-02 2015-10-16 Assist Publ Hopitaux Marseille Composes aminosteroidiens pour une application topique locale pour la decolonisation cutaneo-muqueuse de staphylococcus aureus
FR2985668B1 (fr) 2012-01-12 2014-06-27 Assist Publ Hopitaux Marseille Utilisation de squalamine ou analogue comme agent desinfectant
FR3033563B1 (fr) 2015-03-12 2018-04-13 Virbac Composes analogues de la squalamine utiles comme agents antibacteriens

Also Published As

Publication number Publication date
WO2020053509A1 (fr) 2020-03-19
FR3085679A1 (fr) 2020-03-13

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Year of fee payment: 2

PLSC Publication of the preliminary search report

Effective date: 20200313

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Year of fee payment: 3

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Effective date: 20220505