FR2817867B1 - ISOCOUMARINS INHIBITORS OF AMYLOID PEPTIDE PRODUCTION, PREPARATION, COMPOSITIONS CONTAINING SAME AND USES THEREOF - Google Patents

ISOCOUMARINS INHIBITORS OF AMYLOID PEPTIDE PRODUCTION, PREPARATION, COMPOSITIONS CONTAINING SAME AND USES THEREOF

Info

Publication number
FR2817867B1
FR2817867B1 FR0016060A FR0016060A FR2817867B1 FR 2817867 B1 FR2817867 B1 FR 2817867B1 FR 0016060 A FR0016060 A FR 0016060A FR 0016060 A FR0016060 A FR 0016060A FR 2817867 B1 FR2817867 B1 FR 2817867B1
Authority
FR
France
Prior art keywords
isocoumarins
inhibitors
preparation
compositions containing
amyloid peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0016060A
Other languages
French (fr)
Other versions
FR2817867A1 (en
Inventor
Frederic Bihel
Michel Delaage
Caroline Jouve
Jean Louis Kraus
Olivier Pourquie
Toni Louise Williamson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trophos SA
Original Assignee
Trophos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trophos SA filed Critical Trophos SA
Priority to FR0016060A priority Critical patent/FR2817867B1/en
Priority to AU2002217228A priority patent/AU2002217228A1/en
Priority to PCT/FR2001/003902 priority patent/WO2002048102A2/en
Publication of FR2817867A1 publication Critical patent/FR2817867A1/en
Application granted granted Critical
Publication of FR2817867B1 publication Critical patent/FR2817867B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
FR0016060A 2000-12-11 2000-12-11 ISOCOUMARINS INHIBITORS OF AMYLOID PEPTIDE PRODUCTION, PREPARATION, COMPOSITIONS CONTAINING SAME AND USES THEREOF Expired - Fee Related FR2817867B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR0016060A FR2817867B1 (en) 2000-12-11 2000-12-11 ISOCOUMARINS INHIBITORS OF AMYLOID PEPTIDE PRODUCTION, PREPARATION, COMPOSITIONS CONTAINING SAME AND USES THEREOF
AU2002217228A AU2002217228A1 (en) 2000-12-11 2001-12-10 Isocoumarin inhibiting production of amyloid peptide, preparation, compositions containing same and uses
PCT/FR2001/003902 WO2002048102A2 (en) 2000-12-11 2001-12-10 Isocoumarin inhibiting production of amyloid peptide, preparation, compositions containing same and uses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0016060A FR2817867B1 (en) 2000-12-11 2000-12-11 ISOCOUMARINS INHIBITORS OF AMYLOID PEPTIDE PRODUCTION, PREPARATION, COMPOSITIONS CONTAINING SAME AND USES THEREOF

Publications (2)

Publication Number Publication Date
FR2817867A1 FR2817867A1 (en) 2002-06-14
FR2817867B1 true FR2817867B1 (en) 2006-06-30

Family

ID=8857475

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0016060A Expired - Fee Related FR2817867B1 (en) 2000-12-11 2000-12-11 ISOCOUMARINS INHIBITORS OF AMYLOID PEPTIDE PRODUCTION, PREPARATION, COMPOSITIONS CONTAINING SAME AND USES THEREOF

Country Status (3)

Country Link
AU (1) AU2002217228A1 (en)
FR (1) FR2817867B1 (en)
WO (1) WO2002048102A2 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596822A (en) * 1984-08-20 1986-06-24 Georgia Tech Research Corporation Heterocyclic inhibitors of serine proteases
US4845242A (en) * 1987-04-28 1989-07-04 Georgia Tech Research Corporation Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents
US5089633A (en) * 1987-04-28 1992-02-18 Georgia Tech Research Corporation Substituted isocoumarins
WO1992011850A2 (en) * 1990-12-28 1992-07-23 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
NZ264143A (en) * 1993-08-09 1996-11-26 Lilly Co Eli Use of an aspartyl protease inhibitor to inhibit beta-amyloid peptide production

Also Published As

Publication number Publication date
WO2002048102A2 (en) 2002-06-20
WO2002048102A3 (en) 2004-05-13
FR2817867A1 (en) 2002-06-14
AU2002217228A1 (en) 2002-06-24

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20070831