FR2773324A1 - Composition for filling in wrinkles by injection - Google Patents
Composition for filling in wrinkles by injection Download PDFInfo
- Publication number
- FR2773324A1 FR2773324A1 FR9800003A FR9800003A FR2773324A1 FR 2773324 A1 FR2773324 A1 FR 2773324A1 FR 9800003 A FR9800003 A FR 9800003A FR 9800003 A FR9800003 A FR 9800003A FR 2773324 A1 FR2773324 A1 FR 2773324A1
- Authority
- FR
- France
- Prior art keywords
- pharmaceutical composition
- glucomannan
- composition according
- wrinkles
- filling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Nouvelles préparations à base de olucomannane
et leur utilisation dans le domaine de la médecine
esthétique et réparatrice
La présente invention se rapporte au domaine de la dermatologie et plus particulièrement à celui de la médecine esthétique.New preparations based on olucomannan
and their use in medicine
aesthetic and restorative
The present invention relates to the field of dermatology and more particularly to that of aesthetic medicine.
L'invention a plus précisément pour objet de nouvelles compositions injectables destinées à combler les dépressions de l'épiderme dues principalement aux rides et aux cicatrices. The invention more specifically relates to new injectable compositions intended to fill depressions in the epidermis due mainly to wrinkles and scars.
L'invention concerne spécifiquement de nouvelles compositions à base de
Glucomannane et caractérisées en ce qu'elles contiennent principalement des fibres d'origine végétale hydrosolubles gélifiantes et douées d'une très grande viscosité.The invention relates specifically to new compositions based on
Glucomannan and characterized in that they mainly contain fibers of water-soluble gelling vegetable origin and endowed with a very high viscosity.
Le comblement des rides et cicatrices s'effectue classiquement par l'injection sous cutanée de matériaux de comblement. The filling of wrinkles and scars is conventionally carried out by subcutaneous injection of filling materials.
Les matériaux utilisés sont la plupart du temps des gels d'origine animale bovine comme les collagènes ou aviaires comme l'acide hyaluronique.The materials used are mostly gels of bovine animal origin such as collagens or avians such as hyaluronic acid.
L'utilisation de ces gels n'est pas sans poser de problèmes notamment par le risque de transmission virale et, ou de réactions antigéniques.The use of these gels is not without problems, in particular by the risk of viral transmission and, or of antigenic reactions.
D'autre part les collagènes sont biodégradables et leur efficacité s'amenuise avec le temps ce qui nécessite des interventions successives pour maintenir les résultats souhaités.On the other hand, collagens are biodegradable and their effectiveness decreases over time, which requires successive interventions to maintain the desired results.
Il s'est avéré intéressant de mettre au point de nouvelles substances gélifiantes d'origine végétale et destinées à etre utilisées en médecine esthétique et réparatrice.It has proven to be interesting to develop new gelling substances of plant origin and intended for use in aesthetic and restorative medicine.
Cet objectif est réalisé avec les compositions selon l'invention qui associent une ou plusieurs fibres d'origine végétale ou synthétique seules ou en mélanges.This objective is achieved with the compositions according to the invention which combine one or more fibers of plant or synthetic origin alone or in mixtures.
Le glucomannane, principal constituant du Konjac appelé aussi Konyaku répond parfaitement à ces critères de choix.Glucomannan, the main constituent of Konjac, also called Konyaku, perfectly meets these selection criteria.
Le glucomannane est extrait d'un bulbe végétal l'Amorphophallus Rivieri variété
Konjac dénommé Konjac ou Konyaku cultivé traditionnellement en Asie. Glucomannan is extracted from a plant bulb, the Amorphophallus Rivieri variety
Konjac called Konjac or Konyaku traditionally cultivated in Asia.
Arrivé à maturité le bulbe est recueilli puis séché , broyé et purifié selon des méthodes traditionnelles.When mature, the bulb is collected and then dried, crushed and purified according to traditional methods.
Le glucomannanejprincipal constituant du bulbe est un polysaccharide qui forme un gel en présence d'eau à la température ambiante.The main constituent of the bulb glucomannan is a polysaccharide which forms a gel in the presence of water at room temperature.
L'hydrolyse acide compléte ainsi que la chromatographie en phase gazeuse ont permis de déterminer comme seuls constituants de ce polysaccharide le D glucose et le D mannose.The complete acid hydrolysis as well as the gas chromatography made it possible to determine as the only constituents of this polysaccharide D glucose and D mannose.
L'évaluation quantitative du D mannose et du D glucose contenu dans l'hydrolysat indique un rapport moléculaire D mannose / D glucose de 1,6 .The quantitative evaluation of D mannose and D glucose contained in the hydrolyzate indicates a molecular ratio D mannose / D glucose of 1.6.
IL a d'autre part été démontré que le glucomannane était constitué d'une chaîne principale formée uniquement d'une liaison 14 des deux sucres simples selon la séquence présentée sur la formule (I).It has also been demonstrated that glucomannan consists of a main chain formed only of a bond 14 of the two simple sugars according to the sequence presented in formula (I).
Généralement la chaîne est constituée par la succession linéaire de 13 hexoses.
Generally the chain is constituted by the linear succession of 13 hexoses.
Formule linéaire du Glucomannane de Koniac (I)
G= Glucose
M= Mannose
L'extraction du glucomannane s'effectue à partir de la poudre totale du tubercule.Koniac Glucomannan linear formula (I)
G = Glucose
M = Mannose
The glucomannan is extracted from the total powder of the tuber.
Après traitement et broyage on obtient une poudre granuleuse contenant au moins 75 % de Glucomannane.After treatment and grinding, a granular powder is obtained containing at least 75% of Glucomannan.
Le Glucomannane est alors concentré et purifié pour atteindre une pureté d'environ 90% selon diverses méthodes dont la plus fiable est celle de Sugiyama.The Glucomannan is then concentrated and purified to reach a purity of around 90% according to various methods, the most reliable of which is that of Sugiyama.
Les essais ont montré que la poudre de Konjac ne présentait aucune toxicité par voie orale de même que les produits de son hydrolyse c'est à dire le glucose et le mannose, deux sucres bien connus.Tests have shown that Konjac powder had no oral toxicity, as did the products of its hydrolysis, namely glucose and mannose, two well-known sugars.
D'un point de vue physique, le glucomannane en présence d'eau se transforme en gel dont la viscosité peut aller de 10.000 cps à 120.000 cps selon la qualité et la pureté de la matière première.From a physical point of view, glucomannan in the presence of water turns into a gel whose viscosity can range from 10,000 cps to 120,000 cps depending on the quality and purity of the raw material.
Le glucomannane n'est pas dégradé par les enzymes de l'organisme.Glucomannan is not broken down by the body's enzymes.
Les préparations selon l'invention se caractérisent par le fait que les fibres utilisées sont d'origine végétale, dépourvues de toxicité, extrêmement hygroscopique, gélifiantes et non dégradés par l'organisme, caractérisées en ce quelles comprennent de 30 à 99% de Glucomannane à titre de principe actif et de 1% à 70% d'excipients ou de véhicules pharmaceutiques acceptables. The preparations according to the invention are characterized in that the fibers used are of plant origin, devoid of toxicity, extremely hygroscopic, gelling agents and not degraded by the organism, characterized in that they comprise from 30 to 99% of Glucomannan to as active ingredient and from 1% to 70% of acceptable excipients or pharmaceutical vehicles.
Le Glucomannane sera utilisé seul ou associé à des extraits d'algues ou à d'autres fibres végétales comme l'agar agar, la gomme Xanthane, la gomme de sterculia, les extraits de cellulose.Glucomannan will be used alone or combined with seaweed extracts or other plant fibers such as agar agar, Xanthan gum, sterculia gum, cellulose extracts.
Le gel, une fois réalisé après incorporation de la quantité d'eau nécessaire à l'obtention de la viscosité voulue fera l'objet d'une décontamination soit mécanique, soit par rayonnement stérilisant, soit par les deux méthodes.The gel, once produced after incorporating the amount of water necessary to obtain the desired viscosity, will be subject to decontamination either mechanically, or by sterilizing radiation, or by both methods.
La préparation pharmaceutique ainsi obtenue sera alors conditionnée en seringues stériles pré remplies et prêtes à l'emploi. The pharmaceutical preparation thus obtained will then be packaged in sterile syringes pre-filled and ready for use.
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9800003A FR2773324B1 (en) | 1998-01-02 | 1998-01-02 | NOVEL GLUCOMANNAN PREPARATIONS AND THEIR USE IN THE FIELD OF AESTHETIC AND REPAIRING MEDICINE |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9800003A FR2773324B1 (en) | 1998-01-02 | 1998-01-02 | NOVEL GLUCOMANNAN PREPARATIONS AND THEIR USE IN THE FIELD OF AESTHETIC AND REPAIRING MEDICINE |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2773324A1 true FR2773324A1 (en) | 1999-07-09 |
FR2773324B1 FR2773324B1 (en) | 2000-06-16 |
Family
ID=9521506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9800003A Expired - Fee Related FR2773324B1 (en) | 1998-01-02 | 1998-01-02 | NOVEL GLUCOMANNAN PREPARATIONS AND THEIR USE IN THE FIELD OF AESTHETIC AND REPAIRING MEDICINE |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2773324B1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1480654A1 (en) * | 2002-02-15 | 2004-12-01 | Ultraceuticals R&D Pty Limited | Carbohydrate-based anti-wrinkle and tissue remodelling compounds |
FR2940608A1 (en) * | 2008-12-30 | 2010-07-02 | Oreal | USE OF MONOSACCHARIDES AND COMPOSITION |
FR2940610A1 (en) * | 2008-12-30 | 2010-07-02 | Oreal | ASSOCIATION OF MONOSACCHARIDES WITH C-GLYCOSIDE DERIVATIVES AND ITS USE IN COSMETICS |
US20100255076A1 (en) * | 2007-10-04 | 2010-10-07 | Ultraceuticals R & D Pty Ltd | Composition and method for dermal regeneration |
EP3040104A1 (en) * | 2014-12-29 | 2016-07-06 | Shyam Prasad Kodimule | Compositions of amorphophallus konjac extract and methods for their use in skin care |
US9421157B2 (en) | 2006-07-03 | 2016-08-23 | L'oreal | Use of C-glycoside derivatives as pro-desquamating active agents |
FR3098719A1 (en) * | 2019-07-19 | 2021-01-22 | Laboratoire Promicea | New makeup and / or lip care composition |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2120009A1 (en) * | 1970-12-30 | 1972-08-11 | Shimizu Manzo Shoten Kk | |
JPS5795905A (en) * | 1980-12-05 | 1982-06-15 | Kyoei Kagaku Kogyo Kk | Cosmetic |
JPH0761938A (en) * | 1993-08-25 | 1995-03-07 | Shimizu Kagaku Kk | Medicinal composition for external use consists of hydrophilic polysaccharides |
-
1998
- 1998-01-02 FR FR9800003A patent/FR2773324B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2120009A1 (en) * | 1970-12-30 | 1972-08-11 | Shimizu Manzo Shoten Kk | |
JPS5795905A (en) * | 1980-12-05 | 1982-06-15 | Kyoei Kagaku Kogyo Kk | Cosmetic |
JPH0761938A (en) * | 1993-08-25 | 1995-03-07 | Shimizu Kagaku Kk | Medicinal composition for external use consists of hydrophilic polysaccharides |
Non-Patent Citations (2)
Title |
---|
DATABASE WPI Section Ch Week 9518, Derwent World Patents Index; Class B04, AN 95-136799, XP002079724 * |
PATENT ABSTRACTS OF JAPAN vol. 006, no. 180 (C - 125) 14 September 1982 (1982-09-14) * |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1480654A1 (en) * | 2002-02-15 | 2004-12-01 | Ultraceuticals R&D Pty Limited | Carbohydrate-based anti-wrinkle and tissue remodelling compounds |
EP1480654A4 (en) * | 2002-02-15 | 2007-11-14 | Ultraceuticals R & D Pty Ltd | Carbohydrate-based anti-wrinkle and tissue remodelling compounds |
US9421157B2 (en) | 2006-07-03 | 2016-08-23 | L'oreal | Use of C-glycoside derivatives as pro-desquamating active agents |
EP2229175A4 (en) * | 2007-10-04 | 2015-06-17 | Ultraceuticals R & D Pty Ltd | Composition and method for dermal regeneration |
US20100255076A1 (en) * | 2007-10-04 | 2010-10-07 | Ultraceuticals R & D Pty Ltd | Composition and method for dermal regeneration |
AU2008307152B2 (en) * | 2007-10-04 | 2013-10-10 | Ultraceuticals R & D Pty Ltd | Composition and method for dermal regeneration |
US9433805B2 (en) * | 2007-10-04 | 2016-09-06 | Ultraceuticals R&D Pty Ltd. | Method for dermal regeneration by administering an ether cross-linked glucomannan/hyaluronic acid composition |
EP2204162A1 (en) * | 2008-12-30 | 2010-07-07 | L'oreal | Use of monosaccharides and composition |
EP2206491A1 (en) * | 2008-12-30 | 2010-07-14 | L'oreal | Association of monosaccharides and C-glycoside derivatives and its use in cosmetics |
US8445459B2 (en) | 2008-12-30 | 2013-05-21 | L'oreal | Combination of monosaccharide with C-glycoside derivative and use thereof |
FR2940610A1 (en) * | 2008-12-30 | 2010-07-02 | Oreal | ASSOCIATION OF MONOSACCHARIDES WITH C-GLYCOSIDE DERIVATIVES AND ITS USE IN COSMETICS |
US9364411B2 (en) | 2008-12-30 | 2016-06-14 | L'oreal | Use of monosaccharides and composition therefor |
FR2940608A1 (en) * | 2008-12-30 | 2010-07-02 | Oreal | USE OF MONOSACCHARIDES AND COMPOSITION |
EP3040104A1 (en) * | 2014-12-29 | 2016-07-06 | Shyam Prasad Kodimule | Compositions of amorphophallus konjac extract and methods for their use in skin care |
FR3098719A1 (en) * | 2019-07-19 | 2021-01-22 | Laboratoire Promicea | New makeup and / or lip care composition |
Also Published As
Publication number | Publication date |
---|---|
FR2773324B1 (en) | 2000-06-16 |
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