FR2742055A1 - Liquid plant extract mixture - Google Patents

Abstract

A mixture of liquid plant extracts containing the following proportions of the various extracts corresponding to the extraction of the same quantity of fresh plant material: 8-25 wt.% extract from at least one plant containing xanthines, having a lipo-reducing action; 8-25 wt.% extract of at least one plant containing an analogue of vitamin P, having a capillary tonic activity; 5-12 wt.% extract of at least one plant containing flavonoids having anti-oedematous action; 5-12 wt.% horsetail extract; 5-12 wt.% extract of at least one plant containing alginates; 5-12 wt.% extract of at least one plant having tensor activity to firm cutaneous tissue; 5-12 wt.% extract from at least one plant having a counter-irritant activity; and/or 8-20 wt.% extract from at least one plant having antiinflammatory activity.

Description

 The invention relates to mixtures of plant extracts and their uses, in particular for the local symptomatic treatment of localized subcutaneous adipose overloads.

 Localized subcutaneous adipose overloads or localized gynoid lipodystrophies are mainly encountered in the following adipose regions: retrodeltoid, mammary, sub-umbilical, gluteal, retrosacral, hips, thighs (anterior face and internal face at the root of the knee).

 The normal mechanism is a storage of fat in adipocytes, cells located in the hypodermis grouped in small clusters limited by support spans constituting the connective tissue. In this support tissue are the blood vessels that help eliminate metabolites and provide oxygen.

 These fats are transformed according to the body's need into free fatty acids by a process called lipolysis.

 If the mechanism stops, there is an abnormal accumulation of fat in the adipocytes, which constitutes the congestive stage, then compression of the vessels, the circulatory exchanges can no longer take place, which leads to retention of water and toxins: this constitutes the stage of stasis.

 The surrounding collagen fibers densify, nodules are formed with degeneration of the adipocytes. Collagen is becoming scarce, the connective tissue becomes soft and flaccid, prematurely aged. The compressed vascular bundles prevent exchange and lead to peroxidation of unsaturated fatty acids.

Three phenomena coexist in localized lipodystrophy and are self-sustaining:
- formation of cellulite nodules where we observe accumulation of fats, toxins by peroxidation and water;
- degeneration of the surrounding connective support tissue due to attack by collagen and telastin;
- localized circulatory failure.

 Plant extracts form the basis of many slimming products.

 Plants are known, in particular cola, guarana, coffee, tea containing xanthines, the liporeductive action of which is known. In fact, xanthines act by blocking phosphodiesterase and activating adenylcyclase, leading to an increase in the level of cAMP in adipocytes and, consequently, to the release of free fatty acids.

 Plants containing vitamin P analogs are known to have a tonicapillary action.

Examples of such plants include arnica, cypress, mistletoe,
I'hamamelis, sweet clover, horse chestnut, yarrow, holly, verbena, red vine and various citrus fruits.

 In addition, flavonoids have a more or less significant activity on capillary resistance and on protection against adrenaline, thus promoting the synthesis of antilipoperoxidative ATP.

 A certain number of plants such as hydrocotyle, verbena, piloselle, ulmaire, orthosiphon are known for their anti-edematous action, because of their disinfiltrating and tonicapillary action.

 Plants containing silica or alginates are particularly sought after for their activity on tissue regeneration.

 Horsetail is therefore particularly known for its exceptional silica concentration in the plant kingdom.

 Fucus and kelp are well known for their richness in alginates.

 A number of plants are well known for firming the skin tissue from the first applications, thus acting as skin tensors.

 By way of example of plants exhibiting this "tightening" action, we may mention Agrimony, Angelica, Rosehip, Marjoram, Periwinkle, Plantain, Creeping Ivy, Ratanhia, Sage, Geranium.

 Furthermore, it is known to add to the herbal compositions an active principle making it possible to promote the skin penetration of the active principles contained in the plants during their application to the skin.

 To this end, a plant extract with revulsive activity is generally chosen.

 By way of nonlimiting example of plants exhibiting such activity, mention will be made of plants of the renonculaceae family containing protoanemonin which transforms into anemonine during drying of the plant. A well-known example of such plants is clematis.

 The Applicant, pursuing in-depth research with a view to developing herbal compositions for the local symptomatic treatment of localized subcutaneous adipose overloads, has selected plants for their active principles specified above and has produced a considerable number of associations. . It was thus able to determine specific associations and proportions allowing symptomatic synergistic activity to be obtained on the various factors of localized lipodystrophies.

 Thus, the Applicant has more precisely developed new mixtures of liquid plant extracts which find their applications particularly in cosmetic or pharmaceutical compositions, in particular dermatological compositions, intended for the local symptomatic treatment of localized subcutaneous adipose overloads.

 By "liquid extract" is meant within the meaning of the invention extracts obtained by extraction with a liquid solvent from the plants or parts of plants concerned.

 During its research, the applicant also discovered that, among the liquid extracts entering the selected mixtures, some found their application for the first time in the intended treatment. This is the case, in particular, grapefruit extracts.

Thus, according to one of its essential characteristics, the invention relates to a mixture of liquid plant extracts containing, expressed in percentages by weight, the following proportions of different liquid plant extracts, each quantity of liquid extracts obtained corresponding to extracting the same amount of fresh plants:
- 8 to 25% of liquid extract from at least one plant containing xanthines giving said extract liporeductive activity,
- 8 to 25% of liquid extract from at least one plant containing a vitamin P analog giving said extract a tonicapillary activity,
- 5 to 12% of liquid extract from at least one plant containing flavonoids with anti-edematous activity,
- 5 to 12% of horsetail liquid extract,
- 5 to 13% of liquid extract from at least one plant containing alginates,
- 5 to 12% of liquid extract from at least one plant with so-called tensor activity, intended to firm the skin tissue,
- 5 to 12% of liquid extract from at least one plant with repulsive activity, and / or 8 to 20% of liquid extract from at least one plant with anti-inflammatory activity.

 During its research, the Applicant found that the liporeducing activity due to xanthines depended considerably on the doses of xanthines included in the extract, and that in particular, these doses should not be too great.

 This is why, among the plants known for their liporeductive activity due to the presence of xanthines, according to the invention, those with an average xanthine content are preferred. As such, preferably chosen according to the invention as a plant rich in xanthines giving it liporeducing activity, tea or cola.

 Tea has proved to be particularly advantageous according to the invention and it is preferably the leaves and / or tea buds which will be used to prepare the liquid extracts used in the mixtures of the invention.

 As seen above, plants containing vitamin P analogs are known for their tonicapillary activity. Naringin has this activity remarkably. This molecule is advantageously extracted from grapefruit.

 Thus, according to the invention, the grapefruit is advantageously chosen as the plant containing a vitamin P analog.

 It will also be noted that grapefruit is used for the first time in a composition intended for the local symptomatic treatment of localized subcutaneous adipose overloads.

 When grapefruit is used as a source of vitamin P analog, the whole fruit is used for extraction.

 Among the various plants known for their anti-edematous application, namely in particular hydrocotyle, verbena, piloselle, ulmaire, orthosiphon, it is the ulmar that is preferably chosen according to the invention for the quality of the flavonoids contained in this plant. We will preferably choose to prepare the extract containing these flavonoids the ulmaire leaves.

 Among the plants known for their alginate content, the fucus is preferably chosen which associates the presence of organic iodine with the alginate, thus improving the tissue regeneration factor.

 The liquid extract of fucus is preferably obtained from the thales of this plant.

 Among the plants known for their tensor activity, namely agremony, angelica, rose hips, marjoram, periwinkle, plantain, climbing ivy, ratanhia, sage, geranium, the climbing ivy and the extraction is preferably carried out from the wood of this plant, under conditions where the active ingredient is extracted, ensuring the desired tightening activity, namely hederasaponin C.

 As a plant with revulsive activity, a plant from the renonculaceae family is preferably chosen, preferably clematis. The desired active ingredient, namely protoanemonin and / or anemonon, is extracted using a solvent or mixture of solvents.

 As a plant with anti-inflammatory activity, licorice will be chosen for its both revulsive and anti-inflammatory character. The principle which is extracted using a solvent or mixture of solvents is 18ss-glycyrrhetinic acid.

According to a particularly preferred variant of the invention, the plants entering into the mixture of extracts of the invention are the following
-Tea (Thea Sinensis L.) chosen for its liporeductive activity and its average concentration of xanthines.

 - Fucus (Fucus Vesiculosus L.) chosen for its liporeductive activity due to the presence of iodine and for the presence of synergistic alginate of horsetail activity.

- Grapefruit (Citrus Paradisis M.) chosen for its activity similar to that of vitamin P thanks to its very high concentration of naringin
- Ulmaire (Spiroea Ulmaria L.) chosen for its anti-edematous activity complementary to the activity of naringin. This property is due to the flavonic derivatives it contains, namely spiraeoside and monotropitoside.

 - Horsetail (Equisetum Arvense L.) which acts on the synthesis of collagen due to the silica it contains.

 - Climbing ivy (Hedera Helix L.) which has an astringent activity due to the presence of Hedasaponin C which makes it possible to complete the activity due to horsetail.

 - Clematis (Clematis Vitalba L.) which acts as a repellent due to the presence of protoanemonin.

 - Licorice (Glycyrrhiza glabra L.) whose 18ss-glycyrrhetinic acid has a strong anti-inflammatory activity and at the same time the property of increasing the percutaneous penetration of substances applied to the skin.

The mixtures of plant extracts above contain, preferably, the following proportions of the various liquid plant extracts-tea: 8 to 25%
- grapefruit: 8 to 25%
- wrack: 5 to 12%
- ulcer: 5 to 12%
- horsetail: 5 to 12%
- climbing ivy: 5 to 12%
- clematis: 5 to 12% and / or licorice: 8 to 20%.

 The various liquid plant extracts are obtained in a manner well known to those skilled in the art by treatment of the concerned parts of the plants with a solvent or a mixture of solvents chosen for its ability to extract the active fraction concerned.

 The choice of solvent and the conditions of the extraction, in particular the temperature and the duration of the extraction, therefore closely depend on the nature of the plant selected. However, for each plant useful according to the invention, the solvent will preferably be chosen from water, non-toxic alcohols and mixtures of these alcohols with water.

 These alcohols are advantageously chosen from ethanol, propylene glycol, 1,3-butylene glycol, and 3-methoxy-3-methyl-1-butanol.

 Depending on the active principle and its solubility, the proportions of the aqueous and alcoholic extractive phases will be chosen according to the active principle and its solubility.

 Each of the partial liquid extracts constituting the mixture of liquid extracts according to the invention will advantageously comprise from 20 to 65% of extractive aqueous phase.

Indeed, as is well known when it comes to plant extracts intended for phytotherapy, the main aim is to extract from selected plants the major part of the active fraction sought. This is why, it is advantageously sought to take the preferred organs of fresh or dried plants because of their richness in active ingredient selected. So in the case of selected plants, we will preferably choose
- for climbing ivy, its wood,
- for the ulmar, the flowers,
- for clematis, leaves and / or flowers,
- for the wrack, the thales,
- for grapefruit, whole fruit,
- for tea, leaves and / or buds,
- for horsetail, leaves,
- for liquorice, wood.

 For the preparation of each of the extracts which are then mixed, the parts of the selected plants are ground so as to allow optimal extraction with the chosen solvent and the extraction is carried out at a temperature generally between 30 and 50 ° C. depending on the nature of the plant and of the solvent medium retained. The duration of the treatment with the solvent is calculated so as to ensure sufficient contact for complete extraction of the targeted active fraction.

 As has been specified, depending on the active principle and its solubility, more or less importance will be given to one extractive phase with respect to the other. Thus, for example, in the case of the preparation of the grapefruit extract, the two extractive phases will advantageously be in the proportion of 40% of alcoholic phase for 60% of aqueous phase.

 The liquid extracts prepared are then mixed to form the mixture according to the invention.

 A preservative is then advantageously added to the mixture of liquid extracts.

This preservative can be any preservative known for this type of application, for example a mixture of phenoxyethanol, methylparaben, butylparaben, ethylparaben and propylparaben, well known under the trade name.
Phenonip.

 This preservative is preferably added in contents of between 0.2 and 0.5% by weight relative to the mixture of liquid extracts.

 According to another of its essential aspects, the invention also relates to the use of the mixtures of liquid extracts described above for preparing compositions with cosmetic or pharmaceutical activity, in particular dermatological activity, intended for topical action. These compositions preferably contain from 5 to 70% by weight of a mixture as defined above and a cosmetically or pharmaceutically acceptable vehicle.

 By way of example of these compositions, mention may be made of milks, creams, gels.

 The invention relates very particularly to compositions with cosmetic activity containing the mixtures of extracts defined above as well as a cosmetic treatment method, in particular intended for the local symptomatic treatment of localized subcutaneous adipose overloads, which consists in applying to the parts of the body concerned an effective amount of a mixture as defined above or of a cosmetic composition as defined above.

 The compositions defined above allow in particular the treatment of subcutaneous adipose overloads or localized lipodystrophies of gynoid type, localized in particular in the retrodeltoid, mammary, sub-umbilical, gluteal, gluteal regions, at the hips or thighs.

 The effectiveness of the extracts and compositions of the invention has been demonstrated by means of a test which is both simple and significant, described below in the case of subcutaneous adipose overloads located at the level of the thighs (anterior and inner face, at the root of the knee).

 A point is determined on the external face, 20 cm above the joint, the materiality of which is signified by an indelible ink mark over a period of approximately 3 months. At this point, the circumference of the thigh is regularly measured during local treatment with the product and the variations observed are noted.

Claims (13)

 1. Mixture of liquid plant extracts, characterized in that it contains, expressed in percentages by weight, the following proportions of different liquid plant extracts, each quantity of liquid extracts obtained corresponding to the extraction of the same quantity fresh plants:  - 8 to 25% of liquid extract from at least one plant containing xanthines giving said extract liporeductive activity,  - 8 to 25% of liquid extract from at least one plant containing a vitamin P analog giving said extract a tonicapillary activity,  - 5 to 12% of liquid extract from at least one plant containing flavonoids with anti-edematous activity,  - 5 to 12% of horsetail liquid extract,  - 5 to 12% of liquid extract from at least one plant containing alginates,  -5 to 12% of liquid extract from at least one plant with so-called tensor activity, intended to firm the skin tissue,  - 5 to 12% of liquid extract from at least one plant with repulsive activity, and / or 8 to 20% of liquid extract from at least one plant with anti-inflammatory activity.  2. Mixture according to claim 1, characterized in that the plant with liporeductive activity is tea or cola, preferably tea, preferably leaves and / or tea buds.  3. Mixture according to one of claims 1 or 2, characterized in that said vitamin P analog is naringin, said plant containing said vitamin P analog being grapefruit.  4. Mixture according to claim 1 to 3, characterized in that the plant with anti-edematous activity is the ulmaire, preferably the ulmaire leaves.  5. Mixture according to one of claims 1 to 4, characterized in that the plant containing alginates is an alga chosen from the family of fucus and laminaria, preferably thales of fucus.  6. Mixture according to one of claims 1 to 5, characterized in that the plant with tensing activity is climbing ivy, preferably its wood.  7. Mixture according to one of claims 1 to 6, characterized in that the plant with anti-revulsive activity is a plant of the family of renonculaceae, in particular clematis.  8. Mixture according to one of claims 1 to 7, characterized in that the plant with anti-inflammatory activity is licorice.  9. Mixture according to one of claims 1 to 8, characterized in that it contains the following proportions by weight of the different plants:  - tea: 8 to 25%, said extract preferably being obtained from the leaves and / or buds,  - grapefruit: 8 to 25%, said extract preferably being obtained from the whole fruit,  - fucus: 5 to 12%, said extract preferably being obtained from thales,  - ulcer: 5 to 12%, said extract preferably being obtained from flowers,  - horsetail: 5 to 12%, said extract preferably being obtained from the leaves,  - climbing ivy: 5 to 12%, said extract preferably being obtained from wood,  - clematis: 5 to 12%, said extract preferably being obtained from the leaves and / or flowers and / or licorice: 8 to 20%, said extract preferably being obtained from wood.  10. Mixture according to one of claims 1 to 7, characterized in that it also contains 0.2 to 0.5% by weight of a preservative.  11. Cosmetic or pharmaceutical composition, in particular dermatological, intended for topical action, characterized in that it contains from 5 to 70% by weight of a mixture according to one of claims 1 to 10, in the presence of a vehicle cosmetically or pharmaceutically acceptable.  12. Cosmetic treatment method, in particular intended for the local symptomatic treatment of localized subcutaneous adipose overharges, characterized in that it consists in applying to the parts of the body concerned an effective amount of a mixture according to one of claims 1 to 10 or a cosmetic composition according to claim 11.  13. Cosmetic treatment method, in particular intended for the local symptomatic treatment of localized subcutaneous adipose overharges, characterized in that it consists in applying to the parts of the body concerned an effective amount of a cosmetic composition containing from 8 to 25% grapefruit extract.