DE10349666B4 - Insect repellent preparation - Google Patents

Abstract

Aqueous or aqueous-alcoholic cosmetic preparation containing a combination of a) one or more repellents selected from the group consisting of ethyl 3- (Nn-butyl-N-acetylamino) propionate, 1-piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester andb) one or more extracts selected from the group of aloe vera extract and mutton extract.

Description

The present invention relates to an aqueous or aqueous-alcoholic cosmetic preparation comprising a combination of one or more repellents selected from the group consisting of ethyl 3- (Nn-butyl-N-acetylamino) propionate and 2- (2-hydroxyethyl) 1-piperidinecarboxylic acid. -1-methylpropylester, and one or more extracts selected from the group Aloe Vera and Hammamelis and their use.

Insect repellents (insect repellents, insect repellents, insect repellants, insect repellents, repellents, repellents) are preparations which are used externally to repel and / or drive away insects, but also ticks and mites, and are intended to prevent insects, ticks and mites the skin become active. Insect repellents are designed to protect the skin from nuisance caused by blood-sucking or biting insects and other parasites and / or nuisances by warding them off before they settle on the skin so that there are no stings or bites. Accordingly, the agents do not act as contact poisons, but only as repellants, since they do not kill the animals but only drive them away.

Accordingly, in the sense of the present invention, the term “insect repellants” is not only to be understood as formulations which are effective against insects. Rather, what has been said below naturally also applies to those preparations which ward off or expel other blood-sucking or biting parasites and / or nuisances (e.g. spiders), even if this may not be mentioned in individual cases.

Stings or bites from insects and other parasites usually lead to the formation of wheals, reddening and itching and, in isolated cases, to mostly harmless infections. However, insects, especially mosquitoes, can also transmit parasitic and viral infections (such as malaria, yellow fever or dengue fever). In total there are e.g. B. no less than 3000 different mosquito species, of which about 100 can spread diseases. The defense or expulsion of these insects therefore also serves in particular to protect against such infections.

Insects optically and with the help of “chemical senses” orient themselves towards light, shape and color, warmth and air humidity as well as the air content of carbon dioxide and fragrances. This includes various amino acids as well as ammonia, lactic and butyric acid. They “recognize” promising host organisms for them, in particular by their body temperature, carbon dioxide emissions and the odorous substances generated and emitted by the cutaneous microflora. The attractants are sought in the direction of increasing concentration (P. Finkel, E. Siemer, "Repellents for dermal use", Apoth. J. 8, 1986, pp. 32-37).

Since ancient times, people have been plagued by stinging or biting insects or other parasites. Accordingly, mankind's need for insect repellents is old. A method that has been known since the early history of making annoying or harmful insects their stay near humans unattractive or uncomfortable is lighting fires with aromatic or strongly smelling herbs or woods and strong smoke development. The treatment of the skin with strong-smelling substances to repel insects has also been known since ancient times. At the turn of the last century, a number of natural essential oils were used as insect repellants, such as anise oil, bergamot oil, birchwood tar, camphor, citronell oil, eucalyptus oil, geranium oil, pine oils, coconut oil, lavender oil, nutmeg oil, clove oil, orange blossom oil, polynye oil, peppermint oil (peppermint oil) Pyrethrum, thyme oil and cinnamon oil.

The mode of action of repellent active ingredients is imagined in such a way that they evaporate slowly after application and thus form a fragrance mantle close to the skin, which repels the insects by the active ingredients on the sensors of the insects responsible for the "sense of smell" speak to. They interfere with the locking mechanism. After applying an insect repellent, the insects fly off at a distance from the skin; so to speak, they “make a detour” around the treated skin areas. As the effect diminishes, they come closer and closer until the concentration of repellants has dropped so far that the first contact or stabbing takes place. The mode of action of the repellents is therefore limited to covering up the body's own odorants and providing them with a repellent fragrance component.

Because of their largely insufficient effectiveness despite their intense odor and their sometimes poor tolerance in higher concentrations, natural repellents in today's insect repellants have been largely replaced by more effective synthetic substances. These are predominantly high-boiling liquids or low-melting or sublimating crystalline substances, that evaporate slowly at room temperature. Most repellent active ingredients belong to the classes of amides, alcohols, esters and ethers.

A widely used all-round repellent is, for example, the N, N-diethyl-3-methylbenzamide (DEET), which is effective against mosquitoes, brakes, sand flies, ticks, sting flies, mites, fleas and bugs. Dimethyl phthalate (Palatinol M, DMP), which acts against mosquitoes (especially Aedes and Anopheles species), is also common.

Repellent 3535 ist gegen Stechmücken (Aedes aegypti, Anopheles albimanus), Tsetsefliegen (Glossinae) und Bremsen (Tabanidae) wirksam.Another common repellent active ingredient is ethyl 3- (Nn-butyl-N-acetylamino) propionate (also called ethylbutyl acetylaminopropionate or repellent 3535), which is characterized by the following structural formula:

Repellent 3535 is effective against mosquitoes (Aedes aegypti, Anopheles albimanus), tsetse flies (Glossinae) and brakes (Tabanidae).

und kann unter dem Namen Bayrepel^® (bei der Bayer AG) im Handel erworben werden.More recently, 1-piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester has also been developed as a versatile repellent active ingredient. This has the following structure

and can be purchased under the name Bayrepel ^® (from Bayer AG).

• • Wässrige Repellent-Zubereitungen setzen den Repellent-Wirkstoff nur langsam frei, so dass eine gewisse Zeit vergeht, bevor die Insekten abweisende Wirkung nach dem Auftragen auf die Haut eintritt.
• • Um dieses Problem zu lösen werden die Zubereitungen meist mit Ethanol versetzt. Die wässrig-alkoholischen oder alkoholischen Zubereitungen haben aufgrund ihrer hohen Wirkstoff-Freisetzungsrate nur eine äußerst begrenzte Wirkungszeit. In der Regel beträgt die wirksame Schutzdauer weniger als 2 Stunden.

• • Die hydrolytische Stabilität von Repellentien, insbesondere von 3-(N-n-Butyl-N-acetyl-amino)propionsäureethylester, ist nur begrenzt. Das heißt, dass die Zubereitungen ihre Wirksamkeit mit zunehmenden (Lagerungs-) Alter einbüßen und die Haltbarkeit der Zubereitungen nur begrenzt ist.
• • Die Anwendung herkömmlicher Zubereitungen führt, bedingt durch einen hohen Alkohol- und/oder Repellentienanteil, bei empfindlichen Anwendern zu Hautirritationen.

A large number of insect repellants are therefore known from the prior art. However, these have a number of disadvantages:

• • Aqueous repellent preparations release the repellent active ingredient only slowly, so that a certain time passes before the insect repellent effect occurs after application to the skin.
• • To solve this problem, the preparations are usually mixed with ethanol. Due to their high active ingredient release rate, the aqueous-alcoholic or alcoholic preparations only have an extremely limited duration of action. The effective protection period is usually less than 2 hours.

• • The hydrolytic stability of repellents, in particular ethyl 3- (Nn-butyl-N-acetylamino) propionate, is only limited. This means that the preparations lose their effectiveness with increasing (storage) age and the shelf life of the preparations is only limited.
• • The use of conventional preparations leads to skin irritation in sensitive users due to a high alcohol and / or repellant content.

• • hoch wirksam ist auch gegen besonders aggressive Insekten (z.B. Aedes aegypti, Anopheles albimanus).
• • eine besonders lang anhaltende Wirkung aufweist.
• • besonders schnell nach dem Auftragen seine Wirkung entfaltet.
• • besonders mild/verträglich gegenüber der Haut ist.

It was therefore the object of the present invention to eliminate or at least alleviate the disadvantages of the prior art. Furthermore, it was the object of the present invention to develop an insect repellent which

• • is also highly effective against particularly aggressive insects (eg Aedes aegypti, Anopheles albimanus).
• • has a particularly long-lasting effect.
• • Develops its effect particularly quickly after application.
• • is particularly mild / tolerable to the skin.

1. a) einem oder mehreren Repellentien gewählt aus der Gruppe 3-(N-n-Butyl-N-acetyl-amino)-propionsäureethylester und 1-Piperidincarbonsäure-2-(2-hydroxyethyl)-1-methylpropylester und
2. b) einem oder mehreren Extrakten gewählt aus der Gruppe Aloe vera-Extrakt und Hammamelis-Extrakt.

The tasks are solved surprisingly by an aqueous or aqueous-alcoholic cosmetic preparation comprising a combination of

1. a) one or more repellants selected from the group 3- (Nn-butyl-N-acetylamino) propionic acid ethyl ester and 1-piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester and
2. b) one or more extracts selected from the group of aloe vera extract and mutton extract.

The describes US 6,300,324 B1 Repellent preparations with aloe vera, but this document could not point the way to the present invention, since only mixtures of plant extracts and vitamins are disclosed in it.

In addition, the expert knows the JP 2003-160413 A . WO 02/49433 A2 and WO 00/56346 A1 who also could not point the way to the present invention.

It is advantageous according to the invention if one or more repellents of group a) in a total concentration of 2 to 60% by weight, preferably in a concentration of 5 to 40% by weight and very particularly preferably in a concentration of 10 to 20% by weight. %, each based on the total weight of the preparation, are contained in the preparation.

It is also advantageous for the purposes of the present invention if the preparation according to the invention is characterized in that it contains extracts from group b) in a total concentration of 0.1 to 35% by weight, preferably in a concentration of 0.2 to 15% by weight. % and very particularly preferably in a concentration of 0.2 to 2.5% by weight, based in each case on the total weight of the preparation.

3- (Nn-Butyl-N-acetylamino) propionic acid ethyl ester and 1-piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester are used as repellents according to the invention, 3- (Nn-butyl-N-acetyl- amino) propionate is particularly preferred according to the invention.

Embodiments of the preparation according to the invention are characterized in that aloe vera and / or witch hazel is used as the extract.

Aloe vera gel from Madi Botanical Inc., Aloe S1020 V from Bioextracto and Aloe Vera Terra from Terry Lab. Inc. (CAS No. 8001-97-6) can be used to advantage.

The extract with the CAS number 84696-19-5, for example, can advantageously be used as the Hammamelis extract according to the invention. Such an extract is available, for example, from Amerivan Distilling under the trade name With Hazel (14% Alcohol).

It has also proven to be advantageous for the invention if the weight ratio of the total amount of repellents [a)] to the total amount of extracts [b)] in the preparation according to the invention is from 10: 1 to 50: 1 and preferably from 25: 1 to 50 : 1 is.

In an embodiment which is advantageous for the invention, the preparation according to the invention additionally contains one or more oils selected from the group consisting of iris oil, sandalwood oil, mint oil and lime oil.

The iris oil according to the invention can be purchased, for example, from Symrise under the trade name Irisöl (CAS 8002-73-1).

The sandalwood oil according to the invention can be purchased from Nature, for example, under the trade name sandalwood oil (CAS 8006-87-9).

The mint oil according to the invention can be purchased, for example, from Symrise under the trade name mint oil (CAS 8006-90-4).

The lime oil according to the invention can be purchased, for example, from Nature under the trade name Lime Oil (CAS 8008-26-2).

Furthermore, it is particularly preferred according to the invention to use lime oil-containing perfume oils.

According to the invention, one or more oils are advantageously selected from the group consisting of iris oil, sandalwood oil, mint oil, lime oil in a total concentration of 1 to 10% by weight and preferably in a concentration of 1.5 to 5% by weight, in each case based on the total weight of the preparation used.

beißende Insekten¹ 2,3;4,5-bis-(2-Butylen)-tetra-hydro-2-furaldehyd MGK-Repellent 11

Schaben und beißende Insekten¹ N,N-Capryl-säurediethylamid Repellent 790

Schaben, Stech- , mücken, Stubenfliege, Bremsen, Ameisen, Spinnentiere o-Chlor-N,N-diethylbenzamid in Mischung mit N,N-Diethylbenzamid Kik-Repellent

Stechmücken, Bremsen, Flöhe, Wanzen, Zecken, Fliegen, Läuse

Dimethylcarbat Dimalone

Stechmücken, insbesondere Aedes-Arten¹ Di-n-propylisocinchomeronat MGK-Repellent 326

Hausfliege, Buschfliege¹ 2-Ethylhexan-1,3-diol Rutgers 612

Stechmücken, Bremsen, Fliegen, Flöhe, Milben¹ N-Octyl-bicycloheptendicarboximid MGK 264 Insecticidesynergist

Synergist² Piperonylbutoxid PBO

Synergist² The preparation according to the invention can advantageously contain one or more further repellents according to the invention. Such additional repellents can advantageously be selected according to the invention from the list of the following compounds: Chemical name trade name structure Effectiveness (literature and manufacturer information) Butopyronoxyl Indalone

biting insects ¹ 2,3; 4,5-bis (2-butylene) tetra-hydro-2-furaldehyde MGK repellent 11

Cockroaches and biting insects ¹ N, N-caprylic-oic acid diethylamide Repellent 790

Cockroaches, gnats, mosquitoes, houseflies, brakes, ants, arachnids o-Chloro-N, N-diethylbenzamide mixed with N, N-diethylbenzamide Kik-repellent

Mosquitoes, brakes, fleas, bugs, ticks, flies, lice

Dimethylcarbat Dimalone

Mosquitoes, especially Aedes species ¹ Di-n-propylisocinchomeronat MGK repellent 326

Domestic fly, bush fly ¹ 2-ethyl hexane-1,3-diol Rutgers 612

Mosquitoes, brakes, flies, fleas, mites ¹ N-octyl-bicycloheptendicarboximid MGK 264 Insecticides synergist

Synergist ² piperonyl butoxide PBO

Synergist ²

Dimethylphthalate (Palatinol M, DMP) and emu oil represent further additional repellents which are advantageous according to the invention.

According to the invention, one or more of these additional repellents can advantageously be used in a concentration of 1 to 10% by weight, based on the total weight of the preparation.

The water phase of the preparation according to the invention can advantageously contain customary cosmetic auxiliaries, such as, for example, alcohols, in particular those having a low C number, preferably ethanol and / or isopropanol, diols or polyols having a low C number, and their ethers, preferably propylene glycol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analog products, polymers, foam stabilizers, electrolytes, self-tanning agents (eg DHA), depigmenting agents and in particular one or more thickeners, which one or more can advantageously be selected from the group Silicon dioxide, aluminum silicates, polysaccharides or their derivatives, e.g. B. hyaluronic acid, xanthan gum, hydroxypropylmethyl cellulose, particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of so-called carbopoles, for example carbopoles of types 980, 981, 1382, 2984, 5984, each individually or in combination.

Copolymers of C _10-30 alkyl acrylates and one or more monomers of acrylic acid, methacrylic acid or their esters are also advantageous.

Compounds bearing the INCI name "Acrylates / C _10-30 Alkyl Acrylate Crosspolymer" are advantageous. Particularly advantageous are those available under the trade names Pemulen TR1 and Pemulen TR2 from the BF Goodrich Company.

Compounds which have the INCI name of ammonium acryloyldimethyltaurate / vinylpyrrolidone copolymers are advantageous.

Advantageously according to the invention, the ammonium acryloyldimethyltaurate / vinylpyrrolidone copolymers have the empirical formula [C ₇ H ₁₆ N ₂ SO ₄ ] _n [C ₆ H ₉ NO] _m , corresponding to a statistical structure as follows

Advantageous species for the purposes of the present invention are filed in the Chemical Abstracts under the registration numbers 58374-69-9, 13162-05-5 and 88-12-0 and are available under the trade name Aristoflex® AVC from Clariant GmbH.

Also advantageous are copolymers / crosspolymers comprising acryloyldimethyl taurates, such as Simugel® EG or Simugel® EG from Seppic S.A.

Further thickeners to be used advantageously according to the invention are also water-soluble or dispersible anionic polyurethanes. For the purposes of the present invention, z. B. Polyurethane-1 and / or Polyurethane-4.

Advantageous polyurethanes for the purposes of the present invention are the types available under the trade name Avalure ™ UR from B.F. Goodrich Company, such as, for example, Avalure ™ UR 445, Avalure ™ UR 450 and the like. The polyurethane available under the trade name Luviset Pur from BASF is also advantageous in the sense of the present invention.

According to the invention, particularly preferred are thickeners based on polyacrylates. According to the invention, thickeners can be used in a concentration of 0.05 to 1% by weight and particularly preferably in a concentration of 0.1 to 0.5% by weight, based on the total weight of the preparation.

The preparation according to the invention is in the form of an aqueous or aqueous-alcoholic preparation. It is preferred according to the invention if the preparation is an aqueous-alcoholic preparation. The preferred mixing ratio of water to alcohol is 55:45% by weight. Ethanol is used as the alcohol preferred according to the invention.

Advantageously according to the invention, the preparation according to the invention contains one or more solubilizers. All polyethylene glycol-containing compounds come into consideration as advantageous solubilizers. PPG-1-PEG-9 lauryl glycol ether (Eumulgin L; Cognis) and polyethylene glycol (40) hydrogenated castor oil (Cremophor RH 40; BASF) are very particularly preferred.

According to the invention, pharmaceutically or dermatologically active substances such as skin-calming, anti-inflammatory substances can also advantageously be incorporated. These include, for example, allantoin, tannin, antihistamines, antiphlogistics, glucocorticoids (e.g. hydrocortisone) as well as plant substances such as azulene bisabolol, glycyrrhizin, hamamelin and plant extracts such as chamomile and / or licorice root.

According to the invention, the preparation according to the invention can advantageously contain one or more antioxidants. The antioxidants are advantageously selected from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D- Carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, β-carotene, lycopene) and their derivatives, lipoic acid and their derivatives (e.g. dihydroliponic acid), Aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl) , Oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (e.g. buthioninsulfoximines Homocysteine sulfoximine, buthionine sulfones, penta-, hexa-, heptathioninsul foximin) in very low tolerable doses (e.g. B. pmol to µmol / kg), also (metal) chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, Bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. B. ascorbyl palmitate, Mg - ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) as well as konyferyl benzoate of benzoin, rutinic acid and its derivatives, ferulic acid and its derivatives , Butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguajakharzäure, nordihydroguajaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (e.g. ZnO, ZnSO ₄ ) selenium and its derivatives (e.g. selenomethionine), stilbene and their derivatives (e.g. B. stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active substances.

The amount of the antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05 to 20% by weight, in particular 1 to 10% by weight, based on the total weight of the preparation ,

If vitamin E and / or its derivatives represent the antioxidant (s), it is advantageous to choose their respective concentrations from the range from 0.001 to 10% by weight, based on the total weight of the formulation.

If vitamin A or vitamin A derivatives or carotenes or their derivatives represent the antioxidant (s), it is advantageous to use their respective concentrations in the range from 0.001 to 10% by weight, based on the total weight of the formulation, to choose.

It is particularly advantageous if the cosmetic and / or dermatological preparations according to the present invention contain cosmetic or dermatological active ingredients, preferred active ingredients being antioxidants which can protect the skin from oxidative stress.

Further advantageous active ingredients in the sense of the present invention are natural active ingredients and / or their derivatives, such as. B. alpha-lipoic acid, phytoene, D-biotin, coenzyme Q10, alpha-glucosylrutin, carnitine, carnosine, natural and / or synthetic isoflavonoids, creatine, creatinine, taurine and / or ß-alanine.

The preparation according to the invention can advantageously contain one or more self-tanners according to the invention. According to the invention, the following are advantageously used as self-tanners: glycerol aldehyde, hydroxymethylglyoxal, γ-dialdehyde, erythrulose, 6-aldo-D-fructose, ninhydrin, 5-hydroxy-1,4-naphthoquinone (juglone), 2-hydroxy-1,4- naphtoquinone (Lawson).

The preparation according to the invention can advantageously contain one or more depigmenting agents. Depigmenting agents which are advantageous according to the invention can, for example Dicarboxylic acids such as 8-hexadecen-1,16-dicarboxylic acid (dioic acid, CAS number 20701-68-2), kojic acid, ascorbic acid and azelaic acid and their derivatives are used.

The preparation according to the invention can advantageously contain one or more UV light protection filters. The following compounds can be used, for example, as UV light protection filters which are advantageous according to the invention:

Inorganic pigments

Preferred inorganic pigments are metal oxides and / or other metal compounds which are sparingly soluble or insoluble in water, in particular oxides of titanium (TiO ₂ ), zinc (ZnO), iron (e.g. Fe ₂ O ₃ ), zirconium (ZrO ₂ ), silicon ( SiO ₂ ), manganese (e.g. MnO), aluminum (Al ₂ O ₃ ), cerium (e.g. Ce ₂ O ₃ ), mixed oxides of the corresponding metals and mixtures of such oxides, as well as the sulfate of barium (BaSO ₄ ).

The titanium dioxide pigments can be present both in the rutile and anatase crystal modification and, for the purposes of the present invention, can advantageously be surface-treated (“coated”), with, for example, a hydrophilic, amphiphilic or hydrophobic character being formed or retained. This surface treatment can consist in that the pigments are provided with a thin hydrophilic and / or hydrophobic inorganic and / or organic layer by methods known per se. For the purposes of the present invention, the various surface coatings can also contain water.

Coated and uncoated titanium dioxides described can also be used in the sense of the present invention in the form of commercially available oily or aqueous predispersions. Dispersing aids and / or solubilizing agents can advantageously be added to these predispersions.

The titanium dioxides according to the invention are characterized by a primary particle size between 10 nm to 150 nm. trade name coating additional components of the predispersion Manufacturer MT-100TV Aluminum hydroxide stearic acid - Tayca Corporation MT-100Z Aluminum hydroxide stearic acid - Tayca Corporation MT-100F Stearic acid iron oxide - Tayca Corporation MT 500SAS Alumina, silica silicone - Tayca Corporation MT 100AQ Silica aluminum hydroxide alginic acid - Tayca Corporation Eusolex T-2000 Alumina Simethicone - Merck KgaA Eosolex TS Alumina, stearic acid - Merck KgaA Titanium dioxide P25 none - Degussa Titanium dioxide T805 (Uvinul TiO ₂ ) octyltrimethylsilane - Degussa UV Titan X170 Alumina Dimethicone - Kemira UV-Titan X161 Alumina, silica stearic acid - Kemira Tioveil AQ 10PG Alumina silica Water propylene glycol Solaveil Uniquema Mirasun TiW 60 Alumina silica water Rhone-Poulenc

For the purposes of the present invention, particularly preferred titanium dioxides are the MT-100 Z and MT-100 TV from Tayca Corporation, Eusolex T-2000 and Eusolex TS from Merck and the titanium dioxide T 805 from Degussa.

In the context of the present invention, zinc oxides can also be used in the form of commercially available oily or aqueous predispersions. Zinc oxide particles and predispersions of zinc oxide particles suitable according to the invention are distinguished by a primary particle size of <300 nm and are available under the following trade names from the companies listed: trade name coating Manufacturer Z-Cote HP1 2% dimethicone BASF Z-Cote / BASF ZnO NDM 5% dimethicone MR MZ 707M 7% dimethicone M. Tayca Corp. Nanox 500 / Elementis ZnO neutral / MR

Z-Cote HP1 from BASF and zinc oxide NDM from Haarmann & Reimer are particularly preferred zinc oxides for the purposes of the invention.

The total amount of one or more inorganic pigments in the finished cosmetic preparation is advantageously selected from the range 0.1% by weight to 25% by weight, preferably 0.5% by weight to 18% by weight.

Organic pigments

An advantageous organic pigment for the purposes of the present invention is 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol) [INCI : Bisoctyltriazole], which is available under the trade name Tinosorb® M from CIBA-Chemicals GmbH.

More UV light protection filters

Advantageous UV-A filter substances for the purposes of the present invention are dibenzoylmethane derivatives, in particular 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS No. 70356-09-1), which is available from Givaudan under the Parsol® 1789 brand and is sold by Merck under the trade name Eusolex® 9020.

Further advantageous UV-A filter substances are the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and its salts, especially the corresponding sodium, potassium or triethanolammonium salts , in particular the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt with the INCI name bisimidazylate, which, for example, under the trade name Neo Heliopan AP from Haarmann & Reimer is available.

Also advantageous are the 1,4-di (2-oxo-10-sulfo-3-bornylidenemethyl) benzene and its salts (especially the corresponding 10-sulfato compounds, especially the corresponding sodium, potassium or triethanolammonium salt) , which is also called benzene-1,4-di (2-oxo-3-bornylidenemethyl-10-sulfonic acid).

worin

• • R¹ und R² unabhängig voneinander Wasserstoff, C₁-C₂₀-Alkyl, C₃-C₁₀-Cycloalkyl oder C₃-C₁₀-Cycloalkenyl bedeuten, wobei die Substituenten R¹ und R² gemeinsam mit dem Stickstoffatom, an das sie gebunden sind, einen 5- oder 6-Ring bilden können und
• • R³ einen C₁-C₂₀-Alkyl Rest bedeutet.

Further advantageous UV-A filter substances are hydroxybenzophenones, which are characterized by the following structural formula:

wherein

• • R ¹ and R ² independently of one another are hydrogen, C ₁ -C ₂₀ alkyl, C ₃ -C ₁₀ cycloalkyl or C ₃ -C ₁₀ cycloalkenyl, where the substituents R ¹ and R ² together with the nitrogen atom to which they are bound, can form a 5- or 6-ring and
• • R ^{3 is} a C ₁ -C ₂₀ alkyl radical.

A particularly advantageous hydroxybenzophenone for the purposes of the present invention is 2- (4'-diethylamino-2'-hydoxybenzoyl) benzoic acid hexyl ester (also: aminobenzophenone), which is available under the trade name Uvinul A Plus from BASF.

Advantageous UV filter substances in the sense of the present invention are also so-called broadband filters, i.e. Filter substances that absorb both UV-A and UV-B radiation.

wobei R¹, R² und R³ unabhängig voneinander gewählt werden aus der Gruppe der verzweigten und unverzweigten Alkylgruppen mit 1 bis 10 Kohlenstoffatomen bzw. ein einzelnes Wasserstoffatom darstellen. Insbesondere bevorzugt sind das 2,4-Bis-{[4-(2-Ethyl-hexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin (INCI: Aniso Triazin), welches unter der Handelsbezeichnung Tinosorb® S bei der CIBA-Chemikalien GmbH erhältlich ist.Advantageous broadband filters or UV-B filter substances are, for example, bis-resorcinyltriazine derivatives with the following structure:

where R ¹ , R ² and R ^{3 are} independently selected from the group of branched and unbranched alkyl groups having 1 to 10 carbon atoms or a single hydrogen atom. Particularly preferred are the 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: Aniso triazine ), which is available under the trade name Tinosorb® S from CIBA-Chemicals GmbH.

Particularly advantageous preparations in the sense of the present invention, which are distinguished by a high or very high UV-A protection, preferably contain a plurality of UV-A and / or broadband filters, in particular dibenzoylmethane derivatives [for example 4- (tert-butyl) -4'-methoxydibenzoylmethane], benzotriazole derivatives [e.g. 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol)] , Phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and / or its salts, the 1,4-di (2-oxo-10-sulfo-3-bornylidene methyl ) -Benzene and / or its salts and / or the 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1, 3,5-triazine, individually or in any combination with one another.

aufweisen, sind vorteilhafte UV-Filtersubstanzen im Sinne der vorliegenden Erfindung, beispielsweise die in der Europäischen Offenlegungsschrift EP 570 838 A1 beschriebenen s-Triazinderivate, deren chemische Struktur durch die generische Formel

wiedergegeben wird, wobei

R

einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄- Alkylgruppen, darstellt,

X

ein Sauerstoffatom oder eine NH-Gruppe darstellt,

R₁

einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄- Alkylgruppen, oder ein Wasserstoffatom, ein Alkalimetallatom, eine Ammoniumgruppe oder eine Gruppe der Formel

bedeutet, in welcher

• A einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkyl- oder Arylrest darstellt, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen,
• R₃ ein Wasserstoffatom oder eine Methylgruppe darstellt,
• n eine Zahl von 1 bis 10 darstellt,

R₂

einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄- Alkylgruppen, darstellt, wenn X die NH-Gruppe darstellt, und einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄- Alkylgruppen, oder ein Wasserstoffatom, ein Alkalimetallatom, eine Ammoniumgruppe oder eine Gruppe der Formel

bedeutet, in welcher

• A einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkyl- oder Arylrest darstellt, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen,
• R₃ ein Wasserstoffatom oder eine Methylgruppe darstellt,
• n eine Zahl von 1 bis 10 darstellt,

wenn X ein Sauerstoffatom darstellt.

Also other UV filter substances, which the structural motif

have, are advantageous UV filter substances in the sense of the present invention, for example those in the European patent application EP 570 838 A1 described s-triazine derivatives, the chemical structure of which by the generic formula

is reproduced, whereby

R

represents a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl radical, optionally substituted with one or more C ₁ -C ₄ alkyl groups,

X

represents an oxygen atom or an NH group,

R ₁

a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl radical, optionally substituted with one or more C ₁ -C ₄ alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula

means in which

• A represents a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl or aryl radical, optionally substituted by one or more C ₁ -C ₄ alkyl groups,
• R _{3 represents} a hydrogen atom or a methyl group,
• n represents a number from 1 to 10,

R ₂

represents a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl radical, optionally substituted with one or more C ₁ -C ₄ alkyl groups, when X represents the NH group, and a branched or unbranched C ₁ -C ₁₈ alkyl, a C ₅ -C ₁₂ cycloalkyl, optionally substituted with one or more C ₁ -C ₄ alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula

means in which

• A represents a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl or aryl radical, optionally substituted by one or more C ₁ -C ₄ alkyl groups,
• R _{3 represents} a hydrogen atom or a methyl group,
• n represents a number from 1 to 10,

when X represents an oxygen atom.

wiedergegeben wird, welches im Folgenden auch als Dioctylbutylamidotriazon (INCI: Dioctylbutamidotriazone) bezeichnet wird und unter der Handelsbezeichnung UVASORB HEB bei Sigma 3V erhältlich ist.A particularly preferred UV filter substance in the sense of the present invention is also an asymmetrically substituted s-triazine, the chemical structure of which is represented by the formula

is reproduced, which is also referred to below as dioctylbutylamidotriazon (INCI: dioctylbutamidotriazone) and is available under the trade name UVASORB HEB from Sigma 3V.

A symmetrically substituted s-triazine which is 4,4 ', 4 "- (1,3,5-triazine-2,4,6-triyltriimino) -tris-benzoic acid tris (2- ethylhexyl ester), synonym: 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: octyl triazone), which is derived from the BASF Aktiengesellschaft is marketed under the trade name UVINUL® T 150.

wiedergegeben wird, wobei R₁ , R₂ und A₁ verschiedenste organische Reste repräsentieren.European laid-open specification 775 698 also describes bis-resorcinyltriazine derivatives which are preferably to be used and whose chemical structure is represented by the generic formula

is reproduced, wherein R ₁ , R ₂ and A _{1 represent a} wide variety of organic radicals.

Also advantageous for the purposes of the present invention are 2,4-bis - {[4- (3-sulfonato) -2-hydroxypropyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1, 3,5-triazine sodium salt, the 2,4-bis - {[4- (3- (2-propyloxy) -2-hydroxypropyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) - 1,3,5-triazine, the 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- [4- (2-methoxyethylcarboxyl) phenylamino] -1,3,5-triazine, the 2,4-bis - {[4- (3- (2-propyloxy) -2-hydroxypropyloxy) -2-hydroxy] phenyl} -6- [4- ( 2-ethyl-carboxyl) -phenylamino] -1,3,5-triazine, the 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] phenyl} -6- (1- methyl-pyrrol-2-yl) -1,3,5-triazine, the 2,4-bis - {[4-tris (trimethylsiloxysilylpropyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine, the 2,4-bis - {[4- (2 "-methylpropenyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine and the 2,4-bis - {[4- (1 ', 1', 1 ', 3', 5 ', 5', 5'-heptamethylsiloxy-2 "-methyl-propyloxy) -2-hydroxy] phenyl } -6- (4-methoxyphenyl) -1,3,5-triazine.

An advantageous broadband filter in the sense of the present invention is 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol), which is available under the trade name Tinosorb® M from CIBA-Chemicals GmbH.

Another advantageous broadband filter for the purposes of the present invention is 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [( trimethylsilyl) oxy] disiloxa-nyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane.

• ■ 3-Benzylidencampher-Derivate, vorzugsweise 3-(4-Methylbenzyliden)campher, 3-Benzylidencampher;
• ■ 4-Aminobenzoesäure-Derivate, vorzugsweise 4-(Dimethylamino)-benzoesäure(2-ethylhexyl)ester, 4-(Dimethylamino)benzoesäureamylester;
• ■ 2,4,6-Trianilino-(p-carbo-2'-ethyl-1'-hexyloxy)-1,3,5-triazin;
• ■ Ester der Benzalmalonsäure, vorzugsweise 4-Methoxybenzalmalonsäuredi(2-ethylhexyl)-ester;
• ■ Ester der Zimtsäure, vorzugsweise 4-Methoxyzimtsäure(2-ethylhexyl)ester, 4-Methoxyzimtsäureisopentylester;
• ■ Derivate des Benzophenons, vorzugsweise 2-Hydroxy-4-methoxybenzophenon, 2-Hydroxy-4-methoxy-4'-methylbenzophenon, 2,2'-Dihydroxy-4-methoxybenzophenon
• ■ sowie an Polymere gebundene UV-Filter.

The UV-B and / or broadband filters can be oil-soluble or water-soluble. Advantageous oil-soluble UV-B and / or broadband filter substances are e.g. B .:

• ■ 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
• ■ 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
• 2,4,6-trianilino- (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine;
• ■ esters of benzalmalonic acid, preferably 4-methoxybenzalmalonic acid di (2-ethylhexyl) ester;
• ■ esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
• ■ Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone
• ■ as well as UV filters bound to polymers.

• ■ Salze der 2-Phenylbenzimidazol-5-sulfonsäure, wie ihr Natrium-, Kalium- oder ihr Triethanolammonium-Salz, sowie die Sulfonsäure selbst;
• ■ Sulfonsäure-Derivate des 3-Benzylidencamphers, wie z. B. 4-(2-Oxo-3-bornylidenme-thyl)benzolsulfonsäure, 2-Methyl-5-(2-oxo-3-bornylidenmethyl)sulfonsäure und deren Salze.

Advantageous water-soluble UV-B and / or broadband filter substances are e.g. B .:

• ■ salts of 2-phenylbenzimidazole-5-sulfonic acid, such as its sodium, potassium or triethanolammonium salt, and the sulfonic acid itself;
• ■ sulfonic acid derivatives of 3-benzylidene camphor, such as. B. 4- (2-oxo-3-bornylidene methyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidene methyl) sulfonic acid and their salts.

Particularly advantageous UV filter substances which are liquid at room temperature for the purposes of the present invention are homomenthyl salicylate (INCI: homosalate), 2-ethylhexyl-2-hydroxybenzoate (2-ethylhexyl salicylate, octyl salicylate, INCI: octyl salicylate), 4-isopropyl benzyl salicylate and esters of preferably z 4-methoxycinnamic acid (2-ethylhexyl) ester (2-ethylhexyl-4-methoxycinnamate, INCI: octyl methoxycinnamate) and 4-methoxycinnamic acid isopentyl ester (isopentyl-4-methoxycinnamate, INCI: isoamyl p-methoxycinnamate), 3- (4- (2, ( 2-bis ethoxycarbonylvinyl) phenoxy) propenyl) methoxysiloxane / dimethylsiloxane copolymer (INCI: Dimethicodiethylbenzalmalonat) which is available for example under the trade name Parsol® SLX from Hoffmann La Roche.

A further light protection filter substance according to the invention to be used advantageously is ethylhexyl-2-cyano-3,3-diphenylacrylate, obtainable (octocrylene) from BASF under the name Uvinul ^® N 539th

It can also be of considerable advantage to use polymer-bound or polymeric UV filter substances in preparations according to the present invention, in particular those as described in WO-A-92/20690.

The list of the UV filters mentioned, which can be used in the sense of the present invention, should of course not be limiting.

The preparations according to the invention advantageously contain the substances which absorb UV radiation in the UV-A and / or UV-B range in a total amount of, for. B. 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 20 wt .-%, in particular 1.0 to 15.0 wt .-%, each based on the total weight of the preparations to cosmetic To provide preparations that protect the hair or skin from the entire range of ultraviolet radiation. They can also serve as a sunscreen for the hair or skin.

The preparation according to the invention can advantageously contain moisturizing or moisturizing agents. Advantageous moisturizing or moisturizing agents (so-called moisturizers) for the purposes of the present invention are, for example, glycerol, lactic acid and / or lactates, in particular sodium lactate, butylene glycol, propylene glycol, biosaccaride Gum-1, glycine soybean, ethylhexyloxyglycerol, pyrrolidonecarboxylic acid and urea. Furthermore, it is particularly advantageous to use polymeric moisturizers from the group of water-soluble and / or water-swellable and / or water-gelable polysaccharides. Particularly advantageous are, for example, hyaluronic acid, chitosan and / or a fucose-rich polysaccharide, which is filed in the Chemical Abstracts under the registration number 178463-23-5 and z. B. under the name Fucogel®1000 from the company SOLABIA S.A. is available.

The cosmetic preparations according to the invention can contain cosmetic auxiliaries, as are usually used in such preparations, e.g. B. antioxidants, preservatives, perfumes, antimicrobial agents, anti-foaming agents, dyes, pigments that have a coloring effect, self-tanners, bleaches, thickeners, surface-active substances, emulsifiers, softening substances, moisturizing and / or moisturizing substances, Fats, oils, waxes or other common components of a cosmetic formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.

According to the invention, the use of one or more extracts selected from the group aloe vera and mutton for the stabilization of ethyl 3- (N-n-butyl-N-acetylamino) propionate in aqueous or aqueous-alcoholic preparations.

The cosmetic and / or dermatological preparations according to the invention can be composed as usual and serve to protect the skin and / or the hair from nuisance caused by blood-sucking or biting insects and other parasites. However, they can also be used according to the invention primarily to protect the skin from UV radiation and / or skin aging or as care products for moisturizing the skin, skin care after sunbathing (so-called after-sun or apres-sun products).

According to the invention, the use of the preparation according to the invention as an insect repellent (insect repellent cosmetic).

According to the invention, the preparation according to the invention is used as an after-sun, sun protection, anti-wrinkle, anti-acne preparation or as a moisturizing preparation, day or night cream.

For use, the cosmetic and / or dermatological formulations according to the invention are applied to the skin and / or the hair in a sufficient amount in the manner customary for cosmetics and dermatics.

According to the invention, the preparation according to the invention is advantageously stored in a storage vessel (for example a plastic bottle) and used from there. Advantageously according to the invention, however, the preparation according to the invention can also be in the form of a pump spray or aerosol spray, it being possible for all commercially available product forms to be used advantageously.

The use of the preparation according to the invention as a sprayable preparation in a spray is therefore according to the invention.

However, the preparation according to the invention can also advantageously be applied to the body using an insoluble substrate (e.g. paper, cloth, cotton ball, "pad"). Nonwoven textiles (in particular nonwovens made from viscose fibers and polyester and possibly cotton fibers) are preferred according to the invention. In an embodiment of the present invention which is preferred according to the invention, textiles which have already been impregnated with the preparation are offered to the consumer.

The use of the preparation according to the invention as an impregnation for a textile is therefore according to the invention.

Comparative test

• Es wurden je 300-400 Mücken vom Typ aedes aegypti (Männchen und Weibchen) in einem kubischen Käfig (30 x 30 x 30 cm) für die Tests herangezogen. Um sicher zu stellen, dass die Mücken bei der Durchführung des Tests „hungrig“ waren, bekamen sie seit dem Vorabend des Tests kein Zuckerwasser mehr als Nahrung. Die Tests wurden am Folgetag zwischen 8 und 11 Uhr morgens durchgeführt. Die Tests wurden unter den Standartbedingungen (27 °C, 70 %-80 % relative Luftfeuchtigkeit) durchgeführt.

The surprising effect of the present invention was demonstrated, inter alia, by the following comparative experiment:

• 300-400 mosquitoes of the type aedes aegypti (male and female) in a cubic cage (30 x 30 x 30 cm) were used for the tests. To make sure that the mosquitoes were "hungry" when performing the test, they had not been fed sugar water since the evening before the test. The tests were carried out the following day between 8 a.m. and 11 a.m. The tests were carried out under the standard conditions (27 ° C, 70% -80% relative air humidity).

The tests were carried out on 4 test subjects (2 males, 2 females who volunteered). For this purpose, 2 ml of test substance was distributed over an area of 500 cm ² on her forearms. A preparation (A) according to the invention and a preparation (B) which differed from the preparation according to the invention in that they contained no extracts selected from the group consisting of aloe vera extract, mutton extract, sea extract served as test substance. The hand of the test person was protected by a glove, the upper arm was protected from the mosquitoes by a plastic sleeve.

1. a) Bereitschaft zum Stechen (Positiv-Kontrolle)
2. b) Annäherung an die behandelte Hautfläche auf einen Abstand von weniger als 3 cm
3. c) Niederlassen auf der behandelten Hautfläche über einen Zeitraum von mehr als 2 Sekunden.

To carry out the test, the test person's prepared forearm was held in the mosquito cage for a test period of 10 minutes in such a way that only the skin area treated with the preparation was accessible to the mosquitoes. For the test period, which was carried out at intervals of one and three hours, the number of mosquitoes with the following behavior was recorded:

1. a) Willingness to sting (positive control)
2. b) Approaching the treated skin area at a distance of less than 3 cm
3. c) settling on the treated skin area for a period of more than 2 seconds.

The untreated forearms of test subjects were also measured as a control measurement. The values were rounded to a mosquito.

Method of application: spray

Number of active mosquitoes (positive control) Number of mosquitoes that are less than 3 cm apart Number of mosquitoes that settle on the skin for more than 2 seconds Preparation A (with extract) Preparation B (without extract) Preparation A (with extract) Preparation B (without extract) Preparation A (with extract) Preparation B (without extract 1 hour after application about 150 about 150 10 23 2 4 3 hours after application about 150 about 150 9 14 3 6

Method of application: using a cloth

Number of active mosquitoes (positive control) Number of mosquitoes that are less than 3 cm apart Number of mosquitoes that settle on the skin for more than 2 seconds Preparation A (with extract) Preparation B (without extract) Preparation A (with extract) Preparation B (without extract) Preparation A (with extract) Preparation B (without extract) 1 hour after application about 150 about 150 13 28 6 8th 3 hours after application about 150 about 150 7 22 7 11

In these tests it could be shown that the addition of extracts led to a halving of the mosquito attacks.

The following examples are intended to illustrate the compositions according to the invention, but are not intended to limit the invention to these examples. The numerical values in the examples mean percentages by weight, based on the total weight of the respective preparations.

Examples

Pump spray with repellent

1 2 3 4 5 PPG-1-PEG-9-Laurylglycolether 1.0 2.5 0.4 0.75 5.0 cyclomethicone 0.5 --- --- --- 1.5 ethyl butylacetylaminopropionate 2 10 10 20 40 Perfume q, s, q, s, q, s, q, s, q, s, ethanol 15 20 45 40 20 methylparaben 0.4 0.1 --- 0.3 0.4 marine extract --- --- --- --- --- Aloe vera extract 0.1 0.5 0.1 --- --- Hamamelis extract 0.1 3.5 0.1 5 0.5 glycerin 5 10 10 15 7.5 Benzophenone-2 0.05 --- 0.02 --- --- modified starch --- 2.5 --- 0.15 --- water ad 100 ad 100 ad 100 ad 100 ad 100

Pump spray with repellent

6 7 8th 9 10 polyethylene glycol stearyl ether (21) 1 --- 2.5 2 1.5 stearyl Polyethylenglvcol (2) 1 --- 5.5 3 7.5 ethanol 3 2 --- 1 --- Eumulgiun 3 2 --- 2 --- Polyethylene glycol (40) hydrogenated castor oil 3 4 --- --- 2 marine extract 0.5 0.75 1.0 2.0 0.25 ethyl butylacetylaminopropionate 5 10 15 20 7.5 Aloe vera extract 0.5 1.0 0.75 3.0 0.25 glycerin 5 10 15 3 7.5 panthenol 0.5 1.0 0.75 0.25 0.1 Perfume q, s, q, s, q, s, q, s, q, s, methylparaben 0.4 0.1 0.05 0.3 0.4 Propylparaben 0.3 0.4 0.25 0.15 --- iodopropynylbutylcarbamate --- --- 0.05 --- 0.1 modified starch 0.5 --- --- 0.15 --- water ad 100 ad 100 ad 100 ad 100 ad 100

Spray with repellent

11 12 13 14 15 ethyl butylacetylaminopropionate 5 35 15 20 7.5 N, N-diethyltoluolamide 5 --- --- 1 --- N, N-diethylbenzamide, 1-piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester 5 3.0 2.0 1.5 2.5 1- (3-cyclohexen-1-yl-carbonyl) -2-methylpiperidine 5 --- 2 1 --- Emu Oil 5 5 --- --- 2.5 Hamamelis extract 0.2 5 --- 1 0.2 Aloe vera extract --- --- 1 1 5.0 tocopherol 0.5 0.5 0.75 0.25 0.1 marine extract 0.5 --- 0.75 3.0 0.25 panthenol 0.5 --- 0.75 0.25 0.1 Carbomer 0.05 0.35 --- --- --- Perfume q, s, q, s, q, s, q, s, q, s, sorbitol 10 --- --- 5 --- butylene --- --- --- 5 10 propylene glycol --- --- 10 5 --- glycerin --- 7.5 --- --- --- water ad 100 ad 100 ad 100 ad 100 ad 100

O / W emulsion with repellent

16 17 18 19 20 ethyl butylacetylaminopropionate 5 10 15 20 7.5 Aloe vera extract 2 4 6 1 3 marine extract --- 0.5 0.75 --- --- Hamamelis extract 1 --- 2 1 0.2 sandalwood 2 1 --- --- --- Iris oil 2 --- 1 --- --- mint oil 2 --- --- 1 --- lime oil 2 1.0 0.75 3.0 1 Perfume q, s, q, s, q, s, q, s, q, s, methylparaben 0.4 0.1 0.05 0.3 0.4 glycerin 3 5 8th 12 10 water ad 100 ad 100 ad 100 ad 100 ad 100

Claims (10)

Aqueous or aqueous-alcoholic cosmetic preparation containing a combination of a) one or more repellents selected from the group 3- (N-n-butyl-N-acetylamino) propionic acid ethyl ester, 1-piperidinecarboxylic acid 2- (2-hydroxyethyl) -1-methylpropyl ester and b) one or more extracts selected from the group of aloe vera extract and mutton extract. Preparation after Claim 1 , characterized in that it contains one or more repellents of group a) in a total concentration of 2 to 60% by weight, based on the total weight of the preparation. Preparation according to one of the Claims 1 or 2 , characterized in that it contains extracts of group b) in a total concentration of 0.1 to 35% by weight, based on the total weight of the preparation. Preparation according to one of the Claims 1 to 3 , characterized in that 3- (Nn-butyl-N-acetylamino) propionic acid ethyl ester is used as the repellent. Preparation according to one of the Claims 1 to 4 , characterized in that it additionally contains one or more oils selected from the group consisting of iris oil, sandalwood oil, mint oil and lime oil. Preparation according to one of the Claims 1 to 5 , characterized in that aloe vera and mutton are used as the extract. Preparation according to one of the Claims 1 to 6 , characterized in that the weight ratio of the total amount of repellents [a)] to the total amount of extracts [b)] is from 10: 1 to 50: 1. Use of a preparation according to one of the preceding claims as an insect repellent cosmetic. Use of a preparation according to one of the preceding claims as a sprayable preparation in a pump spray, aerosol spray or as an impregnation for a textile. Use of one or more extracts selected from the group of aloe vera extract and mutton extract to stabilize ethyl 3- (Nn-butyl-N-acetylamino) propionate in aqueous or aqueous-alcoholic preparations.