FR2754424A1 - Synergistic plant fungicides for seed treatment - Google Patents

Abstract

Fungicidal compositions comprise at least one compound of formula (I) and a triazole fungicide selected from triticonazole, flutriafol, difenoconazole and triadimenol, the (I) : fungicide weight ratio being 0.01-30, preferably 0.03-20. A = N or -CH; B = pyrimidinyl-2,4-dioxy; R1 = 1-4C alkyl; R2 = OCH3 or NHCH3; X = halo, CN or 1-4C alkyl, preferably methyl, with X preferably being in the 2 and/or 4 position; n = 1 or 2 ; provided that when n is 2, then X are different

Description

 Synergistic fungicidal composition comprising a triazole compound

 The present invention relates to a synergistic fungicidal composition for seed treatment comprising a triazole compound in combination with a strobilurin-like compound and a method using said composition and intended to protect, curatively or preventatively, the cultures against fungal attacks.

 It also relates to a process for protecting seeds and resulting plants against fungal diseases.

 Fungicidal triazole compounds are known to prevent the growth and development of phytopathogenic fungi that can attack crops.

 However, it is still desirable to improve the spectrum of activity and the effectiveness of such fungicidal compounds, or to strengthen them by combining them with other molecules in order to obtain a more effective product or to prevent it. appearance of fungal strains resistant to these new fungicides.

 It is also very desirable to have fungicidal products having an improved persistence of action, such as to space out the number of phytosanitary treatments necessary for good pest control over time.

 In any case, it is particularly advantageous to be able to reduce the quantity of chemicals spread in the environment, while ensuring effective protection of the crops against fungal attack, and to widen the possibilities of choice offered to the farmer, so that It finds the solution best suited to its particular problem.

 It has now been found that one (or more) of the foregoing objectives could be achieved by the fungicidal composition of the present invention.

dans laquelle:
A est l'atome d'azote ou le groupe -CH,
B est le groupe

The subject of the present invention is therefore, first of all, a synergistic fungicidal composition for seed treatment comprising at least one compound A of formula (I):

in which:
A is the nitrogen atom or the group -CH,
B is the group

R 1 is an alkyl group of 1 to 4 carbon atoms, preferably the methyl group,
R2 is -OCH3 or -NHCH3,
X is a halogen atom, the cyano group or an alkyl group of 1 to 4 carbon atoms, preferably the methyl group, preferably X is in position 2 and / or 4,
n is equal to 1 or 2, with when n is equal to 2 the possibility of having different groups X,
and at least one triazole fungicidal compound B selected from the group consisting of triticonazole, flutriafol, difenoconazole, triadimenol.

 The fungicidal composition according to the invention advantageously comprises the components A and B in a weight ratio A / B of between 0.01 and 30, preferably between 0.03 and 20.

 It is understood that said fungicidal composition may contain a single compound B or more than one such compound, for example 1, 2 or 3 compounds B according to the use for which it is intended. Similarly, the composition may comprise more than one compound A.

 The fungicidal composition according to the invention for which compound A is methyl- (E) - {2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy] phenyl-3-methoxyacrylate is preferred.

Among the more especially preferred meanings of compound B defined above, triticonazole is still preferred. Triticonazole is known for its fungicidal efficacy, in particular by the Pesticide Manual 10th edition, published by the British Crop Protection Council, page 1033, and by patent application EP 378953. However, the effectiveness of this compound is not quite certain. satisfactory, particularly with regard to powdery mildew in cereals (due to
Erisyphus graminis), wheat leaf blotch, or barley leaf blight.

 In a completely unexpected manner, the composition according to the invention then appreciably improves the action of the active ingredients taken separately for a number of fungi which are particularly harmful for the crops.

This improvement is reflected in particular by a decrease in the doses of each of the constituents, which is particularly advantageous for the user and the environment. The fungicidal product thus has synergistic properties attested by the application of the method defined by Limpel, LE, PH Schuldt and
D. Lammont, 1962, Proc. NEWCC 16: 48-53, using the following formula, also called Colby's formula:
E = X + YX.Y / 100
in which:
- E is the expected percentage inhibition of growth of the fungus by a mixture of the two fungicides A and B at defined doses, respectively equal to a and b;
X is the percentage inhibition observed by the fungicide A at the dose a,
Y is the percentage inhibition observed by the fungicide B at the dose b.

When the observed percentage inhibition of the mixture is greater than E, there is synergy. The difference between this percentage obtained (practical efficiency) and E (theoretical efficiency) is called gain of activity (gain) in the rest of this document.

 Preferably, when the component B is triticonazole, the ratio A / B is between 0.03 and 30, preferably between 0.08 and 10 for all the crops envisaged.

Compounds A, analogs of strobilurin, and especially methyl (E) -12- [6- (2-cyanophenoxy) pyrimidin-4-yloxy] phenyl-3-methoxyacrylate (or ICIA5504 or else azoxystrobin), are described in US Pat. international demand
WO 9208703. In addition, ICIA5504 is listed in the book "The pesticide manual" cited below.

The structures corresponding to the common names of the fungicidal active ingredients in the definition of B are given in at least one of the following 2 works:
- "The pesticide manual" published by Clive TOMLIN and published by the
British Crop Protection Council, 10th edition;
- the 1996 phytosanitary index, published by the Association de
Agricultural Technical Coordination, 32nd edition.

 The fungicidal composition according to the invention comprises, as active ingredient, at least one compound A and at least one compound B in admixture with solid or liquid carriers, acceptable in agriculture and / or surfactants also acceptable in agriculture. In particular, the usual inert carriers and surfactants are usable. These compositions not only cover the compositions that are ready to be applied to the seed to be treated by means of a suitable device, such as a spraying or dusting device, but also the commercial concentrated compositions that must be diluted before application to the culture. . Active ingredient means the combination of at least one compound A with at least one compound B.

 These compositions may also contain any other kind of ingredients such as, for example, protective colloids, adhesives, thickeners, thixotropic agents, penetration agents, stabilizers, sequestering agents, etc. More generally the compounds A and B can be combined with any solid or liquid additives corresponding to the usual techniques of formulation.

 In general, the compositions according to the invention usually contain from 0.05 to 95% (by weight) of active material, one or more solid or liquid carriers and, optionally, one or more surfactants.

 By the term "carrier" in this specification is meant an organic or inorganic material, natural or synthetic, with which the active ingredient is combined to facilitate its application to parts of the plant. This support is therefore generally inert and must be acceptable in agriculture. The support may be solid (clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, etc.) or liquid (water, alcohols, especially butanol, etc.).

 The surfactant may be an emulsifier, dispersant or wetting agent of ionic or nonionic type or a mixture of such surfactants. There may be mentioned, for example, salts of polyacrylic acids, salts of lignosulfonic acids, salts of phenolsulphonic or naphthalenesulphonic acids, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines. substituted phenols (especially alkylphenols or arylphenols), salts of sulfosuccinic acid esters, taurine derivatives (especially alkyltaurates), phosphoric esters of polyoxyethylated alcohols or phenols, acid esters and polyols, sulfates, sulfonates and phosphates-based derivatives of the foregoing compounds. The presence of at least one surfactant is generally indispensable when the active ingredient and / or the inert carrier are not soluble in water and the application carrier agent is water.

 Thus, the compositions for agricultural use according to the invention may contain the active ingredient within very wide limits, ranging from 0.05% to 95% (by weight). Their content of surfactant is advantageously between 5% and 40% by weight. Unless otherwise indicated the percentages given in this specification, including the claims, are by weight.

 These compositions according to the invention are themselves in quite diverse forms, solid or liquid.

 As forms of solid compositions, mention may be made of dusting powders (with an active matter content of up to 100%) and granules, in particular those obtained by extrusion, by compacting, by impregnation of a granulated support, by granulation from a powder (the content of active material in these granules being between 0.5 and 80% for the latter cases).

 The fungicidal composition according to the invention can also be used in the form of dusting powders; a composition comprising 50 g of active material and 950 g of talc can also be used; a composition comprising 20 g of active material, 10 g of finely divided silica and 970 g of talc can also be used; these constituents are mixed and milled and the mixture is applied by dusting.

 As forms of liquid compositions or intended to constitute liquid compositions during application, mention may be made of solutions, in particular water-soluble concentrates, emulsions, concentrated suspensions, wettable powders (or powder for spraying). .

 The concentrated suspensions, applicable in spraying, are prepared in such a way as to obtain a stable fluid product which does not settle and usually contain from 10 to 75% of active substance, from 0.5 to 15% of surfactants, from 0 to 1 to 10% of thixotropic agents, from 0 to 10% of suitable additives, such as antifoams, corrosion inhibitors, stabilizers, penetrating agents and adhesives and, as carrier, water or an organic liquid in which the active ingredient is little or not soluble: some organic solids or mineral salts can be dissolved in the support to help prevent sedimentation or as antifreezes for water.

For example, here is a concentrated suspension composition:
Example SC 1:
active ingredient 500 g
- polyethoxylated tristyrylphenol phosphate 50 g
polyethoxylated alkylphenol 50 g
- sodium polycarboxylate 20 g
- ethylene glycol 50 g
- organopolysiloxane oil (antifoam) 1 g
- polysaccharide 1.5 g
water 316.5 g
Wettable powders (or spray powder) are usually prepared to contain from 20 to 95% active ingredient, and usually contain, in addition to the solid support, from 0 to 30% of a wetting agent, at 20% of a dispersing agent, and, when necessary, from 0.1 to 10% of one or more stabilizers and / or other additives, such as penetrating agents, adhesives, or anti-caking agents, dyes, etc.

 In order to obtain the spraying powders or wettable powders, the active ingredients in the appropriate mixers are intimately mixed with the additional substances and milled with suitable mills or other mills. Spray powders are thus obtained, the wettability and suspension of which are advantageous; they can be suspended with water at any desired concentration and these suspensions can be used very advantageously, especially for application to, for example, plant leaves or seeds.

By way of example, here are various compositions of wettable powders (or powders for spraying):
Example PM 1
- active ingredient 50%
- ethoxylated fatty alcohol (wetting agent) 2.5%
- ethoxylated phenylethylphenol (dispersing agent) 5%
- chalk (inert support) 42.5%
Example PM 2:
- active ingredient 10%
- oxo synthetic alcohol of branched type, in
C13 ethoxylated with 8 to 10 ethylene oxide
(wetting agent) 0.75%
- neutral calcium lignosulfonate (agent
dispersant) 12%
- calcium carbonate (inert filler) qs 100%
Example PM 3:
This wettable powder contains the same ingredients as in the previous example, in the following proportions:
- active ingredient 75%
- wetting agent 1.50%
- dispersing agent 8%
- calcium carbonate (inert filler) qs 100%
Exempt PM 4:
- active ingredient 90%
- ethoxylated fatty alcohol (wetting agent) 4%
- ethoxylated phenylethylphenol (dispersing agent) 6%
Exempt PM 5:
- active ingredient 50%
- mixture of anionic surfactants and
nonionic (wetting agent) 2.5%
- sodium lignosulfonate (dispersing agent) 5%
- kaolinic clay (inert support) 42.5%
The aqueous dispersions and emulsions, for example the compositions obtained by diluting with water a wettable powder according to the invention, are included in the general scope of the present invention. The emulsions may be of the water-in-oil or oil-in-water type and may have a thick consistency such as that of a "mayonnaise".

 The fungicidal compositions according to the invention may be formulated in the form of water-dispersible granules also included in the scope of the invention.

 These dispersible granules, having an apparent density generally of between approximately 0.3 and 0.6, have a particle size generally of between approximately 150 and 2000 and preferably between 300 and 1500 microns.

 The active ingredient content of these granules is generally between about 1% and 90%, and preferably between 25% and 90%.

 The rest of the granule is essentially composed of a solid filler and optionally surfactant adjuvants conferring on the granule properties of dispersibility in water. These granules can be essentially of two distinct types depending on whether the charge retained is soluble or not in water. When the filler is water soluble, it may be inorganic or, preferably, organic. Excellent results have been obtained with urea. In the case of an insoluble filler, it is preferably mineral, such as kaolin or bentonite. It is then advantageously accompanied by surfactants (in a proportion of 2 to 20% by weight of the granule) of which more than half is, for example, constituted by at least one dispersing agent, essentially anionic, such as polynaphthalene. alkali or alkaline earth metal sulphonate or an alkali or alkaline earth lignosulfonate, the remainder being nonionic or anionic wetting agents such as an alkaline or alkaline earth alkyl naphthalene sulphonate.

 On the other hand, although not essential, other adjuvants such as antifoam agents may be added.

 The granulate according to the invention can be prepared by mixing the necessary ingredients and then granulating according to several techniques known per se (dredger, fluid bed, atomizer, extrusion, etc ...). It is generally finished by crushing followed by sieving at the particle size chosen within the limits mentioned above. It is also possible to use granules obtained as above and then impregnated with a composition containing the active ingredient.

 Preferably, it is obtained by extrusion, operating as indicated in the examples below.

Example GDt: dispersible granules
In a mixer, 90% by weight of active ingredient is mixed with
10% urea beads. The mixture is then milled in a pin mill.

A powder is obtained which is moistened with about 8% by weight of water. The wet powder is extruded in a perforated roll extruder. A granule is obtained which is dried, then crushed and sieved so as to keep only the granules with a size of between 150 and 2000 microns respectively.

Example GD2: Dispersible granules
In a mixer, the following constituents are mixed:
- active ingredient 75%
- wetting agent (sodium alkylnaphthalene sulphonate) 2%
- dispersing agent (sodium polynaphthalene sulphonate) 8%
- inert load insoluble in water (kaolin) 15%
This mixture is granulated in a fluid bed, in the presence of water, then dried, crushed and sieved so as to obtain granules with a size of between 0.15 and 0.80 mm.

 These granules can be used alone, in solution or dispersion in water so as to obtain the desired dose. They can also be used to prepare combinations with other active ingredients, especially fungicides, the latter being in the form of wettable powders, or aqueous granules or suspensions.

 As regards the compositions suitable for storage and transport, they more preferably contain from 0.5 to 95% (by weight) of the combination of triazole, preferably triticonazole, and compound A.

 n may be the concentrated composition that is to say the commercial product combining triticonazole and compound A. It may also be the diluted composition ready to be applied to the seeds to be treated. In the latter case the dilution with water can be carried out either from a commercial concentrated composition containing triticonazole and compound A (this mixture is called "ready to use" or "ready mix", in the language English), or by means of the extemporaneous mixture (called "tank mix") of two commercial concentrated compositions each containing triticonazole or compound A.

 The compositions according to the invention are useful for treating seeds of cereals (wheat, rye, triticale and barley in particular), potatoes, cotton, peas, rapeseed, maize, linseed or seeds of forest trees (especially softwood).

It should be noted in this connection that in the jargon of the skilled person, the term "seed treatment" refers to the treatment of seeds. Application techniques are well known to those skilled in the art and can be used without disadvantage in the context of the present invention. For example, film-coating or coating may be mentioned.

 Another subject of the invention is a method of controlling, as a curative or preventive measure, phytopathogenic fungi in crops, characterized in that a non-phytotoxic effective amount of a combination of seeds is applied to the seeds of the plants. at least one compound A and at least one compound B, for example in a fungicidal composition according to the invention.

 By "effective and non-phytotoxic amount" is meant a quantity of composition according to the invention which is sufficient to allow the control or destruction of fungi present or likely to appear on the cultures, and which does not cause for said cultures any noticeable symptoms of phytotoxicity.

Such an amount is likely to vary within wide limits depending on the fungus to be fought, the type of culture, the climatic conditions, and the compounds included in the fungicidal composition according to the invention. This amount can be determined by systematic field tests, within the reach of the skilled person.

 The invention finally relates to a method of preventive or curative protection of plant propagation products, and plants resulting therefrom, against fungal diseases, characterized in that said products are coated with an effective dose and not phytotoxic composition of the invention.

 Among the multiplication products of the plants concerned, mention may in particular be made of seeds or seeds, and tubers.

 It is preferred to use the method according to the invention in the case of seeds.

 As indicated above, the methods for recovering plant propagation products, in particular seeds, are well known in the art and make particular use of film-coating or coating techniques.

Among the plants targeted by the method according to the invention, mention may be made of:
- wheat, as regards the fight against the following diseases of the seeds: fusarioses (Microdochium nivale and Fusarium roseum), caries (Tilletia caries, Tilletia controversa or Tilletia indica), septoria (Septoria nodorum);
- Wheat, with regard to the control of the following diseases of the aerial parts of the plant: the pied-trotter (Pseudocercosporella herpotricholdes), the foot-and-mouth disease (Gaeumannomyces graminis), the Fusarium blight (F. culmorum, F. graminearum) ), rhizoctonia (Rhizoctonia cerealis), powdery mildew (Erysiphe graminisforma specie tritici), rust (Puccinia striifonnis and Puccinia recondita) and septoria diseases (Septoria tritici and Septoria nodorum);
- barley, as regards the control of the following seed diseases: helminthosporiosis (Pyrenophora graminea, Pyrenophora teres and Cochliobolus sativus), bare smut (Ustilago nuda) and fusariosis (Microdochium nivale and Fusarium roseum);
- barley, with regard to the control of the following diseases of the aerial parts of the plant, the swedespot (Pseudocercosporella herpotrichoides), the helminthosporiosis (Pyrenophora teres and Cochliobolus sativus), the powdery mildew (Erysiphe graminis forma specie hordei) , dwarf rust (Puccinia hordei) and rhynchosporiosis (Rhynchosporium secalis);
- potatoes, as regards the control of tuber diseases (in particular Helminthosporium solani, Phoma tuberosa, Rhizoctonia solani, Fusarium solani);
- cotton, with regard to the control of the following diseases of young plants derived from seeds: root fern and neck necrosis (Rhizoctonia solani, Fusarium oxysporum), black root rot (Thielaviopsis basicola);
- pea, as regards the control of the following seed diseases: anthracnose (Ascochyta pisi, Mycosphaerella pinodes), fusarium wilt (Fusarium oxysporum), gray mold (Botrytis cinerea)
- rapeseed, as regards the control of the following diseases of seeds: Phoma lingam and Alternaria brassicae;
- maize, as regards the control of seed diseases (Rhizopus sp., Phytium sp., Penicillium sp., Trichoderma sp., Aspergillus sp.
Gibberella fujikuroif);
- flax, as regards the fight against seed disease
Alternaria linicola;
- forest trees, with regard to the control of furrow (Fusarium oxysporum, Phytium sp., Rhizoctonia solani).

 Wheat and barley are the preferred plants for carrying out the method according to the invention.

 The dose of composition applied is, in general, advantageously such that the dose of triazole is between 2 and 200 g / 100 kg, preferably between 3 and 150 g / 100 kg, and the dose of compound A is included between 2 and 60 g / 100 kg, preferably between 5 and 60 g / 100 kg, ie a total dose of composition according to the invention of between 4 and 260 g / q (quintal), preferably between 8 and 210 g / q.

 The dose of composition applied is, in general, advantageously such that the dose of triticonazole is between 2 and 150 g / 100 kg, preferably between 3 and 120 g / 100 kg, and that the dose of compound A is comprised between 5 and 60 g / 100 kg, preferably between 10 and 30 g / 100 kg, ie a total dose of composition according to the invention of between 7 and 210 g / q, preferably between 13 and 150 g / q.

 The invention finally relates to a product comprising at least one compound A and at least one compound B for the control of phytopathogenic fungi of a medium by simultaneous, sequential or separate application.

 The following examples are given without limitation of the advantageous properties of the compositions according to the invention and demonstrate a synergistic effect according to the definition of Colby.

Example: Tests on Microdochium nivale of wheat and Pyrenophora graminea of barley.

The compounds used in this example are:
for compound A: starting from a concentrated suspension for the treatment of 250 mg azoxystrobin seeds employed at the doses of 0.3-0.6-1.2-2.5 and 5 g / q.

 for compound B: starting from a concentrated suspension for triticonazole seed treatment at 21 such used at doses of 0.15-0.6-1.2-2.5 and 5 g / q.

 -for associations: doses and dose ratios are clearly shown in the table below.

a) doubled case:
Naturally contaminated hybrid wheat (Hynoprecia var.) Seeds (4346%) are treated with both fungicides and mixtures at the rates indicated in the table below and then sown in a peat moss substrate at a rate of 25%. seeds / pot (4 repetitions per dose). The pots are placed in a culture cell at 5 ° C. for 24 days and then placed at 10 ° C. for an additional 7 days, and then transported in a greenhouse under natural light at 20 ° C. The grading is done 35 days after sowing. It consists of counting the healthy plants (plants having raised and not having the typical necrosis at the base of the stem). Compared to an untreated control, the efficiency percentage obtained is calculated using the following formula:
% efficiency E = (% contamination T -% contamination E /% contamination T) xt00
where E = Test and T = Control.

 Using the aforementioned Colby formula, the activity gain (in%) of the composition is also determined relative to the products alone (these gain values are in parentheses in the following table).

(b) case of barley:
Barley seeds (var Agneta) naturally contaminated (approx 30%) are treated with both fungicides and mixtures at the doses indicated in the table below and then sown in a substrate (peat-pozzolan mixture). at a rate of 25 seeds / pot (4 repetitions per dose). The pots are placed in culture cell at 5 ° C for 24 days and then placed at 10 ° C for an additional 7 days.

They are then transported in a greenhouse under natural light at 20 ° C. The grading is carried out 42 days after sowing and consists of counting the diseased plants (plants that have emerged and have the typical necrosis along the veins of the barley leaves). Compared to an untreated control, the efficiency percentage obtained is calculated using the following formula
% efficiency E = (% contamination T -% contamination E /% contamination T) x 100
where E = Test and T = Control.

Using the aforementioned Colby formula, the activity gain (in%) of the composition is also determined relative to the products alone (these gain values are in parentheses in the following table).

<Tb>

<SEP> Wheat <SEP> Barley <SEP>
<tb><SEP> Doses <SEP> (glu) <SEP> Eff. <SEP> obtained <SEP>% <SEP> (gain) <SEP> Eff. <SEP> obtained <SEP>% <SEP> (gain)
<tb><SEP> 0.15 <SEP> 7.4 <SEP> 32.0
<tb><SEP> 0.6 <SEP> 2.3 <SEP> 41.6
<tb><SEP> Compound <SEP> B <SEP> 1,2 <SEP> 9.5 <SEP> 38.6
<tb> (triticonazole) <SEP> 2.5 <SEP> 9.5 <SEP> 50.4
<tb><SEP> 5 <SEP> 8.4 <SEP> 71.8
<tb><SEP> 0.3 <SEP> 18.7 <SEP> 63.7
<tb><SEP> 0.6 <SEP> 63.8
<tb><SEP> Compound <SEP> A <SEP> 1,2 <SEP> 15.6 <SEP> 88.0 <SEP>
<tb> (azoxystrobin) <SEP> 2.5 <SEP> 28.0 <SEP> 81.2
<tb><SEP> 5 <SEP> 37.2 <SEP> 94.7
<tb><SEP> 0.6 + 0.6 <SEP> 95.0 (16.1) <SEP>
<tb><SEP> B / A <SEP> 1,2 + 1,2 <SEP> 24,9 (1,3) <SEP> 95,0 (2,4) <SEP>
<tb><SEP> ratio <SEP> 1/1 <SEP> 2.5 + 2.5 <SEP> 36.2 <SEP> (1.4) <SEP> 97, 5 <SEP> (6.8 )
<tb><SEP> 5 + 5 <SEP> 50.6 <SEP> (8.1) <SEP> 100.0 (1.5)

Claims (10)

B is the group A is the nitrogen atom or the group -CH,  in which:

 1. A synergistic fungicidal composition for seed treatment comprising at least one compound A of formula (I):  said composition comprising components A and B in a weight ratio A / B of between 0.01 and 30, preferably between 0.03 and 20.  and at least one triazole fungicidal compound B selected from the group consisting of triticonazole, flutriafol, difenoconazole, triadimenol,  n is equal to 1 or 2, with when n is equal to 2 the possibility of having different groups X,  X is a halogen atom, the cyano group or an alkyl group of 1 to 4 carbon atoms, preferably the methyl group, preferably X is in position 2 and / or 4,  R2 is -OCH3 or -NHCH3,  R 1 is an alkyl group of 1 to 4 carbon atoms, preferably the methyl group, 2. Fungicidal composition according to claim 1, characterized in that the compound A is methyl- (E) - (2- [6- (2-cyanophenoxy) pyrimidin-4-yloxy] phenyl} -3-methoxyacrylate and the compound B is triticonazole. 3. Fungicidal composition according to any one of claims 1 or 2, characterized in that the ratio A / B is between 0.03 and 30, preferably between 0.08 and 10. 4. Fungicidal composition according to any one of claims 1 to 3, characterized in that it comprises the compounds A and B in admixture with solid or liquid carriers acceptable in agriculture and / or surfactants also acceptable in agriculture. 5. Fungicidal composition according to any one of claims 1 to 4, characterized in that it comprises from 0.05 to 95% (by weight) of active material. 6. A method for controlling the phytopathogenic fungi of a medium, characterized in that at least one compound A and at least one compound B are applied to said medium, said compounds being as defined in claim 1, and the combination of these compounds being in a synergistic and non-phytotoxic effective total amount 7. A method for controlling, curative or preventive, against phytopathogenic fungi of crops, characterized in that is applied to plant seeds an effective and non-phytotoxic amount of a fungicidal composition according to any one of the claims. 1 to 5. 8. A method for controlling phytopathogenic fungi of cultures according to claim 7, characterized in that a dose of between 4 and 260 g / q, preferably between 8 and 210 g / q, of composition is applied. 9. A method for controlling phytopathogenic fungi of cultures according to claim 8, characterized in that a dose of between 7 and 210 g / q, preferably between 13 and 150 g / q, of composition in which the compound B is triticonazole. 10. A product comprising at least one compound A and at least one compound B for controlling phytopathogenic fungi of a medium by simultaneous, sequential or separate application.