FR2908985A1 - Cosmetic use of octane-1,2-diol as antioxidant or antiradical agent to prevent e.g. effects of oxidative stress or free radicals on the skin and/or its integument, fine lines and wrinkles, age spots and/or dull appearances - Google Patents

Abstract

Cosmetic use of octane-1,2-diol (I) as an antioxidant or antiradical agent in a composition containing a medium, is claimed. An independent claim is included for a composition comprising octane-1,2-diol and 0.01 wt.% of procystein, in a medium. ACTIVITY : Dermatological. MECHANISM OF ACTION : None given.

Description

The field of the invention relates to the use of 1,2-octolediol or

  of cosmetic compositions containing it for combating the effects of oxidative stress on the skin and / or its integuments.

  By `skin 'is meant according to the invention an extended definition to the skin, scalp and semi-mucous membranes, including the lips. By 'dander', we mean hair, eyelashes, and / or nails.

  The present invention relates to the cosmetic use of 1,2-octane diol in a composition containing a physiologically acceptable medium, as an antioxidant or antiradical agent. The octane 1,2 diol is especially intended as such according to the invention to prevent and / or treat chronological aging and / or photoinduced, in particular chronological and / or photoinduced skin aging, in particular premature cutaneous aging. The invention also relates to the use of a cosmetic composition containing octane 1,2 diol to prevent and / or reduce the dull and / or heterogeneous appearance of the complexion. It also relates to the use of a cosmetic composition containing octane 1,2 diol as sole antiradical agent for preventing and / or treating chronological or photoinduced skin aging. The invention also relates to particular compositions associating 1,2-octane diol with procysteine. The role of cell oxidation in aging, especially cutaneous, whether intrinsic or extrinsic, in particular photoinduced, is known. This aging is reflected by various clinical signs including the appearance of fine lines and wrinkles, and the appearance of age spots, increasing with age. In addition, the appearance of the skin or scalp deteriorates. The complexion of the skin is generally modified: it is paler, dull, yellow and sometimes gray; the complexion has heterogeneity and diffuse irritations may exist in some areas. Another clinical sign of aging is the dry, rough appearance of the skin, which is essentially due to increased desquamation. Finally, there is a loss of firmness and tone 2908985 2 of the skin which, as for wrinkles and fine lines, is at least partly explained by a dermal and epidermal atrophy and a flattening of the whole dermis / epidermis . The skin is softer, flaccid, thinned. Thus, the clinical signs of skin aging result essentially from a dysfunction of the main biological mechanisms involved in the skin. Among these biological mechanisms, oxidative stress largely contributes to the skin aging phenomenon. Oxidative stress is the result of an imbalance between the production of reactive oxygen species, including superoxide anion, hydrogen peroxide and hydroxyl radical, and antioxidant mechanisms. of cellular defense. Reactive oxygen species are produced during respiration, inflammation and other cellular metabolic events. Oxidative stress is also related to external agents such as ultraviolet radiation (especially UVA), pollution or various chemical agents with which the skin may be in contact (chlorine, cleaning products, etc.). It is in particular known that ultraviolet radiation, as well as certain pollutants such as ozone and heavy metals present in the environment, generate free radicals which are particularly likely to reduce the ability of fibroblasts to produce collagen and the decompose (OKADA Tomio, Bulletin of KOSHO-KAI, 1993, Vol 17, No. 4, pp. 202-206), but also to promote the crosslinking of collagen fibers (HIROSE Suberu et al., J. Soc Cosmet. Chem., Japan, 1993, Vol 26, No. 4, pp. 289-294) and to fragment mucopolysaccharides (KASHIMURA Naoki, "Active Oxygen", pp. 464-468, KYORITSU Publishing Company, 1990), so that they contribute to the premature aging of the skin.

  The production of reactive oxygen species causes damage to DNA, proteins or lipids. The cells have developed mechanisms developed to avoid these consequences, for example enzymes (superoxide dismutase, catalase, glutathione peroxidase) or non-enzymatic antioxidant systems.

  Preventing or treating the damage caused by free radicals on the skin, scalp or hair, especially cutaneous aging, whether intrinsic or extrinsic, and the clinical signs described previously, is to maintain or improve the appearance of the skin, scalp or hair.

The Applicant has now unexpectedly discovered that octane 1,2 diol, otherwise known as caprylyl glycol, may constitute an excellent active agent for preventing and / or reducing the effects of oxidative stress on the skin and / or its integuments, in particular the effects of free radicals on the skin.

Octane 1,2 diol has been used heretofore in cosmetics and dermatology as a preservative. EP655904 B1 also described its moisturizing properties. But to the knowledge of the Applicant, octane 1,2 diol had never been described for its antioxidant or anti-free radicals (ARL). The invention therefore relates to the cosmetic use of 1,2-octolediol in a composition containing a physiologically acceptable medium, as an antioxidant or antiradical agent or anti-free radicals (ARL). The octane 1,2 diol is especially intended as such according to the invention to prevent and / or reduce the effects of oxidative stress or free radicals on the skin and / or its integuments.

In particular, octane 1,2 diol is used according to the invention as an agent intended to prevent and / or treat chronological and / or photoinduced skin aging, in particular premature aging. "Premature aging" is understood to mean, in particular, the first signs of cutaneous aging, which generally affects persons aged 25 to 30, and is particularly reflected in the appearance of fine lines and a dull and / or heterogeneous appearance of the complexion. . The invention also relates to the use of a cosmetic composition comprising, in a physiologically acceptable medium, at least 1,2-octane diol, to prevent and / or reduce the dull and / or heterogeneous appearance of the complexion.

Another object of the invention is the use of a composition containing, in a physiologically acceptable medium, 1,2-octane diol as sole antiradical agent, for preventing and / or treating chronological skin aging or photoinduced.

The 1,2-octane diol as such or a composition according to the invention containing 1,2-octane diol as sole antiradical agent, is especially intended to prevent and / or treat fine lines and wrinkles, and / or age spots, and / or the dull and / or heterogeneous appearance of the complexion, and / or the dry and / or dry appearance of the skin, and / or loss of firmness and / or elasticity and / or skin tone, and / or thinned skin.

The invention aims to care for and / or treat any type of skin and advantageously skin with signs of skin aging. In particular, there are: skins presenting the first signs of skin aging otherwise known as premature aging; this aging generally concerns people aged 25 to 30; This premature aging usually results in the appearance of fine lines and a dull and / or heterogeneous complexion; older skin (30-50 years), even mature skin (50-60 years old), or very mature (at least 60 years old); in these persons, the signs of skin aging are more marked and characterized in particular by wrinkles, age spots, a dry and / or rough appearance of the skin, a soft and / or flabby and / or thinned skin. The amount of 1,2-octane diol contained in the compositions of the invention is, of course, a function of the desired antioxidant effect and can therefore vary to a large extent. To give an order of magnitude, the compositions used according to the invention contain 1,2-octanediol in a content ranging from 0.001% to 5%, preferably from 0.01 to 1%, more preferably from 0.1% to 0.1% by weight. at 0.5%, and even more preferably from 0.3 to 0.5% by weight relative to the total weight of the composition. According to one particular embodiment of the invention, the composition may further comprise at least one agent chosen from other antipollution or antiradical agents, anti-glycation agents, NO-synthase inhibiting agents, and mixtures thereof.

By way of examples of agents which can be used in combination with caprylyl glycol to supplement or boost its antiradical effect, mention may be made of: 1) other antipollution or antiradical agents: by the term "anti-pollution agent" is meant any compound capable of trapping ozone, mono- or polycyclic aromatic compounds such as benzopyrene and / or heavy metals such as cobalt, mercury, cadmium and / or nickel. By "anti-radical agent" is meant any compound capable of trapping free radicals.

As antipollution agents, mention may be made in particular of vitamin C and its derivatives including ascorbyl glucoside; olive leaf extracts; tea extracts, especially green tea; rosemary extracts; phenolic acids, in particular chorogenic acid stilbenes, in particular resveratrol; chelating agents such as EDTA, ethylenediamine tetramethylene phosphonic pentasodium salt, and N, N'-bis (3,4,5-trimethoxybenzyl) ethylenediamine or a salt, metal complex or ester thereof phytic acid; chitosan derivatives; sulfur amino acids such as cysteine water hyacinth extracts (Eichornia crassipes); and the water soluble fraction of corn marketed by the company SOLABIA under the trade name Phytovityl.

The anti-radical agents which can be used in the composition according to the invention comprise, in addition to certain anti-pollution agents mentioned above, vitamin E and its derivatives such as tocopheryl acetate; bioflavonoids; coenzyme Q10 or ubiquinone; certain enzymes such as catalase, superoxide dismutase and wheat germ extract containing them, lactoperoxidase, glutathione peroxidase and quinone reductases; glutathione; benzylidene camphor; benzylcyclanones substituted naphthalenones; pidolates; phytantriol; gamma-oryzanol; guanosine; lignans; procysteine or 2-oxothiazolidine-4-carboxylic acid, an extract of Vitreoscilla filiformis such as that described in application EP 1 354 593, and melatonin. Procysteine or 2-oxothiazolidine-4-carboxylic acid and its esters have been described as being useful for protecting the body against various stresses (US-4,335,210, US-4,434,158, US-4,438,124 and US-4,467,751).

Preferred antipollution or antiradical agents are vitamin C and its derivatives, procysteine and its esters, Vitreoscilla filiformis extract, green tea extracts, EDTA and mixtures thereof.

And even more preferentially, procystine will be used as the antiradical agent. 2) anti-glycation agents. The term "anti-glycation agent" is intended to mean a compound which prevents and / or reduces the glycation of skin proteins, in particular dermal proteins, such as collagen. Examples of anti-glycation agents are plant extracts of the family Ericaceae, such as a bilberry extract (Vaccinium angusfifollium), for example that sold under the name BLUEBERRY HERBASOL EXTRACT PG by COSMETOCHEM, ergothioneine and its derivatives, hydroxystilbenes and their derivatives, such as resveratrol and 3,3 ', 5,5'-tetrahydroxystilbene (these anti-glycation agents are described in applications FR 2 802 425, FR 2 810 548, FR 2 796 278 and FR 2 802 420, respectively), dihydroxystilbenes and their derivatives, arginine and lysine polypeptides, such as the product sold under the name Amadorine by the company Solabia, carcinine hydrochloride (marketed by Exsymol under the trademark US Pat. ALISTIN), an extract of Helianthus annuus such as Silab's Antiglyskin, wine extracts such as white wine powder extract on a maltodextrin support sold under the name White Wine Dice hydrated 2F by Givaudan, thioctic acid (or alpha lipoic acid), a mixture of bearberry extract and marine glycogen such as Aglycal LS 8777 from Laboratoires Sériobiologiques, a black tea extract such as Sederma Kombuchka 25 and their mixtures. 3) agents having a NO synthase inhibiting action such as chosen from OPCs (procyanidolic oligomers); plant extracts of the Vitis vinifera species, sold in particular by the company Euromed under the name 30 leucocyanidins of extra grapes, or by the company Indena under the name Leucoselect, or finally by Hansen under the name grape marc extract ; plant extracts of the species Olea europaea preferably obtained from olive leaves and especially marketed by the company Vinyals in the form of dry extract, or by Biologia & Technologia under the trade name Eurol BT; the extracts of a plant of the species Gingko biloba preferably a dry aqueous extract of this plant sold by Beaufour under the trade name Ginkgo biloba standard extract and mixtures thereof.

These additional agents will generally be present in the composition in a content ranging from 0.001% to 10% by weight relative to the total weight of the composition, preferably from 0.01% to 5% by weight, and still more preferably from 0.1% to 1% by weight. in weight relative to the total weight of the composition. Galenic The composition according to the invention is suitable for application topically to the skin and / or its integuments. This composition may be a care composition or a make-up composition. Preferably, it will be a care composition. The composition may be a cosmetic or dermatological composition. Preferably, it will be a cosmetic composition, in particular a composition for the care of the skin and / or the scalp and / or the lips.

The composition according to the invention comprises a physiologically acceptable medium, that is to say compatible with the skin and / or its integuments. It is preferably a cosmetically acceptable medium, that is to say which has a pleasant color, odor and feel and that does not generate unacceptable discomfort (tingling, tightness, redness), likely to divert the consumer from using this composition. For topical application to the skin and / or its integuments, the composition according to the invention may be in any of the galenical forms conventionally used for topical application. In particular, the composition may have the form of an aqueous, alcoholic, hydroalcoholic or oily solution; a dispersion of the lotion or aqueous gel or serum type; a multi-phase lotion (ex: bi-phasic); emulsions of liquid or semiliquid consistency of the milk type, obtained by dispersion of a fatty phase in an aqueous phase (O / W) or conversely (W / O), or suspensions or emulsions of soft, semi-solid consistency or solid of the cream, gel, serum, stick, mask or multiple emulsions (E / H / E or H / E / H); microemulsions, vesicular dispersions of ionic and / or nonionic type, or wax / aqueous phase dispersions; microcapsules or microparticles; a foam; an aerosol composition also comprising a propellant under pressure; or in the form of a patch.

These compositions are prepared according to the usual methods. It may especially be a composition for the care of the face, the contour of the eyes or the lips, or for the body, for example, day creams, night cream, SPF composition for protecting from the sun, body milk. of protection or care, after-sun milks, lotion, gel or mousse for the care of the skin. According to a preferred embodiment of the invention, the composition is in the form of an O / W emulsion (eg cream) or E / H (ex: serum) or of an aqueous type gel (ex: lotion). When the composition is an emulsion, the proportion of the fatty phase of the composition in question may range, for example, from 5 to 80% by weight and in particular from 5 to 50% by weight relative to the total weight of the composition. The aqueous phase may consist essentially of water or comprise a mixture of water and water-miscible organic solvent (miscibility in water greater than 25 to 50% by weight at 25 ° C.) such as lower monoalcohols having 1 with 5 carbon atoms such as ethanol, isopropanol, glycols having 2 to 8 carbon atoms such as propylene glycol, ethylene glycol, 1,3-butylene glycol, dipropylene glycol, ketones at 03-04, and C2-C4 aldehydes; polyols such as glycerol. This aqueous phase (water and optionally the water-miscible organic solvent) may be present in the base composition in a content ranging from 1% to 95% by weight, in particular ranging from 3% to 80% by weight, and in particular ranging from 5% to 60% by weight relative to the total weight of the base composition.

The fatty phase of the composition may contain fatty or oily compounds, and optionally waxes, gums, pasty fatty substances of vegetable, animal, mineral or synthetic origin, silicone or not.

As oils which may be used in the composition according to the invention, mention may be made of: hydrocarbon-based oils of animal origin, such as perhydrosqualene; hydrocarbon oils of plant origin, such as liquid triglycerides of fatty acids containing from 4 to 10 carbon atoms, or else, for example, vegetable oils such as apricot kernel oil and shea butter oil; esters and synthetic ethers, in particular of fatty acids, such as the oils of formulas R'COOR2 and R'OR2 in which R 'represents the residue of a fatty acid containing from 8 to 29 carbon atoms, and R2 represents a hydrocarbon chain, branched or unbranched, containing from 3 to 30 carbon atoms; Linear or branched hydrocarbons of mineral or synthetic origin, such as paraffin oils, volatile or not, and their derivatives, isohexadecane, isododecane, petroleum jelly, polydecenes, hydrogenated polyisobutene such as oil of Parleam; - natural or synthetic essential oils; branched fatty alcohols having from 8 to 26 carbon atoms, such as octyldodecanol; Partially fluorinated hydrocarbon oils and / or silicone oils such as those described in document JP-A-2-295912; silicone oils such as volatile or non-volatile polymethylsiloxanes (PDMS) with a linear or cyclic silicone chain, which are liquid or pasty at room temperature, in particular cyclopolydimethylsiloxanes (cyclomethicones) such as cyclohexasiloxane and cyclopentasiloxane; polydimethylsiloxanes comprising alkyl, alkoxy or phenyl groups, during or at the end of the silicone chain, groups having from 2 to 24 carbon atoms; phenyl silicones such as phenyltrimethicones, phenyldimethicones, phenyltrimethylsiloxydiphenylsiloxanes, diphenyldimethicones, diphenylmethyldiphenyltrisiloxanes, 2-phenylethyltrimethylsiloxysilicates, and polymethylphenylsiloxanes; and - their mixtures. Other fatty substances that may be present in the oily phase are, for example, fatty acids containing from 8 to 30 carbon atoms, such as stearic acid, lauric acid, palmitic acid and oleic acid; linear fatty alcohols such as cetyl and / or stearyl alcohols; pasty fatty substances such as lanolin; waxes; and gums such as silicone gums (dimethiconol). These fatty substances may be chosen in a varied manner by those skilled in the art in order to prepare a composition having the desired properties, for example of consistency or texture.

This composition may also contain various adjuvants commonly used in the cosmetics field, such as emulsifiers including stearic acid, fatty acid and polyethylene glycol esters, optionally polyoxyethylenated fatty acid and sorbitan esters, polyoxyethylenated fatty alcohols and esters or ethers of fatty acids and sugars such as sucrose or glucose; conservatives; Sequestering agents; perfumes ; and thickeners and / or gelling agents, in particular polyacrylamides, acrylic homo- and copolymers and homo- and copolymers of acrylamido methylpropanesulphonic acid; charges ; and photoprotective agents active in the UVA and / or UVB, otherwise known as UV filters.

Examples of fillers which may be mentioned are polyamide particles (nylon) in spherical form or in the form of microfibers; polymethyl methacrylate microspheres; ethylene-acrylate copolymer powders; expanded powders such as hollow microspheres and especially microspheres formed of a terpolymer of vinylidene chloride, acrylonitrile and methacrylate and sold under the name EXPANCEL; powders of natural organic materials such as starch powders, especially corn starch, wheat or rice, crosslinked or otherwise, such as starch powders crosslinked with octenylsuccinic anhydride; silicone resin microbeads such as those sold under the name TOSPEARL by Toshiba Silicone; silica; metal oxides such as titanium dioxide or zinc oxide; mica; hollow hemispherical silicone particles such as NLK506 marketed by Takemoto Oil and Fat; polyurethane powders, in particular the product marketed by the company Toshiki Pigment under the name PLASTIC POWDER and their mixtures.

In particular, the composition according to the invention will comprise at least one active photoprotective agent in the UVA and / or the UVB.

As UV filters or active photoprotective agents in the UVA and / or UVB that can be used in the composition of the invention, mention may be made in particular of organic or inorganic photoprotective agents.

The organic photoprotective agents are in particular chosen from anthranilates; cinnamic derivatives; dibenzoylmethane derivatives; salicylic derivatives, camphor derivatives; triazine derivatives such as those described in patent applications US 4367390, EP863145, EP517104, EP570838, EP796851, EP775698, EP878469, EP933376, EP507691, EP507692, EP790243, EP944624; benzophenone derivatives; 13,13-diphenylacrylate derivatives; benzotriazole derivatives; benzalmalonate derivatives; benzimidazole derivatives; imidazolines; bis-benzoazolyl derivatives as described in patents EP669323 and US 2,463,264; p-aminobenzoic acid derivatives (PABA); methylene bis (hydroxyphenyl benzotriazole) derivatives as described in US5,237,071, US5,166,355, GB2303549, DE 197 26 184 and EP893119; and filter polymers and silicone filters such as those described in particular in the application WO-93/04665; dimers derived from α-alkylstyrene such as those described in patent application D E 19855649.

The inorganic photoprotective agents are chosen from pigments or even nanopigments (average size of the primary particles: generally between 5 nm and 100 nm, preferably between 10 nm and 50 nm) of coated or uncoated metal oxides such as, for example, nanopigments of titanium oxide (amorphous or crystallized in rutile and / or anatase form), iron, zinc, zirconium or cerium which are all UV photoprotective agents well known per se. Conventional coating agents are, moreover, alumina and / or aluminum stearate. Such nanopigments of metal oxides, coated or uncoated, are in particular described in patent applications EP518772 and EP518773.

The photoprotective agents are generally present in the composition according to the invention in proportions ranging from 0.1 to 20% by weight relative to the total weight of the composition, and preferably ranging from 0.2 to 15% by weight relative to the total weight of the composition. relative to the total weight of the composition.

Of course, those skilled in the art will take care to choose this or these optional additional compounds and / or their amount in such a way that the properties of the composition according to the invention are not, or not substantially, impaired by the addition envisaged. The invention also relates to a composition comprising, in a physiologically acceptable medium, 1,2-octane diol and at least 0.01% of procysteine by weight relative to the total weight of the composition. In particular, the composition comprises 1,2-octane diol and at least 0.05% by weight of procysteine relative to the total weight of the composition, more preferably at least 0.1% of procysteine, or even at least 0.2 % of procysteine by weight relative to the total weight of the composition. The procysteine content may range in particular from 0.01% to 10% by weight, preferably from 0.05% to 5% by weight and even more preferably from 0.1% to 1% by weight relative to the total weight of the composition. The 1,2-octanediol will be present in the said composition in a content ranging from 0.001% and 5%, preferably from 0.01 to 1%, more preferably from 0.1 to 0.5%, and even more preferably from 0, 3 to 0.5% by weight relative to the total weight of the composition.

These compositions may be in any of the galenical forms applicable to the skin, as described above.

The invention also relates to a cosmetic treatment method for preventing and / or reducing the dull and / or heterogeneous appearance of the complexion, characterized in that a cosmetic composition containing octane 1 is applied to the skin, 2 diol. In particular, the composition containing 1,2-octanediol will be applied to persons having a dull and / or heterogeneous appearance of the complexion.

In a particular embodiment, the 1,2-octolediol will be the sole antiradical active ingredient of the composition.

The invention also relates to a method for treating the cutaneous signs of aging chronologically and / or photoinduced, characterized in that a cosmetic composition containing as sole anti-free radical active agent is applied to the skin. octane 1,2 diol. By "cutaneous signs of aging" is meant in particular fine lines and wrinkles, age spots, the dull and / or heterogeneous appearance of the complexion, the dry and / or rough appearance of the skin, a loss of firmness and / or elasticity and / or tonicity of the skin, and / or thinned skin. According to one particular embodiment, the composition according to the invention is applied to an aged and / or wrinkled skin, and / or to a skin presenting age spots, and / or to a skin with a dull and / or heterogeneous appearance. complexion, and / or on a skin with a dry and / or rough appearance, and / or on a soft and / or flaccid and / or thinned skin.

The composition according to the invention may be applied to anyone and advantageously to persons with the first signs of age or premature aging (25-30 years). This premature aging usually results in the appearance of fine lines and a dull and / or heterogeneous complexion.

25 But it can also be applied to older people (30-50 years), even to people with mature skin (50-60 years), or even people with very mature skin (at least 60 years). In these persons, the signs of skin aging are more marked and characterized in particular by wrinkles, age spots, a dry and / or rough appearance of the skin, a soft and / or flabby and / or thinned skin. The composition may be applied daily to the skin of the face and / or body. Preferably, the composition will be applied once a day, morning or evening, or twice daily, morning and evening.

The invention will now be illustrated in the following non-limiting examples. EXAMPLES Example 1: Demonstration of the antiradical properties of the 1,2-octane diol Protocol The 1,2-octanecol of the antiradical activity (ARL) was evaluated by the measurement in gas phase chromatography (GC) of the ethylene formed from the oxidation of methionine by the hydroxyl radical. This is generated by a ferro-catalyzed Fenton reaction maintained by the continuous generation of superoxide radicals. The O 2 radicals are produced by 365 nm photochemical reduction of riboflavin by a hydrogen donor. RE RBFH 02. *. H20.2 + 202} 2114 202 '2H ":); L-Fe. 02+ L-Fe`- 'F222 + LF g LFe' '' -O`l-. Off` CH -S -CH 2 -CH COOP NH2. The neutralization of the OH radicals results in an inhibition of the production of ethylene. A reaction medium buffered with: 50011I 50mM phosphate buffer KH2PO4 pH7.4 10011I solution L-Methionine 200mM 10011I 4mM ferric chloride solution or buffer (control) 10011I 4mM EDTA solution 10011I 400mM NADH solution 2908985 100 I riboflavin solution 2 mM. In parallel solutions of 20 ml of buffer are added to which 1,2-octane diol is added with a final concentration of 0.11% and 0.21% by weight relative to the total weight of the solution. In a Head Space tube, mixtures of reaction medium and of solution containing 1,2-octanediol with final concentrations of 1,2-octane diol are respectively 0.03%, 0.06% and 0.15% by weight relative to the weight. total of the reaction mixture. It is irradiated with 1J of UVA. The reaction is stopped with 0.5 ml of 1 N NaOH and the sample is then protected from light. The sample is then placed in an autosampler and gas chromatography is started on a Perkin Elmer HS40 Autosampler.

Results Test compounds Final concentration in% inhibition of the reaction mixture ethylene formation Control 0% 0% Octane 1,2 Diol 0.03% 5% 0.06% 10% 0.15% 25% It is also known that vitamin C (Anti-free radical positive control) at 0.3% by weight relative to the reaction mixture in a similar test inhibits 50% ethylene formation. These results show that 1,2-octane diol inhibits the production of ethylene, from the concentration of 0.03%, with a dose effect.

This effect is correlated with an antiradical effect of 1,2-octolediol, which is used in the cosmetic compositions according to the invention. Example 2 Formulations The compositions are prepared according to the usual methods. The values are expressed in% by weight. Fluid SPF15 10 Caprylyl glycol 0.5% Silica 2.0% UV filters 9.3% Fat 1.0% Oils 2.0% 15 Emulsifiers 3.6% Cyclohexasiloxane 3.0% Denatured alcohol 5.0% Glycerin 7 0% Preservatives 1.9% 20 Water qs 100% SPF 15 is applied daily in the morning to the areas of the face, to provide effective protection against the effects of stress on the skin, in particular the heterogeneous appearance of the skin. complexion or the appearance of age spots. Oven cream Caprylyl glycol 0.5% Procysteine 0.01% Oils 8.0% 30 Emulsifiers 3.8% Volatile silicas 6.5% Glycerin 7.0% Propylene glycol 3.0% Surfactant 3.0% 35 Preservatives 2 , 25% Water qs 100% 2908985 17 The day cream is applied daily to the facial areas of people 25-30 years to ensure a soothing and protective effect against the effects of stress on the skin. The skin is smoothed, relaxed and has a more even complexion. Eye serum Caprylyl glycol 0.6% Silicone elastomer 4.8% Volatile oils 23% Glycerine 5% Propylene glycol 6.25% Preservatives 0.8% Water gsp100% This antioxidant serum is applied to the eye contour of 50-year-olds, preferably in the evening.

Claims (17)

  1. Cosmetic use of 1,2-octolediol in a composition containing a physiologically acceptable medium, as an antioxidant or antiradical agent.   2. Cosmetic use according to claim 1, characterized in that the 1,2-octane diol is intended to prevent and / or reduce the effects of oxidative stress or free radicals on the skin and / or its integuments.   3. Cosmetic use of 1,2-octane diol, in a composition containing a physiologically acceptable medium, as an agent for preventing and / or treating chronological and / or photoinduced skin aging. 15   4. Use of a cosmetic composition comprising, in a physiologically acceptable medium, at least 1,2-octane diol, for preventing and / or reducing the dull and / or heterogeneous appearance of the complexion.   5. Use of a composition containing in a physiologically acceptable medium, 1,2-octane diol as sole antiradical agent, for preventing and / or treating chronological or photoinduced skin aging.   6. Use according to any one of the preceding claims, characterized in that 1,2-octol diol as such or said composition containing it as sole antioxidant agent, is intended to prevent and / or treat fine lines and wrinkles. and / or age spots, and / or the dullness of the complexion, and / or the heterogeneous appearance of the complexion, and / or the dry and / or dry appearance of the skin, and / or a loss of firmness and / or elasticity and / or tone of the skin, and / or thinned skin. 30   7. Use according to any one of the preceding claims, characterized in that the octane 1,2 diol is present in the composition in a content ranging from 0.001 to 5% by weight relative to the total weight of the composition, preferably from 0.01 to 1% by weight, still more preferably from 0.01 to 0.5% by weight, and more preferably from 0.3% to 0.5% by weight relative to the total weight of the composition. 10 2908985 19   8. Use according to any one of the preceding claims with the exception of claim 5, characterized in that the composition further comprises at least one agent selected from other antiradical or antipollution agents, antiglycation agents, and agents NO-synthase inhibitors.   9. Use according to claim 8, characterized in that the other antiradical or antipollution agent is selected from procysteine and its esters, an extract of Vitreoscilla filiformis, and mixtures thereof. 10   10. Use according to any one of the preceding claims, characterized in that the composition further comprises at least one UV filter.   11. Composition comprising, in a physiologically acceptable medium, 1,2-octane diol and at least 0.01% of procysteine by weight relative to the total weight of the composition.   12. Composition according to claim 11, characterized in that the 1,2-octane diol is present in the composition in a content ranging from 0.001 to 5% by weight relative to the total weight of the composition, preferably from 0.01 to 1 % by weight, more preferably from 0.01 to 0.5% by weight, and more preferably from 0.3% to 0.5% by weight relative to the total weight of the composition.   13. Cosmetic treatment process for preventing and / or reducing the dull and / or heterogeneous appearance of the complexion, characterized in that a cosmetic composition containing octane is applied to the skin and / or the integuments; 1,2 diol.   14. A method of treating cutaneous signs of chronological aging and / or photoinduced, characterized in that one applies to the skin a cosmetic composition containing as sole antiradical agent, 1,2-octane diol. 30   15. The method of claim 14, characterized in that the cutaneous signs of aging are selected from fine lines and wrinkles, age spots, the dullness of the complexion, the heterogeneous appearance of the complexion, the dry appearance and / or rough skin, a loss of firmness and / or elasticity and / or tone of the skin, and / or skin thinned. 2908985 20   16. Method according to one of claims 13 to 15, characterized in that the composition is applied to people from 25 to 30 years to prevent and / or treat premature skin aging. 5   17. Method according to one of claims 13 to 15, characterized in that the composition is applied to people with mature skin or very mature.