BE906054A - ESTERS OF AZONIASPIRONORTROPANOLS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM. - Google Patents

ESTERS OF AZONIASPIRONORTROPANOLS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM.

Info

Publication number
BE906054A
BE906054A BE2/61142A BE2061142A BE906054A BE 906054 A BE906054 A BE 906054A BE 2/61142 A BE2/61142 A BE 2/61142A BE 2061142 A BE2061142 A BE 2061142A BE 906054 A BE906054 A BE 906054A
Authority
BE
Belgium
Prior art keywords
azoniaspironortropanols
esters
preparation
medicaments containing
alkyl
Prior art date
Application number
BE2/61142A
Other languages
French (fr)
Inventor
Grimminger Wolf
Gorler Klaus
Peter Odenthal Karl
Original Assignee
Madaus & Co Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853546218 external-priority patent/DE3546218A1/en
Priority claimed from DE19853546165 external-priority patent/DE3546165A1/en
Application filed by Madaus & Co Dr filed Critical Madaus & Co Dr
Publication of BE906054A publication Critical patent/BE906054A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ces composés répondent à la formule générale I dans laquelle R1 et R2 représentent H ou halogène ou alcoyle, alcoxy acyle, alcoylé, cyclohexyle, phényle, alcoylphényle, alcoxyphényle, halogénophényle, thiényle ou furyle, A- est l'anion d'un acide minéral. Ces composés sont utilisables en tant que spasmolytiques et plus particulièrement en tant qu'agents antiasthmatiques et broncholytiques.These compounds correspond to the general formula I in which R1 and R2 represent H or halogen or alkyl, alkoxy acyl, alkyl, cyclohexyl, phenyl, alkylphenyl, alkoxyphenyl, halophenyl, thienyl or furyl, A- is the anion of a mineral acid . These compounds can be used as spasmolytics and more particularly as anti-asthma and broncholytic agents.

BE2/61142A 1985-12-27 1986-12-29 ESTERS OF AZONIASPIRONORTROPANOLS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM. BE906054A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853546218 DE3546218A1 (en) 1985-12-27 1985-12-27 AZONIA SPIRONORTROPANOLESTER, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENT
DE19853546165 DE3546165A1 (en) 1985-12-27 1985-12-27 USE OF AZONIA SPIRONORTROPANOLESTERS AS ASTHMATHERAPEUTIC AND AS BRONCHOLYTIC

Publications (1)

Publication Number Publication Date
BE906054A true BE906054A (en) 1987-06-29

Family

ID=25839393

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2/61142A BE906054A (en) 1985-12-27 1986-12-29 ESTERS OF AZONIASPIRONORTROPANOLS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM.

Country Status (18)

Country Link
KR (1) KR930000113B1 (en)
AT (1) AT397962B (en)
AU (1) AU584266B2 (en)
BE (1) BE906054A (en)
CA (1) CA1304369C (en)
CH (1) CH677793A5 (en)
ES (1) ES2004177A6 (en)
FI (1) FI865295A (en)
FR (1) FR2598417B1 (en)
GB (1) GB2184726B (en)
HU (1) HU201930B (en)
IT (1) IT1198263B (en)
NL (1) NL193184C (en)
PL (1) PL150843B1 (en)
PT (1) PT84022B (en)
SE (1) SE8605531L (en)
SU (1) SU1711674A3 (en)
YU (1) YU46038B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007510654A (en) * 2003-11-04 2007-04-26 スパーナス ファーマシューティカルズ インコーポレイテッド Controlled release of positively charged pharmacologically active molecules from matrices containing polymers with polarized oxygen atoms.
AU2004289222B2 (en) * 2003-11-04 2010-01-21 Supernus Pharmaceuticals Inc. Compositions of quaternary ammonium containing bioavailability enhancers
CN101684117B (en) * 2008-09-27 2013-06-12 宁波市医药技术研究有限公司 Method for preparing nor-tropine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1194422B (en) * 1963-03-05 1965-06-10 Robert Pfleger Chem Fab Dr Process for the production of azonia spironortropane derivatives
US3480626A (en) * 1967-05-18 1969-11-25 Chem Fab Dr R Pfleger Certain azoniaspironortropine derivatives
DE1670257A1 (en) * 1967-08-04 1972-03-02 Boehringer Sohn Ingelheim Cyclic amino compounds and processes for their preparation
IT1140998B (en) * 1980-06-18 1986-10-10 Valeas Ind Chimica E Farmaceut ENDO-8-METHYL-8-SIN-ALCHIL-8-AZONIABICYCLE OPEN SALTS PAR. SQUARE 3.2.1. CLOSED PAR. QUADRATA-OTTAN-3-ALCHILCARBOSSILATI, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC COMPOSITIONS THAT CONTAIN THEM AS AN ACTIVE INGREDIENT

Also Published As

Publication number Publication date
PL150843B1 (en) 1990-07-31
FI865295A0 (en) 1986-12-23
FR2598417A1 (en) 1987-11-13
AU584266B2 (en) 1989-05-18
YU224986A (en) 1988-04-30
NL8603303A (en) 1987-07-16
FI865295A (en) 1987-06-28
CH677793A5 (en) 1991-06-28
ATA339286A (en) 1993-12-15
HUT43060A (en) 1987-09-28
PL263216A1 (en) 1988-04-14
SE8605531L (en) 1987-06-28
AU6698586A (en) 1987-07-02
YU46038B (en) 1992-12-21
AT397962B (en) 1994-08-25
NL193184B (en) 1998-10-01
GB8630809D0 (en) 1987-02-04
IT8622877A0 (en) 1986-12-24
ES2004177A6 (en) 1988-12-16
GB2184726A (en) 1987-07-01
PT84022B (en) 1989-07-31
SU1711674A3 (en) 1992-02-07
SE8605531D0 (en) 1986-12-22
NL193184C (en) 1999-02-02
GB2184726B (en) 1990-10-03
IT8622877A1 (en) 1988-06-24
CA1304369C (en) 1992-06-30
IT1198263B (en) 1988-12-21
FR2598417B1 (en) 1993-10-29
KR870005998A (en) 1987-07-08
HU201930B (en) 1991-01-28
KR930000113B1 (en) 1993-01-09
PT84022A (en) 1987-01-01

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: DR. MADAUX G.M.B.H. & CO

Effective date: 20001231