FR2883297B1 - Genes de la biosynthese de la monacoline k - Google Patents

Genes de la biosynthese de la monacoline k

Info

Publication number
FR2883297B1
FR2883297B1 FR0602598A FR0602598A FR2883297B1 FR 2883297 B1 FR2883297 B1 FR 2883297B1 FR 0602598 A FR0602598 A FR 0602598A FR 0602598 A FR0602598 A FR 0602598A FR 2883297 B1 FR2883297 B1 FR 2883297B1
Authority
FR
France
Prior art keywords
monacolin
biosynthesis
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0602598A
Other languages
English (en)
Other versions
FR2883297A1 (fr
Inventor
Yi Pei Chen
Li Ling Liaw
Chun Lin Wang
Chung Tsai Lee
Ing Er Hwang
Ching Ping Tseng
Gwo Fang Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Food Industry Research and Development Institute
Original Assignee
Food Industry Research and Development Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Food Industry Research and Development Institute filed Critical Food Industry Research and Development Institute
Priority to FR0602598A priority Critical patent/FR2883297B1/fr
Publication of FR2883297A1 publication Critical patent/FR2883297A1/fr
Application granted granted Critical
Publication of FR2883297B1 publication Critical patent/FR2883297B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01088—Hydroxymethylglutaryl-CoA reductase (1.1.1.88)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR0602598A 2003-12-24 2006-03-24 Genes de la biosynthese de la monacoline k Active FR2883297B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR0602598A FR2883297B1 (fr) 2003-12-24 2006-03-24 Genes de la biosynthese de la monacoline k

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53264303P 2003-12-24 2003-12-24
FR0413916A FR2864548B1 (fr) 2003-12-24 2004-12-24 Genes de la biosynthese de la monacoline k
FR0602598A FR2883297B1 (fr) 2003-12-24 2006-03-24 Genes de la biosynthese de la monacoline k

Publications (2)

Publication Number Publication Date
FR2883297A1 FR2883297A1 (fr) 2006-09-22
FR2883297B1 true FR2883297B1 (fr) 2014-07-25

Family

ID=34860180

Family Applications (2)

Application Number Title Priority Date Filing Date
FR0413916A Active FR2864548B1 (fr) 2003-12-24 2004-12-24 Genes de la biosynthese de la monacoline k
FR0602598A Active FR2883297B1 (fr) 2003-12-24 2006-03-24 Genes de la biosynthese de la monacoline k

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR0413916A Active FR2864548B1 (fr) 2003-12-24 2004-12-24 Genes de la biosynthese de la monacoline k

Country Status (7)

Country Link
US (1) US7482157B2 (fr)
JP (1) JP2005185283A (fr)
KR (1) KR100662700B1 (fr)
CN (1) CN1637143A (fr)
DE (1) DE102004062386B4 (fr)
FR (2) FR2864548B1 (fr)
TW (1) TWI297358B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170088589A1 (en) * 2014-04-23 2017-03-30 Danmarks Tekniske Universitet Statin resistance and export
CN104140933B (zh) * 2014-08-06 2016-06-08 浙江省农业科学院 土曲霉zrv2011f5及其应用
CN106987529A (zh) * 2017-04-13 2017-07-28 北京工商大学 高产MonacolinK的红曲霉基因工程菌的构建方法及其应用
CN113373165B (zh) * 2021-07-05 2024-04-23 北京工商大学 紫色红曲菌comp52338_c2基因过表达菌株的构建方法及其应用
CN114231554B (zh) * 2021-12-27 2023-07-28 安徽工程大学 一种维生素k2系列产物的生物合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
WO1995012661A1 (fr) * 1993-11-02 1995-05-11 Merck & Co., Inc. Adn codant une triol-polycetide-synthase
JP2002525026A (ja) 1998-07-02 2002-08-13 ザ ボード オブ リージェンツ オブ ザ レランド スタンフォード ジュニア ユニバーシティ ポリケチドを作製するための方法
US6391583B1 (en) * 1998-12-18 2002-05-21 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents
EP1325929B1 (fr) 2002-01-07 2009-03-25 Cyplasin Biomedical Ltd. Cyplasin cytotoxique du lièvre du mer, Aplysia punctata, clonage du cDNA et expression des composants bioréactives

Also Published As

Publication number Publication date
DE102004062386A1 (de) 2005-09-29
JP2005185283A (ja) 2005-07-14
DE102004062386B4 (de) 2010-06-24
TW200521230A (en) 2005-07-01
KR20050065437A (ko) 2005-06-29
FR2864548A1 (fr) 2005-07-01
FR2883297A1 (fr) 2006-09-22
US20050227262A1 (en) 2005-10-13
US7482157B2 (en) 2009-01-27
TWI297358B (en) 2008-06-01
CN1637143A (zh) 2005-07-13
KR100662700B1 (ko) 2007-01-02
FR2864548B1 (fr) 2009-04-17

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