FR287F - 7- {3- [2- (3,4-Dihydroxyphenyl) -2-hydroxyethylaminol] propyl} -theophylline hydrochloride - Google Patents
7- {3- [2- (3,4-Dihydroxyphenyl) -2-hydroxyethylaminol] propyl} -theophylline hydrochloride Download PDFInfo
- Publication number
- FR287F FR287F FR152055A FR152055A FR287F FR 287 F FR287 F FR 287F FR 152055 A FR152055 A FR 152055A FR 152055 A FR152055 A FR 152055A FR 287 F FR287 F FR 287F
- Authority
- FR
- France
- Prior art keywords
- dihydroxyphenyl
- propyl
- hydroxyethylaminol
- hydrochloride
- theophylline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 3,4-Dihydroxyphenyl Chemical group 0.000 title description 6
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 title description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 239000012458 free base Substances 0.000 description 3
- 229960000278 theophylline Drugs 0.000 description 3
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000001813 broncholytic effect Effects 0.000 description 1
- 230000000572 bronchospasmolytic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229960001789 papaverine Drugs 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
RÉPUBLIQUE FRANÇAISEFRENCH REPUBLIC
MINISTERE DU DEVELOPPEMENT INDUSTRIEL ET SCIENTIFIQUEMINISTRY OF INDUSTRIAL AND SCIENTIFIC DEVELOPMENT
SERVICE >!<■ U PROPRIÉTÉ INDUSTRIELLESERVICE>! <■ INDUSTRIAL PROPERTY
2e ADDITION2nd ADDITION
AU BREVET D'INVENTIONPATENT OF INVENTION
N° 5.969 MNo. 5.969 M
P.V. n 152.055 Classification internationale :NP 152.055 International Classification:
N° 287 CAM A 61 k // C 07 dN ° 287 CAM A 61 k // C 07 d
Chlorhydrate de 7- (3-[2-(3,4-dihydroxyphényl)-2-hydroxy-éthylamino]-propyl)-théophylline.7- (3- [2- (3,4-dihydroxyphenyl) -2-hydroxyethylamino] propyl) -theophylline hydrochloride.
Société dite : DEUTSCHE GOLD- UND SILBER SCHEIDEANSTAL VORMALS-ftëi^ER résidant en Allemagne Fédérale. ÏHir IgcI. F/1Company known as: DEUTSCHE GOLD-UND SILBER SCHEIDEANSTAL VORMALS-FEDERAL resident in Federal Germany. IgcI. F / 1
(Brevet principal pris le 14 janvier 1966.) ^ Qj(T. 1971(Principal patent taken on January 14, 1966.) ^ Qj (T. 1971
Demandée le 16 mai 1968, à 15b 37m, à Paris.Requested May 16, 1968, 15b 37m, in Paris.
Délivrée par arrêté du 24 novembre 1969.Issued by order of 24 November 1969.
(Bulletin officiel de la Propriété industrielle [B.S.M.], n° 1 du 5 janvier 1970.)(Official Bulletin of Industrial Property [B.S.M.], No. 1 of January 5, 1970.)
1" addition n° 199 CAM.Addition No. 199 CAM.
Le brevet principal a pour objet le chlorhydrate de j 7 - [3- [2 - (3,4-dihydroxyphényl)-2-hydroxy-éthy-lamino]-propyljthéophyUine, qui est un médicament bronchospasmolytique et contre l'asthme, dont l'effet broncholytique est 7 000 à 8 000 fois supérieur à celui de la papavérine.The main patent relates to 7 - [3- [2- (3,4-dihydroxyphenyl) -2-hydroxyethylamino] -propyl] thioophylline hydrochloride, which is a bronchospasmolytic and asthma drug, of which The broncholytic effect is 7,000 to 8,000 times greater than that of papaverine.
Le présent certificat d'addition a pour objet la base libre, donc la 7-j3-[2-(3,4-dihydroxyphényl)-2-hydroxyéthylamino] - propyl j - théophylline, ainsi que les sels de cette base formés avec des acides pharmaceutiquement acceptables autres que l'acide chlorhydrique.The subject of this certificate of addition is the free base, that is, 7- [3- [2- (3,4-dihydroxyphenyl) -2-hydroxyethylamino] propyl] theophylline, and the salts of this base formed with pharmaceutically acceptable acids other than hydrochloric acid.
On obtient facilement la base libre à partir du chlorhydrate, comme décrit dans l'exemple 1 du brevet principal, et on obtient facilement les sels de cette base en faisant réagir celle-ci, de la façon habituelle, avec des acides pharmaceutiquement acceptables.The free base is readily obtained from the hydrochloride salt as described in Example 1 of the main patent, and the salts of this base are readily obtained by reacting it in the usual manner with pharmaceutically acceptable acids.
Ladite base libre et lesdits sels ont les mêmes propriétés thérapeutiques que le chlorhydrate et s'emploient de la même façon que celui-ci.Said free base and said salts have the same therapeutic properties as the hydrochloride and are employed in the same way as this one.
RÉSUMÉRESUME
Le présent certificat d'addition concerne la 7 - j 3 - [2 - (3,4 - dihydroxyphényl) - 2 - hydroxy -éthyiamino1-propyl j -théophylline, ainsi que les sels de cette base formée avec les acides pharmaceutiquement acceptables autres que l'acide chlorhydrique, ces composés ayant les mêmes indications thérapeutiques et s'employant de la même façon que le chlorhydrate de 7- ) 3-[2-(3,4-dihydroxyphényl)-2 - hydroxyéthylamino] - propyl! - théophylline suivant le brevet principal.This certificate of addition relates to 7 - [3 - [2- (3,4-dihydroxyphenyl) -2-hydroxyethylamino-propyl] -theophylline, as well as salts of this base formed with pharmaceutically acceptable acids other than hydrochloric acid, these compounds having the same therapeutic indications and employed in the same way as 7-) 3- [2- (3,4-dihydroxyphenyl) -2-hydroxyethylamino] -propyl hydrochloride; - theophylline according to the main patent.
Société dite : DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLERCompany known as: DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER
Par procuration :Vicarious :
Office BlétryOffice Blétry
AVIS DOCUMENTAIRE SUR LA NOUVEAUTÉDOCUMENTARY NOTICE ON NEW
Documents susceptibles de porter atteinte à la nouveauté du médicament :Documents likely to affect the novelty of the drug:
— Brevet belge n° 630.124,- Belgian Patent No. 630,124,
Le présent avis a été établi] après les observations présentées par le titulaire du brevet.This notice has been drawn up after the observations submitted by the patentee.
0 210030 70 210030 7
Pour la vente des fascicules, s'adresser à I'Imprimerie Nationale, 27, rue de la Convention, Paris (15e).For the sale of the booklets, please contact the Imprimerie Nationale, 27, rue de la Convention, Paris (15th).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR152055A FR287F (en) | 1966-01-14 | 1968-05-16 | 7- {3- [2- (3,4-Dihydroxyphenyl) -2-hydroxyethylaminol] propyl} -theophylline hydrochloride |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR45941A FR5969M (en) | 1966-01-14 | 1966-01-14 | 7- {3- [2- (3,4-dihydroxyphenyl) -2-hydroxy-ethylaminol] -propyl} -theophylline hydrochloride |
| FR75854A FR199F (en) | 1965-09-09 | 1966-09-09 | 7- {3- [2- (3,4-dihydroxyphenyl) -2-hydroxy-ethylaminol] -propyl} -theophylline hydrochloride |
| FR152055A FR287F (en) | 1966-01-14 | 1968-05-16 | 7- {3- [2- (3,4-Dihydroxyphenyl) -2-hydroxyethylaminol] propyl} -theophylline hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR287F true FR287F (en) | 1970-01-05 |
Family
ID=8598719
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR45941A Expired FR5969M (en) | 1965-09-09 | 1966-01-14 | 7- {3- [2- (3,4-dihydroxyphenyl) -2-hydroxy-ethylaminol] -propyl} -theophylline hydrochloride |
| FR152055A Expired FR287F (en) | 1966-01-14 | 1968-05-16 | 7- {3- [2- (3,4-Dihydroxyphenyl) -2-hydroxyethylaminol] propyl} -theophylline hydrochloride |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR45941A Expired FR5969M (en) | 1965-09-09 | 1966-01-14 | 7- {3- [2- (3,4-dihydroxyphenyl) -2-hydroxy-ethylaminol] -propyl} -theophylline hydrochloride |
Country Status (1)
| Country | Link |
|---|---|
| FR (2) | FR5969M (en) |
-
1966
- 1966-01-14 FR FR45941A patent/FR5969M/en not_active Expired
-
1968
- 1968-05-16 FR FR152055A patent/FR287F/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR5969M (en) | 1968-06-21 |
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