FR2963351B1 - Particules formees d'un complexe polyelectrolyte de chitosane et d'un polysaccharide anionique, presentant une stabilite amelioree - Google Patents

Particules formees d'un complexe polyelectrolyte de chitosane et d'un polysaccharide anionique, presentant une stabilite amelioree

Info

Publication number
FR2963351B1
FR2963351B1 FR1056300A FR1056300A FR2963351B1 FR 2963351 B1 FR2963351 B1 FR 2963351B1 FR 1056300 A FR1056300 A FR 1056300A FR 1056300 A FR1056300 A FR 1056300A FR 2963351 B1 FR2963351 B1 FR 2963351B1
Authority
FR
France
Prior art keywords
chitosan
improved stability
particles formed
polyelectrolyte complex
anionic polysaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR1056300A
Other languages
English (en)
Other versions
FR2963351A1 (fr
Inventor
Thierry Delair
Bernard Verrier
Franck Gaudin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite Claude Bernard Lyon 1 UCBL
Original Assignee
INST NAT SCIENCES APPLIQ
Centre National de la Recherche Scientifique CNRS
Universite Claude Bernard Lyon 1 UCBL
Institut National des Sciences Appliquees de Lyon
Universite Jean Monnet Saint Etienne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST NAT SCIENCES APPLIQ, Centre National de la Recherche Scientifique CNRS, Universite Claude Bernard Lyon 1 UCBL, Institut National des Sciences Appliquees de Lyon , Universite Jean Monnet Saint Etienne filed Critical INST NAT SCIENCES APPLIQ
Priority to FR1056300A priority Critical patent/FR2963351B1/fr
Priority to PCT/FR2011/051794 priority patent/WO2012013895A1/fr
Priority to EP11752293.8A priority patent/EP2598567A1/fr
Priority to US13/812,179 priority patent/US20130216592A1/en
Publication of FR2963351A1 publication Critical patent/FR2963351A1/fr
Application granted granted Critical
Publication of FR2963351B1 publication Critical patent/FR2963351B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/286—Alkyl ethers substituted with acid radicals, e.g. carboxymethyl cellulose [CMC]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/14—Amylose derivatives; Amylopectin derivatives
    • C08L3/18—Ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/02—Dextran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/10—Heparin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/16—Biodegradable polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
    • C08J2405/02—Dextran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
    • C08J2405/10—Heparin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
FR1056300A 2010-07-30 2010-07-30 Particules formees d'un complexe polyelectrolyte de chitosane et d'un polysaccharide anionique, presentant une stabilite amelioree Active FR2963351B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR1056300A FR2963351B1 (fr) 2010-07-30 2010-07-30 Particules formees d'un complexe polyelectrolyte de chitosane et d'un polysaccharide anionique, presentant une stabilite amelioree
PCT/FR2011/051794 WO2012013895A1 (fr) 2010-07-30 2011-07-26 Particules formees d'un complexe polyelectrolyte de chitosane et d'un polysaccharide anionique, presentant une stabilite amelioree
EP11752293.8A EP2598567A1 (fr) 2010-07-30 2011-07-26 Particules formees d'un complexe polyelectrolyte de chitosane et d'un polysaccharide anionique, presentant une stabilite amelioree
US13/812,179 US20130216592A1 (en) 2010-07-30 2011-07-26 Particles consisting of a chitosan polyelectrolyte complex and of an anionic polysaccharide, and having improved stability

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1056300A FR2963351B1 (fr) 2010-07-30 2010-07-30 Particules formees d'un complexe polyelectrolyte de chitosane et d'un polysaccharide anionique, presentant une stabilite amelioree

Publications (2)

Publication Number Publication Date
FR2963351A1 FR2963351A1 (fr) 2012-02-03
FR2963351B1 true FR2963351B1 (fr) 2013-03-08

Family

ID=43332609

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1056300A Active FR2963351B1 (fr) 2010-07-30 2010-07-30 Particules formees d'un complexe polyelectrolyte de chitosane et d'un polysaccharide anionique, presentant une stabilite amelioree

Country Status (4)

Country Link
US (1) US20130216592A1 (fr)
EP (1) EP2598567A1 (fr)
FR (1) FR2963351B1 (fr)
WO (1) WO2012013895A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
FR3029116B1 (fr) 2014-12-01 2018-03-30 Advanced Chitosan Solutions Biotech Procede d'obtention d'un gel de cartilage pour la reparation cartilagineuse, comprenant du chitosane et des chondrocytes
FR3038318B1 (fr) * 2015-07-02 2017-08-04 Univ De Lille 1 Sciences Et Technologies Procede de fabrication d'hydrogel a base de chitosan et de polyelectrolytes charges negativement et materiau poreux alveolaire issu dudit hydrogel
EP3386551A4 (fr) * 2015-12-11 2018-10-24 The General Hospital Corporation Nanoparticules de dextrane pour l'imagerie et la thérapie spécifiques des macrophages
SE1651136A1 (en) * 2016-08-24 2018-02-25 Organoclick Ab Bio-based pec compositions as binders for fiber based materials, textiles, woven and nonwoven materials
CN109689761B (zh) * 2016-08-24 2022-07-08 有机点击股份公司 包含非水溶性颗粒的生物基聚电解质络合物组合物
EP3504262B1 (fr) 2016-08-24 2021-01-27 OrganoClick AB Compositions polyelectrolytiques a base bio contenant des graisses avec une hydrophobicité accrue
CN110511408B (zh) * 2019-09-04 2020-11-03 合肥工业大学 Lm/ta-壳聚糖盐酸盐复合纳米颗粒、其制备方法和应用
CA3170988A1 (fr) * 2020-02-12 2021-08-19 Benanova Inc. Formulations de particules colloidales a fonctionnalite avancee
US20220080628A1 (en) * 2020-09-17 2022-03-17 Nutech Ventures Method of reinforcement for keratin materials
CN115028754B (zh) * 2022-06-30 2023-08-11 上海市农业科学院 硫酸化猴头菌子实体β-葡聚糖、硫酸化β-葡聚糖-壳聚糖纳米颗粒及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006064331A1 (fr) 2004-12-17 2006-06-22 Medipol Sa Particules hydrophiles a base de derives de chitosanes cationiques
US7381716B2 (en) 2005-11-21 2008-06-03 Gp Medical, Inc. Nanoparticles for protein drug delivery
WO2007031812A1 (fr) * 2005-09-16 2007-03-22 Medipol Sa Particules a base de chitosane
EP1774971A1 (fr) * 2005-10-14 2007-04-18 Advanced in Vitro Cell Technologies, S.L. Nanoparticules comprenant de chitosane et d'héparine
WO2007135164A1 (fr) * 2006-05-24 2007-11-29 Advanced In Vitro Cell Technologies, S.A. Nanoparticules de chitosane et de hyaluronane pour l'administration de molécules actives
DK2037899T3 (da) * 2006-07-07 2011-05-09 Univ Aarhus Nanopartikler til nukleinsyreafgivelse
CA2675378A1 (fr) 2007-01-29 2008-08-07 Medipol Sa Particules colloidales a base de chitosane pour la delivrance d'arn

Also Published As

Publication number Publication date
US20130216592A1 (en) 2013-08-22
FR2963351A1 (fr) 2012-02-03
WO2012013895A1 (fr) 2012-02-02
EP2598567A1 (fr) 2013-06-05

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