FR2913016B1 - Derives d'indole, benzimidazole ou benzotriazole, comprenant un noyau piperidine ou piperazine, comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire - Google Patents

Derives d'indole, benzimidazole ou benzotriazole, comprenant un noyau piperidine ou piperazine, comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire

Info

Publication number
FR2913016B1
FR2913016B1 FR0753486A FR0753486A FR2913016B1 FR 2913016 B1 FR2913016 B1 FR 2913016B1 FR 0753486 A FR0753486 A FR 0753486A FR 0753486 A FR0753486 A FR 0753486A FR 2913016 B1 FR2913016 B1 FR 2913016B1
Authority
FR
France
Prior art keywords
benzimidazole
benzotriazole
piperidine
inhibitors
cell proliferation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0753486A
Other languages
English (en)
Other versions
FR2913016A1 (fr
Inventor
Fabrice Balavoine
Alexandre Batch
Catherine Rolland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cerep SA
Original Assignee
Cerep SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerep SA filed Critical Cerep SA
Priority to FR0753486A priority Critical patent/FR2913016B1/fr
Priority to PCT/EP2008/052204 priority patent/WO2008107322A1/fr
Publication of FR2913016A1 publication Critical patent/FR2913016A1/fr
Application granted granted Critical
Publication of FR2913016B1 publication Critical patent/FR2913016B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0753486A 2007-02-23 2007-02-23 Derives d'indole, benzimidazole ou benzotriazole, comprenant un noyau piperidine ou piperazine, comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire Expired - Fee Related FR2913016B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR0753486A FR2913016B1 (fr) 2007-02-23 2007-02-23 Derives d'indole, benzimidazole ou benzotriazole, comprenant un noyau piperidine ou piperazine, comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire
PCT/EP2008/052204 WO2008107322A1 (fr) 2007-02-23 2008-02-22 Derives d'indole, benzimidazole ou benzotriazole, comprenant un noyau piperidine ou piperazine, comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0753486A FR2913016B1 (fr) 2007-02-23 2007-02-23 Derives d'indole, benzimidazole ou benzotriazole, comprenant un noyau piperidine ou piperazine, comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire

Publications (2)

Publication Number Publication Date
FR2913016A1 FR2913016A1 (fr) 2008-08-29
FR2913016B1 true FR2913016B1 (fr) 2009-04-24

Family

ID=38659648

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0753486A Expired - Fee Related FR2913016B1 (fr) 2007-02-23 2007-02-23 Derives d'indole, benzimidazole ou benzotriazole, comprenant un noyau piperidine ou piperazine, comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire

Country Status (2)

Country Link
FR (1) FR2913016B1 (fr)
WO (1) WO2008107322A1 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503907B2 (en) * 2000-11-28 2003-01-07 Hoffmann-La Roche Inc. Indole and dihydroindole derivatives

Also Published As

Publication number Publication date
WO2008107322A1 (fr) 2008-09-12
FR2913016A1 (fr) 2008-08-29

Similar Documents

Publication Publication Date Title
FR20C1064I2 (fr) Derives d'indazole substitues actifs comme inhibiteurs de kinases
ATE520671T1 (de) Pyrimidin-harnstoff-derivate als kinase-hemmer
ATE524467T1 (de) Neuartige aza-heterozyklen als kinase-inhibitoren
ATE452631T1 (de) N-2-adamantanyl-2-phenoxy-acetamid-derivate als 11-betahydroxysteroid-dehydrogenase-hemmer
DK2118101T3 (da) IMIDAZO (1,5-A)-PYRIDinderivater som glutaminylcyclaseinhibitorer
DE602006015607D1 (de) Thiazol-4-carboxamid-derivate als mglur5-antagonisten
ATE400271T1 (de) Aryl-pyridinderivate als 11-beta-hsd1-hemmer
DK1926722T3 (da) Substituerede benzimidazoler som kinaseinhibitorer
DK1740569T3 (da) Imidazol-derivater som TAFla-inhibitorer
ATE420076T1 (de) Indozolonderivate als 11b-hsd1-inhibitoren
IL173935A0 (en) N3 alkylated benzimidazole derivatives as mek inhibitors
ATE524466T1 (de) 3-azabicycloä3.3.0üoktanverbindungen
AP2006003705A0 (en) Quinoline derivatives for use as mycobacterial inhibitors
DE602008002934D1 (de) 2-cyclopropylthiazolderivate
RS54413B1 (en) [4- (5-AMINOMETHYL-2-FLUORO-PHENYL) -PIPERIDIN-1-IL] - [7-FLUORO-1- (2-METHOXY-ETHYL) -4TRIFLUOROMETOXY-1H-INDOL-3-IL] METHANONE AS INHIBITOR MASTOCYT TRIPTASES
IL190952A0 (en) Piperazine derivatives as antimalarial agents
ATE537149T1 (de) Sulfonyl-pyrazolinyl-1-carboxamidinderivate als 5-ht6-antagonisten
RS53138B (en) 4- [2- (4-METHYLPHENYLSULPHANYL) PHENYL] PIPERIDINE FOR THE TREATMENT OF INJURED INTENTION SYNDROME (IBS).
IL190902A0 (en) Piperazine derivatives useful as ccr5 antagonists
ZA200800213B (en) Benzimidazole derivatives as 5-HT6, 5-HT24
ZA200703835B (en) Heterocyclic substituted bisarylurea derivatives as kinase inhibitors
ZA200608998B (en) Imidazole derivatives as tyrosine kinase inhibitors
IL173892A0 (en) Paroxetine cholate or cholic acid derivative salts, and composition comprising paroxetine and cholic acid or cholic acid derivatives
ATE389658T1 (de) Heterocyclische kondensierte pyrazolderivate als kinaseinhibitoren
FR2913016B1 (fr) Derives d'indole, benzimidazole ou benzotriazole, comprenant un noyau piperidine ou piperazine, comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire

Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20091030