FR3027901B1 - Nouveaux procedes appartenant a la famille des pyridazinones. - Google Patents

Nouveaux procedes appartenant a la famille des pyridazinones. Download PDF

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Publication number
FR3027901B1
FR3027901B1 FR1460501A FR1460501A FR3027901B1 FR 3027901 B1 FR3027901 B1 FR 3027901B1 FR 1460501 A FR1460501 A FR 1460501A FR 1460501 A FR1460501 A FR 1460501A FR 3027901 B1 FR3027901 B1 FR 3027901B1
Authority
FR
France
Prior art keywords
pyridazinones
family
novel methods
methods belonging
belonging
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1460501A
Other languages
English (en)
Other versions
FR3027901A1 (fr
Inventor
Stephane GERARD
Jean-Philippe BOUILLON
Azzaq Belaaouaj
Eric HENON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Rouen
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Reims Champagne Ardenne URCA
Original Assignee
Universite de Rouen
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Reims Champagne Ardenne URCA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1460501A priority Critical patent/FR3027901B1/fr
Application filed by Universite de Rouen, Institut National de la Sante et de la Recherche Medicale INSERM, Universite de Reims Champagne Ardenne URCA filed Critical Universite de Rouen
Priority to CA2963705A priority patent/CA2963705A1/fr
Priority to EP15798525.0A priority patent/EP3212190A1/fr
Priority to JP2017542345A priority patent/JP2017536413A/ja
Priority to US15/523,378 priority patent/US20170247335A1/en
Priority to PCT/FR2015/052929 priority patent/WO2016066973A1/fr
Priority to CN201580059238.4A priority patent/CN107148271A/zh
Publication of FR3027901A1 publication Critical patent/FR3027901A1/fr
Application granted granted Critical
Publication of FR3027901B1 publication Critical patent/FR3027901B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR1460501A 2014-10-31 2014-10-31 Nouveaux procedes appartenant a la famille des pyridazinones. Expired - Fee Related FR3027901B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR1460501A FR3027901B1 (fr) 2014-10-31 2014-10-31 Nouveaux procedes appartenant a la famille des pyridazinones.
EP15798525.0A EP3212190A1 (fr) 2014-10-31 2015-10-30 Pyridazin-3-ones fluorées pour leur utilisation dans le traitement des maladies pulmonaires
JP2017542345A JP2017536413A (ja) 2014-10-31 2015-10-30 肺疾患の治療に用いるフッ素化ピリダジン−３−オン
US15/523,378 US20170247335A1 (en) 2014-10-31 2015-10-30 Fluorinated pyridazin-3-ones for the use thereof in the treatment of lung diseases
CA2963705A CA2963705A1 (fr) 2014-10-31 2015-10-30 Pyridazin-3-ones fluorees pour leur utilisation dans le tratitement des maladies pulmonaires
PCT/FR2015/052929 WO2016066973A1 (fr) 2014-10-31 2015-10-30 Pyridazin-3-ones fluorées pour leur utilisation dans le traitement des maladies pulmonaires
CN201580059238.4A CN107148271A (zh) 2014-10-31 2015-10-30 用于治疗肺部疾病的氟化哒嗪‑3‑酮化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1460501A FR3027901B1 (fr) 2014-10-31 2014-10-31 Nouveaux procedes appartenant a la famille des pyridazinones.
FR1460501 2014-10-31

Publications (2)

Publication Number Publication Date
FR3027901A1 FR3027901A1 (fr) 2016-05-06
FR3027901B1 true FR3027901B1 (fr) 2018-03-16

Family

ID=52684342

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1460501A Expired - Fee Related FR3027901B1 (fr) 2014-10-31 2014-10-31 Nouveaux procedes appartenant a la famille des pyridazinones.

Country Status (7)

Country Link
US (1) US20170247335A1 (fr)
EP (1) EP3212190A1 (fr)
JP (1) JP2017536413A (fr)
CN (1) CN107148271A (fr)
CA (1) CA2963705A1 (fr)
FR (1) FR3027901B1 (fr)
WO (1) WO2016066973A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109620829B (zh) * 2018-12-29 2021-04-06 温州医科大学附属第一医院 一种治疗急性呼吸窘迫综合征的药物组合物及其制备方法
FR3103701B1 (fr) 2019-11-28 2021-11-26 Inst Nat Sante Rech Med Composés de typen2-arylméthyl-4-haloalkyl-pyridazin-3-one et leur utilisation
CN113754521B (zh) * 2020-06-03 2023-12-19 马鞍山科思化学有限公司 一种阿伏苯宗的合成工艺方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK159431C (da) * 1984-05-10 1991-03-18 Byk Gulden Lomberg Chem Fab 6-phenyl-3(2h)-pyridazinoner, fremgangsmaade til fremstilling deraf, laegemidler indeholdende disse samt anvendelse af forbindelserne til fremstilling af laegemidler
ES2232306B1 (es) * 2003-11-10 2006-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
KR101641596B1 (ko) * 2007-11-15 2016-07-21 엠에스디 이탈리아 에스.알.엘. Ｐａｒｐ 억제제로서의 피리다지논 유도체
JO3470B1 (ar) * 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv

Also Published As

Publication number Publication date
FR3027901A1 (fr) 2016-05-06
WO2016066973A1 (fr) 2016-05-06
EP3212190A1 (fr) 2017-09-06
JP2017536413A (ja) 2017-12-07
CA2963705A1 (fr) 2016-05-06
US20170247335A1 (en) 2017-08-31
CN107148271A (zh) 2017-09-08

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