FR3032203B1 - Procede pour induire des recombinaisons meiotiques ciblees - Google Patents

Procede pour induire des recombinaisons meiotiques ciblees Download PDF

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Publication number
FR3032203B1
FR3032203B1 FR1550707A FR1550707A FR3032203B1 FR 3032203 B1 FR3032203 B1 FR 3032203B1 FR 1550707 A FR1550707 A FR 1550707A FR 1550707 A FR1550707 A FR 1550707A FR 3032203 B1 FR3032203 B1 FR 3032203B1
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FR
France
Prior art keywords
inducing target
meiotic recombinations
recombinations
meiotic
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1550707A
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English (en)
Other versions
FR3032203A1 (fr
Inventor
Giacomo Bastianelli
Alexandre Serero
Alain Nicolas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut Curie
Sorbonne Universite
Meiogenix SAS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Pierre et Marie Curie Paris 6
Institut Curie
Meiogenix SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1550707A priority Critical patent/FR3032203B1/fr
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Pierre et Marie Curie Paris 6, Institut Curie, Meiogenix SAS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to PCT/EP2016/052000 priority patent/WO2016120480A1/fr
Priority to ES16703283T priority patent/ES2894882T3/es
Priority to CA2974681A priority patent/CA2974681A1/fr
Priority to BR112017016045-5A priority patent/BR112017016045A2/pt
Priority to EP16703283.8A priority patent/EP3250688B1/fr
Priority to EP20205199.1A priority patent/EP3798302A1/fr
Priority to US15/547,084 priority patent/US11248240B2/en
Priority to AU2016211118A priority patent/AU2016211118B2/en
Publication of FR3032203A1 publication Critical patent/FR3032203A1/fr
Application granted granted Critical
Publication of FR3032203B1 publication Critical patent/FR3032203B1/fr
Priority to US17/670,549 priority patent/US20220162647A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne une protéine de fusion comprenant un domaine Cas9 et un domaine Spo11, ainsi que l'utilisation de cette protéine pour induire des recombinaisons méiotiques ciblées dans une cellule eucaryote.
FR1550707A 2015-01-29 2015-01-29 Procede pour induire des recombinaisons meiotiques ciblees Active FR3032203B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR1550707A FR3032203B1 (fr) 2015-01-29 2015-01-29 Procede pour induire des recombinaisons meiotiques ciblees
AU2016211118A AU2016211118B2 (en) 2015-01-29 2016-01-29 Method for inducing targeted meiotic recombinations
CA2974681A CA2974681A1 (fr) 2015-01-29 2016-01-29 Procede pour induire des recombinaisons meiotiques ciblees
BR112017016045-5A BR112017016045A2 (pt) 2015-01-29 2016-01-29 método para induzir recombinações meióticas endereçadas em uma célula eucariótica, proteína de fusão, ácido nucleico, cassete de expressão ou um vetor, célula hospedeira, método para gerar variantes de um organismo eucariótico, método para identificar ou localizar as informações genéticas, kit, e, uso de um kit
EP16703283.8A EP3250688B1 (fr) 2015-01-29 2016-01-29 Procede pour induire des recombinaisons meiotiques ciblees
EP20205199.1A EP3798302A1 (fr) 2015-01-29 2016-01-29 Procede pour induire des recombinaisons meiotiques ciblees
PCT/EP2016/052000 WO2016120480A1 (fr) 2015-01-29 2016-01-29 Procede pour induire des recombinaisons meiotiques ciblees
ES16703283T ES2894882T3 (es) 2015-01-29 2016-01-29 Procedimiento para inducir recombinaciones meióticas dirigidas
US15/547,084 US11248240B2 (en) 2015-01-29 2016-01-29 Method for inducing targeted meiotic recombinations
US17/670,549 US20220162647A1 (en) 2015-01-29 2022-02-14 Method for inducing targeted meiotic recombinations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1550707A FR3032203B1 (fr) 2015-01-29 2015-01-29 Procede pour induire des recombinaisons meiotiques ciblees

Publications (2)

Publication Number Publication Date
FR3032203A1 FR3032203A1 (fr) 2016-08-05
FR3032203B1 true FR3032203B1 (fr) 2021-04-23

Family

ID=53269654

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1550707A Active FR3032203B1 (fr) 2015-01-29 2015-01-29 Procede pour induire des recombinaisons meiotiques ciblees

Country Status (1)

Country Link
FR (1) FR3032203B1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7273758B2 (en) * 2002-07-19 2007-09-25 Centre National De La Recherche Scientifique Methods for inducing targeted stimulation of meiotic recombination and kits for performing said methods
DK2938184T3 (en) * 2012-12-27 2018-12-17 Keygene Nv Method of removing a genetic linkage in a plant

Also Published As

Publication number Publication date
FR3032203A1 (fr) 2016-08-05

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