FR2818125A1 - REPULSIVE COSMETIC COMPOSITION ACTIVE AGAINST SCHISTOSOME FURCOCERCIARIES - Google Patents

REPULSIVE COSMETIC COMPOSITION ACTIVE AGAINST SCHISTOSOME FURCOCERCIARIES Download PDF

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FR2818125A1
FR2818125A1 FR0016820A FR0016820A FR2818125A1 FR 2818125 A1 FR2818125 A1 FR 2818125A1 FR 0016820 A FR0016820 A FR 0016820A FR 0016820 A FR0016820 A FR 0016820A FR 2818125 A1 FR2818125 A1 FR 2818125A1
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composition
agent
composition according
acetyl
butyl
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FR2818125B1 (en
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Jean Luc Clamou
Sonia Jourlait
Georges Lacroix
Nicole Leger
Laforet Sonia Steffen
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ASEPTA LAB
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Priority to AU2002228109A priority patent/AU2002228109A1/en
Priority to PCT/FR2001/004047 priority patent/WO2002049433A2/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dermatology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention concerns a repellent cosmetic composition. The repellent cosmetic composition active against furcocercariae (infesting forms of schistosomes) is characterised in that it consists of: a repellent agent acting on cercariae, an anti-inflammatory agent having likewise a soothing function, a binder, a preservative, a carrier, a fragrance. The repellent agent is butyl-acetyl-ethyl-aminopropionate. The invention is useful for preventing furcocercariae from penetrating under human skin.

Description

<Desc/Clms Page number 1> <Desc / Clms Page number 1>

L'invention a pour objet une composition cosmétique répulsive active contre les furcocercaires de schistosomes, notamment celles responsables dans nos régions de la dermatite des nageurs, désagrément des baignades estivales.  The subject of the invention is a cosmetic repellent composition active against furcocercariae of schistosomes, in particular those responsible in our regions for swimmers' dermatitis, unpleasantness in summer bathing.

Cette affection cutanée est due à la pénétration transcutanée chez l'homme de larves de bilharzies d'origine animale, notamment en Europe, de furcocercaires ocellées de trichobilharzies, de vers parasites du système vasculaire des oiseaux aquatiques.  This skin condition is due to the transcutaneous penetration in humans of bilharzia larvae of animal origin, especially in Europe, ocellated furcocercariae of trichobilharzia, parasitic worms of the vascular system of aquatic birds.

Cette pénétration chez un hôte anormal (l'homme) constitue une impasse parasitaire, la larve qui s'est ainsi fourvoyée ne pouvant évoluer jusqu'au stade adulte.  This penetration into an abnormal host (man) constitutes a parasitic dead end, the larva which has thus gone astray cannot evolve until the adult stage.

La pathologie induite est due à la réaction violente de l'agressé dont le système immunitaire entre en action dès la phase de pénétration de l'intrus.  The pathology induced is due to the violent reaction of the victim whose immune system comes into action from the penetration phase of the intruder.

Les Schistosomoses sont des maladies à vecteur. L'hôte définitif est un vertébré. Dans le cas des espèces inféodées aux oiseaux, il s'agit d'oiseaux aquatiques le plus souvent Anatidae tel le canard Colvert trouvé fréquemment infesté dans les foyers français.  Schistosomiasis is a vector-borne disease. The final host is a vertebrate. In the case of species subservient to birds, they are aquatic birds most often Anatidae such as the mallard duck found frequently infested in French households.

Les parasites se localisent dans les fins vaisseaux sanguins de la région nasale.  The parasites are localized in the fine blood vessels of the nasal region.

Les oeufs munis d'un éperon terminal sont rejetés en même temps que le mucus nasal dans l'eau où ils éclosent presqu'immédiatement libérant une première forme larvaire (le miracidium) qui nage vers l'hôte intermédiaire un mollusque gastéropode (une limnée dans les foyers français étudiés).  The eggs fitted with a terminal spur are rejected at the same time as the nasal mucus in the water where they hatch almost immediately releasing a first larval form (the miracidium) which swims towards the intermediate host a gastropod mollusk (a limnea in the French households studied).

Au bout d'un mois environ, le mollusque rejette des centaines de furcocercaires qui sont attirés par l'hôte définitif le canard colvert mais peuvent également pénétrer accidentellement chez les mammifères dont l'homme.  After about a month, the mollusk rejects hundreds of furcocercariae which are attracted to the definitive host, the mallard, but can also accidentally enter mammals, including humans.

Dans les milieux protégés, réserves naturelles, etc., il est difficile d'agir à l'encontre des canards colverts et/ou de traiter les milieux de baignade par faucardage. De même,  In protected areas, nature reserves, etc., it is difficult to act against mallards and / or to treat bathing areas by cutting. Likewise,

<Desc/Clms Page number 2><Desc / Clms Page number 2>

l'emploi de mollusquicides n'est pas sans danger pour l'équilibre des biocénoses aquatiques.  the use of mollusquicides is not without danger for the balance of aquatic biocenoses.

En dehors du traitement de cette maladie par les produits classiques, le confort des baigneurs ou des usagers peut être grandement amélioré dans ces zones aquatiques à risque par une composition répulsive.  Apart from the treatment of this disease with conventional products, the comfort of bathers or users can be greatly improved in these aquatic areas at risk by a repellent composition.

L'état de la technique peut être défini par le brevet suivant : - FR-A-2. 464.027 : la présente invention concerne donc un moyen de lutte contre les cercaires responsables de la transmission à l'homme des bilharzioses ; ce moyen consiste à ajouter aux eaux contenant les cercaires au moins un agent tensio-actif, plus particulièrement et de préférence un agent de surface amphotère, et, notamment, un agent ampliotère du type alkybêtatne ou alkylamidobétaine.  The state of the art can be defined by the following patent: - FR-A-2. 464.027: the present invention therefore relates to a means of combating the cercariae responsible for the transmission to humans of bilharziasis; this means consists in adding to the waters containing the cercariae at least one surfactant, more particularly and preferably an amphoteric surfactant, and, in particular, an ampliotic agent of the alkybêtatne or alkylamidobétaine type.

Ce brevet décrit un traitement de l'eau contenant les cercaires.  This patent describes a treatment of water containing cercariae.

Cette invention ne peut pas être utilisée pour des grandes surfaces telles que des lacs.  This invention cannot be used for large areas such as lakes.

L'invention concerne une composition cosmétique répulsive spécifique pour agir sur les cercaires.  The invention relates to a specific repellent cosmetic composition for acting on cercariae.

Cette composition cosmétique doit être non nocive et agir aussi bien dans l'eau qu'en dehors de l'eau.  This cosmetic composition must be non-harmful and act both in water and outside of water.

A cet effet, la composition cosmétique répulsive pour agir contre les cercaires selon l'invention est composée : - d'un agent répulsif agissant sur les cercaires, d'un agent anti-inflammatoire ayant une fonction également apaisante, d'un liant, d'un conservateur, d'un excipient, d'une fragrance.  To this end, the cosmetic repellent composition for acting against the cercariae according to the invention is composed of: - a repellant acting on the cercariae, an anti-inflammatory agent having a function also soothing, a binder, d 'a preservative, an excipient, a fragrance.

Selon une composition particulière, la composition est sous forme de gel.  According to a particular composition, the composition is in the form of a gel.

<Desc/Clms Page number 3> <Desc / Clms Page number 3>

Selon une composition particulière, la composition est sous forme d'huile sèche.  According to a particular composition, the composition is in the form of dry oil.

Dans la composition huile sèche, ladite composition contient une huile végétale destinée à faciliter la pénétration de ladite composition dans la peau.  In the dry oil composition, said composition contains a vegetable oil intended to facilitate the penetration of said composition into the skin.

L'agent répulsif est du butyl-acetyl-ethyl aminoproprionate.  The repellant is butyl-acetyl-ethyl aminoproprionate.

La combinaison de l'agent répulsif, de l'agent anti-

Figure img00030001

inflammatoire et d'un liant est la suivante : butyl-acetyl-ethyl aminoproprionate, caprylic, capric triglycéride, acide glycyrrhetinique. The combination of the repellant, the anti-
Figure img00030001

inflammatory and a binder is as follows: butyl-acetyl-ethyl aminoproprionate, caprylic, capric triglyceride, glycyrrhetinic acid.

Selon le mode de réalisation où la composition est sous

Figure img00030002

forme d'huile sèche, les constituants sont les suivants : agent répulsif liant et anti-inflammatoire : butyl-acetyl-ethyl aminoproprionate 200,00 g caprylic, capric triglycéride 150,00 g acide glycyrrhetinique 2,00 g agent augmentant la pénétration dans la peau zea mays + glycine soja + helianthus annuus 10,00 g - agent adoucissant et excipient : paraffinum liquidum + prunus armeniaca + calendula officinalis 5 g - conservateur : tocopherol 2 g glyceryl linoleate + glyceryl linolenate 10,00 g - excipient : isododecane 611,00 g - fragrance 10,00 g
Figure img00030003

---------- 1000, 00 g According to the embodiment where the composition is under
Figure img00030002

form of dry oil, the constituents are as follows: binder and anti-inflammatory agent: butyl-acetyl-ethyl aminoproprionate 200.00 g caprylic, capric triglyceride 150.00 g glycyrrhetinic acid 2.00 g agent increasing penetration into the zea mays skin + soy glycine + helianthus annuus 10.00 g - softening agent and excipient: paraffinum liquidum + prunus armeniaca + calendula officinalis 5 g - preservative: tocopherol 2 g glyceryl linoleate + glyceryl linolenate 10.00 g - excipient: isododecane 611, 00 g - fragrance 10.00 g
Figure img00030003

---------- 1000, 00 g

<Desc/Clms Page number 4> <Desc / Clms Page number 4>

Figure img00040001

Selon le mode de réalisation où la composition est sous forme de gel, les constituants sont les suivants : - agent répulsif butyl-acetyl-ethyl aminoproprionate 200,00 g - agent anti-inflammatoire propylène glycol + eau + calendula officinalis + extraits aloe barbadensis + triticum vulgare 10,00 g - agent liant polyacrylamide + C13-C14 isoparaffin + laureth-7 30,00 g - agent excipient et conservateur phenoxyethanol + chlorphenesin + mehylparaben 8 g alcool dénaturé 50,00 g propylène glycol 220,00 g imidazolidinyl urea 4,00 g colorant 0,40 g - fragrance 3,00 g
1000, 00 g
Figure img00040001

According to the embodiment where the composition is in the form of a gel, the constituents are as follows: - butyl-acetyl-ethyl aminoproprionate repellant 200.00 g - anti-inflammatory agent propylene glycol + water + calendula officinalis + aloe barbadensis extracts + triticum vulgare 10.00 g - polyacrylamide binding agent + C13-C14 isoparaffin + laureth-7 30.00 g - excipient and preservative agent phenoxyethanol + chlorphenesin + mehylparaben 8 g denatured alcohol 50.00 g propylene glycol 220.00 g imidazolidinyl urea 4 .00 g coloring 0.40 g - fragrance 3.00 g
1000.00g

Claims (8)

REVENDICATIONS 1. Composition cosmétique répulsive pour agir contre les furcocercaires caractérisée par le fait qu'elle est composée : - d'un agent répulsif agissant sur les cercaires, d'un agent anti-inflammatoire ayant une fonction également apaisante, d'un liant, d'un conservateur, d'un excipient, d'une fragrance.  1. Cosmetic repellent composition for acting against furcocercariae, characterized by the fact that it is composed of: - a repellent agent acting on cercariae, an anti-inflammatory agent having a also soothing function, a binder, d 'a preservative, an excipient, a fragrance. 2. Composition selon la revendication 1 caractérisée par le fait que la composition est sous forme de gel.  2. Composition according to Claim 1, characterized in that the composition is in the form of a gel. 3. Composition selon la revendication 1 caractérisée par le fait que la composition est sous forme d'huile sèche.  3. Composition according to claim 1 characterized in that the composition is in the form of dry oil. 4. Composition selon la revendication 1 ou 3 caractérisée par le fait que dans la composition huile sèche, ladite composition contient une huile végétale destinée à faciliter la pénétration de ladite composition dans la peau.  4. Composition according to claim 1 or 3 characterized in that in the dry oil composition, said composition contains a vegetable oil intended to facilitate the penetration of said composition into the skin. 5. Composition selon l'une quelconque des revendications 1 à 4 caractérisée par le fait que l'agent répulsif est du butyl-acetyl-ethyl aminoproprionate.  5. Composition according to any one of claims 1 to 4 characterized in that the repellant is butyl-acetyl-ethyl aminoproprionate. 6. Composition selon l'une quelconque des revendications 1, 3 ou 5 caractérisée par le fait que la combinaison de l'agent répulsif, de l'agent anti-  6. Composition according to any one of claims 1, 3 or 5 characterized in that the combination of the repellant, the anti-
Figure img00050003
Figure img00050003
 inflammatoire et d'un liant est la suivante : butyl-acetyl-ethyl aminoproprionate, caprylic, capric triglycéride, acide glycyrrhetinique.  inflammatory and a binder is as follows: butyl-acetyl-ethyl aminoproprionate, caprylic, capric triglyceride, glycyrrhetinic acid. <Desc/Clms Page number 6> <Desc / Clms Page number 6> 7. Composition selon l'une quelconque des revendications 1, 3, 5 ou 6 caractérisée par le fait que selon le mode de réalisation où la composition est sous forme d'huile sèche, les constituants sont les suivants : agent répulsif liant et anti-inflammatoire : butyl-acetyl-ethyl aminoproprionate 200,00 g caprylic, capric triglycéride 150,00 g acide glycyrrhetinique 2,00 g agent augmentant la pénétration dans la peau zea mays + glycine soja + helianthus annuus 10,00 g - agent adoucissant et excipient : paraffinum liquidum + prunus armeniaca + calendula officinalis 5 g - conservateur : tocopherol 2 g glyceryl linoleate + glyceryl linolenate 10,00 g - excipient : isododecane 611,00 g - fragrance 10,00 g  7. Composition according to any one of claims 1, 3, 5 or 6 characterized in that according to the embodiment where the composition is in the form of dry oil, the constituents are the following: repellant binding and anti inflammatory: butyl-acetyl-ethyl aminoproprionate 200.00 g caprylic, capric triglyceride 150.00 g glycyrrhetinic acid 2.00 g agent increasing penetration into the skin zea mays + soy glycine + helianthus annuus 10.00 g - softening agent and excipient : paraffinum liquidum + prunus armeniaca + calendula officinalis 5 g - preservative: tocopherol 2 g glyceryl linoleate + glyceryl linolenate 10.00 g - excipient: isododecane 611.00 g - fragrance 10.00 g
Figure img00060001
Figure img00060001
 ----------  ---------- 1000,00 g1000.00 g 8. Compostion selon l'une quelconque des revendications 1, 2 ou 5 caractérisée par le fait que selon le mode de réalisation où la composition est sous forme de gel, les constituants sont les suivants : - agent répulsif butyl-acetyl-ethyl aminoproprionate 200,00 g - agent anti-inflammatoire propylène glycol + eau + calendula officinalis + extraits aloe barbadensis + triticum vulgare 10,00 g - agent liant polyacrylamide + C13-C14 isoparaffin + laureth-7 30,00 g 8. Composition according to any one of claims 1, 2 or 5 characterized in that according to the embodiment where the composition is in the form of a gel, the constituents are the following: - repellent agent butyl-acetyl-ethyl aminoproprionate 200 .00 g - propylene glycol anti-inflammatory agent + water + calendula officinalis + aloe barbadensis extracts + triticum vulgare 10.00 g - polyacrylamide binding agent + C13-C14 isoparaffin + laureth-7 30.00 g <Desc/Clms Page number 7><Desc / Clms Page number 7> 1000, 00 g 1000.00g - agent excipient et conservateur phenoxyethanol + chlorphenesin + mehylparaben 8 g alcool dénaturé 50,00 g propylène glycol 220,00 g imidazolidinyl urea 4,00 g colorant 0,40 g - fragrance 3,00 g - excipient and preservative agent phenoxyethanol + chlorphenesin + mehylparaben 8 g denatured alcohol 50.00 g propylene glycol 220.00 g imidazolidinyl urea 4.00 g coloring 0.40 g - fragrance 3.00 g
FR0016820A 2000-12-19 2000-12-19 REPULSIVE COSMETIC COMPOSITION ACTIVE AGAINST SCHISTOSOME FURCOCERCIARIES Expired - Fee Related FR2818125B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR0016820A FR2818125B1 (en) 2000-12-19 2000-12-19 REPULSIVE COSMETIC COMPOSITION ACTIVE AGAINST SCHISTOSOME FURCOCERCIARIES
AU2002228109A AU2002228109A1 (en) 2000-12-19 2001-12-19 Repellent cosmetic composition active against schistosome furcocercaria
PCT/FR2001/004047 WO2002049433A2 (en) 2000-12-19 2001-12-19 Repellent cosmetic composition active against schistosome furcocercaria

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FR0016820A FR2818125B1 (en) 2000-12-19 2000-12-19 REPULSIVE COSMETIC COMPOSITION ACTIVE AGAINST SCHISTOSOME FURCOCERCIARIES

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FR2818125B1 FR2818125B1 (en) 2004-04-02

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10349666B4 (en) * 2003-10-24 2020-02-06 Beiersdorf Ag Insect repellent preparation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4127672A (en) * 1972-09-21 1978-11-28 Beiersdorf Aktiengesellschaft Insect repellants
US4659738A (en) * 1985-02-15 1987-04-21 The United States Of America As Represented By The Secretary Of The Army Topical prophylaxis against schistosomal infections
DE3619030A1 (en) * 1986-06-06 1987-12-10 Bayer Ag Compositions for topical use
JPH05310508A (en) * 1992-05-13 1993-11-22 Kanebo Ltd Dermal external preparation composition
WO1998034604A1 (en) * 1997-02-11 1998-08-13 Bernard Salafsky ANTI-PARASITIC ACTION OF N,N-DIETHYL-m-TOLUAMIDE (DEET) AND FORMULATIONS THAT PROLONG ITS ACTIVITY IN THE SKIN
US6159452A (en) * 1992-06-25 2000-12-12 Iguana, Llc Water resistant sunscreen and insect repellent composition

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4127672A (en) * 1972-09-21 1978-11-28 Beiersdorf Aktiengesellschaft Insect repellants
US4659738A (en) * 1985-02-15 1987-04-21 The United States Of America As Represented By The Secretary Of The Army Topical prophylaxis against schistosomal infections
DE3619030A1 (en) * 1986-06-06 1987-12-10 Bayer Ag Compositions for topical use
JPH05310508A (en) * 1992-05-13 1993-11-22 Kanebo Ltd Dermal external preparation composition
US6159452A (en) * 1992-06-25 2000-12-12 Iguana, Llc Water resistant sunscreen and insect repellent composition
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