FR2968547A1 - Composition, useful as e.g. make-up products, sun protection products and cosmetics for the cosmetic treatment of e.g. skin, comprises at least one ureidopyrimidone compounds, and at least one 4-carboxy 2-pyrrolidinone derivative - Google Patents

Abstract

Composition comprises: (i) at least one ureidopyrimidone compounds (A); and (ii) at least one 4-carboxy 2-pyrrolidinone derivative (B) or its salts, optical isomers, stereoisomers, enantiomers and diastereoisomers, or geometrical isomers. Composition comprises: (i) at least one ureidopyrimidone compounds (A) of formula (I) or (II); and (ii) at least one 4-carboxy 2-pyrrolidinone derivative of formula (B) or its salts, optical isomers, stereoisomers, enantiomers and diastereoisomers, or geometrical isomers. n : 1-3, preferably 1; m : 0 or 1; w, q : 0 or 1, which is determined by the nature of the groups A1 and A2; R1, R2 : H, -OH, -NRR1a, or optionally saturated and aromatic 1-18C alkyl containing one or more heteroatoms of O, S or N; R1 : -Z1a-A1; Z : a multivalent radical (divalent with tetravalent, according to the value of n) comprising (i) carbon-based radical, preferably optionally saturated 1-32C hydrocarbon (optionally interrupted or substituted, one or more times, by optionally aromatic 3-12C (hetero)cycle group), (ii) optionally aromatic 3-12C (hetero)cyclic hydrocarbon (optionally substituted by one or more carbon groups, preferably optionally saturated 1-32C hydrocarbon), or (iii) 5-6C-cycloalkyl-1-12C alkyl group, where the groups (i)-(iii) are optionally substituted with -OH, -SO 3R, -OSO 3R, -SO 3H, -OSO 3H, -COOH, -COOR, -CONRR1a, 1-4C alkyl, or -N +>RR1aR2a, or An ->, and/or interrupted or terminated by 1-5 groups comprising -S-, -NH- (=NH), -O-, -C(O)-, -SO 2-, -NHC(O)-, -C(O)NH- , -OC(O)-, -C(O)O-, piperazine groups of formula (a), pyridine groups of formula (b)-(d), -NR1a-, (-N +>R2aR1a)(An ->), trazine group of formula (e), imidazole groups of formula (f); Raa : H, halo (preferably Cl) or 1-6C alkyl; R, R1a, R2a : H or 1-12C alkyl group, provided that the Z comprises at least one heteroatoms of N, O or S, and when Z is interrupted or substituted by a cationic group of electroneutrality of (I) is provided by an anion or its mixtures (An ->); Z1, Z1a : divalent radical Z0; Z0 : a covalent bond of (I) when n is 1 and q is 0, Z1a can not be a covalent bond; Z2 : 1-32C divalent radical, provided that when w is 0, then A1 and A2 are not terminated by N; A1 : para-aminobenzoate group of formula (IIIa) (where w is 1), cinnamate, benzalmalonate or cyanoacrylate group of formula (IVa) (where x is 0 or 1), benzophenone group of formula (Va) (where w is 1), benzylidenecamphor group of formula (VIa) (where w is 1), (VIIa) (where w is 0) or (VIIIa) (where w is 0), benzotriazole group of formula (IXa) (where q and w are 1), (Xa) (where q is 0, X is O or NH) or (XIa) (where q is 1, and w is 0), or s-triazine group of formula (XIIa) (where w is 0); A2 : para-aminobenzoate group of formula (IIIb) (where w is 1 and X is O or NH), cinnamate, benzalmalonate or cyanoacrylate group of formula (IVb) (where w is 1 and X is O or NH), benzophenone group of formula (Vb) (w is 0), benzylidenecamphor group of formula (VIb) (w is 0), or s-triazine group of formula (VIIb) (w is 0); A3, A4 : (IIIa)-(VIa) or (IXa). In formula (IIIa)-(XIIa) and (IIIb)-(VIIb): Ak : saturated divalent 1-6C, preferably 2C alkyl; R1 : 1-30C alkyl, 3-30C alkenyl containing one or more hydroxyl substituents and an alkyl ring in the carbon chain, one or more heteroatoms comprising O, N or Si, or optionally substituted 6-20C aryl; either R2, R2a : 1-10C alkoxy, 1-10C alkyl, 2-8C alkenyl or-OSi(CH 3) 3; or R2R2 : alkylidenedioxy group in which the group alkylidene contains 1-2C (i.e. -O-(CH 2) t-O-); t : 1 or 2; p, p1 : 0-2; R3 : H, 1-4C alkyl, or a group comprising -(C=O)XR1, -CN, -(C=O)R1, or R1-SO 2R4; R4 : 1-12C alkyl, or optionally substituted 6-20C aryl; R5 : a divalent 2-8C alkyl group; X : O or -NR6; and R6 : 1-8C alkyl. In formula (B): R3 : H, 1-20C alkyl, linear or branched 3-20C alkyl; R4 : linear 1-20C or branched 3-20C alkyl containing 5-6C ring, branched 3-20C alkyl, 5-6C cycloalkyl optionally substituted by one or two methyl groups, phenyl, benzyl or phenethyl group; and R5, R6 : H, linear 1-12C or branched 3-12C alkyl, when R3 is H, then (B) is in the form of free acid or its salt. Independent claims are included for: use of at least one 4-carboxy 2-pyrrolidinone derivative (B): as a solvent and/or an agent for improving the solubility of a ureidopyrimidone compound (I) or (II); and in a composition comprising, in a medium, at least one ureidopyrimidone compound (I) or (II), for increasing the sun protection factor. [Image] [Image] [Image] [Image] [Image].

Description

USE OF 4-CARBOXY 2-PYRROLIDINONE DERIVATIVES AS SOLVENTS OF UREIDOPYRIMIDONE COMPOUNDS; The present invention relates to the use of 4-carboxy-2-pyrrolidinone derivatives of formula (B) which will be defined later in detail as solvents of ureidopyrimidone compounds of formula (I) or (II) that the we will define further.

The present invention also relates to a composition comprising in a cosmetically acceptable medium: a) at least one ureidopyrimidone compound of formula (I) or (II); b) at least one 4-carboxy-2-pyrrolidinone derivative of formula (B) which will be defined later in detail. The present invention also relates to the use of at least one 4-carboxy-2-pyrrolidinone derivative of formula (B) which will be defined later in detail in a composition comprising in a cosmetically acceptable medium at least one ureidopyrimidone compound of formula (I) or (II), for the purpose of increasing the sun protection factor.

It is known that the luminous radiations of wavelengths between 280 nm and 400 nm allow the browning of the human epidermis, and that the wavelength rays more particularly between 280 and 320 nm, known under the name UV-B, cause erythema and skin burns that can affect the development of natural tanning. For these reasons as well as for aesthetic reasons, there is a constant demand for means of control of this natural tan to thereby control the color of the skin; it is therefore necessary to filter this UV-B radiation. It is also known that UV-A rays of wavelengths between 320 and 400 nm, which cause browning of the skin, are likely to induce an alteration thereof, particularly in the case of sensitive skin or skin continuously exposed to solar radiation. UV-A rays cause in particular a loss of elasticity of the skin and the appearance of wrinkles leading to premature cutaneous aging. They promote the triggering of the erythematous reaction or amplify this reaction in some subjects and may even be the cause of phototoxic or photoallergic reactions. Thus, for aesthetic and cosmetic reasons such as the preservation of the natural elasticity of the skin for example, more and more people wish to control the effect of UV-A on their skin. It is therefore desirable to also filter the UV-A radiation.

In order to ensure protection of the skin and keratin materials against UV radiation, antisolar compositions comprising organic screening agents which are active in the UV-A and active in the UV-B are generally used.

These antisolar compositions are quite often in the form of an emulsion, of the oil-in-water type (ie a cosmetically and / or dermatologically acceptable support consisting of an aqueous dispersant continuous phase and a discontinuous phase. dispersed fatty) or water-in-oil (aqueous phase dispersed in a continuous fat phase), which contains, in various concentrations, one or more conventional organic filters, lipophilic and / or metal oxide mineral pigments, capable of selectively absorb harmful UV radiation, these filters (and their amounts) being selected according to the desired sun protection factor, the solar protection factor (SPF) being expressed mathematically by the ratio of the UV radiation dose required to to reach the erythematogenic threshold with the UV filter with the dose of UV radiation necessary to reach the erythematogenic threshold without UV filter. In such emulsions, the hydrophilic filters are present in the aqueous phase and the lipophilic filters are present in the fatty phase.

The oil-in-water emulsions are, in general, more appreciated by the consumer than the water-in-oil emulsions, in particular because of their pleasant touch (close to water) and their presentation in the form of water. milk or non-fat cream; however, they also lose their effectiveness in UV protection when they come into contact with water; in fact, hydrophilic filters tend to disappear with water, by swimming in the sea or in the pool, in the shower or when practicing water sports; thus, the sunscreen compositions containing them, alone or in combination with the lipophilic filters, no longer provide the initial protection sought, provided that the substrate (skin or hair) on which they have been applied comes into contact with the water.

Sunscreen compositions having improved water resistance can be provided using water-in-oil emulsions. Indeed, a hydrophilic filter is more remanent to water in a water-in-oil emulsion than in an oil-in-water emulsion. However, as indicated above, such compositions are not yet entirely satisfactory in that they leave after application a fat print particularly unpleasant for the user. Thus, there is still the need to find new UV filters that can be deposited on the surface of the skin and / or hair and that are more persistent after the usual attacks during use such as water, washing, the bath, the pool, the sand, the perspiration, the sebum, the friction that the classic UV filters. Patent application FR1050011 has already proposed UV-45 ureidopyrimidone filters for improving the persistence with water. Unfortunately, in general, their solubility is often limited in the usual cosmetic media containing oils such as oxyethylenated or oxypropylenated (mono / poly) fatty alcohols ("CETIOL HE" from Henkel or "WITCONOL APM" from Witco) or fatty esters such as the benzoate of C12-C15 alcohols ("FINSOLV TN" from Finetex), triglycerides of fatty acids, for example Miglyol® 812 marketed by DYNAMIT NOBEL, acid derivatives Amines ("Eldew SL205" from Ajinomoto), makes their implementation sometimes difficult in these oils commonly used in formulation. This has the consequence: either the appearance over time, crystallization in the formulas that hinder the good quality, stability and effectiveness of solar products; or to limit the concentration of filters in the formulas which does not allow to obtain sufficiently effective products.

There is therefore the need to find new solvents for effectively dissolving the ureidopyrimidone filters to improve their solubility in oils in the carriers of cosmetic or dermatological formulations containing them without the disadvantages listed above.

Now, the Applicant has now surprisingly discovered a new family of effective solvents consisting of 4-carboxy-2-pyrrolidinone ester derivatives of formula (B), the definition of which will be given below, making it possible to attain this goal. These compounds can be incorporated into many cosmetic products.

This discovery is the basis of the present invention.

The present invention relates to a composition comprising in a cosmetically acceptable medium: a) at least one ureidopyrimidone compound of formula (I) or (II) which will be defined below in detail. ; b) at least one 4-carboxy-2-pyrrolidinone derivative of formula (B) which will be defined later in detail.

The present invention relates to the use of a 4-carboxy-2-pyrrolidinone derivative of formula (B) which will be defined later in detail or of one of its salts, its optical isomers, stereoisomers, enantiomers and diastereoisomers or one of its geometric isomers as solvents of ureidopyrimidone compounds of formula (I) or (II) which will be defined below.

The present invention also relates to a composition comprising in a cosmetically acceptable medium: a) at least one ureidopyrimidone compound of formula (I) or (II); b) at least one 4-carboxy-2-pyrrolidinone derivative of formula (B) which will be defined later in detail or one of its salts, optical isomers, stereoisomers, enantiomers and diastereoisomers or one of its geometric isomers

The present invention also relates to the use of at least one 4-carboxy-2-pyrrolidinone derivative of formula (B) which will be defined later in detail or one of its salts, its optical isomers, stereoisomers, enantiomers and diastereoisomers or one of its geometric isomers in a composition comprising in a cosmetically acceptable medium at least one ureidopyrimidone compound of formula (I) or (II), for the purpose of increasing the sun protection factor. Other features, aspects and advantages of the invention will appear on reading the detailed description which follows.

By "cosmetically acceptable" is meant compatible with the skin and / or its integuments, which has a pleasant color, odor and feel and which does not generate unacceptable discomfort (tingling, tightness, redness), which can divert the consumer to use this composition.

UREIDOPYRIMIDONE COMPOUNDS The ureidopyrimidone compounds according to the invention correspond to one of the following formulas (I) or (II): ## STR2 ##

0 NN-Z [L L f L II l jw I Al J q n

R1 N, HO R2 (I) HH 1 1 0 NNN-ZI NH RI N, HO R2 f O l 1 rj O l HH [Il] w ~~ Z A2Jm r [L II Jw N ~ Z1 NN H q OH, NR 1 R2 15

in which: n = 1.2 or 3; preferably n = 1 - m = 0 or 1; W = 0 or 1; The value of w is conditioned by the nature of the groups AI and A2 as explicitly mentioned in the definition of said groups. - q = 0 or 1; The value of q is conditioned by the nature of the groups AI and A2 as explicitly mentioned in the definition of said groups. R1 and R2, which are identical or different within the same formula, represent hydrogen, -OH, -NRR '; or a linear or branched and / or cyclic, in particular saturated or unsaturated, optionally saturated, C1-C18, carbon-containing group which may contain one or more heteroatoms chosen from O, S and N; IR can also be the radical:; Z represents a multivalent radical (divalent to tetravalent, according to the value of n) chosen from: (i) a linear or branched, in particular saturated or non-saturated, carbon-based, C1-C32 carbon radical; optionally interrupted or substituted, one or more times, with an optionally aromatic C3-C12 (hetero) ring; or (ii) an optionally aromatic C3-C12 hydrocarbon radical (hetero) cyclic; optionally substituted with one or more carbon radicals, in particular linear or branched, saturated or unsaturated, C1-C32 hydrocarbon radicals; (iii) a (C 5 -C 6) -cycloalkyl-C 1 -C 12 -alkyl radical, said Z radical possibly being: (1) substituted with 1 to 12 identical or different groups chosen from -OH, -SO 3 R, -OSO 3 R, -SO 3 H, -OSO3H, -OOOH, -OO0R, -CONRR ', C1-C4 alkyl, and - N + RR'R ", An- and / or (2) interrupted or terminated with 1 to 5 identical or different groups selected from groups divalent: -S-, -NH- (or = NH), -O-, -C (O) -, -SO2-, or combinations thereof such as for example -NHC (O) -, -C (O) NH -, -OC (0) -, - C (O) O-, or -An- An- / \ R "+ + -N \ / N- -N- -NNNR 'R' - / with Ra = H or halogen, especially Cl, or C1-C6 alkyl; R, R 'and R ", which may be identical or different, being H or a linear or branched C1-C12 alkyl radical, it being understood that said radical Z comprises at least one heteroatom chosen from N, O and S; or substituted by a cationic group the electroneutrality of the compounds of formula (I) is ensured by an anion or a mixture of An-cosmetically acceptable anions; Z1 and Z'l, which may be identical or different, denote a divalent radical Z; - Z may further designate a covalent bond for the compounds of formula (I) when n = 1 and q = 0, Z'1 can not designate a covalent bond - Z2 is a divalent alkyl radical C1-C32, linear or branched with the proviso that when w = 0, then the radical AI and the diradical A2 can not be terminated by a nitrogen - the monoradicals AI corresponding to one of the following formulas (IIIa) to (XIIa): ) para-aminobenzoate: 6 (IIIa) b) cinnamate, benzalmalonate or cyanoacrylate (I Va) H 1 N x = 0 or 1 with the proviso that q = w = x = 1 when Z is not a covalent bond and q = x = 0 when Z is a covalent bond -N 1 H i0 c) benzophenone w = 1; D) benzylidene camphor: (Va) w = 1; 7N-H (Vla) 00 w = 0; (Villa) e) benzotriazole: q = w = 1; H N HO N (IXa) (R'2) p. q = 0; (Xa) with X = O or NH Ak = divalent linear saturated C1-C6 alkyl radical, preferably C2. (XIa) 10 O 5 e) s-triazine: A3 i w = 0; NN (XIIIa) A3 with the radicals A3, identical or different, representing the radicals AI of formula (IIIa), (IVa), (Va), (Vla) or (IXa); the diradicals A2 corresponding to one of the following formulas (IIIb) to (Vllb): 9a / para-amino benzoate: w = 1; MW-N H X- (IIIb) with X = O or NH b / cinnamate; benzalmalonate or cyanoacrylate: W = 1; ## STR2 ## where X = O or NH 3 / benzophenone: w = 0; (Vb) d / benzylidene camphor: (Vlb) e / s-triazine: 1 w = 0; NO (Vllb)

A4 with A4, representing a radical of formula (IIIa), (IVa), (Va), (Vla) or (IXa); in which: R 'represents a linear or branched C 3 -C 30 alkyl or C 3 -C 30 alkenyl radical which may carry one or more hydroxyl substituents and which may contain in the carbon chain an alkyl ring, one or more heteroatoms chosen from oxygen, nitrogen and silicon atoms, an optionally substituted C 6 -C 20 aryl radical; R2 and R'2 independently represent a linear or branched C1-C10 alkoxy radical, a linear or branched C1-C10 alkyl radical, a linear or branched C2-C8 alkenyl radical, or -OSi (CH3) 3 two adjacent radicals R 2 may together form an alkylidene dioxy group in which the alkylidene group contains 1 to 2 carbon atoms (i.e., a group -O- (CH 2) tO- with t = 1 or 2 ), - p and p 'are independently 0, 1 or 2, - R3 is hydrogen, a C1-C4 alkyl radical, or a radical chosen from 20 - (C = O) XR', -CN, - ( C = O) R ', -SO 2 R 4 with R' having the same definition as above and - R 4 represents a linear or branched C 1 -C 12 alkyl radical or an optionally substituted C 6 -C 20 aryl radical, - R 5 represents a C2-C8 divalent alkyl radical; X represents oxygen or a radical -NR6 with R6 being a linear or branched C1-C8 alkyl radical.

Compounds of formula (1) or (II) in which: - nest1; -Mest0 or 1; R1 is Hou-Z'1-A1; R2 is the linear or branched C1-C3 alkyl radical; the radical Z (or Z1 and / or Z'i) denotes a linear C1-C12 divalent alkyl radical, the divalent C3-C8 cycloalkyl radical optionally substituted with one or more identical or different linear C1-C4 alkyl radicals; or branched or the following divalent radicals: H * NO * Z may further designate a covalent bond when n = 1 and q = 0. Z2 denotes a C2-C20 divalent linear alkyl radical and in the radicals AI and / or A2, - R 'is a C1-C8 alkyl, optionally substituted with 1 or 2 hydroxyl groups, - X is -O-, - p = p '= 0, - R3 is -CN or -COOR1 io - R5 is -CH2CH2- Even more preferably,

- nest1; - mest or 1; -R1 is Hou-Z'1-A1; R2 is the linear or branched C1-C3 alkyl radical; the radical Z (or Z1 and / or Z'i) denotes a divalent C1-12 linear alkyl radical, preferably a 1,2-ethylene radical; 1,6-hexylene; 1,4-butylene, or a divalent radical:

Z * may further designate a covalent bond when n = 1 and q = 0. Z2 denotes a C2-C20 divalent linear alkyl radical, in particular a tetradecyl radical; R 'is C 1 -C 8 alkyl, optionally substituted with 1 or 2 hydroxyl groups, - X is -O-, - p = p' = O, - R 3 is -CN or -COOR 1 - R 5 is -CH 2 CH 2 -

Preferably, the molecular weight (Mw) of the compounds of formula (I) or (II) according to the invention is less than 2000 g / mol. Particularly preferred derivatives are: 12 para-aminobenzoate derivatives - those of formula (I) for which A1 corresponds to the formula (IIIa) ## STR1 ## O (2) lo - those of formula (II) for which A2 corresponds to formula (IIIb) (5) 2 / cinnamate derivatives: - those of formula (I) for which Al corresponds to formula (IVa) ON embedded image - those of formula (II) for which A2 corresponds to formula (IVb): ## STR1 ## ## STR5 ## has the formula (IVa) (7) embedded image HHHO Ny NxN NOHH (9) IIIHHH (10) o HHON .--- NOHHH 10 o HH 15 4 / cyano acrylate derivatives

those of formula (I) for which Al corresponds to formula (IVa):

0

Embedded image - those of formula (II) for which A2 corresponds to formula (IVb): ## STR1 ## wherein Al has the formula: ## STR1 ## wherein R 1 has the formula (I) for which Al has the formula (VIa): HHH (17) NN-NyN HO N. O - those of formula (1) for which A1 corresponds to the formula (VIIa): ## STR2 ## those of formula (II) for which A2 corresponds to formula (VIb): HHNOO \ N, N ~ Ny HO 7 / benzotriazole derivatives - those of formula (I) for which Al has the formula (IXa): (18) (19) OHHHNNN NN 1 1 HH (20) - those of formula (I) for which A1 corresponds to formula (Xa): HHH 1 1 IN 1 HON, i 16 10 8 / s-triazine derivatives: - those of formula (I) for which AI corresponds to formula (XIIa) OHHON "N) LN INIIIHHH (22) OOHNN l ~ NN 1 1 1 HH H (23) O5 - those of formula (II) for which A2 corresponds to the formula (VIIIb) in which A4 represents a radical of formula (IVa) ## STR2 ## in which A represents a radical of formula (IVa) ## STR2 ##

H (26) o o

## STR1 ## ## STR1 ## ## STR4 ## ## STR2 ## ## STR2 ## ## STR2 ## obtained by reaction between a reactive function Y linked to the group A'l, with a reactive function W attached to Z of the derivative of formula (XIII), the two reactive functions being of course capable of reacting with each other, as described in the diagram next .

The products of formulas (II) can be obtained by reaction between a reactive function Y linked to the group A'2 with a reactive function W attached to Z1 of the derivative of formula (XIII), the two reactive functions being, of course, capable of reacting between them, as described in the following diagram. (28) HHII ONNN-zW + Y-A'l (I) HO 1 R2 (X111) HH 1 1 0 NNN-Z W 2 + Y-A'd-Z2 A'2Y R 1 The reactive functions W and Y can preferably be selected from the functions: - isocyanate -N = C = O; isothiocyanate -N = C = S; - carboxylic acid or ester-1000Ra or COORb activated ester with Ra being H or a linear or branched C1-C4 alkyl radical, and more preferably a methyl or ethyl radical; and ORb being selected from phenoxy, 4-nitrophenoxy, 2,4,5-trichlorophenoxy and the following radicals: Ph ON, HO R2 (X111 ') A'1 and A'2 are such that after reaction between the reactive groups W and Y, there are obtained compounds (I) or (II) respectively containing the radicals A1 and A2. ~ - -So 2 O Ph - acyl halide, 15-acyl imidazole or acyl benzotriazole of formula: O - acid anhydride, - activated carbamic acid -NHCOX with X = Cl, imidazole or ORb with ORb as defined herein -above; hydroxyl (OH) or activated hydroxyl, for example in O-tosylate form, primary or secondary amine -NHRa, where Ra is as defined above;

Preferably, the reactive functions W and Y precursor of the bond between Z or Z1 and AI or A2 (or A'1 and A'2) are chosen from isocyanate, amine or hydroxyl functions; A particular method for obtaining the derivative of formula (XIII) or (XIII ') is that described in the article by Katritzky et al., Comprehensive Organic Functional Group Transformations. , Pergamon: Oxford, 1995, vol 6, pp.500-506 or Arkiv der Pharmazie, 314 (1), 34-41, 1981.

To obtain the compound (XIII), it is possible in particular to react: - an isocytosine B with an activated carbamic acid: B - an isocytosine B with an isocyanate derived from amine: H H 1

## STR2 ## an activated carbamoyl-functional isocytosine C with an amine: ## STR1 ##

R ~ N H + H2N-Z 1 R2 CH H 1

Embedded image - a R-ketoester D (with R 1 being H) with a guanylalkylurea derivative E: R 1 = H O -O H

HN NN -Z

+ NH2 O R O R2 H H1 \ 1 NN-Z

The same procedure is used to obtain the compounds (XIII ').

Another process for the preparation of the derivatives of formulas (I) or (II) for which w = 1 consists of synthesizing the following compound (with R1 = H and R2 = methyl): HH 1 1 O, NNNZ N R1 = H R2 = 0E13 O R2 and then reacting on the (respectively) function (s) Y = alcohol or amine of the compound Y-A'1 (respectively of the compound Y-A'2- [Z2-A'2] ,,, -Y).

Another process for preparing the derivatives of formulas (I) or (II) consists of synthesizing the following compound (with R1 = H and R2 = methyl):

And then reacting it on the (respectively) function (s) Y = activated carboxylic acid or sulfonic acid of the compound Y-A'1 (respectively of the compound Y-A'2-). [Z2-A'2] ,,, - Y).

The ureidopyrimidone compound (s) according to the invention may be present in the compositions according to the invention at a concentration of between 0.1 and 15%, preferably between 0.2 and 10%, by weight relative to the total weight. of the composition. R1 = H R2 = CH3 4-CARBOXY 2-PYRROLIDINONE DERIVATIVES

The 4-carboxy-2-pyrrolidinone derivatives according to the invention are chosen from those corresponding to the following general formula (B) or one of its salts, its optical isomers, stereoisomers, enantiomers and diastereoisomers, or one of its geometrical isomers: wherein R3 denotes hydrogen or a C1-C20 linear or branched C3-C20 alkyl radical. R 4 denotes a linear C 1 -C 20 or branched C 3 -C 20 alkyl radical which may contain a C 5 -C 6 ring, a C 3 -C 20 branched alkyl radical or a C 5 -C 6 cycloalkyl radical optionally substituted with one or two methyl radicals, the phenyl radical, the benzyl radical or the phenethyl radical. R5 and R6 independently of one another are hydrogen, a C1-C12 linear or branched C3-C12 alkyl radical; when R3 is hydrogen, the compounds may be in their free acid form or in the form of their cosmetically acceptable salts. Preferably, R 3 denotes hydrogen, a C 1 -C 14 linear alkyl radical or a C 3 -C 14 branched alkyl radical; R 4 denotes the phenyl radical, the benzyl radical, the phenethyl radical, a C 5 -C 5 cycloalkyl radical; C6, a C1-C20 linear alkyl radical or a C3-C20 branched alkyl radical. R 5 and R 6 denote, independently of each other, a hydrogen or a linear C 1 -C 4 alkyl radical. In formula (B), among the alkyl groups, mention may especially be made of methyl, ethyl, n propyl, isopropyl, n-butyl, iso-butyl, tert-butyl, n-octyl, 2-ethylhexyl, dodecyl, hexadecyl, cyclohexyl or methylcyclohexyl.

Acceptable salts of the compounds described in the present invention include conventional non-toxic salts of said compounds such as those formed from organic or inorganic acids. By way of example, mention may be made of the salts of mineral acids, such as sulfuric acid, hydrochloric acid, hydrobromic acid and phosphoric acid. It is also possible to mention the salts of organic acids, which may comprise one or more carboxylic acid, sulphonic acid or phosphonic acid groups. It may be linear, branched or cyclic aliphatic acids or aromatic acids. These acids may furthermore comprise one or more heteroatoms chosen from O and N, for example in the form of hydroxyl groups. There may be mentioned in particular propionic acid, acetic acid, terephthalic acid, citric acid and tartaric acid and lactic acid.

Organic or inorganic base salts such as ammonium salts, alkanolamine salts such as triethanolamine, aminopropanediol, alkali metal or alkaline earth metal salts such as sodium, potassium, calcium, magnesium.

The preferred salts are those obtained from hydrochloric, sulfuric, acetic, tartaric, citric, lactic acids as well as alkali metal salts such as sodium, potassium, calcium.

The preferred products are those of formula (I) in which R3 and R4 are hydrogen. Among the compounds of formula (I), use will be made more particularly of the following products (a) to (by) or one of their salts, optical isomers, stereoisomers, enantiomers and diastereoisomers or geometric isomers: o (a) RN = 59857-86-2 o (b) RN = 10080-92-9 (d) RN = 100911-29-3 R = 428518-32-5 (c) o (e) RN = 102943-44-2 RN = 428518-33-6 o (h) R = 443304-01-6 O (i) RN = 100453-61-0 RN = 59857-87-3 o (k) RN = 428518-34-7 O (I) RN = 192717-78-5 RN = 856637-16-6 RN = 101572-83-2 0 (P) RN = 59857-85-1 (q) RN = 873969-57-4 (r) RN = 60298- 19-3 (s) (t) (u) RN = 593253-22-6 OOOOO

NNNOO p (Y) (ag) RN = 100878-04-4 O. O \ NOCO (ah) RN = 147452-59-3 (ak) RN = 856636-64-1 RN = 66397-80-6 RN = 106783 RN = 101572-84-3 RN = 102444-77-9 RN = 102180-23-4 (aps) RN = 100718-54-5 (aq) RN = 64320-92-9 O 0 O (at) RN = 91957-98-1 (as) RN = 1 01 1 05-62-8 o (av) RN = 52743-73-4 (ay) RN = 299920-47-1 (az) RN = 208 1 8-23-4 (ba) RN = 43094-86-6 ## STR2 ## RN = b) RN = 845546-13-6 RN = 157687-77-9 RN = 944648- Embedded image RN = 696647-92-4 RN = 944511-54-0 OH OH OH (b) RN = 1211449-66-9 OH RN = 10054-19-0 CH3 (bw) ) ow 30 35 (by) 5

The products even more preferred are the products of formulas (I), (n), (o), (ac), (am), (at), (au), (ba), (bg), (b1), (bm), (bp), (br), (bw) and (by) as well as their salts, their optical isomers, stereoisomers, enantiomers and diastereoisomers and their geometric isomers.

The derivatives of formula (B) can be obtained according to the syntheses described in the following articles: J. Org. Chem., 26, pp. 1519-24 (1961); Tetrahedron Asymmetric, 12 (23), pages 3241-9 (2001); J. Industrial & Engineering Chem., 47, pp. 1572-8 (1955); J. Am. Chem. Soc., 60, pp. 402-6 (1938); and in patents EP 0069512, US 2811496 (1955), US 2826588, US 3136620, FR 2290199 and FR 2696744 can be easily obtained:

According to one particular form of the invention, the derivative (s) will be used in a sufficient quantity which alone makes it possible to completely solubilize the ureidopyrimidone compound (s) present in the composition.

Preferably, the derivative (s) of formula (B) according to the invention are present in the compositions of the invention at contents ranging from 1 to 30% by weight and more preferably from 3 to 20% by weight. relative to the total weight of the composition.

ADDITIONAL FILTERS

The compositions in accordance with the invention may comprise, in addition to other, additional lipid-soluble or insoluble UVA and / or UVB-active organic or inorganic UV filters as well as water-soluble UVB filters in the commonly used cosmetic solvents.

Of course, those skilled in the art will take care to choose the optional additional filters and / or their amounts in such a way that the advantageous properties intrinsically attached to the compositions according to the invention are not, or not substantially, impaired. by the addition or additions envisaged.

The additional organic screening agents are especially chosen from dibenzoylmethane derivatives; anthranilates; cinnamic derivatives; salicylic derivatives, camphor derivatives; benzophenone derivatives; 13,13-diphenylacrylate derivatives; triazine derivatives other than those of formula (I); benzalmalonate derivatives including those cited in US5624663; benzimidazole derivatives; imidazolines; p-aminobenzoic acid (PABA) derivatives; benzotriazole derivatives; methylene bis- (hydroxyphenylbenzotriazole) derivatives as described in US5,237,071, US 5,166,355, GB2303549, DE 197 26 184 and EP893119; benzoxazole derivatives as described in patent applications EP0832642, EP1027883, EP1300137 and DE10162844; filter polymers and screening silicones such as those described in particular in application WO-93/04665; dimers derived from α-alkylstyrene such as those described in patent application DE19855649; 4,4-diarylbutadienes as described in applications EP0967200, DE19746654, DE19755649, EP-A-1008586, EP1133980 and EP133981; merocyanine derivatives such as those described in WO04006878, WO05058269 and WO06032741; patent indanylidene filters EP-A-0823418 and EP-A-1341752.

As examples of organic UV filters, mention may be made of those referred to below under their INCI name: Dibenzoylmethane derivatives Butyl Methoxy Dibenzoylmethane, sold under the trade name "PARSOL 1789" by the company DSM NUTRITIONAL PRODUCTS 30 Derivatives of the para-aminobenzoic acid: PABA, Ethyl PABA, Ethyl Dihydroxypropyl PABA, Ethylhexyl Dimethyl PABA sold in particular under the name "ESCALOL 507" by ISP, Glyceryl PABA, PEG-25 PABA sold under the name "UVINUL P25" by BASF,

Salicylic Derivatives: Homosalate sold under the name "Eusolex HMS" by Rona / EM Industries, Ethylhexyl Salicylate sold under the name "Neo Heliopan OS" by Symrise, Dipropylene glycol salicylate sold under the name "DIPSAL" by SCHER, TEA Salicylate, sold under the name "NEO HELIOPAN TS" by Symrise, 45 Cinnamic derivatives: Ethylhexyl Methoxycinnamate sold in particular under the trade name "PARSOL MCX" by DSM NUTRITIONAL PRODUCTS Isopropyl Methoxy cinnamate, Isoamyl Methoxy cinnamate sold under the trade name "NEO HELIOPAN E 1000" by Symrise , Cinoxate, DEA Methoxycinnamate, Diisopropyl Methylcinnamate, Glyceryl Ethylhexanoate Dimethoxycinnamate Derivatives of [3, [3-diphenylacrylate: Octocrylene sold in particular under the trade name "UVINUL N539" by BASF, Etocrylene, sold in particular under the trade name "UVINUL N35" by BASF

Derivatives of benzophenone: Benzophenone-1 sold under the trade name Uvinul 400 by BASF, Benzophenone-2 sold under the trade name Uvinul D50 by BASF Benzophenone-3 or Oxybenzone, sold under the trade name Uvinul M40 by BASF, Benzophenone-4 sold under the trade name "UVINUL MS40" by BASF, Benzophenone-5-Benzophenone-6 sold under the trade name "Helisorb 11" by Norquay Benzophenone-8 sold under the trade name "Spectra-Sorb UV- 24 "by American Cyanamid Benzophenone-9 sold under the trade name" UVINUL DS-49 "by BASF, 25 Benzophenone-12 2- (4-diethylamino-2-hydroxybenzoyl) -benzoate benzene sold under the trade name" UVINUL A + "or as a mixture with octylmethoxycinnamate under the trade name" UVINUL A + B "by BASF, 1,1 '- (1,4-piperazinediyl) bis [1- [2- [4- (diethylamino)) 2-hydroxybenzoyl] phenyl] methanone (CAS 919803-06-8)

Derivatives of benzylidene camphor: 3-Benzylidene camphor manufactured under the name "MEXORYL SD" by CHIMEX, 4-Methylbenzylidene camphor sold under the name "EUSOLEX 6300" by 35 MERCK, Benzylidene Camphor Sulfonic Acid manufactured under the name "MEXORYL SL" by CHIMEX , Camphor Benzalkonium Methosulfate manufactured under the name "Mexoryl SO" by Chimex, 40 Terephthalylidene Dicamphor Sulfonic Acid manufactured under the name "Mexoryl SX" by Chimex, Polyacrylamidomethyl Benzylidene Camphor manufactured under the name "Mexoryl SW" by Chimex,

45 Phenylbenzimidazole derivatives: Phenylbenzimidazole Sulfonic Acid sold in particular under the trade name "Eusolex 232" by Merck, Disodium Phenyl Dibenzimidazole Tetrasulfonate sold under the trade name "Neo Heliopan AP" by Symrise, 50 35 Derivatives of benzotriazole: Drometrizole Trisiloxane sold under the name "Silatrizole" by RHODIA CHIMIE Methylene bis-Benzotriazolyl Tetramethylbutylphenol, sold in solid form under the trade name "MIXXIM BB / 100" by FAIRMOUNT CHEMICAL or in micronized form in aqueous dispersion under the trade name "TINOSORB M" by CIBA SPECIALTY CHEMICALS,

Triazine derivatives: Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine sold under the trade name "Tinosorb S" by Ciba Geigy, Ethylhexyl triazone sold in particular under the trade name "UVINUL T150" by BASF, Diethylhexyl Butamido Triazone sold under the trade name "UVASORB HEB" SIGMA 3V, 2,4-bis (n-butyl 4'-aminobenzalmalonate) -6 - [(3- {1,3,3,3-tetramethyl-1 - [(trimethylsilyl) oxy] disiloxanyl} propyl) amino] -s-triazine, 2,4,6-tris- (4'-amino benzalmalonate diisobutyl) -s-triazine, 2,4,6-tris (4'-amino benzalmalonate dineopentyl) -s- triazine, 2,4-bis (4'-amino benzalmalonate dineopentyl) -6- (4-n-butyl 4-aminobenzoate) -s-triazine, n-2,4-bis (4'-aminobenzoate) butyl) -6 - [(3- {1,3,3,3-tetramethyl-1 - [(trimethylsilyl) oxy] disiloxanyl} propyl) amino] -s-triazine, the symmetrical triazine filters described in US Pat. No. 6,225,467 application WO2004 / 085412 (see compounds 6 and 9) or the document "Symetrical Triazine 25 Derivatives" IP.COM Journ et al., IP.COM INC. WEST HENRIETTA, NY, US (September 20, 2004) in particular 2,4,6-tris (biphenyl) -1,3,5-triazines (in particular 2,4,6-tris ( biphenyl-4-yl-1,3,5-triazine) and 2,4,6-tris (terphenyl) -1,3,5-triazine which is incorporated in the applications of Beiersdorf WO06 / 035000, WO06 / 034982, WO06 / 034991, WO06 / 035007, WO2006 / 034992, WO2006 / 034985.

Anthranilic Derivatives: Menthyl Anthranilate sold under the trade name "Neo Heliopan MA" by Symrise, Imidazoline Derivatives: Ethylhexyl Dimethoxybenzylidene Dioxoimidazoline Propionate,

Derivatives of benzalmalonate: 40 Di-neopentyl 4'-methoxybenzalmalonate Polyorganosiloxane with benzalmalonate functions such as Polysilicone-15 sold under the trade name "PARSOL SLX" by DSM NUTRITIONAL PRODUCTS

45 4,4-Diarvlbutadiene derivatives: 1,1-dicarboxy (2,2'-dimethylpropyl) -4,4-diphenylbutadiene

Benzoxazole derivatives: 2,4-bis- [5-1 (dimethylpropyl) benzoxazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) -5,5-imino-1,3,5-triazine sold under the name Uvasorb K2A by Sigma 3V and mixtures thereof.

Preferred complementary organic screening agents are chosen from ethylhexyl methoxycinnamate homosalate ethylhexyl salicylate, octocrylene, butyl methoxy dibenzoylmethane terephthalylidene diacamphor sulphonic acid disodium phenyl dibenzimidazole tetrasulfonate phenylbenzimidazole sulphonic acid, benzophenone-3 2- (4-diethylamino-2-hydroxybenzoyl) benzoate n-hexyl 1,1 '- (1,4-piperazinediyl) bis [1- [2- [4- (diethylamino) -2-hydroxybenzoyl] phenyl] -15-methanone, 4-methylbenzylidene camphor, ethylhexyl triazone, Bis- Ethylhexyloxyphenol Methoxyphenyl Triazine, Diethylhexyl Butamido Triazone, 2,4-bis (N-butyl 4'-aminobenzalmalonate) -6 - [(3- {1,3,3,3-tetramethyl-1 - [(trimethylsilyl)) oxy] disiloxanyl} propyl) amino] -s-triazine, 2,4,6-tris (biphenyl-4-yl-1,3,5-triazine, 2,4,6-tris (4'-amino benzalmalonate dineopentyl) ) -s-triazine, 2,4,6-tris- (4'-amino benzalmalonate diisobutyl) -s-triazine, 2,4-bis (4'-amino benzalmalonate dineopentyl) -6- (4'- n-butyl aminobenzoate) -s-triazine, n-butyl 2,4-bis (4-aminobenzoate) -6 - [(3- {1,3,3,3-tetramethyl-1 - [(trimethylsilyl) oxy] disiloxanyl} propyl) amino] -s-triazine, Methylene bis-benzotriazolyl tetramethylbutylphenol, Drometrizole Trisiloxane Polysilicone-15 Di-neopentyl 4'-methoxybenzalmalonate 1,1-dicarboxy (2,2'-dimethyl-propyl) -4,4-diphenylbutadiene 2 , 4-bis- [5-1 (dimethylpropyl) benzoxazol-2-yl- (4-phenyl) imino] -6- (2-ethylhexyl) -35-imino-1,3,5-triazine and mixtures thereof.

The complementary inorganic UV filters used in accordance with the present invention are metal oxide particles having an average particle size of less than or equal to 100 nm, more preferably between 5 nm and 100 nm, and even more preferably between 10 nm and 100 nm. nm and 100 nm, and preferably between 15 and 50 nm.

They may be chosen in particular from oxides of titanium, zinc, iron, zirconium, cerium or their mixtures

More preferably, titanium oxide pigments (TiO2) will be used. This titanium oxide may be in a crystallized form of rutile and / or anatase type, and / or in an amorphous or substantially amorphous form. Such metal oxide pigments, coated or uncoated, are in particular described in the application. EP-A-0518 773. As commercial pigments, mention may be made of the products sold by Kemira, Tayca, Merck and Degussa.

The metal oxide pigments may be coated or uncoated.

The coated pigments are pigments which have undergone one or more surface treatments of a chemical, electronic, mechanochemical and / or mechanical nature with compounds such as amino acids, beeswax, fatty acids, fatty alcohols, anionic surfactants, lecithins, sodium, potassium, zinc, iron or aluminum salts of fatty acids, metal alkoxides (of titanium or aluminum), polyethylene, silicones, proteins (collagen, elastin), alkanolamines, silicon oxides, metal oxides or sodium hexametaphosphate.

The coated pigments are more particularly titanium oxides coated with: - silica such as the product "Sunveil" from the company IKEDA, 20 - silica and iron oxide such as the product "SUNVEIL F" from the company IKEDA, silica and alumina such as the products "MICROTITANIUM DIOXIDE MT 500 SA" and "MICROTITANIUM DIOXIDE MT 100 SA" from the company TAYCA, "TIOVEIL" from the company TIOXIDE, 25-alumina such as the products "TIPAQUE TTO-55 (B) "and" TIPAQUE TTO-55 (A) "from ISHIHARA, and" UVT 14/4 "from KEMIRA, - rutile TiO2 treated with alumina and silica coated with glycerol such as the product "UV TITAN M212" from KEMIRA, - rutile TiO2 treated with alumina and dimethicone such as the commercial product "UV TITAN M195" from KEMIRA, - alumina and stearate such as the products "MICROTITANIUM DIOXIDE MT 100 T, MT 100 TV, MT 100 TX, MT 100 Z, MT-01" of the company TAYCA, the p products "Solaveil CT-10 W" and "Solaveil CT 100" from the company UNIQEMA and the product "Eusolex T-AVO" from the company Merck, 35 - silica, alumina and alginic acid such as the product " MT-100 AQ "from the company TAYCA, - aluminum alumina and laurate such as the product" MICROTITANIUM DIOXIDE MT 100 S "from the company TAYCA, - iron oxide and iron stearate such as the product "MICROTITANIUM 40 DIOXIDE MT 100 F" from the company TAYCA, - zinc oxide and zinc stearate such as the product "BR 351" from TAYCA, - silica and alumina and treated with a silicone such as the products "MICROTITANIUM DIOXIDE MT 600 SAS", "MICROTITANIUM DIOXIDE MT 45 500 SAS" or "MICROTITANIUM DIOXIDE MT 100 SAS" from the company TAYCA, - silica, alumina, aluminum stearate and treated with a silicone such as the product "STT-30-DS" of the company TITAN KOGYO, - alumina and treated with a silicone such as the products "TIPAQUE TTO-55 (S)" of the company ISHIHARA, or "UV TITAN M 262" from KEMIRA, - triethanolamine such as the product "STT-65-S" from TITAN KOGYO, - stearic acid such as the product "TIPAQUE TTO-55 ( C) "of the company ISHIHARA, sodium hexametaphosphate such as the product" MICROTITANIUM DIOXIDE MT 150 W "from the company TAYCA. the TiO 2 treated with octyl trimethyl silane sold under the trade name "T 805" by the company Degussa Silices, the TiO 2 treated with a polydimethylsiloxane sold under the trade name "70250 Cardre UF TiO2SI3" by CARDRE, 10 - the anatase / rutile TiO2 treated with a polydimethylhydrogensiloxane sold under the trade name "MICRO TITANIUM DIOXIDE USP GRADE HYDROPHOBIC" by the company COLOR TECHNIQUES. rutile TiO 2 treated with alumina, stearic acid sold under the trade name "UV TITAN M160" by KEMIRA. Uncoated titanium oxide pigments are for example sold by the company Tayca under the trade names "MICROTITANIUM DIOXIDE MT 500 B" or "MICROTITANIUM DIOXIDE MT600 B", by the company DEGUSSA under the name "P 25", by the WACKHER company under the name "transparent titanium oxide PW", by the company MIYOSHI KASEI under the name "UFTR", by the company TOMEN under the name "ITS" and by the company TIOXIDE under the name "TIOVEIL AQ".

The non-coated zinc oxide pigments are, for example: those marketed under the name "Z-cote" by the company Sunsmart; those marketed under the name "Nanox" by Elementis; those marketed under the name "Nanogard WCD 2025" by Nanophase Technologies; The coated zinc oxide pigments are, for example: those sold under the name "Zinc Oxide CS-5" by the company Toshibi (ZnO coated with polymethylhydrogenosiloxane); those marketed under the name "Nanogard Zinc Oxide FN" by the company Nanophase Technologies (as a 40% dispersion in Finsolv TN, benzoate of C12-C15 alcohols); those marketed under the name "DAITOPERSION ZN-30" and "DAITOPERSION Zn-50" by the company Daito (dispersions in cyclopolymethylsiloxane / polydimethylsiloxane oxyethylenated, containing 30% or 40% of zinc nano-oxides coated with silica and the polymethylhydrogensiloxane); those marketed under the name "NFD Ultrafine ZnO" by the company Daikin (ZnO coated with perfluoroalkyl phosphate and a copolymer based on perfluoroalkylethyl dispersed in cyclopentasiloxane); 45 - those sold under the name "SPD-Z1" by the company Shin-Etsu (ZnO coated with silicone-grafted acrylic polymer, dispersed in cyclodimethylsiloxane); those marketed under the name "Escalol Z100" by the company ISP (ZnO treated alumina and dispersed in the mixture methoxycinnamate 50 ethylhexyl / PVP-hexadecene copolymer / methicone); those marketed under the name "Fuji ZnO-SMS-10" by the company Fuji Pigment (ZnO coated with silica and polymethylsilsesquioxane); those marketed under the name "Nanox Gel TN" by Elementis (ZnO dispersed at 55% in benzoate of C12-C15 alcohols with hydroxystearic acid polycondensate).

The uncoated cerium oxide pigments may be, for example, those sold under the name "COLLOIDAL CERIUM OXIDE" by the company RHONE POULENC. Mention may also be made of mixtures of metal oxides, in particular titanium dioxide and cerium dioxide, including the titanium dioxide and cerium dioxide-coated cerium alloy mixture, sold by the company IKEDA under the name SUNVEIL. A ", as well as the mixture of titanium dioxide and zinc dioxide coated with alumina, silica and silicone such as the product" M 261 "sold by the company Kemira or coated with alumina, silica and glycerin such as the product "M 211" sold by the company Kemira.

The additional UV filters are generally present in the compositions according to the invention in proportions ranging from 0.01% to 20% by weight relative to the total weight of the composition, and preferably ranging from 0.1% to 10% by weight. relative to the total weight of the composition.

The compositions in accordance with the present invention may also comprise water and / or conventional cosmetic adjuvants, chosen especially from fatty substances, organic solvents, ionic or nonionic thickeners, hydrophilic or lipophilic, softeners, humectants. , opacifiers, stabilizers, emollients, silicones, anti-foam agents, perfumes, preservatives, anionic, cationic, nonionic, zwitterionic or amphoteric surfactants, actives, fillers, polymers, propellants, alkalinizing or acidifying agents or any other ingredient usually used in the cosmetic and / or dermatological field.

The fatty substances may consist of an oil or a wax other than the apolar waxes as defined above or their mixtures. By oil is meant a liquid compound at room temperature. By wax is meant a compound that is solid or substantially solid at room temperature and whose melting point is generally greater than 35 ° C.

As oils, there may be mentioned mineral oils (paraffin); vegetable (sweet almond oil, macadamia oil, blackcurrant seed oil, jojoba oil); synthetic such as perhydrosqualene, alcohols, fatty amides (such as isopropyl lauroyl sarcosinate sold under the name "Eldew SL-205" by the company Ajinomoto), acids or fatty esters such as benzoate 45 alcohols C12-C15 sold under the trade name "Finsoly TN" or "Witconol TN" by the company WITCO, 2-ethylphenyl benzoate as the commercial product sold under the name X-TEND 226® by the company ISP, the palmitate of octyl, isopropyl lanolate, triglycerides, including those of capric / caprylic acids, dicaprylyl carbonate sold under the name "Cetiol CC" by the company Cognis), oxyethylenated or oxypropylenated esters and fatty ethers; silicone oils (cyclomethicone, polydimethylsiloxane or PDMS) or fluorinated oils, polyalkylenes, trialkyl trimellitates such as tridecyl trimellitate.

As waxy compounds, mention may be made of carnauba wax, beeswax, hydrogenated castor oil, polyethylene waxes and polymethylene waxes, such as that sold under the name Cirebelle 303 by the company SASOL.

Among the organic solvents, lower alcohols and polyols may be mentioned. These can be selected from glycols and glycol ethers such as ethylene glycol, propylene glycol, butylene glycol, dipropylene glycol or diethylene glycol.

As hydrophilic thickeners, mention may be made of carboxyvinyl polymers such as Carbopols (Carbomers) and Pemulen (acrylate / C10-C30-alkylacrylate copolymer); polyacrylamides, for example crosslinked copolymers sold under the names Sepigel 305 (CTFA name: polyacrylamide / C13-14 isoparaffin / Laureth 7) or Simulgel 600 (CTFA name: acrylamide / sodium acryloyldimethyltaurate copolymer / isohexadecane / polysorbate 80) by the company Seppic; polymers and copolymers of 2-acrylamido-2-methylpropanesulphonic acid, optionally crosslinked and / or neutralized, such as poly (2-acrylamido-2-methylpropanesulphonic acid) marketed by Hoechst under the trade name "Hostacerin AMPS" ( CTFA name: ammonium polyacryloyldimethyl taurate or SIMULGEL 800 marketed by the company SEPPIC (CTFA name: sodium polyacryolyldimethyl taurate / polysorbate 80 / sorbitan oleate); copolymers of 2-acrylamido-2-methylpropanesulfonic acid and hydroxyethyl acrylate such as SIMULGEL NS and SEPINOV 30 EMT 10 marketed by the company SEPPIC, cellulose derivatives such as hydroxyethylcellulose, polysaccharides and especially gums such as Xanthan gum, water-soluble or water-dispersible silicone derivatives such as acrylic silicones, polyether silicones and cationic silicones and mixtures thereof As lip thickeners ophiles include synthetic polymers such as poly C10-C30 alkyl acrylates sold under the name "IPA INTELIMER 13-1" and "INTELIMER IPA 13-6" by the company Landec or modified clays such as hectorite and its derivatives, such as the products sold under the trade name Bentone.

Of course, those skilled in the art will take care to choose the optional additional compound or compounds mentioned above and / or their amounts in such a way that the advantageous properties intrinsically attached to the compositions 45 in accordance with the invention are not, or substantially not, altered by the addition or additions envisaged, including the improvement of the photostability of the dibenzoylmethane derivative.

The compositions according to the invention may be prepared according to the techniques well known to those skilled in the art. They can be in particular in the form of an emulsion, simple or complex (O / W, W / O, O / W / H or W / O / W) such as cream, milk or cream gel; in the form of an aqueous gel; in the form of a lotion. They may optionally be packaged in aerosol and be in the form of foam or spray. Preferably, the compositions according to the invention are in the form of an oil-in-water or water-in-oil emulsion.

Emulsification processes that can be used are of the pale or helical type, rotor-stator and HHP.

It is also possible, by HHP (between 50 and 800bars), to obtain stable dispersions with drop sizes up to 100 nm. The emulsions generally contain at least one emulsifier chosen from amphoteric, anionic, cationic or nonionic emulsifiers, used alone or as a mixture. The emulsifiers are suitably selected according to the emulsion to be obtained (W / O or O / W). Exemplary emulsifying surfactants for the preparation of W / O emulsions include, for example, alkyl esters or ethers of sorbitan, glycerol or sugars; silicone surfactants such as dimethicone copolyols such as the mixture of cyclomethicone and dimethicone copolyol, sold under the name "DC 5225 C" by the company Dow Corning, and alkyl dimethicone copolyols such as Laurylmethicone copolyol sold under the name " Dow Corning 5200 Formulation Aid "by Dow Corning; Cetyl dimethicone copolyol such as the product sold under the name Abil EM 90R by the company Goldschmidt and the mixture of cetyl dimethicone copolyol, polyglycerol isostearate (4 moles) and hexyl laurate sold under the name ABIL WE 09 by the company Goldschmidt. One or more coemulsifiers may also be added, which advantageously may be selected from the group consisting of alkylated polyol esters.

Examples of alkylated polyol esters that may be mentioned include polyethylene glycol esters such as PEG-30 dipolyhydroxystearate, such as the product marketed under the name Arlacel P135 by the company ICI.

Examples of glycerol and / or sorbitan esters that may be mentioned are polyglycerol isostearate, such as the product sold under the name Isolan GI 34 by the company Goldschmidt; sorbitan isostearate, such as the product sold under the name Arlacel 987 by the company ICI; sorbitan isostearate and glycerol, such as the product sold under the name Arlacel 986 by the company ICI, and mixtures thereof. Examples of O / W emulsions which may be mentioned as emulsifiers are nonionic emulsifiers such as oxyalkylenated (more particularly polyoxyethylenated) fatty acid esters of glycerol; oxyalkylenated fatty acid and sorbitan esters; oxyalkylenated fatty acid esters (oxyethylenated and / or oxypropylenated) such as the PEG-100 Stearate / Glyceryl Stearate mixture marketed for example by the company ICI under the name Arlacel 165; oxyalkylenated fatty alcohol ethers (oxyethylenated and / or oxypropylenated); sugar esters such as sucrose stearate; fatty alcohol and sugar ethers, in particular alkylpolyglucosides (APG) such as decylglucoside and laurylglucoside sold, for example, by Henkel under the respective names Plantaren 2000 and Plantaren 1200, cetostearylglucoside optionally mixed with cetostearyl alcohol; , marketed for example under the name Montanov 68 by the company Seppic, under the name Tegocare CG90 by the company Goldschmidt and under the name Emulgade KE3302 by Henkel, as well as arachidyl glucoside, for example in the form of a mixture of arachidic and behenic alcohols and arachidylglucoside sold under the name Montanov 202 by the company Seppic. According to a particular embodiment of the invention, the mixture of the alkylpolyglucoside as defined above with the corresponding fatty alcohol may be in the form of a self-emulsifying composition, as described for example in the document WO -A-92/06778.

In the case of an emulsion, the aqueous phase thereof may comprise a nonionic vesicular dispersion prepared by known methods (Bangham, Standish and Watkins, J. Mol Biol 13, 238 (1965)). , FR 2 315 991 and FR 2 416 008).

The compositions according to the invention find their application in a large number of treatments, in particular cosmetics, of the skin, lips and hair, including the scalp, in particular for the protection and / or care of the skin, lips and / or hair, and / or for makeup of the skin and / or lips.

Another object of the present invention is the use of the compositions according to the invention as defined above for the manufacture of products for the cosmetic treatment of the skin, lips, nails, hair, eyelashes. , eyebrows and / or scalp, including skincare products, sunscreen products and make-up products. The cosmetic compositions according to the invention may for example be used as a makeup product.

The cosmetic compositions according to the invention may, for example, be used as a skincare and / or sun protection product for the face and / or body of liquid to semi-liquid consistency, such as milks, more or less creamy creams. , gel-creams, pasta. They may optionally be packaged in aerosol and be in the form of foam or spray. The compositions according to the invention in the form of vaporizable fluid lotions according to the invention are applied to the skin or the hair in the form of fine particles by means of pressurizing devices. The devices according to the invention are well known to those skilled in the art and include 50 non-aerosol pumps or "atomizers", aerosol containers comprising a propellant and aerosol pumps using compressed air as a propellant. These are described in US Pat. Nos. 4,077,441 and 4,850,517.

The aerosol-conditioned compositions in accordance with the invention generally contain conventional propellants such as, for example, hydrofluorinated compounds, dichlorodifluoromethane, difluoroethane, dimethyl ether, isobutane, n-butane, propane and trichlorofluoromethane. They are preferably present in amounts ranging from 15 to 50% by weight, based on the total weight of the composition.

The compositions according to the invention may also comprise, in addition, additional cosmetic and / or dermatological active ingredients.

Among the active agents, mention may be made of: vitamins (A, C, E, K, PP) and their derivatives or precursors, alone or in mixtures, anti-glycation agents; soothing agents, NO-synthase inhibitors; agents stimulating the synthesis of dermal or epidermal macromolecules and / or preventing their degradation; agents stimulating the proliferation of fibroblasts; agents stimulating the proliferation of keratinocytes; Muscle relaxants; tensing agents, mattifying agents, keratolytic agents, desquamating agents; Moisturizing agents such as, for example, polyols such as glycerin, butylene glycol, propylene glycol. anti-inflammatory agents; agents acting on the energetic metabolism of cells; insect repellents; antagonists of substances P or CRGP. - anti-hair loss and / or hair regrowth agents - anti-wrinkle agents. Of course, those skilled in the art will take care to choose the optional additional compound or compounds mentioned above and / or their amounts in such a way that the advantageous properties intrinsically attached to the compositions in accordance with the invention are not, or substantially not, altered by the addition or additions envisaged.

The person skilled in the art will choose the said active agent (s) depending on the desired effect on the skin, the hair, the eyelashes, the eyebrows and the nails.

The composition may furthermore comprise at least one ingredient such as blooming fillers or agents promoting the natural coloration of the skin, intended to supplement the biological effect of these active ingredients or to provide an immediate visual anti-aging effect. .

For the care and / or makeup of oily skin, those skilled in the art will preferably choose at least one active agent selected from desquamating agents, sebo-regulating or anti-seborrhoeic agents, astringent agents.

OTHER ADDITIONAL INGREDIENTS

The composition may further comprise at least one additional ingredient intended to complement the effect of these assets or to provide an immediate visual effect; mention may in particular be made of matting agents, fillers with a blooming effect, fluorescent agents, agents promoting the naturally rosy coloration of the skin and abrasive or exfoliating fillers. To complement and / or optimize the effects conferred by cosmetic active ingredients and / or dermatological cited above on keratin materials, it may be advantageous to incorporate in the compositions of the invention other additional ingredients.

In particular, these additional ingredients may confer an immediate visual effect that will be relayed by the effect of the assets mentioned above. They can also, via a mechanical action (eg abrasive fillers), amplify the effect of the biological assets mentioned above.

Mattifying agents

By "matting agent" is meant agents intended to make the skin visibly duller, less glossy.

The matting effect of the agent and / or of the composition containing it can in particular be evaluated using a gonioreflectometer, by measuring the ratio R between the specular reflection and the diffuse reflection. A value of R less than or equal to 2 generally reflects a matting effect. The matting agent may especially be chosen from a rice starch or a corn starch INCI name: ZEA MAYS (CORN) STARCH as in particular the product sold under the trade name "FARMAL CS 3650 PLUS 036500" by National Starch, the kaolinite, talc, pumpkin seed extract, cellulose microbeads, vegetable fibers, synthetic fibers, in particular polyamides, expanded acrylic copolymer microspheres, polyamide powders, silica powders, powders polytetrafluoroethylene, silicone resin powders, acrylic polymer powders, wax powders, polyethylene powders, elastomeric crosslinked organopolysiloxane powders coated with silicone resin, talc / titanium dioxide powder powders. alumina / silica, amorphous mixed silicate powders, silicate particles and in particular mixed silicate, and mixtures thereof.

Examples of matting agents that may be mentioned include: rice or maize starch, in particular starch octenyl succinate aluminum sold under the name Dry Flo® by the company National Starch, kaolinite; - silicas; - talc; an extract of pumpkin seeds as marketed under the name Curbilene® by the company Indena; cellulose microbeads as described in patent application EP 1 562 562; - fibers, such as silk, cotton, wool, flax, cellulose fibers extracted in particular from wood, vegetables or algae, polyamide (Nylon®), modified cellulose, poly-p-phenylene terephtamide, acrylic, polyolefin, glass, silica, aramid, carbon, Teflon®, insoluble collagen, polyesters, polyvinyl chloride or vinylidene, polyvinyl alcohol, polyacrylonitrile, chitosan, polyurethane, polyethylene phthalate, fibers formed from a mixture of polymers, resorbable synthetic fibers, and mixtures thereof described in patent application EP 1 151 742; Microspheres of expanded acrylic copolymers such as those sold by EXPANCEL under the trade names EXPANCEL 551®, fillers with an optical effect as described in patent application FR 2 869 796, in particular: polyamides (Nylon®), such as, for example, Arkema's Orgasol-type nylon 12 particles having a mean size of 10 microns and a refractive index of 1.54, and silica powders, for example Silica beads SB150 from Miyoshi. of average size 5 microns and refractive index 1.45, 30 - polytetrafluoroethylene powders, such as PTFE ceridust 9205F Clariant average size 8 microns and refractive index 1.36, - the powders of resin of Silicone such as Silicon resin Tospearl 145A of GE Silicone of average size 4.5 microns and refractive index 1.41, the powders of acrylic copolymers, especially of methyl poly (meth) acrylate, such as P particles. MMA Jurymer MBI from Nihon Junyoki with an average size of 8 microns and a refractive index of 1.49, or the Micropearl M100® and F 80 ED® particles from Matsumoto Yushi-Seiyaku, - wax powders such as Paraffin wax particles micro-wavelength 114S micropowders of average size 7 microns and refractive index 1.54, 40 - polyethylene powders, especially comprising at least one ethylene / acrylic acid copolymer, and in particular consisting of ethylene / acrylic acid copolymers such as particles Flobeads EA 209 from Sumitomo (average size 10 microns and refractive index 1.48), elastomeric crosslinked organopolysiloxane powders coated with silicone resin, in particular silsesquioxane resin, as described, for example, in US Pat. 5,538,793. Such elastomer powders are sold under the names "KSP-100", "KSP-101", "KSP-102", "KSP-103", "KSP-104", "KSP-105" by the company SHIN ETSU, and - the powders com talc / titanium dioxide / alumina / silica positions such as those sold under the name Coverleaf® AR-80 by Catalyst & chemicals, - their mixtures, - absorbing and / or adsorbent sebum compounds as described in the application for Patent FR 2 869 796. Mention may in particular be made of: silica powders, such as, for example, the porous silica microspheres sold under the name "Silica Beads SB-700" marketed by the company MYOSHI, the "SUNSPHERE® H51", " SUNSPHERE® H33 ", io" SUNSPHERE® H53 "sold by ASAHI GLASS; polydimethylsiloxane-coated amorphous silica microspheres sold under the name "SA SUNSPHERE® H-33" and "SA SUNSPHERE® H-53" marketed by the company ASAHI GLASS; mixed amorphous silicate powders, in particular aluminum and magnesium, such as for example the one marketed under the name "NEUSILIN UFL2" by Sumitomo. polyamide (nylon®) powders, such as for example "ORGASOL® 4000" marketed by Arkema, and acrylic polymer powders, especially of polymethyl methacrylate, such as for example "COVABEAD® LH85" marketed by WACKHERR; polymethyl methacrylate / ethylene glycol dimethacrylate, such as, for example, "DOW CORNING 5640 MICROSPONGE® SKIN OIL ADSORBER" marketed by Dow Corning, or "Ganzpearl® GMP-0820" marketed by Ganz Chemical; allyl polymethacrylate / ethylene glycol dimethacrylate, such as for example "POLY-PORE® L200" or "POLY-PORE® E200" marketed by AMCOL; ethylene glycol dimethacrylate / lauryl methacrylate copolymer, such as, for example, "POLYTRAP® 6603" marketed from Dow Corning; Silicate particles, such as alumina silicate; mixed silicate particles, such as: magnesium aluminum silicate particles, such as saponite or magnesium aluminum silicate, hydrated with a sodium sulphate marketed under the trademark Sumecton® by the company Kunimine; the magnesium silicate complex, hydroxyethylcellulose, black cumin oil, pumpkin oil and phospholipids or Matipure® from Lucas Meyer, and their mixtures. As preferred matting agents, it is possible to use, according to the invention, a pumpkin seed extract, a rice or maize starch, kaolinite, silicas, talc, polyamide powders, polyethylene powders, powders of acrylic copolymers, expanded acrylic copolymer microspheres, silicone resin microbeads, mixed silicate particles and mixtures thereof. 45 Characters with a flutter effect

These fillers can be any material capable of modifying the wrinkles by its intrinsic physical properties and of masking them. These fillers can in particular modify the wrinkles by a tightening effect, a camouflage effect, or a blurring effect.

As a filler, the following compounds can be exemplified: porous silica microparticles, for example Myochi's Silica Beads® SB 150 and SB 700 with a mean size of 5 μm and Asahi's SUNSPHERESO series H Glass, such as H33, H51 of sizes of 3.5 and 5 μm respectively, the hollow hemispherical particles of silicone resins, such as the NLK io 500®, NLK 506® and NLK 510® from Takemoto Oil and Fat, described in particular in US Pat. A-1579849, - Silicone resin powders such as Silicone Resin TospearI0 145 A DE GE Silicone medium size of 4.5pm. powders of acrylic copolymers, in particular of methyl poly (meth) acrylate, for instance PMMA Jurimer MBIO particles of Nihon Junyoki with an average size of 8 μm, the hollow spheres of PMMA sold under the name COVABEADO LH 85 by the company Wackherr and expanded vinylidene / acrylonitrile / methylene methacrylate microspheres sold under the name ExpanceI0. Wax powders such as paraffin wax microloase O 114S particles of micropowders of average size of 7 μm. polyethylene powders in particular comprising at least one ethylene / acrylic acid copolymer, for example the FLOBEADSO EA 209 E from Sumimoto with an average size of 10 μm. Crosslinked elastomeric organopolysiloxane powders coated with silicone resin, in particular silsesquioxane under the name KSP 100®, KSP 1010, KSP 102®, KSP 103®, KSP 104® and KSP 105® by the company Shin Etsu. Talc / dioxide or titanium / alumina / silica composite powders such as for example Coverleaf AR 800 from Catalyst & Chemical. talc, mica, kaolin, lauryl glycine, starch powders crosslinked with octyanyl succinate anhydride, boron nitride, polytetrafluoroethylene powders, precipitated calcium carbonate, carbonate of hydrocarbone magnesium, barium sulfate, hydroxyapatite, calcium silicate, cerium dioxide and glass or ceramic microcapsules. synthetic or natural hydrophilic or hydrophilic fibers, mineral or organic fibers such as silk, cotton, wool, flax, cellulose fibers extracted in particular from wood, vegetables or algae, polyamide (Nylon®), modified cellulose, poly-p-phenylene terephtamide, acrylic, polyolefin, glass, silica, aramid, carbon, polytetrafluoroethylene (Teflon®), insoluble collagen, polyesters, polyvinyl chloride or of vinylidene, polyvinyl alcohol, polyacrylonitrile, chitosan, polyurethane, polyethylene phthalate, fibers formed from a mixture of polymers, resorbable synthetic fibers, and mixtures thereof described in patent application EP 1 151 742 crosslinked elastomeric spherical silicones, such as Trefil E-505C® or E-506 C® from Dow Corning. abrasive fillers which, by a mechanical effect, provide a smoothing of the cutaneous microrelief, such as abrasive silica, for example abrasive SPO from Semanez or powders of nuts or shells (apricot, walnut for example from Cosmetochem).

The fillers having an effect on the signs of aging are chosen in particular from porous silica microparticles, hollow hemispherical silicone particles, silicone resin powders, acrylic copolymer powders, polyethylene powders, polyethylene powders, crosslinked elastomeric organopolysiloxanes coated with silicone resin, talc / titanium dioxide / alumina / silica composite powders, precipitated calcium carbonate, magnesium hydrocarbonate carbonate, barium sulfate, hydroxyapatite, silicate calcium, cerium dioxide and microcapsules of glass or ceramics, silk fibers, cotton fibers, and mixtures thereof.

The charge can be a "soft focus" charge.

By "soft-focus" load is meant a load which in addition gives transparency to the complexion and a fuzzy effect. Preferably, the "soft-focus" charges have an average particle size of less than or equal to 15 microns. These particles can be of any shape and in particular be spherical or nonspherical. More preferably, these fillers are nonspherical. The "soft-focus" fillers may be chosen from silica powders and silicates, in particular alumina, polymethyl methacrylate (PMMA) powders, talc, silica / TiO2 or silica / zinc oxide composites, polyethylene powders, starch powders, polyamide powders, styrene / acrylic copolymer powders, silicone elastomers, and mixtures thereof. In particular, mention may be made of talc with a mean size of less than or equal to 3 microns, for example talc with a mean size of 1.8 microns and in particular that sold under the trade name Talc P3® by the company Nippon. Talc, Nylon® 12 powder, in particular that sold under the name Orgasol 2002 Extra D Nat Cos® by the company Atochem, the silica particles treated on the surface with a mineral wax 1 to 2% (INCI name: hydrated silica ( and) paraffin) such as those sold by the company Degussa, amorphous silica microspheres, such as those sold under the name Sunsphere, for example reference H-53® by the company Asahi Glass, and silica micro-beads such as than those sold under the name SB-700® or SB-150® by the company Miyoshi, this list is not exhaustive.

The concentration of these fillers having an effect on the signs of aging in the compositions according to the invention may be between 0.1 and 40%, or even between 0.1 and 20% by weight relative to the total weight of the composition. .

Elements promoting the naturally rosy coloration of the skin 50 Mention may in particular be made of: 40 - a self-tanning agent, that is to say an agent which, applied to the skin, in particular on the face, makes it possible to obtain a tanning effect appearance more or less similar to that which may result from prolonged exposure to the sun (natural tanning) or under a UV lamp; an additional coloring agent, that is to say any compound having a particular affinity for the skin enabling it to confer on the latter a durable, non-covering coloration (ie not having a tendency to opacify the skin) and which is not removable with water or solvent, and which is both abrasive and wash resistant with a solution containing surfactants. Such durable coloration is therefore distinguished from the superficial and momentary coloration provided for example by a makeup pigment; and their mixtures.

Examples of self-tanning agents that may be mentioned include: dihydoxyacetone (DHA), erythrulose, and the combination of a catalytic system consisting of: salts and oxides of manganese and / or zinc, and alkali hydrogencarbonates and / or alkaline earth.

The self-tanning agents are generally chosen from mono or polycarbonyl compounds such as, for example, isatin, alloxane, ninhydrin, glyceraldehyde, mesotartaric aldehyde, glutaraldehyde, erythrulose, pyrazolin-4 derivatives, 5-diones as described in patent application FR 2,466,492 and WO 97/35842, dihydroxyacetone (DHA), 4,4-dihydroxypyrazolin-5-ones derivatives as described in patent application EP 903 342 DHA will preferably be used.

DHA may be used in free form and / or encapsulated for example in lipid vesicles such as liposomes, in particular described in application WO 97/25970.

In general, the self-tanning agent is present in an amount of from 0.01 to 20% by weight, and preferably in an amount of from 0.1 to 10% by weight of the total weight of the composition.

It is also possible to use other compounds, dyes, which make it possible to modify the color produced by the self-tanning agent. These dyes may be chosen from synthetic direct dyes or natural dyes.

These dyes may be chosen, for example, from red or orange dyes of the fluoran type, such as those described in the patent application FR2840806. For example, the following dyes may be mentioned: tetrabromofluorescein or eosin known under the name CTFA: Cl 45380 or Red 21 phloxine B known under the name CTFA: Cl 45410 or Red 27 50 diiodofluorescein known under the name CTFA Cl 45425 or Orange 10; dibromofluorescein known under the name CTFA: Cl 45370 or Orange 5. the sodium salt of tetrabromofluorescein known under the name CTFA: Cl 45380 (Na knows) or Red 22; the sodium salt of phloxine B known under the name CTFA name: Cl 45410 (Na s know) or Red 28 - the sodium salt of diiodofluorescein known as CTFA: Cl 45425 (Na knows) or Orange 11; Erythrosine known under the name CTFA: Cl 45430 or Acid Red 51. Phloxine known under the name CTFA: Cl 45405 or Acid Red 98. These dyes may also be chosen from the antraquinones, the caramel, the carmine, charcoal black, azulene blues, methoxalene, trioxalene, guajazulene, chamuzulene, bengal rose, cosine 10B, cyanosine, daphinin. These dyes may also be chosen from indole derivatives such as the monohydroxyindoles as described in the patent FR2651126 (ie: 4-, 5-, 6- or 7-hydroxyindole) or the di-hydroxyindoles as described in the EP-patent. B-0425324 (ie: 5,6-dihydroxyindole, 2-methyl-5,6-dihydroxyindole, 3-methyl-5,6-dihydroxyindole, 2,3-dimethyl-5,6-dihydroxyindole);

Abrasive stains or exfoliating agents

Examples of exfoliating agents that may be used in rinsed compositions according to the invention include exfoliating or exfoliating particles of mineral, vegetable or organic origin. Thus, for example, beads or polyethylene powder, nylon powder, polyvinyl chloride powder, pumice, ground apricot kernels or nut shells can be used. sawdust, glass beads, alumina, and mixtures thereof. Exfogreen® from Solabia (bamboo extract), strawberry akenes (Greentech strawberry Akenes), peach kernel powder, apricot kernel powder, and finally the field of vegetable powders with abrasive effect include the cranberry powder. Preferred abrasive fillers or exfoliating agents according to the invention include peach kernel powder, apricot kernel powder, cranberry kernel powder, strawberry achene extracts, bamboo extracts. .

The following examples serve to illustrate the invention without being limiting in nature. In these examples, the amounts of the ingredients compositions are given in% by weight relative to the total weight of the composition. EXAMPLE 1 Diisobutyl-2- [4- (6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) aminolcarbonyl) amino) benzylidenelmalonate (9)

Preparation of (9) from N- (6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) -1H-5-imidazole-1-carboxamide (9) To a solution of diisobutyl 2 - (4-Aminobenzylidene) malonate (2.248 g, 7.04x10-3 mol) in 100 ml of 1,2-dichloroethane and under argon bubbling of N- (6-methyl-4-oxo-1, 4-dihydropyrimidin-2-yl) -1H-imidazole-1-carboxamide (1.4 g, 6.4x10-3 mol). The reaction mixture is refluxed and kept at this temperature for 20 hours. The solvent is evaporated under vacuum. The yellow residue obtained is taken up in acetone. The insoluble material is filtered and rinsed with acetone. 3.01 g (86% yield) of the product (9) is obtained as a pale yellow solid. UV (dmso / Ethanol): λmax = 330 nm; Emax = 19290; E1% = 410.

EXAMPLE 2 Diisobutyl 2- {4 - [({[6 - ({[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-20-yl) aminolcarbonyl} amino) hexyllamino} carbonyl) aminolbenzylidene} matonate (10)

Preparation of (10) from 1- (6-isocyanatohexyl) -3- (6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) urea N H H H (10)

To a solution of diisobutyl 2- (4-aminobenzylidene) malonate (0.419 g, 1.31x10-3 mole) in 20 ml of 1,2-dichloroethane and under argon bubbling was added the 1- (4-aminobenzylidene) malonate. isocyanatohexyl) -3- (6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) urea (0.35 g, 1.19x10-mole). The reaction mixture is refluxed and maintained at this temperature for 21 hours. The solvent is evaporated under vacuum. The yellow residue obtained is taken up in acetone. The insoluble material is filtered and rinsed with acetone. It is taken up in 30 ml of hot ethanol to which 3 ml of water are added. The precipitate is filtered and dried under vacuum.

0.35 g (yield 47%) of the product (10) is obtained in the form of a pale yellow solid. UV (Ethanol): λmax = 331 nm; Emax = 22060; E1% = 360.

Example 3: 2-ethylhexyl (2Z) -2-cyano-3- [4 - ({[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) aminolcarbonyl} amino) phenylacrylate (12)

Preparation of (12) from N- (6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) -1H-imidazole-1-carboxamide (12) To a solution of 2- ethylhexyl (2Z) -3- (4-aminophenyl) -2-cyanoacrylate (0.529 g, 1.76x10-3 mol) in 20 ml of 1,2-dichloroethane and under argon bubbling; methyl-4-oxo-1,4-dihydropyrimidin-2-yl) -1H-imidazole-1-carboxamide (0.35 g, 1.6x10-3 mol). The reaction mixture is refluxed and kept at this temperature for 25 hours. The solvent is evaporated under vacuum. The yellow residue obtained is taken up in hot ethanol and filtered. The insoluble material is taken up in dichloromethane and filtered. The yellow solid obtained is dried. 0.722 g (72% yield) of the product (12) is obtained in the form of a yellow solid. UV (dmso / Ethanol):? Max = 368 nm; Emax = 20410; E1% = 452.

EXAMPLE 4 Diisobutyl 2- {4 - {(6- [(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) aminolcarbonyl} amino) hexyllamino} carbonyl) aminolbenzylidene} matonate (13) Preparation of (13) from 1- (6-isocyanatohexyl) -3- (6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) urea NN (13) to a solution of 2 2-ethylhexyl (2Z) -3- (4-aminophenyl) -2-cyanoacrylate (1.126 g, 3.7x10-3 mol) in 20 ml of 1,2-dichloroethane and under 1-argon bubbling ( 6-isocyanatohexyl) -3- (6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) urea (1 g, 3.4x10-3 mol). The reaction mixture is refluxed and maintained at this temperature for 24 hours. The solvent is evaporated under vacuum. The yellow residue obtained is taken up in 100 ml of hot ethanol to which 30 ml of water are added. The precipitate obtained is filtered and dried under vacuum. 0.85 g (yield 42%) of the product (13) are obtained in the form of a yellow solid. UV (CHCl 3):? Max = 369 nm; Emax = 24100; E1% = 390. EXAMPLE 5 Dibutyl 4,4 '- [(6 - {[4 - ({[(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl) aminolcarbonyl} amino) butyllamino } -1,3,5-triazine-2,4-diyl) diiminol dibenzoate (22) Preparation of (22) from N- (4-aminobutyl) -N '- (6-methyl-4-oxo-1) A suspension of butyl 4 - [(4 - {[4- (butoxycarbonyl) phenyl] amino} -6-chloro-1,3,5-triazin-4-dihydropyrimidin-2-yl) urea hydrochloride. 2-yl) amino] benzoate (0.1 g, 0.2 mmol) in 4 ml of acetonitrile are added N- (4-aminobutyl) -N '- (6-methyl-4-oxo-1,4) -dihydropyrimidin-2-yl) urea hydrochloride (4.8 mg, 0.2 mmol) and 66 microliter of diisopropylethylamine (0.4 mmol). The solution is stirred for 6 hours under reflux. The final product is obtained by precipitation in water and then dried under reduced pressure.

0.06 g (40% yield) of the product (22) is obtained in the form of a white powder.

UV (CHCl 3):? Max = 310 nm; Emax = 79940; El% = 1140.

Claims (15)

REVENDICATIONS1. A composition comprising in a cosmetically acceptable medium: i) at least one ureidopyrimidone compound corresponding to one of the following formulas (I) or (II): ## STR1 ## wherein: n = 1, 2 or 3; preferably n = 1 -m = 0 or 1; - w = 0 or 1; The value of w is conditioned by the nature of the groups AI and A2 as explicitly mentioned in the definition of said groups. - q = 0 or 1; The value of q is conditioned by the nature of the groups AI and A2 as explicitly mentioned in the definition of said groups. R 1 and R 2, which are identical or different within the same formula, represent hydrogen, -OH, -NRR '; or a linear or branched and / or cyclic, in particular saturated or unsaturated, optionally saturated, C1-C18, carbon-containing group which may contain one or more heteroatoms chosen from O, S and N; RI can also be the radical: -Z'1-A1; Z represents a multivalent radical (divalent to tetravalent, according to the value of n) chosen from (i) a carbon radical, in particular hydrocarbon radical, linear or branched, saturated or unsaturated, C1-C32; optionally interrupted or substituted one or more times with an optionally aromatic (hetero) C3-C12 ring; or (ii) an optionally aromatic C3-C12 hydrocarbon radical (hetero) cyclic; optionally substituted with one or more carbon radicals, in particular linear or branched, saturated or unsaturated, C1-C32 hydrocarbon radicals; (Iii) a (C 5 -C 6) -cycloalkyl-C 1 -C 12 -alkyl radical, said radical Z possibly being: (1) substituted with 1 to 12 identical or different groups chosen from -OH, -SO 3 R, -OSO 3 R, -SO 3 H , -OSO3H, -OOOH, -OO0R, -CONRR ', C1-C4 alkyl, and - N + RR'R ", An- and / or (2) interrupted or terminated with 1-5 identical or unsubstituted groups selected from the divalent groups: -S-, -NH- (or = NH), -O-, -C (O) -, -SO2-, or combinations thereof such as for example -NHC (O) -, -C (0 ) NH-, -OC (O) -, - C (O) O-, or i0 An- An- / \ R "+ + -N \ / N- -N- -NNN 'R' - / R with Ra = H or halogen, especially Cl, or C1-C6 alkyl; R, R 'and R ", which may be identical or different, being H or a linear or branched C1-C12 alkyl radical, it being understood that said radical Z comprises at least one heteroatom chosen from N, O and S; or substituted by a cationic group, the electroneutrality of the compounds of formula (I) is ensured by an anion or a mixture of An-cosmetically acceptable anions; Z1 and Z'1, which may be identical or different, denote a divalent radical Z; - Z may further designate a covalent bond for the compounds of formula (I) when n = 1 and q = 0, Z'1 can not designate a covalent bond - Z2 is a divalent alkyl radical C1-C32, linear or branched with the proviso that when w = 0, then the radical A1 and the diradical A2 can not be terminated by a nitrogen, the monoradicals Al corresponding to one of the following formulas (IIIa) to (XIIa): para-aminobenzoate: (R2) p H X-R 1 1 w = 1; N (IIIa) b) cinnamate, benzalmalonate or cyanoacrylate (IVa) H 1 N x = 0 or 1 with the proviso that q = w = x = 1 when Z is not a covalent bond and q = x = 0 when Z is a covalent bond -N 1 H io c) benzophenone w = 1; d) benzylidene camphor: (Va) w = 1; 53N-H (Vla) 00 w = 0; (Villa) 54e) benzotriazole: q = w = 1; H N HO N (IXa) (R'2) p. q = 0; (Xa) with X = O or NH Ak = divalent linear saturated C1-C6 alkyl radical, preferably C2. (XIa) 10 O 5 e) s-triazine: A3 i w = 0; NN (XIIIa) A3 with the radicals A3, identical or different, representing the radicals AI of formula (IIIa), (IVa), (Va), (Vla) or (IXa); the diradicals A2 corresponding to one of the following formulas (IIIb) to (Vllb): 55a / para-amino benzoate: w = 1; MW-N H X- (IIIb) with X = O or NH b / cinnamate; benzalmalonate or cyanoacrylate: W = 1; ## STR2 ## where X = O or NH 3 / benzophenone: w = 0; (Vb) d / benzylidene camphor: (Vlb) e / s-triazine: 1 w = 0; NO (VIII) A4 with A4, representing a radical of formula (IIIa), (IVa), (Va), (Vla) or (IXa); in which: R 'represents a linear or branched C 3 -C 30 alkyl or C 3 -C 30 alkenyl radical which may carry one or more hydroxyl substituents and which may contain in the carbon chain an alkyl ring, one or more heteroatoms chosen from oxygen, nitrogen and silicon atoms, an optionally substituted C 6 -C 20 aryl radical; R2 and R'2 independently represent a linear or branched C1-C10 alkoxy radical, a linear or branched C1-C10 alkyl radical, a linear or branched C2-C8 alkenyl radical or -OSi (CH3) 3 two adjacent radicals R 2 may together form an alkylidene dioxy group in which the alkylidene group contains from 1 to 2 carbon atoms (i.e. a -O- (CH 2) tO- group with t = 1 or 2), - p and p 'are independently 0, 1 or 2, - R3 is hydrogen, a C1-C4 alkyl radical, or a radical selected from 20 - (C = O) XR', -ON, - (C = O) R ', -SO 2 R 4 with R' having the same definition as above and - R 4 represents a linear or branched C 1 -C 12 alkyl radical or an optionally substituted C 6 -C 20 aryl radical, - R 5 represents a C2-C8 divalent alkyl radical; -X represents oxygen or a -NR6 radical with R6 being a linear or branched C1-C8 alkyl radical. (Ii) at least one 4-carboxy-2-pyrrolidinone derivative of the following formula (B) or one of its salts, optical isomers, stereoisomers, enantiomers and diastereoisomers or one of its geometric isomers: B) in which: R3 denotes hydrogen or a linear or branched C1-C20 alkyl radical C3-C20. R4 denotes a C1-C20 linear or branched C3-C20 alkyl radical which may contain a C5-C6 ring, a C3-C20 branched alkyl radical or a C5-C6 cycloalkyl radical optionally substituted with one or two methyl radicals, phenyl radical, benzyl radical or phenethyl radical. R5 and R6 independently of one another are hydrogen, linear C1-C12 or branched C3-C12 alkyl radicals; when R3 is hydrogen, the compounds may be in their free acid form or in the form of their cosmetically acceptable salts. 2. The composition according to claim 1, wherein the compounds of formula (I) or (II) are chosen from those for which: - mest or 1; -R1 isHou-Z'1-A1; R2 is the linear or branched C1-C3 alkyl radical; the radical Z (or Z1 and / or Z'i) denotes a divalent C1-12 linear alkyl radical, preferably a 1,2-ethylene radical; 1,6-hexylene; 1,4-butylene, or a divalent radical: N o * Z may further designate a covalent bond when n = 1 and q = 0. Z2 denotes a C2-C20 divalent linear alkyl radical, in particular a tetradecyl radical; R 'is C 1 -C 8 alkyl, optionally substituted with 1 or 2 hydroxyl groups, - X is -O-, - p = p' = O, - R 3 is -CN or -000 R 1 - R 5 is -CH 2 CH 2 30 3. The composition according to claim 1 or 2, wherein the compounds of formula (I) or (II) are para-aminobenzoate derivatives and selected from the following compounds: ## STR1 ## - O LHHH (2) 10 HH i NAN HH (5) 5 4. Composition according to claim 1 or 2, wherein the compounds of formula (I) or (II) are cinnamate derivatives and chosen from the following compounds: ## STR2 ## ## STR2 ## (8) 5. Composition according to claim 1 or 2, wherein the compounds of formula (I) lo are benzalmalonate derivatives and chosen from the following compounds: (7) HHHO NYNyN NxN NOHH (9) IIIHHHHHONN / \ N (10) HH 15 HH 10 6. Composition according to claim 1 or 2, wherein the compounds of formula (I) or (II) are cyanoacrylate derivatives and chosen from the following compounds: ## STR2 ## O 01 1 (12) N N N ~ - ,,, N H H H O o H H H O NYNyN NxN N O H H 7. Composition according to claim 1 or 2 wherein the compounds of formula (I) are benzophenone derivatives and are the following compound: ## STR2 ## 8. A composition according to claim 1 or 2 wherein the compounds of formula (I) or (II) are benzylidene camphor derivatives and selected from the following compounds: HHH (17) N NyNN1N ~ ---- 1 1 HON ## STR1 ## ## STR2 ## 9. The composition of claim 1 or 2 wherein the compounds of formula (I) are benzotriazole derivatives and selected from the following compounds: H (18) HHH 1 1 1 NN ~ NNHON \ (20) 0 H 10 HHH 1 1 1 NHO NIA / 10. Composition according to claim 1 or 2, wherein the compounds of formula (I) or (II) are s-triazine derivatives and chosen from the following compounds: ## STR2 ## (22) HHNN lNN 1 1 1 HHH (23) O (24) 5o o NOHHON ~ NNNN N NNN III II IIIIHHH NN HHHN, H (26) oo OHHON - '"- \ NNNyNYN ~ - N Name \ HHH NIINII HHH, NH (27) O, OH OH, NNNNN, N, N, N, III, IHHHN, NHHHN, H 11. Composition according to any one of claims 1 to 10, wherein the 4-carboxy 2-pyrrolidinone derivative of formula (B) is chosen from those for which io-R 3 denotes hydrogen, a linear C 1 -C 14 alkyl radical. or a C 3 -C 14 branched alkyl radical; R 4 denotes the phenyl radical, the benzyl radical, the phenethyl radical, a C 5 -C 6 cycloalkyl radical, a linear C 1 -C 20 alkyl radical or a C 3 -C 20 branched alkyl radical; . R5 and R6 denote independently of one another a hydrogen and a C1-C4 linear alkyl radical, (28) 12. Composition according to claim 11, wherein the 4-carboxy-2-pyrrolidinone derivative of formula (B) is chosen from the following compounds or one of their salts, optical isomers, stereoisomers, enantiomers or diastereoisomers or geometric isomers: o (c) oo (a) (b) (d) o (e) o (f) oo (h) o (k) o (p) oo G) (9) (r) (s) 15O (t) (u) (V) / (w) ooo r NNNOO r O (Y) (ad) 5 (ap) (aq) (av) (as) 50 (ay) (az) (ba) OH OH OH (bd) OH (bh) OH (bh) O (bb) OH (bn) 10OH CH3 (bw) ow (by) 13. Composition according to claim 12, wherein the 4-carboxy-2-pyrrolidinone derivative of formula (B) is chosen from those of structure (I), (n), (o), (ac), (am), ( at), (au), (ba), (bg), (b1), (bm), (bp), (br), (bw) and (by). 14. Use of at least one 4-carboxy 2-pyrrolidinone derivative of formula (B) as defined in any one of claims 1, 11, 12 and 13 as a solvent and / or an agent for improving the solubility of a ureidopyrimidone compound of formula (I) or (II) as defined in any one of claims 1 to 10. 15. Use of at least one 4-carboxy 2-pyrrolidinone derivative of formula (B) as defined in any one of claims 1, 11, 12 and 13 in a composition comprising in a cosmetically acceptable medium at least one ureidopyrimidone compound of formula (I) or (II) as defined in any one of claims 1 to 10 for the purpose of increasing the sun protection factor.