FR2940973B1 - Identification de nouvelles toxines antagonistes de canaux calcique type-t a visee analgesique - Google Patents

Identification de nouvelles toxines antagonistes de canaux calcique type-t a visee analgesique

Info

Publication number
FR2940973B1
FR2940973B1 FR0900174A FR0900174A FR2940973B1 FR 2940973 B1 FR2940973 B1 FR 2940973B1 FR 0900174 A FR0900174 A FR 0900174A FR 0900174 A FR0900174 A FR 0900174A FR 2940973 B1 FR2940973 B1 FR 2940973B1
Authority
FR
France
Prior art keywords
analgesic
toxins
channels
identification
view
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0900174A
Other languages
English (en)
French (fr)
Other versions
FR2940973A1 (fr
Inventor
Emmanuel Bourinet
Pierre Escoubas
Fabrice Marger
Joel Nargeot
Michel Lazdunski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique
Université Côte d'Azur
Original Assignee
Centre National de la Recherche Scientifique
Université Côte d'Azur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0900174A priority Critical patent/FR2940973B1/fr
Application filed by Centre National de la Recherche Scientifique, Université Côte d'Azur filed Critical Centre National de la Recherche Scientifique
Priority to EP10703318.5A priority patent/EP2387581B1/fr
Priority to JP2011545778A priority patent/JP5519702B2/ja
Priority to US13/144,734 priority patent/US8664179B2/en
Priority to ES10703318.5T priority patent/ES2524564T3/es
Priority to PCT/FR2010/000037 priority patent/WO2010081971A1/fr
Priority to CA2749824A priority patent/CA2749824C/fr
Publication of FR2940973A1 publication Critical patent/FR2940973A1/fr
Application granted granted Critical
Publication of FR2940973B1 publication Critical patent/FR2940973B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
FR0900174A 2009-01-15 2009-01-15 Identification de nouvelles toxines antagonistes de canaux calcique type-t a visee analgesique Expired - Fee Related FR2940973B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0900174A FR2940973B1 (fr) 2009-01-15 2009-01-15 Identification de nouvelles toxines antagonistes de canaux calcique type-t a visee analgesique
JP2011545778A JP5519702B2 (ja) 2009-01-15 2010-01-15 鎮痛を目的とする、ｔ型カルシウムチャンネルの新規拮抗薬である毒素の同定
US13/144,734 US8664179B2 (en) 2009-01-15 2010-01-15 Identification of novel antagonist toxins of T-type calcium channel for analgesic purposes
ES10703318.5T ES2524564T3 (es) 2009-01-15 2010-01-15 Identificación de nuevas toxinas antagonistas de canales de calcio de tipo T de aplicación analgésica
EP10703318.5A EP2387581B1 (fr) 2009-01-15 2010-01-15 Identification de nouvelles toxines antagonistes de canaux calciques type-t a visee analgesique
PCT/FR2010/000037 WO2010081971A1 (fr) 2009-01-15 2010-01-15 Identification de nouvelles toxines antagonistes de canaux calciques type-t a visee analgesique
CA2749824A CA2749824C (fr) 2009-01-15 2010-01-15 Identification de nouvelles toxines antagonistes de canaux calciques type-t a visee analgesique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0900174A FR2940973B1 (fr) 2009-01-15 2009-01-15 Identification de nouvelles toxines antagonistes de canaux calcique type-t a visee analgesique

Publications (2)

Publication Number Publication Date
FR2940973A1 FR2940973A1 (fr) 2010-07-16
FR2940973B1 true FR2940973B1 (fr) 2013-05-24

Family

ID=40834515

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0900174A Expired - Fee Related FR2940973B1 (fr) 2009-01-15 2009-01-15 Identification de nouvelles toxines antagonistes de canaux calcique type-t a visee analgesique

Country Status (7)

Country Link
US (1) US8664179B2 (enExample)
EP (1) EP2387581B1 (enExample)
JP (1) JP5519702B2 (enExample)
CA (1) CA2749824C (enExample)
ES (1) ES2524564T3 (enExample)
FR (1) FR2940973B1 (enExample)
WO (1) WO2010081971A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014045126A2 (en) * 2012-09-18 2014-03-27 Uti Limited Partnership Treatment of pain by inhibition of usp5 de-ubiquitinase
US20220089663A1 (en) * 2019-01-18 2022-03-24 Memorial Sloan Kettering Cancer Center PROTEINS AND FLUOROPHORE-CONTAINING COMPOUNDS SELECTIVE FOR NaV1.7
US20230241259A1 (en) * 2020-06-10 2023-08-03 Memorial Sloan Kettering Cancer Center IMAGING COMPOUNDS SELECTIVE FOR NaV1.7

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776896A (en) * 1996-01-03 1998-07-07 Zeneca Limited Analgesic peptides from venom of grammostola spatulata and use thereof
US5756663A (en) * 1996-01-03 1998-05-26 Zeneca Limited Antiarrhythmic peptide from venom of spider Grammostola spatulata
AU6109698A (en) 1998-02-20 1999-09-06 Zeneca Limited Analgesic peptides from venom of (grammostola spatulata) and use thereof

Also Published As

Publication number Publication date
JP5519702B2 (ja) 2014-06-11
WO2010081971A1 (fr) 2010-07-22
JP2012514992A (ja) 2012-07-05
EP2387581A1 (fr) 2011-11-23
EP2387581B1 (fr) 2014-10-08
CA2749824A1 (fr) 2010-07-22
FR2940973A1 (fr) 2010-07-16
US8664179B2 (en) 2014-03-04
ES2524564T3 (es) 2014-12-10
US20120040909A1 (en) 2012-02-16
CA2749824C (fr) 2017-05-02

Similar Documents

Publication Publication Date Title
NL301291I2 (nl) sparsentan of een farmaceutisch aanvaardbaar zout daarvan
NL301187I2 (nl) Rimegepant of een farmaceutisch aanvaardbaar zout daarvan
NL301305I2 (nl) Vibegron of een farmaceutisch aanvaardbaar zout daarvan
NL301166I2 (nl) Avacopan of een farmaceutisch aanvaardbaar zout daarvan
NL301035I2 (nl) upadacitinib of een farmaceutisch aanvaardbaar zout daarvan
NL301248I2 (nl) atogepant of een farmaceutisch aanvaardbaar zout daarvan
NL301157I2 (nl) odevixibat of een farmaceutisch aanvaardbaar zout daarvan
NL301071I2 (nl) alpelisib of een farmaceutisch aanvaardbaar zout ervan
NL301096I2 (nl) Filgotinib of een zout daarvan
NL301028I2 (nl) Gilteritinib of een zout ervan
CY2022014I2 (el) Ανταγωνιστες c5ar
NL300901I2 (nl) pibrentasvir of een farmaceutisch aanvaardbaar zout daarvan
NL301214I2 (nl) Lasmiditan en farmaceutisch aanvaardbare zouten daarvan
FI20095570A0 (fi) Kontekstin tunnistaminen mobiileissa laitteissa
EP2506816A4 (en) DISPOSABLE DIAPERS
UY33102A (es) Antagonistas de pcsk9
CR20130327A (es) Comprimido de desintegración oral
EP2653263A4 (en) TOOL CARRIER FOR A TOOL MAGAZINE
BRPI1011453A2 (pt) formulacao, forma de dosagem de um medicamento, e, sal de hemipamoato de asenapina
BR112013015979A2 (pt) tampão de fratura modular e método para a construção do mesmo
FI20096189L (fi) Vuoteen turvakaide
FR2951075B1 (fr) Aiguille perforante
PL2488158T3 (pl) Ulepszone lecznicze preparaty aerozolowe
EP2404631A4 (en) MEDICAL NEEDLE
IT1400100B1 (it) Fermacravatte

Legal Events

Date Code Title Description
PLFP Fee payment

Year of fee payment: 8

PLFP Fee payment

Year of fee payment: 9

PLFP Fee payment

Year of fee payment: 10

PLFP Fee payment

Year of fee payment: 12

ST Notification of lapse

Effective date: 20210905