WO2002048102A3 - Isocoumarin inhibiting production of amyloid peptide, preparation, compositions containing same and uses - Google Patents

Isocoumarin inhibiting production of amyloid peptide, preparation, compositions containing same and uses Download PDF

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Publication number
WO2002048102A3
WO2002048102A3 PCT/FR2001/003902 FR0103902W WO0248102A3 WO 2002048102 A3 WO2002048102 A3 WO 2002048102A3 FR 0103902 W FR0103902 W FR 0103902W WO 0248102 A3 WO0248102 A3 WO 0248102A3
Authority
WO
WIPO (PCT)
Prior art keywords
amyloid peptide
preparation
inhibiting production
isocoumarin
compositions containing
Prior art date
Application number
PCT/FR2001/003902
Other languages
French (fr)
Other versions
WO2002048102A2 (en
Inventor
Frederic Bihel
Michel Delaage
Caroline Jouve
Jean-Louis Kraus
Olivier Pourquie
Toni-Louise Williamson
Cyrille Drouot
Original Assignee
Trophos
Frederic Bihel
Michel Delaage
Caroline Jouve
Jean-Louis Kraus
Olivier Pourquie
Toni-Louise Williamson
Cyrille Drouot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trophos, Frederic Bihel, Michel Delaage, Caroline Jouve, Jean-Louis Kraus, Olivier Pourquie, Toni-Louise Williamson, Cyrille Drouot filed Critical Trophos
Priority to AU2002217228A priority Critical patent/AU2002217228A1/en
Publication of WO2002048102A2 publication Critical patent/WO2002048102A2/en
Publication of WO2002048102A3 publication Critical patent/WO2002048102A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention concerns novel compounds inhibiting production of amyloid peptide, their preparation and their uses. The invention also concerns methods for identifying or characterising compounds inhibiting production of amyloid peptide (and in particular non-toxic for embryonic development). The invention further concerns methods and uses of said compounds for treating nervous system disorders, in particular neurodegenerative pathologies such as Alzheimer's disease.
PCT/FR2001/003902 2000-12-11 2001-12-10 Isocoumarin inhibiting production of amyloid peptide, preparation, compositions containing same and uses WO2002048102A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002217228A AU2002217228A1 (en) 2000-12-11 2001-12-10 Isocoumarin inhibiting production of amyloid peptide, preparation, compositions containing same and uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR00/16060 2000-12-11
FR0016060A FR2817867B1 (en) 2000-12-11 2000-12-11 ISOCOUMARINS INHIBITORS OF AMYLOID PEPTIDE PRODUCTION, PREPARATION, COMPOSITIONS CONTAINING SAME AND USES THEREOF

Publications (2)

Publication Number Publication Date
WO2002048102A2 WO2002048102A2 (en) 2002-06-20
WO2002048102A3 true WO2002048102A3 (en) 2004-05-13

Family

ID=8857475

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2001/003902 WO2002048102A2 (en) 2000-12-11 2001-12-10 Isocoumarin inhibiting production of amyloid peptide, preparation, compositions containing same and uses

Country Status (3)

Country Link
AU (1) AU2002217228A1 (en)
FR (1) FR2817867B1 (en)
WO (1) WO2002048102A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596822A (en) * 1984-08-20 1986-06-24 Georgia Tech Research Corporation Heterocyclic inhibitors of serine proteases
US4845242A (en) * 1987-04-28 1989-07-04 Georgia Tech Research Corporation Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents
US5089633A (en) * 1987-04-28 1992-02-18 Georgia Tech Research Corporation Substituted isocoumarins
WO1992011850A2 (en) * 1990-12-28 1992-07-23 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
EP0652009A1 (en) * 1993-08-09 1995-05-10 Eli Lilly And Company Identification and use of protease inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596822A (en) * 1984-08-20 1986-06-24 Georgia Tech Research Corporation Heterocyclic inhibitors of serine proteases
US4845242A (en) * 1987-04-28 1989-07-04 Georgia Tech Research Corporation Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents
US5089633A (en) * 1987-04-28 1992-02-18 Georgia Tech Research Corporation Substituted isocoumarins
WO1992011850A2 (en) * 1990-12-28 1992-07-23 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
EP0652009A1 (en) * 1993-08-09 1995-05-10 Eli Lilly And Company Identification and use of protease inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J.C. POWERS: "REACTION OF PORCINE PANCREATIC ELASTASE WITH 7-SUBSTITUTED 3-ALKOXY-4-CHLOROISOCOUMARINS:", BIOCHEMISTRY., vol. 29, no. 12, 1990, AMERICAN CHEMICAL SOCIETY. EASTON, PA., US, pages 3108 - 3118, XP002193881, ISSN: 0006-2960 *
J.E.KERRIGAN: "MECHANISM BASED ISOCOUMARIN INHIBITORS", JOURNAL OF MEDICINAL CHEMISTRY., vol. 38, no. 3, 1995, AMERICAN CHEMICAL SOCIETY. WASHINGTON., US, pages 544 - 552, XP002174884, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2002048102A2 (en) 2002-06-20
FR2817867B1 (en) 2006-06-30
AU2002217228A1 (en) 2002-06-24
FR2817867A1 (en) 2002-06-14

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