FR2895253A1 - Cosmetic use of a neuropeptide Y antagonistic compound to increase the size and/or volume of the lips and/or to model and/or embellish the smoothness of the lips - Google Patents

Abstract

Cosmetic use of a neuropeptide Y (NPY) antagonistic compound to increase the size and/or volume of the lips and/or to model and/or embellish the smoothness of the lips. Independent claims are included for: (1) a composition in the form of lipstick, liquid gloss, lip paste, lip liner pencil, lip balm or lip varnish, comprising the NPY antagonistic compound in a medium; and (2) cosmetic process of embellishing the damaged lips and/or treating the fragile/sensitive lips, comprising applying the composition on the lips. ACTIVITY : Dermatological. MECHANISM OF ACTION : Neuropeptide Y antagonist.

Description

The field of the invention relates to the care and / or the make-up of the lips,

  especially the natural makeup of the lips.

  By natural makeup of the lips is meant according to the invention a means for coloring and / or plumping naturally lips, as opposed to conventional makeup of the lips which uses makeup agents such as dyes, pigments or specific reflective particles capable of conferring an optical effect of coloration and / or volume (pulping effect) of the lips. By coloring naturally, according to the invention is meant to stimulate the naturally rosy coloring of the lips. Plumping according to the invention increases the size and / or volume and / or thickness of the lips and / or reshape and / or smooth and / or give them a more inflated or fleshy appearance.

  The invention relates to the cosmetic use of at least one agonist of neuropeptide Y in a make-up and / or lip care composition, as an agent for plumping and / or coloring the lips naturally.

  Neuropeptide Y (NPY) is a peptide of 36 amino acids highly expressed in the central nervous system. It is a mediator who plays an important role in energy homeostasis. NPY is an extremely potent stimulator of eating behavior, it has been shown that NPY is associated with a greater body fat mass and more food intake is the orexigenic effect (PNAS 1985, 82, 3940 - 3943).

  The pharmacological effects of NPY on pain have also been known for a long time (J. Pharma, Exp Ther 1991, 258, 243-248). From an anatomical point of view, pain stimuli are carried by sensory nerve fibers from the dorsal root ganglia of the spinal cord. Within these ganglia, nociceptive neurons are characterized by their small size. Their central axonal endings are found in the superficial layers of the dorsal horn of the spinal cord, from where the signal is transmitted to supraspinal structures. The expression of Y1 receptors at NPY by these small sensory neurons (PNAS 1997, 94, 729-734) would explain the analgesic effects observed in animals when administering specific agonists (Brain 1999, 833, 251-257 ). At the same time, neuropeptide Y is involved in neurogenic inflammation where it promotes the release of substance P via Y1 type receptors.

  Several other physiological roles have been assigned to NPY: circadian rhythm control, sexual function, anxiety, vascular resistance and control of immune processes. To date, several NPY receptors have been characterized: Y1, Y2, Y5 and Y6 (m / s) 2001, 17, 519-522). The role or roles of each of these receptors are not yet fully understood. In addition to the roles described below, Y1, as well as Y5, would intervene in the orexigenic effect. The Y2 receptor has been detected in sensory neurons only after injury to the sciatic nerve and the induction of its expression is believed to be the basis of the analgesic effects of Y2 agonists.

  Finally, the effects of NPY can be variable from one organ to another, in particular, NPY is a powerful vasoconstrictor in the heart and brain but acts as a vasodilator in the skin (Wallengren et al. J. Investig.Dermatol, Symp., Proc., 1997, 2 (1) 49-55). The Applicant has discovered the existence of an important expression of NPY in the lips. This discovery is astonishing compared to other innervated regions of the face, such as the eyelids where the expression of NPY is weak.

  According to another of its objects, the invention also relates to particular compositions for the care and / or make-up of the lips containing the said NPY agonist compound, as well as to a cosmetic process aimed at making the lips naturally colored and / or luscious. implementing said compositions.

  Fine lips, especially in women, may be considered unsightly. To increase the thickness of the lips, women use techniques such as cosmetic surgery, injections or tattooing, and the use of these techniques tends to become widespread including in women with normal lips, eager to fleshy or luscious lips. However, these 35 techniques are expensive, may give for some an irreversible result (ex: cosmetic surgery, tattooing), or be generating for other side effects of the infection or allergy type (ex: collagen injection, tattoo .. .).

  US Pat. No. 5,571,794 describes the use of mixtures of agents chosen from (i) local vasodilators such as beta-adrenergic receptor blocking agents or muscarinic acetylcholine receptor activating agents; (ii) local irritants; and (iii) homeopathic dose elements; to increase the size of the lips.

  More recently, the application WO03 / 072039 describes compositions containing a polymer of 7 to 15 units of L-Arginine for increasing the size of keratin materials such as skin, hair, lips and gums.

  There remains, however, the need to find effective agents for natural lip makeup, especially agents capable of coloring and / or plumping the lips naturally, which are cosmetically acceptable and formable in compositions for topical application to the lips.

  The Applicant proposes to use an NPY agonist compound on the lips to meet this need.

  Thus the subject of the present invention relates to the cosmetic use of an effective amount of at least one NPY agonist compound to improve the appearance of the lips, in particular, their texture, size and color.

  More particularly, the invention relates to the use of at least one agonist compound of neuropeptide Y (NPY) to increase the size and / or the volume of the lips and / or to shape them and / or to make them smoother. . The compounds according to the invention are also intended to stimulate the naturally rosy coloring of the lips.

  The NPY agonist compounds are either chemical, peptide or non-peptide molecules, or any type of extract characterized by an NPY agonist type activity, preferentially Y1 type.

  These compounds can be identified on the basis of receptor binding to the Y1 NPY receptor, for example described by the methods of Fuhlendorf J. et al (PNAS-USA, 1990, 87, p182) or Wieland et al. (J. Pharmacol Exp Ther, 1995, 275, 143-149).

  As an example of NPY agonists, mention may be made of the NPY peptide itself, for example obtained by biotechnological process, NPY agonists of plant origin, [34Pro] NPY, NPY [13-36], [Leu3I, Pro34] NPY.

  The compound will be present in the compositions according to the invention in an amount effective to obtain the desired effect, namely the repulping effect of the lips and / or the natural coloring effect of the lips. This effect can be directly measured by simple visual observation or by comparative analysis of images. By way of example, said compound will be present in the composition in an amount ranging from 10-8 to 10% by weight relative to the total weight of the composition, preferably from 10-6 to 5% and better still from 10-4. at 2%, and more preferably 10-2 to 1% by weight relative to the total weight of the composition.

  Advantageously, said compound used according to the invention may be incorporated into a system allowing its release at the lips, after application of the composition thereon.

  In particular, said compound may be adsorbed or incorporated into particle structures of size ranging from 1 nm to a few m (10 m), such as, for example, microcapsules, microparticles, ionic-type vesicular dispersions (liposomes or oleosomes) and or nonionic (niosomes) and / or nanosphere dispersions. These particles may be advantageously porous and consist of silicates or aluminosilicates. Examples of such formulations are described in particular in patents EP 0 199 636, EP 0 375 520, EP 0 447 318, EP 0 557 489, WO 97/12602, EP 1 151 741 or US 5,914,126.

  By way of example, the microspheres may be prepared according to the method described in patent application EP 0 375 520. The nanospheres may be in the form of an aqueous suspension and may be prepared according to the methods described in patent applications FR 00 15686. and FR 01 01438.

  The oleosomes consist of an oil-in-water emulsion formed by oily globules provided with a lamellar liquid crystal coating dispersed in an aqueous phase (see patent applications EP 0 641 557 and EP 0 705 593). The agent according to the invention may also be encapsulated in nanocapsules consisting of a lamellar coating obtained from a silicone surfactant such as described in the patent application EP 0 780 115; the nanocapsules may also be prepared based on water-dispersible sulfonic polyesters according to, for example, the technique described in the patent application FR 01 13337.

  According to another of its objects, the present invention relates to a composition comprising, in a physiologically acceptable medium, at least one NPY agonist. The composition may also comprise at least one agent chosen from solvents, oils, waxes, pastes, gums, fillers, dyestuffs, cosmetic active ingredients, thickeners, surfactants, moisturizers and softeners. , sequestering agents, perfumes, neutralizers, preservatives, antioxidants, UV filters, bactericides, trace elements, odor absorbers and mixtures thereof. The amounts of these different agents are those conventionally used in the field under consideration, for example from 0.01 to 20% of the total weight of the composition.

  The composition may be in any galenical form normally used for topical application and especially in anhydrous form, in the form of an oily or aqueous solution, an oily or aqueous gel, an oil-in-water or water emulsion. - in-oil, a multiple emulsion, an oil dispersion in water through vesicles located at the oil / water interface. The composition of the invention may be in the form of a liquid, a solid or semisolid, in particular a product cast in a stick or a dish, a stick, a paste or a more or less fluid cream.

  The composition of the invention can be obtained according to the preparation methods conventionally used in cosmetics.

  By physiologically acceptable medium is meant a medium compatible with the lips of humans. The physiologically acceptable medium will be adapted to the nature of the support on which the composition is to be applied and to the form in which the composition is intended for use. be packaged, especially solid or fluid at room temperature and atmospheric pressure.

  The composition according to the invention may comprise an aqueous cosmetic medium and / or a fatty phase. The composition may comprise water or a mixture of water and hydrophilic organic solvents such as alcohols and in particular linear or branched lower monoalcohols having from 2 to 5 carbon atoms, such as ethanol, isopropanol or n-butanol. propanol, polyols such as glycerine, diglycerine, propylene glycol, sorbitol, penthylene glycol, polyethylene glycols. The hydrophilic phase may further contain 02 ethers and hydrophilic 02-04 aldehydes. The water or the mixture of water and hydrophilic organic solvents may be present in the composition according to the invention, or one of the base and / or surface compositions, in a content ranging from 0% to 90%. 0 (in particular 0.1% to 90%) by weight, relative to the total weight of the composition, and preferably from 0% to 60% by weight (in particular 0.1% to 60% by weight).

  The composition may also comprise a fatty phase, especially consisting of fatty substances that are liquid at room temperature (generally 25 ° C.) and / or fatty substances that are solid at ambient temperature, such as waxes, pasty fatty substances, gums and mixtures thereof. This fatty phase may, in addition, contain lipophilic organic solvents.

  As liquid fatty substances at room temperature, often called oils, which can be used in the invention, mention may be made of: vegetable hydrocarbon-based oils such as liquid triglycerides of fatty acids with 4 to 10 carbon atoms, such as triglycerides of heptanoic or octanoic acids or sunflower, corn, soybean, grape seed, sesame, apricot, macadamia, castor oil, avocado oil, caprylic / capric acid triglycerides, jojoba oil, shea butter; linear or branched hydrocarbons of mineral or synthetic origin, such as liquid paraffins and derivatives thereof, petroleum jelly, polydecenes, hydrogenated polyisobutene such as parleam; esters and synthetic ethers, in particular of fatty acids, for example purcellin oil, isopropyl myristate, 2-ethylhexyl palmitate, octyl-2-dodecyl stearate, erucate octyl-2-dodecyl, isostearyl isostearate; hydroxylated esters such as isostearyl lactate, octyl hydroxystearate, octyldodecyl hydroxystearate, diisostearyl malate, triisocetyl citrate, heptanoates, octanoates, decanoates of fatty alcohols; polyol esters such as propylene glycol dioctanoate, neopentyl glycol diheptanoate, diethylene glycol diisononanoate; and pentaerythritol esters; fatty alcohols having 12 to 26 carbon atoms such as octyldodecanol, 2-butyloctanol, 2-hexyldecanol, 2-undecylpentadecanol, oleyl alcohol; partially hydrocarbon and / or silicone fluorinated oils; silicone oils, such as volatile or nonvolatile polymethylsiloxanes (PDMS), linear or cyclic, liquid or pasty at room temperature, such as cyclomethicones, dimethicones, optionally comprising a phenyl group, such as phenyl trimethicones, phenyltrimethylsiloxydiphenylsiloxanes or diphenylmethyldimethyltrisiloxanes, diphenyl dimethicones, phenyl dimethicones, polymethylphenyl siloxanes; their mixtures. These oils may be present in a content ranging from 0.01 to 90%, and better still from 0.1 to 85% by weight, relative to the total weight of the composition.

  The composition of the invention may further advantageously comprise a solid or pasty fatty substance at room temperature, such as gums or waxes.

  The waxes may be hydrocarbon-based, fluorinated and / or silicone-based and may be of vegetable, mineral, animal and / or synthetic origin. In particular, the waxes may have a melting temperature of greater than 25 ° C. and better still greater than 45 ° C. As wax which can be used in the composition of the invention, mention may be made of beeswax, Carnauba wax or Candelilla wax, paraffin, microcrystalline waxes, ceresin or ozokerite; synthetic waxes such as polyethylene or Fischer Tropsch waxes, silicone waxes such as alkyl or alkoxy dimethicone having from 16 to 45 carbon atoms.

  The gums that can be used are generally high molecular weight polydimethylsiloxanes (PDMS) or cellulose gums or polysaccharides and the pasty substances are generally hydrocarbon compounds such as lanolines and their derivatives or else PDMSs.

  By pasty is meant a lipophilic fat compound, reversible solid / liquid state change, having at 23 C a liquid fraction and a solid fraction. Paste is also understood to mean vinyl polylaurate.

  The pasty compounds are advantageously chosen from: lanolin and its derivatives, fluorinated compounds which may or may not be polymeric, silicone compounds which may or may not be polymeric, vinyl polymers, in particular: homopolymers of olefins and copolymers of olefins homopolymers and copolymers of hydrogenated dienes; linear or branched oligomers, homopolymers or copolymers of alkyl (meth) acrylates preferably having a C 8 -C 30 alkyl group; homo and copolymeric oligomers of vinyl esters having alkyl groups; C8-C30-homopolymers and copolymers of vinyl ethers having C8-C30 alkyl groups, liposoluble polyethers resulting from the polyetherification between one or more C2-C100 diols, preferably C2-C50 diols, and their mixtures.

  Among the liposoluble polyethers, copolymers of ethylene oxide and / or propylene oxide with long-chain C 6 -C 30 alkylene oxides are preferred, more preferably such as the weight ratio of ethylene oxide. and / or propylene oxide with alkylene oxides in the copolymer is from 5:95 to 70:30. In this family, mention will in particular be made of copolymers such as long-chain alkylene oxides are arranged in blocks having an average molecular weight of 1,000 to 10,000, for example a polyoxyethylene / polydodecyl glycol block copolymer such as dodecanediol ethers (22 mol) and polyethylene glycol (45 EO) marketed under the trademark ELFACOS ST9 by Akzo Nobel.

  Among the pasty esters, the following are particularly preferred: esters of an oligomeric glycerol, in particular the diglycerol esters, in particular the adipic acid and glycerol condensates, for which part of the hydroxyl groups of the glycerols have reacted with a mixture of fatty acids such as stearic acid, capric acid, stearic acid and isostearic acid and 12-hydroxystearic acid, such as those marketed under the trademark Softisan 649 by the company Sasol, arachidyl propionate sold under the name Waxenol 801 by Alzo, phytosterol esters, non-crosslinked polyesters resulting from the polycondensation between a linear or branched C 8 -C 50 diacid or polycarboxylic acid and a C2 diol or polyol -050, different from the polyester described above, the ester aliphatic esters resulting from the esterification of an aliphatic hydroxycarboxylic acid ester by a monocarboxylic acid aliphatic hatique; and their mixtures, such as the ester resulting from the esterification reaction of hydrogenated castor oil with isostearic acid in proportions 1 to 1 (1/1) or hydrogenated castor oil monoisostearate, the ester resulting from the esterification reaction of hydrogenated castor oil with isostearic acid in proportions 1 to 2 (1/2) or hydrogenated castor oil diisostearate, the ester resulting from the esterification reaction hydrogenated castor oil with isostearic acid in proportions 1 to 3 (1/3) or hydrogenated castor oil triisostearate, and mixtures thereof. Among the pasty compounds of vegetable origin, a mixture of soy sterols and oxyethylenated (5OE) oxypropylene pentaerythritol (5 PO), marketed under the reference Lanolide by the company VEVY, will preferably be chosen.

  The pasty compound is preferably 1 to 99%, more preferably 1 to 60%, more preferably 2 to 30% and more preferably 5 to 15% by weight of the composition.

  The nature and quantity of the solid bodies depend on the mechanical properties and textures sought. The composition may contain from 0 to 50% by weight of wax, based on the total weight of the composition and more preferably from 1 to 30% by weight. By fillers is meant any colorless or white, mineral or synthetic particles of any form, insoluble in the medium of the composition irrespective of the temperature at which the composition is made. These fillers serve in particular to modify the rheology or the texture of the composition. The fillers can be mineral or organic of any shape, platelet, spherical or oblong, irrespective of the crystallographic form (for example sheet, cubic, hexagonal, orthorhombic, etc.). Mention may be made of talc, mica, silica, kaolin, polyamide (nylon) powders (Orgasol from Atochem), poly-13-alanine and polyethylene, tetrafluoroethylene polymer powders (Teflon), lauroyl-lysine, starch, boron nitride, polymeric hollow microspheres such as those of polyvinylidene chloride / acrylonitrile such as Expancel (Nobel Industrie), copolymers of acrylic acid (Polytrap 603 from the company Dow Corning) and silicone resin microbeads (Toshiba Tospearls, for example), elastomeric polyorganosiloxane particles, precipitated calcium carbonate, magnesium carbonate and hydrocarbonate, hydroxyapatite, hollow silica microspheres (Silica Maprecos beads), glass or ceramic microcapsules, metal soaps derived from organic carboxylic acids having from 8 to 22 carbon atoms, preferably from 12 to 18 carbon atoms, for example zinc, magnesium or lithium stearate, zinc laurate, magnesium myristate, Polypore L 200 (Chemdal Corporation). Mention may also be made of silica-based fillers such as Aerosil 200 and Aerosil 300; Sunsphare L-31, Sunphare H-31 marketed by Asahi Glass; Chemicelen marketed by Asahi Chemical; silica and titanium dioxide composites such as the TSG series marketed by Nippon Sheet Glass. Finally, mention may be made of polyurethane powders, in particular crosslinked polyurethane powders comprising a copolymer, said copolymer comprising trimethylol hexyl lactone. In particular, it may be a hexamethylene diisocyanate / trimethylol hexyllactone polymer. Such particles are in particular commercially available, for example under the name PLASTIC POWDER D-400 or PLASTIC POWDER D-800 from TOSHIKI. The filler content may range from 0.01% to 50% by weight, preferably ranging from 0.01% to 30% by weight relative to the total weight of the composition.

  For the purposes of the present invention, the term "dyestuff" means a compound capable of producing an optical effect when it is formulated in sufficient quantity in a suitable cosmetic medium. The dyestuffs may be present in the composition in a content ranging from 0.01% to 50% by weight, relative to the weight of the composition, preferably from 0.1% to 30% by weight. The dyestuff may in particular be chosen from dyes, pigments, pearlescent agents and their mixtures.

  The dyes are preferably fat-soluble dyes, although water-soluble dyes can be used. Liposoluble dyes are, for example, Sudan Red, D & C Red 17, D & C Green 6, 13-carotene, soybean oil, Sudan Brown, D & C Yellow 11, D & C Violet 2, D & C orange 5, yellow quinoline, annatto. They may represent from 0 to 20% of the weight of the composition and better still from 0.1 to 6%. When used, the water-soluble dyes include beetroot juice, methylene blue and may represent from 0.1 to 6% by weight of the composition.

  The pigments may be selected from inorganic pigments, organic pigments, and composite pigments (i.e., pigments based on mineral and / or organic materials). By pigments, it is necessary to include particles of any shape, with an optical effect, mineral or synthetic, insoluble in the medium of the composition regardless of the temperature at which the composition is manufactured. The inorganic pigments can be chosen from metal oxide pigments, titanium dioxide coated mica, bismuth oxychloride coated mica, iron oxide coated titanium mica, ferric blue coated mica-titanium. , titanium mica coated with chromium oxide, and mixtures thereof. The metal oxide pigments are, for example, iron oxides, titanium dioxide, zinc oxides, zirconium oxides, cerium oxides, and mixtures thereof. The inorganic pigments are preferably metal oxide pigments. The pigments may be present in the composition in a content ranging from 0.01 to 25% by weight, relative to the total weight of the composition, and preferably ranging from 1 to 12% by weight, and preferably ranging from 3 to 8% by weight.

  The organic pigments may be selected from the pigments and lacquers cited in International Cosmetic Ingredient Dictionary and Handbook, Edition 1997, pages 371 to 386 and 524 to 528, published by The Cosmetic, Toiletry, and Fragrance Association. Content is incorporated herein by reference.

  The nacres may be chosen for example from mica coated with titanium oxide, iron oxide, natural pigment or bismuth oxychloride such as colored titanium mica.

  The compositions according to the invention may also contain active agents having a simillary or complementary activity of NPY agonists.

  In particular, as active agents, it may be compounds that act via (i) stimulation of vasodilation and / or an anticoagulant effect and / or an antihypertensive effect, mention may be made of: antihypertensive agents; in particular openers of potassium channels; inhibitors of phosphodiesterases; plant extracts with vasodilator properties; non-NO donor vasodilator peptides; other vasodilator agents, for example, capsaicin, derivatives of minoxidil, anticalcic compounds.

  The NPY agonists may also be combined in the compositions according to the invention with hydrophilic or lipophilic cosmetic active ingredients, in particular with the aim of enhancing the appearance of the lips. These active agents may be chosen in particular from: - agents stimulating the synthesis of dermal or epidermal macromolecules and / or preventing their degradation (eg collagen synthesis, elastin, etc.), - moisturizing agents, - anti-pollution or anti-agents -radical, - soothing agents, - tensor agents.

  Agents stimulating the synthesis of macromolecules Dermal cells, in particular fibroblasts, produce molecules of collagen, elastin and glycoproteins. These molecules confer volume and density to the lips and their outline, as well as their firmness. With the effect of age or even under the effect of UV rays, there is a notable decrease in these molecules and a degradation of collagen and elastin fibers under the effect of collagenase or elastase. This degradation or decrease in the production of these molecules induces a loss of firmness of the lips and their outline, causing in particular the appearance of wrinkles. Among the active agents stimulating the macromolecules of the dermis or preventing their degradation, there may be mentioned those which act: either on the synthesis of collagen, such as extracts of Centella asiatica; asiaticosides and derivatives; ascorbic acid or vitamin C and its derivatives, such as its salts or its esters, in particular 5,6-di-O-dimethylsilylascorbate (sold by Exsymol under the reference PRO-AA), the potassium salt of dl-alpha tocopheryl-dl-ascorbyl-phosphate (sold by Senju Pharmaceutical under the reference SEPIVITAL EPC), magnesium ascorbyl phosphate, sodium ascorbyl phosphate (sold by Roche under the reference Stay-C 50) and ascorbyl glucoside (sold by Hayashibara); synthetic peptides such as iamin, biopeptide CL or palmitoyloligopeptide marketed by SEDERMA; peptides extracted from plants, such as the soy hydrolyzate marketed by COLETICA under the trade name Phytokine; plant hormones such as auxins and lignans; palmitoyl pentapeptide lysine-threonine-threonine-lysine-serine sold in particular under the name MATRIXYL by SEDERMA: dimethyl amino ethanol; Bupleurum Chinensis ricehome extracts, such as those sold under the names PLEURIMINCYL, LIPOCARE by SEDERMA; hydrolyzates of wheat protein acylated in particular by a palmitoyl group, such as that sold under the name LIPACID PVB by SEPPIC; creatine; coenzyme Q10; or on the synthesis of elastin, such as the extract of Saccharomyces cerivisiae sold by LSN under the trade name Cytovitin; and the algae extract Macrocystis pyrifera marketed by SECMA under the trade name Kelpadelie; melibiose; soy protein; or on the synthesis of glycosaminoglycans, such as the product of fermentation of milk with Lactobacillus vulgaris, marketed by BROOKS under the trade name Biomin yogourth; the extract of the brown alga Padina pavonica sold by Alban Müller under the trade name HSP3; and the extract of Saccharomyces cerevisiae available in particular from SILAB under the trade name Firmalift or from LSN under the trade name Cytovitin; or on the synthesis of fibronectin, such as the Salina zooplankton extract marketed by SEPORGA under the trade name GP4G; yeast extract available in particular from ALBAN MÜLLER under the trademark Drieline; and the palmitoyl pentapeptide sold by SEDERMA under the trademark Matrixil; C-glycosides and their derivatives as described in EP 1 345 919; - Or on the inhibition of metalloproteinases (matrix metalloproteinases or MMP) such as more particularly the MMP 1, 2, 3, 9. There may be mentioned: retinoids and derivatives, oligopeptides and lipopeptides, lipoamino acids, malt extract marketed by Coletica under the trade name Collalift; extracts of blueberry or Rosmarinus officinale; lycopene; isoflavones, their derivatives or plant extracts containing them, in particular extracts of soya (marketed for example by ICHIMARU PHARCOS under the trade name Flavosterone SB), red clover, flax, kakkon or sage; or on the inhibition of serine proteases such as leukocyte elastase or cathepsin G. Mention may be made of: the peptide extract of leguminous seeds (Pisum sativum) sold by LSN under the trademark Parelastyl; heparinoids; and pseudodipeptides such as {2- [acetyl- (3-trifluoromethylphenyl) -amino] -3-methyl-butyrylamino} acetic acid.

  Among the active ingredients stimulating fillagrine and keratins, mention may be made in particular of the lupine extract marketed by SILAB under the trademark Structurine; the extract of beech buds Fagus sylvatica marketed by Gattefosse under the trade name Gatuline; and Salina zooplankton extract marketed by SEPORGA under the trade name GP4G.

  Preferably, the agents stimulating the synthesis of dermal or epidermal macromolecules and / or preventing their degradation are chosen from extracts of Centella asiatica, ascorbic acid and its derivatives, peptides extracted from plants, such as commercialized soy hydrolyzate by COLETICA under the trade name Phytokine, the extract of Saccharomyces cerivisiae sold by LSN under the trade name Cytovitin; the extract of the brown alga Padina pavonica sold by Alban Müller under the trade name HSP3; retinoids and derivatives; extracts of Rosmarinus officinalis; the peptide extract of leguminous seeds (Pisum sativum) marketed by LSN under the trademark Parelastyl; {2- [acetyl- (3-trifluoromethyl-phenyl) -amino] -3-methyl-butyrylamino} acetic acid and the analogs as described in EP 1 292 608; lupine extract; and their mixtures.

  Moisturizing agents By "moisturizing agent" is meant: - either a compound acting on the barrier function, with a view to maintaining the hydration of the stratum corneum, or an occlusive compound. There may be mentioned ceramides, sphingoid-based compounds, lecithins, glycosphingolipids, phospholipids, cholesterol and its derivatives, phytosterols (stigmasterol, 13-sitosterol, campesterol), essential fatty acids, 1-2 diacylglycerol, 4-chromanone, pentacyclic triterpenes such as ursolic acid, petrolatum and lanolin; or a compound directly increasing the water content of the stratum corneum, such as thralose and its derivatives, hyaluronic acid and its derivatives, glycerol, pentanediol, sodium pidolate, serine, xylitol, lactate sodium, glycerol polyacrylate, ectoin and its derivatives, chitosan, oligo- and polysaccharides such as the product marketed under the reference Pentavitin, honey, alginates (in particular the product Sobalg PH 154 marketed by Grindsted), carbonates cyclic N-lauroyl pyrrolidone carboxylic acid or its salts, especially the sodium salt sold under the reference Nalidone, and Na-benzoyl-L-arginine; or a compound that activates the sebaceous glands, such as steroid derivatives (including DHEA, its 7-oxidized and / or 17-alkylated derivatives and sapogenins), methyl dihydrojasmonate, and vitamin D and its derivatives. These compounds may represent from 0.001 to 30%, and preferably from 0.01 to 20%, of the total weight of the composition according to the invention.

  Anti-pollution or anti-radical agent By the term "anti-pollution agent" is meant any compound capable of trapping ozone, mono- or polycyclic aromatic compounds such as benzopyrene and / or heavy metals such as cobalt, mercury, cadmium and / or nickel. By "anti-radical agent" is meant any compound capable of trapping free radicals. As ozone-trapping agents that may be used in the composition according to the invention, mention may be made in particular of vitamin C and its derivatives, including the glucoside d ascorbyl; phenols and polyphenols, in particular tannins, ellagic acid and tannic acid and epigallocatechin and natural extracts containing them; olive leaf extracts; tea extracts, especially green tea; anthocyanins; rosemary extracts phenolic acids, especially chorogenic acid; stilbenes, in particular resveratrol; sulfur-containing amino acid derivatives, in particular S-carboxymethylcysteine; ergothioneine; N-acetylcysteine; chelating agents such as N, N'-bis- (3,4,5-trimethoxybenzyl) ethylenediamine or a salt thereof, metal complexes or esters; carotenoids such as crocetin; and various raw materials such as the mixture of arginine, histidine ribonucleate, mannitol, adenosinetriphosphate, pyridoxine, phenylalanine, tyrosine and hydrolysed RNA marketed by the Serobiological Laboratories under the trade name CPP LS 2633-12F, the water-soluble fraction of corn marketed by the company SOLABIA under the trade name Phytovityl, the mixture of fumitory extract and lemon extract marketed under the name Unicotrozon C-49 by Induchem, and the mixture of extracts of ginseng, apple, peach, wheat and barley sold by PROVITAL under the trade name Pronalen Bioprotect.

  As scavengers for mono- or polycyclic aromatic compounds that can be used in the composition according to the invention, mention may be made in particular of tannins such as ellagic acid; indole derivatives, in particular indol-3-carbinol; tea extracts especially green tea, extracts of water hyacinth or eichornia crassipes; and the water soluble fraction of corn marketed by SOLABIA under the trade name Phytovityl.

  Finally, as scavengers for heavy metals that may be used in the composition according to the invention, there may be mentioned in particular chelating agents such as EDTA, the pentasodium salt of ethylenediamine tetramethylene phosphonic acid, and N, N'-bis- ( 3,4,5-trimethoxybenzyl) ethylenediamine or a salt thereof, metal complexes or esters phytic acid; chitosan derivatives; tea extracts, especially green tea tannins such as ellagic acid; sulfur-containing amino acids such as cysteine; water hyacinth (Eichornia crassipes) extracts; and the water-soluble corn fraction marketed by SOLABIA under the trade name Phytovityl. The anti-radical agents that can be used in the composition according to the invention comprise, in addition to certain anti-pollution agents mentioned above, vitamin E and its derivatives such as tocopheryl acetate; bioflavonoids; coenzyme Q10 or ubiquinone; certain enzymes such as catalase, superoxide dismutase and wheat germ extracts containing it, lactoperoxidase, glutathione peroxidase and quinone reductases; glutathione; benzylidene camphor; benzylcyclanones; substituted naphthalenones; pidolates; phytantriol; gamma-oryzanol; guanosine; lignans; and melatonin.

  Soothing agents As quenching agents that can be used in the composition according to the invention, mention may be made of: pentacyclic triterpenes and plant extracts (eg Glycyrrhiza glabra) containing them, such as 13-glycyrrhetinic acid and its salts and / or derivatives thereof ( glycyrrhetinic acid monoglucuronide, stearyl glycyrrhetinate, 3-stearoyloxy glycyrrhetic acid), ursolic acid and its salts, oleanolic acid and its salts, betulinic acid and its salts, plant extracts such as Paeonia suffruticosa and / or lactiflora, Laminaria saccharina, Boswellia serrata, Centipeda cunnighami, Helianthus annuus, Linum usitatissimum, Cola nitida, Epilobium Angustifolium, Aloe vera, Bacopa monieri, salts of salicylic acid and in particular zinc salicylate, canola oil, bisabolol and chamomile extracts, allantoin, EPP Seppic SEEP (Sepsic Vitamin E and diesterphosphoric acid), unsaturated omega 3 oils such as hui musk rose, cassis, ecchium, or fish, plankton extracts, capryloyl glycine, Seppicalm VG (sodium palmitoylproline and nymphea alba) from Seppic, tocotrienols, piperonal, clove extract , phytosterols, cortisone, hydrocortisone, indomethacin and beta methasone. Thus, the antogonists of substance P or CGRP described in EP 0 680 749 and EP 0 723 774, the thermal waters of the Vichy basin or Roche Posay, the extracts of Vitreoscilla filiformis described in patent applications FR 2 279 382, EP0765667, EP 0 876 813 and EP 1 531 158.

  Tensoring agents Mention may in particular be made of: (1) synthetic polymers, such as polyurethane latices or acrylic-silicone latices, in particular those described in patent application EP-1038519, such as a propylthio grafted polydimethyl siloxane (polyacrylate) methyl), propylthio (polymethyl methacrylate) and propylthio (methacrylic acid), or a polydimethyl siloxane grafted propylthio (isobutyl polymethacrylate) and propylthio (poly methacrylic acid). Such grafted silicone polymers are especially sold by the company 3M under the trade names VS 80, VS 70 or LO 21, (2) polymers of natural origin, in particular (a) polyholosides, for example (i) in the form of starch obtained especially from rice, maize, potato, cassava, peas, wheat, oats, etc ... or (ii) in the form of carrageenans, alginates, agars, gellans, cellulosic polymers and pectins , advantageously in aqueous dispersion of gel microparticles, and (b) the latex consisting of shellac resin, sandarac gum, dammars, elemis, copals, cellulose derivatives, and mixtures thereof, (3) proteins and vegetable protein hydrolysates, in particular of maize, rye, wheat, buckwheat, sesame, pepper, pea, bean, lentil, soybean and lupine, (3) mixed silicates, especially phyllosilicates and in particular the Laponites, (4) the microparticles of ire, chosen for example from Carnauba, Candelila or Alfa waxes, (5) colloidal particles of inorganic filler having a number average diameter of between 0.1 and 100 nm, preferably between 3 and 30 nm, and chosen for example from: silica, silica-alumina composites, cerium oxide, zirconium oxide, alumina, calcium carbonate, barium sulfate, calcium sulphate, zinc and titanium dioxide.

  The composition for care and / or makeup of the lips may be in the form of a lipstick stick, a liquid gloss, a paste of lipsticks, a pencil for the contour of the lips, a lip balm, a nail polish otherwise known as lip lacquer.

  The lip balm will be especially intended to protect the lips from cold and / or sun and / or wind. The liquid gloss, also called liquid lipstick or lip gloss, is a fluid product intended to be applied to the lips and packaged for example in a container provided with an applicator, this applicator comprising a gripping member which also serves as a In a particular embodiment of the invention, said natural repulping agent and / or stimulating the coloring of the lips used in the compositions of the invention is associated with at least one embodiment of the invention. an optical volume makeup agent. This makeup agent with an optical volume effect is intended to reinforce the volume effect obtained by the first agent and / or to give the composition applied to the lips an immediate volumizing optical effect relayed over time by the natural volumizing effect. mediated by the first agent. The presence of the first agent in the composition also makes it possible to reduce the normally effective concentrations of the second agent in order to obtain the desired effect on the volume and / or color of the lips, so as to favor the natural appearance of the makeup.

  As a makeup agent with an optical effect of volume, it is possible, for example, to use goniochromatic pigments, reflecting particles and their mixtures.

  By goniochromatic pigment is meant in particular a pigment capable of producing different colors depending on the incidence of light and the angle of observation. Preferably, the goniochromatic pigments are goniochromatic pigments with an interferential multilayer structure. In particular, the goniochromatic pigments described in application EP 1 382 323 may be used.

  The multilayer structure of the goniochromatic pigments may comprise at least two layers, each layer, independently or not of the other layer (s), being made of at least one material selected from the group consisting of the following materials : MgF2, CeF3, ZnS, ZnSe, Si, SiO2, Ge, Te, Fe2O3, Pt, Va, Al2O3, MgO, Y2O3, S2O3, SiO, HfO2, ZrO2, CeO2, Nb2O5, Ta2O5, TiO2, Ag, Al, Au , Cr, Cu, Rb, Ti, Ta, W, Zn, MoS2i cryolite, alloys, polymers and their combinations. By way of example, these pigments may be the pigments of silica / titania / tin oxide structure marketed under the name XIRONA MAGIC by MERCK, the silica / brown iron oxide structural pigments marketed under the name XIRONA INDIAN SUMMER. by MERCK and the silica / titania / mica / tin oxide structural pigments marketed under the name XIRONA CARRIBEAN BLUE by MERCK. One can also mention Sicopearl Fantastico manufactured or marketed by BASF, Colorstream manufactured or marketed by MERCK, Chromaflair manufactured or marketed by FLEX, Xirallic manufactured or marketed by MERCK; INFINITE COLORS pigments from SHISEIDO.

  Mention may be made, by way of example of pigments with a polymeric multilayer structure, those marketed by 3M under the name COLOR GLITTER. As liquid crystal goniochromatic particles, it is possible, for example, to use those sold by CHENIX as well as those sold under the name HELICONE HC by WACKER.

  In general, the structure is composed of alternating layers of low optical index and high optical index.

  The goniochromatic pigments may be present in the composition according to the invention in a content ranging from 0.01 to 50% by weight, relative to the total weight of the composition, preferably from 0.1 to 30% by weight, and better from 0.3 to 20% by weight.

  By reflective particles is meant in particular particles whose size, structure, and surface state allow them to reflect the incident light with sufficient intensity to be able to create on the surface of the claimed composition, when the latter is applied on the medium to make up, points of highlighting visible with the naked eye, that is to say more luminous points which contrast with their environment while appearing to shine. For example, the particles comprising a natural or synthetic substrate, at least partially coated with a layer of at least one metal, the particles with a synthetic substrate at least partially coated with at least one layer of a metal compound and in particular of a metal oxide, the particles formed of a stack of at least two layers with different refractive indices, in particular two layers of polymers, and the particles of metal oxides. The metal may be chosen for example from Ag, Au, Cu, Al, Ni, Sn, Mg, Cr, Mo, Ti, Pt, Va, Rb, W, Zn, Ge, Te, Se and their alloys. Ag, Au, Al, Zn, Ni, Mo, Cr, Cu and their alloys (eg, bronzes and brasses) are preferred metals. By way of example, platelet-coated glass-substrate particles, sold as MICROGLASS METASHINE REFSX 2025 PS by TOYAL, may be used; or particles with a glass substrate coated with a nickel / chromium / molybdenum alloy sold under the name CRYSTAL STAR GF 550, GF 2525 by the same company. The reflective particles, regardless of their shape, may also be chosen from particles with a synthetic substrate at least partially coated with at least one layer of at least one metal compound, in particular a metal oxide, chosen, for example, from oxides titanium, in particular TiO2, iron, in particular Fe2O3, tin, chromium, barium sulfate and the following compounds: MgF2, CrF3, ZnS, ZnSe, SiO2, Al2O3, MgO, Y2O3, SeO3, SiO, HfO2, ZrO2 , CeO 2, Nb 2 O 5, Ta 2 O 5, MoS 2 and mixtures or alloys thereof. By way of example of such particles, mention may be made, for example, of particles comprising a synthetic mica substrate coated with titanium dioxide, or glass particles coated with either brown iron oxide or titanium oxide, tin oxide or a mixture thereof such as those sold under the trade name REFLECKS by ENGELHARD. Also suitable for the invention are the pigments of the METASHINE 1080R range marketed by NIPPON SHEET GLASS CO. LTD. These pigments, more particularly described in the patent application JP 2001-11340, are C-GLASS glass flakes comprising 65 to 72% SiO 2, coated with a titanium oxide layer of rutile type (TiO 2). These glass flakes have an average thickness of 1 micron and an average size of 80 microns is a ratio average size / average thickness of 80. They have blue, green, yellow or silver-tone reflections depending on the thickness of the layer of TiO2. There may also be mentioned particle size between 80 and 100 m, comprising a synthetic mica substrate (fluorophlogopite) coated with titanium dioxide representing 12% of the total weight of the particle, sold under the name PROMINENCE by NIHON KOKEN.

  The reflective particles may be present in the composition by being dispersed homogeneously, for example at a content ranging from 0.1 to 20% relative to the total weight of the composition, preferably from 1 to 15% by weight, and better still 1 to 10% by weight, for example about 2%, especially for a composition intended to be applied to the lips.

  The invention also relates to a cosmetic composition comprising, in a physiologically acceptable medium, at least one NPY agonist compound, and characterized in that it is in the form of a lipstick, a liquid gloss, a lip paste, a lip contour pencil, a lip balm, or a lip lacquer otherwise known as a lip lacquer. In particular, said compound is chosen from the NPY itself, [34Pro] NPY peptide, NPY [13-36], [Leu3I, Pro34] NPY, NPY agonists of plant origin.

  Advantageously, said compound will be incorporated in a system allowing its release at the skin, after application of the composition thereon. In particular, said compound may be adsorbed on or encapsulated in particulate structures as described above.

  The composition may be in any galenic form suitable for topical application to the lips, in particular one of those described previously in the description.

  In a particular composition of the invention, said compound is associated with at least one makeup agent with an optical effect on the volume of the lips, preferably chosen from goniochromatic pigments, reflecting particles and their mixtures, as described above.

  The composition may also comprise at least one agent chosen from fillers, dyestuffs, cosmetic active agents, thickeners, surfactants, moisturizers, softeners, sequestering agents, perfumes, neutralizers, preservatives, antioxidants, UV filters, bactericides, trace elements and mixtures thereof. Examples of such compounds are described previously in the description.

  The invention also relates to a process for makeup and / or care of the lips, characterized in that a composition as defined above is applied to the lips.

  In particular, the composition is applied to thin lips or thin-lipped women.

  The examples given below are presented as non-limiting illustrations of the invention. EXAMPLES

  EXAMPLE 1 Demonstration of the Presence of Neuropeptide Y in the Lips - Immunolabeling The detection was carried out by fluorescent immunostaining on tissue sections (eyelids and lips). The tissues taken are fixed in Zamboni medium at 4 ° C. and then frozen at -80 ° C. The sections are then made at 10 μιη and incubated with the primary antibody (anti-NPY, Chemicon AB1915, 1/300, 3h).

  After rinsing, they are incubated with fluorescent secondary antibody (coupled with Alexa 488, Molecular Probes, 1 h). Finally, they are rinsed then counter-stained with DAPI and mounted on slides. - Image Capture Image captures were performed on a fluorescent Pathfinder Morphoscan system. Figures 1 and 2: the clichés obtained demonstrate the presence of NPY in the lips, unlike the eyelids. The immunofluorescence of the stratum corneum that appears on the eyelid clichés is an autofluorescence artifact. In conclusion, irrespective of the level of tissue innervation, the lips have the peculiarity of expressing very strongly the NPY

  Example 2 - lip balm composition The percentages are expressed by weight. poly (isobornyl acrylate / isobutyl methacrylate / isobutyl acrylate) polymer 90.7 - Polyisobutene Hydrogen 2.1 - Octyldodecanol 0.9 - Phenyltrimethicone (DC 556, 20 cSt, Dow Corning) 2.1 - Vinylpyrrolidone / 1-eicosene Copolymer (Antaron V-220, ISP) 1,2-NPY [13-36] 10-3 Procedure 1. All the ingredients of the formula are mixed together. 2. The Rayneri stirring mixture is placed for 45 minutes at room temperature. 23

Claims (16)

  1. Use of at least one neuropeptide Y (NPY) agonist compound to increase the size and / or volume of the lips and / or to shape them and / or to make them smoother.   2. Use according to claim 1, characterized in that said compound is intended to stimulate the naturally pinkish color of the lips. 10   3. Use according to claim 1, characterized in that said compound is characterized by a receptor affinity for NPY receptors, especially the Y1 type.   4. Use according to any one of claims 1 to 3, characterized in that said compound is selected from vegetable extracts, the peptide [34Pro] NPY, NPY [13-36], [Leu3l, Pro34] NPY, the NPY peptide.   5. Use according to any one of claims 1 to 4, characterized in that said agent is present in the composition in an amount ranging from 10 "8 to 10% by weight relative to the total weight of the composition, preferably from 10-6 to 5%, and even more preferably from 104 to 2% by weight relative to the total weight of the composition.   6. Use according to any one of claims 1 to 5, characterized in that said agent is adsorbed or incorporated into particles of size ranging from 1 nm to 10 μm.   7. Use according to any one of claims 1 to 6, characterized in that the composition further comprises at least one agent selected from solvents, oils, waxes, pastes, gums, fillers dyestuffs, cosmetic active ingredients, thickeners, surfactants, moisturizers, softeners, sequestering agents, fragrances, neutralizers, preservatives, antioxidants, UV filters, bactericides, odor absorbers, trace elements and their mixtures. 35   8. Use according to claim 7, characterized in that the cosmetic active agents are chosen from agents stimulating the synthesis of dermal or epidermal macromolecules and / or preventing their degradation, moisturizing agents, anti-pollution or anti-radical agents, soothing agents, tensors.   9. Use according to any one of claims 1 to 8, characterized in that said agent is combined in the composition with at least one makeup agent with optical effect of volume of the lips, such as goniochromatic pigments, reflective particles and their mixtures.   10. Use according to any one of claims 1 to 9, characterized in that the composition is in the form of a lipstick, a liquid gloss, a lipstick, a lip contour pencil, a lip balm. lips, a nail polish.   11. Cosmetic composition comprising, in a physiologically acceptable medium, at least one NPY agonist compound and characterized in that it is in the form of a lipstick, a liquid gloss, a lipstick, a lip contour pencil, a lip balm, or a lip polish.   12. Composition according to one of claims 11, characterized in that said compound is present in the composition in an amount ranging from 10-8 to 10% by weight relative to the total weight of the composition, preferably 10-6 at 5%, and even more preferably from 10-4 to 2% by weight relative to the total weight of the composition.   13. A composition according to claim 11 or 12, characterized in that said agent is associated in the composition with at least one makeup agent with an optical effect of volume of the lips, such as goniochromatic pigments, reflective particles and mixtures thereof.   14. Composition according to any one of claims 11 to 13, characterized in that the composition further comprises at least one agent chosen fillers, dyestuffs, cosmetic actives, thickeners, surfactants, moisturizers, softeners , sequestering agents, perfumes, neutralizers, preservatives, antioxidants, UV filters, bactericides, trace elements and mixtures thereof.   15. Composition according to any one of claims 11 to 14, characterized in that said agent is adsorbed or incorporated into particles of size ranging from 1 nm to 10pm.   16. A cosmetic process for making the lips naturally luscious and / or colored, characterized in that a composition as defined in claims 11 to 15 is applied to the lips.