FR2774589A3 - Cosmetic slimming compositions having lipolytic activity, containing mucopolysaccharidase and escin - Google Patents

Abstract

Cosmetic slimming compositions contain a mucopolysaccharidase (I) and escin (II).

Description

 The present invention relates to new slimming cosmetic compositions. In what follows, the same adjective will designate "slimming" compositions which cause not only a thinning, but also a mobilization of fats resulting in real weight loss.

 Cellulite is the manifestation of a certain metabolic imbalance in the fat cells. There is a proliferation of ss-adrenergic sites on the adipocyte membrane, which promotes lipogenesis at the expense of lipolysis. In addition, the increase in the adipose layer is accompanied by the development and crosslinking of the sclero-hyaline tissue which encapsulates the adipocytes.

 Slimming cosmetic products generally contain active ingredients that stimulate lipolysis. However, the structural modifications of the sclero-hyaline tissue prevent the contact between the active principles and the receptor sites of the adipocytes. If these active agents have a good activity in vitro on adipocytes in culture, they very often have weak or nonexistent activities when they are used by consumers.

 There therefore remains the need for slimming cosmetic compositions capable of both attacking the sclero-hyaline tissue and of stimulating lipolysis.

 Following significant research carried out in the field mentioned above, the Applicant has considered the use of a mucopolysaccharidase in association with escin.

 Thus, in accordance with the object of the present invention, new slimming cosmetic compositions are now proposed which are essentially characterized by the fact that they contain a mucopolysaccharidase and escin.

 The mucopolysaccharidase allows by its enzymatic activity, to eliminate the gangue which surrounds the adipocytes. The escin masks the p-adrenergic receptor sites, present on the adipocyte membrane, and thus activates lipolysis.

 According to a particularly preferred embodiment of the present invention, the mucopolysaccharidase is a hyaluronidase, used in proportions of between 0.001 and 10% by weight relative to the total weight of the composition, when the enzymatic activity is 300,000 IU / g, and preferably between 0.01 and 2%.

According to an advantageous embodiment of the invention,
escine is brought in the form of extract of horse chestnut The steep proportion of the compositions of the invention are preferably between 0.001 and 50% by weight relative to the total weight of the composition, and better still, between 0.1 and 5%.

 The compositions according to the invention may also contain all the constituents conventionally used, in particular other slimming active agents, in cosmetic slimming compositions such as for example the xanthic derivatives (caffeine, theophylline), the organic silicon derivatives (monomethylsilanetriol, dimethyl silanol). Their preferred proportion is between 1 and 20% by weight relative to the total weight of the composition, and better still between 1 and 10%.

 The composition according to the invention can be in all the galenical forms conventionally used in cosmetic compositions.

 Concrete, but in no way limiting, examples illustrating the invention will now be given.

Example 1:
Mucopolysaccharidase 0, 1%
Escine 2%
0.2% steareth-20
0.25% methyl paraben
0.01% calcium chloride
Magnesium chloride 0.01%
Water qs 100%
Steareth- 2 1.3%
Cetyl stearyl alcohol 4%
Myristyl myristate 4%
Isopropyl myristate 4%
Glycerin 1%
Dimethicone 0.5%
Lanolic alcohols 0.5%
Propyl paraben 0.25%
Example 2:
Mucopolysaccharidase 0.05%
Escin 0.1%
2% silicon
0.2% steareth-20
0.25% methyl paraben
0.01% calcium chloride
Magnesium chloride 0.01%
Water qs. 100%
Steareth-2 1.3%
Cetyl stearyl alcohol 4%
Myristyl myristate 4%
Isopropyl myristate 4%
Glycerin 1%
Dimethicone 0.5%
Lanolic alcohols 0.5%
Propyl paraben 0.25%
Example 3
Mucopolysaccharidase 0.05%
Escin 0.1%
Theophylline 0.5%
Caffeine 0.5%
0.2% steareth-20
0.25% methyl paraben
0.01% calcium chloride
Magnesium chloride 0.01%
Water qs. 100%
Steareth-2 1.3%
Cetyl stearyl alcohol 4%
Myristyl myristate 4%
Isopropyl myristate 4%
Glycerin 1%
Dimethicone 0.5%
Lanolic alcohols 0.5%
Propyl paraben 0.25%

Claims (8)

 1 - Slimming cosmetic compositions characterized by the fact that they contain a mucopolysaccharidase and escin.  2 - Compositions according to claim i, characterized in that said mucopolysaccharidase is a hyaluronidase.  3 - Compositions according to claim 2, characterized in that the hyaluronidase content is between 0.001 and 10% by weight relative to the total weight of the composition.  4 - Compositions according to claim 3 characterized in that said content is between 0.01 and 2%.  5 - Compositions according to any one of the preceding claims, characterized in that the escine content is between 0.001 and 50% by weight relative to the total weight of the composition.  6 - Compositions according to claim 5, characterized in that said content is between 0.1 and 5%.  7 - Compositions according to any one of the preceding claims, characterized in that the escin is provided in the form of extract of chestnut from India.  8 - Compositions according to any one of the preceding claims, characterized in that they contain from 1 to 20% by weight relative to the total weight of the composition, slimming active agents conventionally used in cosmetic slimming compositions, and preferably from 1 to 10%.