FR2729050A1 - Synergistic compsn. with microbicidal properties - Google Patents
Synergistic compsn. with microbicidal properties Download PDFInfo
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- FR2729050A1 FR2729050A1 FR9502134A FR9502134A FR2729050A1 FR 2729050 A1 FR2729050 A1 FR 2729050A1 FR 9502134 A FR9502134 A FR 9502134A FR 9502134 A FR9502134 A FR 9502134A FR 2729050 A1 FR2729050 A1 FR 2729050A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
Abstract
Description
COMPOSITIONS RESISTANT A LA DEGRADATION MICROBIENNE
La présente invention conceme de nouvelles compositions, en particulier cosmétiques, dermatologiques, pharmaceutiques ou alimentaires, résistant à, ou permettant de lutter contre, la dégradation microbienne, et comprenant dans un véhicule physiologiquement acceptable, un système à activité microbicide contenant au moins un polyol en C2-C6 en association avec au moins un mono(C3-Cg)alkyl-ou (C3-Cg)alcényléther de glycérol, ledit système étant par ailleurs exempt d'agents conservateurs classiques et ne contenant que des quantités limitées, ou nulles, de monoalcool(s) aliphatique(s).COMPOSITIONS RESISTANT TO MICROBIAL DEGRADATION
The present invention relates to novel compositions, in particular cosmetic, dermatological, pharmaceutical or food compositions, which are resistant to, or which make it possible to combat, microbial degradation, and comprising in a physiologically acceptable vehicle a microbicide-active system containing at least one polyol in C2-C6 in combination with at least one mono (C3-Cg) alkyl- or (C3-Cg) alkenyl ether of glycerol, said system being otherwise free of conventional preservatives and containing only limited, or no, amounts of monoalcohol (s) aliphatic (s).
Pour assurer la conservation de nombreuses compositions, en particulier des compositions cosmétiques, dermatologiques, pharmaceutiques ou alimentaires, on introduit généralement dans ces demières, un ou plusieurs agents conservateurs qui permettent de les protéger de la dégradation engendrée par les microorganismes tels que les bactéries, les levures, ou autres.To ensure the preservation of numerous compositions, in particular cosmetic, dermatological, pharmaceutical or food compositions, one generally introduces in these last, one or more preserving agents which make it possible to protect them from the degradation caused by the microorganisms such as bacteria, yeasts, or others.
Les agents conservateurs les plus couramment employés sont des composés organiques de synthèse parmi lesquels on peut citer, par exemple, I'acide salicylique et ses sels, I'acide sorbique et ses sels, I'acide parahydroxybenzoique, ses sels et ses esters, le 2-bromo 2-nitro 1,3-propanediol (Bronopol),
I'imidazolidinyl urée ou le 2-phénoxyéthanol.The most commonly used preserving agents are synthetic organic compounds among which may be mentioned, for example, salicylic acid and its salts, sorbic acid and its salts, parahydroxybenzoic acid, its salts and esters, 2-bromo 2-nitro 1,3-propanediol (Bronopol),
Imidazolidinyl urea or 2-phenoxyethanol.
D'une manière générale, la plupart des conservateurs classiquement utilisés ou utilisables à ce jour sont régulièrement inscrits sur des listes positives de substances autorisées (voir par exemple la Directive Cosmétique de la C.E.E.In general, most of the preservatives conventionally used or usable to date are regularly registered on positive lists of authorized substances (see for example the Cosmetics Directive of the C.E.E.
76f768-Annexe Vl-Conservateursde mars 1993)
Or, la tendance actuelle, et la législation y afférente, évoluent de plus en plus vers la suppression de ces composés car ils ne sont pas tous totalement dépourvus de toxicité ou d'effets indésirables.76f768-Appendix VI-Conservativesof March 1993)
However, the current trend, and the legislation relating thereto, evolve more and more towards the suppression of these compounds because they are not all totally devoid of toxicity or undesirable effects.
On sait par ailleurs qu'il est possible d'obtenir des compositions présentant une activité microbicide en introduisant dans ces demières des quantités relativement élevées de monoalcools, en particulier de l'alcool éthylique.It is also known that it is possible to obtain compositions having a microbicidal activity by introducing in these relatively high amounts of monoalcohols, in particular ethyl alcohol.
Ainsi dans la demande de brevet EP-A-547 727, il est décrit des compositions aqueuses pour aseptiser la peau et désinfecter les mains, comprenant 35% en poids d'alcool éthylique et 1% en poids de 1 d2-ethylhexyl)glycerylether. Thus, in the patent application EP-A-547 727, there are described aqueous compositions for sanitizing the skin and disinfecting the hands, comprising 35% by weight of ethyl alcohol and 1% by weight of 1 d2-ethylhexyl) glycerylether.
Toutefois, dans le domaine cosmétique notamment, lorsqu'on cherche à éliminer ou limiter la présence des conservateurs traditionnellement employés tout en assurant une protection bactériologique convenable des compositions, on ne peut pas recourir à l'alcool éthylique; en effet, pour que la protection bactériologique par l'alcool éthylique soit efficace, il faut en utiliser de trop fortes proportions, à savoir au moins 35 à 40% en poids, et le plus souvent entre 60 et 80%, et à ces taux élevés en alcool éthylique, les compositions deviennent irritantes et desséchantes pour la peau ou le cuir chevelu, et ne peuvent pas être utilisées dans la plupart des compositions à usages capillaires ou corporels.However, in the cosmetic field in particular, when seeking to eliminate or limit the presence of traditionally used preservatives while ensuring a suitable bacteriological protection of the compositions, one can not use the ethyl alcohol; indeed, for the bacteriological protection by ethyl alcohol to be effective, it is necessary to use too high proportions, namely at least 35 to 40% by weight, and most often between 60 and 80%, and at these rates high in ethyl alcohol, the compositions become irritating and drying for the skin or scalp, and can not be used in most compositions for hair or body use.
Le besoin existe donc encore à ce jour quant à pouvoir disposer de compositions présentant une activité microbicide propre, qui soient exemptes d'agents conservateurs classiques et qui contiennent en outre des quantités limitées, ou nulles, de monoalcools, en particulier d'éthanol.The need therefore still exists so far as to be able to have compositions having a clean microbiocidal activity, which are free from conventional preserving agents and which also contain limited or zero amounts of monoalcohols, in particular ethanol.
Par quantités limitées, on vise plus particulièrement selon la présente invention, des quantités n'excédant pas 15% en poids par rapport à l'ensemble de la composition.In limited quantities, it is more particularly in accordance with the present invention, amounts not exceeding 15% by weight relative to the entire composition.
Ainsi, après de nombreuses recherches menées sur la question, la demanderesse a maintenant découvert, de façon totalement inattendue et surprenante, qu'un système comprenant, dans un véhicule physiologiquement acceptable, au moins un polyol en C2-C6 associé à au moins un mono(Q-
Cg)alkyl-ou (C3-Cg)alcényléther de glycérol, présentait intrinséquement une action antimicrobienne importante et synergique, permettant d'assurer, par sa seule présence, la conservation des compositions dans lesquelles il est introduit.Thus, after much research conducted on the subject, the Applicant has now discovered, in a totally unexpected and surprising manner, that a system comprising, in a physiologically acceptable vehicle, at least one C2-C6 polyol associated with at least one mono (Q-
Cg) alkyl-or (C3-C8) alkenyl ether of glycerol, had intrinsically an important and synergistic antimicrobial action, making it possible to ensure, by its very presence, the preservation of the compositions into which it is introduced.
Cette découverte est à la base de la présente invention.This discovery is the basis of the present invention.
La présente invention a ainsi pour objet de nouvelles compositions résistant à, ou permettant de lutter contre, la dégradation microbienne, et qui sont caractérisées par le fait qu'elles comprennent, dans un véhicule physiologiquement acceptable, un système microbicide contenant au moins un polyol en C2-C6 et au moins un mono(C3-Cg)alkyl-ou (C,-Cg)alcényléther de glycérol, lesdites compositions ne contenant pas plus de 15% en poids de monoalcool(s) aliphatique(s), et étant exemptes d'agents conservateurs.The subject of the present invention is thus novel compositions which are resistant to, or which make it possible to combat, microbial degradation, and which are characterized in that they comprise, in a physiologically acceptable vehicle, a microbicidal system containing at least one polyol in C2-C6 and at least one mono (C3-Cg) alkyl or (C, -Cg) alkenyl ether of glycerol, said compositions containing not more than 15% by weight of aliphatic mono-alcohol (s), and being exempt preservatives.
La présente invention a également pour objet des compositions de ce type à usage cosmétique, dermatologique, pharmaceutique ou alimentaire.The present invention also relates to compositions of this type for cosmetic, dermatological, pharmaceutical or food use.
La présente invention a enfin pour objet l'utilisation d'une association entre au moins un polyol en C2-C6 et au moins un mono(C3-Cg)alkyl-ou (C3-Cg)alcényléther de glycérol, comme unique système microbicide dans des, ou pour la fabrication de, compositions cosmétiques, dermatologiques, pharmaceutiques ou alimentaires.The present invention finally relates to the use of an association between at least one C2-C6 polyol and at least one mono (C3-Cg) alkyl or (C3-Cg) alkenyl ether of glycerol, as the sole microbicidal system in or, for the manufacture of, cosmetic, dermatological, pharmaceutical or food compositions.
Mais d'autres caractéristiques, aspects, objets et avantages de l'invention apparaîtront encore plus clairement à la lecture de la description et des exemples qui suivent.But other features, aspects, objects and advantages of the invention will emerge even more clearly on reading the description and examples which follow.
Le ou les polyols en CTCG qui peuvent être utilisés selon l'invention, sont choisis de préférence parmi la glycérine, le propylèneglycol, le butylèneglycol,
I'isoprèneglycol, le sorbitol, ou un mélange de deux ou plusieurs de ces polyols. The CTCG polyol (s) which can be used according to the invention are preferably chosen from glycerine, propylene glycol and butylene glycol.
Isoprene glycol, sorbitol, or a mixture of two or more of these polyols.
Les mono(C3-Cg)alkyl-ou (C3-Cg)alcényléthers de glycérol utilisables dans le cadre de l'invention, sont des produits connus en soi et sont faciles à préparer; leur fabrication est décrite dans la littérature, en particulier dans E. Baer, H. O. L. The mono (C 3 -C 8) alkyl or (C 3 -C 8) alkenyl ether glycerol that can be used in the context of the invention are products that are known per se and are easy to prepare; their manufacture is described in the literature, in particular in E. Baer, H. O. L.
Fischer - J. Biol. Chem. 140-397-1941.Fischer - J. Biol. Chem. 140-397-1941.
Parmi ces mono(C3-Cg)alkyl-ou (C3-Cg)alcényléther de glycérol, on préfère mettre en oeuvre le 3-((2-ethylhexyl)oxy1-1 ,2-propanediol, le 3(heptyl)oxy]-1 ,2- propanediol, le 3-[(octyl)oxy]-1,2-propanediol et le 34(allyl)oxyl-1 ,2prnpanediol. Among these mono (C 3 -C 8) alkyl or (C 3 -C 8) alkenyl ether glycerol, it is preferred to use 3 - ((2-ethylhexyl) oxy] -1,2-propanediol, 3 (heptyl) oxy] - 1,2-propanediol, 3 - [(octyl) oxy] -1,2-propanediol and 34 (allyl) oxyl-1,2,2-pentanediol.
Un mono(C3-Cg)alkyléther de glycérol plus particulièrement préféré selon la présente invention est le 3-[(2-ethylhexyl)oxy]-1,2-propanediol, vendu par la société SCHULKE & MAYR G.m.b.H. sous la dénomination commerciale
SENSIVA SC 50.A more particularly preferred mono (C 3 -C 8) alkyl ether of glycerol according to the present invention is 3 - [(2-ethylhexyl) oxy] -1,2-propanediol, sold by SCHULKE & MAYR GmbH under the trade name
SENSIVA SC 50.
Parmi les compositions résistant à la dégradation microbienne selon l'invention, on préfère celles dont le système microbicide comprend, dans un véhicule physiologiquement acceptable, soit une association entre la glycérine et du 3-[(2- ethylhexyl)oxy]-1,2-propanediol, soit une association entre du propylèneglycol et du 3-[(2-ethylhexyl)oxy]-1,2-propanediol, soit une association entre du butylèneglycol et du 3-[(2ethylhexyl)oxy]-1,2-propanediol, soit enfin une association entre de l'isoprèneglycol et du 3-[(2-ethylhexyl)oxy]-1,2-propanediol.Among the compositions resistant to microbial degradation according to the invention, those whose microbicidal system comprises, in a physiologically acceptable vehicle, an association between glycerin and 3 - [(2-ethylhexyl) oxy] -1,2 are preferred. -propanediol, an association between propylene glycol and 3 - [(2-ethylhexyl) oxy] -1,2-propanediol, or an association between butylene glycol and 3 - [(2ethylhexyl) oxy] -1,2-propanediol or an association between isoprene glycol and 3 - [(2-ethylhexyl) oxy] -1,2-propanediol.
De façon tout à fait surprenante, le système microbicide selon l'invention procède d'un effet de synergie, I'activité antimicrobienne de ce système s'étant en effet révélée, à quantités comparables en produits actifs, nettement supérieure à celle du polyol en C2-C6 seul et à celle du mono(C3-Cg)alkyl-ou (C3Cg)alcényléther de glycérol seul.Surprisingly, the microbicidal system according to the invention proceeds from a synergistic effect, the antimicrobial activity of this system has indeed been revealed, in comparable amounts of active products, significantly higher than that of the polyol in C2-C6 alone and that of mono (C3-Cg) alkyl- or (C3Cg) alkenyl ether of glycerol alone.
Dans les compositions résistant à la dégradation microbienne selon la présente invention, le ou les polyols en C2-C6 sont généralement présents dans des concentrations pondérales comprises entre environ 0,1 et 30%, de préférence entre environ 1 et 20%, et plus particulièrement encore entre environ 5 et 15%, le ou les mono(C3-C9)alkylou (C3-Cg)alcényléthers de glycérol sont généralement présents dans des concentrations pondérales comprises entre environ 0,1 et 10%, de préférence entre environ 0,5 à 5%, et plus particulièrement encore entre environ 0,5 et 1,5%, à chaque fois par rapport au poids total des compositions.In the compositions resistant to microbial degradation according to the present invention, the C2-C6 polyol or polyols are generally present in weight concentrations of between about 0.1 and 30%, preferably between about 1 and 20%, and more particularly still between about 5 and 15%, the mono (C3-C9) alkyl or (C3-Cg) alkenyl ether glycerol are generally present in weight concentrations of between about 0.1 and 10%, preferably between about 0.5 at 5%, and more particularly between about 0.5 and 1.5%, each time relative to the total weight of the compositions.
Bien entendu les proportions entre le polyol en C2C6 et le mono(C3-Cg)alkyl-ou (C3-Cg)alcényléther de glycérol sont de préférence ajustées de manière telle que l'effet de synergie mentionné cidessus soit obtenu de manière optimale.Of course, the proportions between the C2C6 polyol and the mono (C3-C8) alkyl or (C3-C8) alkenyl ether of glycerol are preferably adjusted in such a way that the synergistic effect mentioned above is optimally obtained.
Comme indiqué précédemment, les compositions selon l'invention présentent une quantité en monoalcool(s) aliphatique(s) qui n'excède pas 15% du poids total de la composition.As indicated above, the compositions according to the invention have an amount of aliphatic monohydric alcohol (s) which does not exceed 15% of the total weight of the composition.
De préférence cette teneur n'excède pas 10% en poids, de préférence encore ne dépasse pas 5% en poids. Preferably this content does not exceed 10% by weight, more preferably not more than 5% by weight.
Selon un mode particulièrement préféré de réalisation des compositions selon l'invention, ces demières sont substantiellement, ou, de préférence encore, totalement exemptes, de tout monoalcool aliphatique.According to a particularly preferred embodiment of the compositions according to the invention, these latter are substantially or, more preferably, completely free of any aliphatic monoalcohol.
Le véhicule physiologiquement acceptable peut être un milieu aqueux épaissi ou non épaissi, une émulsion huile-dans-eau, une émulsion eau-dans-huile, ou autre.The physiologically acceptable carrier may be a thickened or non-thickened aqueous medium, an oil-in-water emulsion, a water-in-oil emulsion, or the like.
Les compositions selon la présente invention, résistant à la dégradation microbienne, peuvent se présenter sous toutes les formes habituelles requises pour l'utilisation dans les domaines cosmétique, dermatologique, pharmaceutique ou alimentaire (dispersions et suspensions aqueuses, crèmes, gels, gel-crèmes, etc...).The compositions according to the present invention, resistant to microbial degradation, may be in any of the usual forms required for use in the cosmetic, dermatological, pharmaceutical or food fields (aqueous dispersions and suspensions, creams, gels, gel-creams, etc ...).
Selon les utilisations envisagées, ces compositions peuvent également contenir d'autres ingrédients ou actifs bien connus de l'état de la technique du domaine considéré.Depending on the intended uses, these compositions may also contain other ingredients or active agents well known from the state of the art of the field in question.
Des exemples concrets, mais nullement limitatifs, illustrant l'invention vont maintenant être donnés. Concrete but non-limiting examples illustrating the invention will now be given.
EXEMPLES:
On a préparé des compositions cosmétiques sous la forme de crèmes, de composition suivante:
EXAMPLES:
Cosmetic compositions in the form of creams of the following composition have been prepared:
<tb> Alcool <SEP> cétylstéarylique <SEP> (C161C18 <SEP> - <SEP> 30/70) <SEP> 4,8 <SEP> g <SEP>
<tb> Mélange <SEP> de <SEP> mono <SEP> et <SEP> distéarate <SEP> de <SEP> glycéryle <SEP> (Cerasynth <SEP> SD <SEP> de <SEP> 2 <SEP> 9 <SEP>
<tb> l.S.P.)
<tb> Alcool <SEP> cétylstéarylique <SEP> (C16/C18 <SEP> - <SEP> 30170) <SEP> oxyéthyléné <SEP> par <SEP> 33 <SEP> moles
<tb> d'oxyde <SEP> d'éthylène <SEP> 1,2 <SEP> 9 <SEP>
<tb> Mélange <SEP> de <SEP> 2-éthylhexanoate <SEP> de <SEP> cétostéaryle <SEP> / <SEP> Myristate
<tb> d' <SEP> isopropyle <SEP> (90110) <SEP> 4 <SEP> g <SEP>
<tb> Huile <SEP> de <SEP> silicone <SEP> (Silbione <SEP> Huile <SEP> 70 <SEP> 047 <SEP> V300 <SEP> de <SEP> Rhône <SEP> Poulenc
<tb> Silicones) <SEP> 1,5 <SEP> 9 <SEP>
<tb> Alcool <SEP> cétylique <SEP> pur <SEP> bidistillé <SEP> 1,5 <SEP> 9 <SEP>
<tb> Alcool <SEP> stéarylique <SEP> 19
<tb> Huile <SEP> de <SEP> vaseline <SEP> 15 <SEP> g <SEP>
<tb> 3-[(2-ethylhexyl)oxy]-1,2-propanediol <SEP> (Sensiva <SEP> SC <SEP> 50 <SEP> de <SEP> Schulke <SEP> & BR<
<tb> Mayr <SEP> G.m.b.H.) <SEP> (actif <SEP> 1) <SEP> x <SEP> g
<tb> Polyol <SEP> en <SEP> C2-C6 <SEP> (actif <SEP> 2) <SEP> y <SEP> g <SEP>
<tb> Eau <SEP> déminéralisée <SEP> qsp <SEP> 100 <SEP> g <SEP>
<tb>
L'activité antimicrobienne de ces formules a été évaluée sur 4 microorganismes::
Escherichia coli (bactérie gram-), Pseudomonas aeruginosa (bactérie gram-),
Streptococcus faecalis (bactérie gram+), Candida albicans (levure), au moyen d'un test adapté de la Pharmacopée Européenne (1991 - Efficacité de la protection antimicrobienne).<tb> Alcohol <SEP> cetylstearyl <SEP> (C161C18 <SEP> - <SEP> 30/70) <SEP> 4.8 <SEP> g <SEP>
<tb> Mixture <SEP> of <SEP> mono <SEP> and <SEP> distearate <SEP> of <SEP> glyceryl <SEP> (Cerasynth <SEP> SD <SEP> of <SEP> 2 <SEP> 9 <September>
<tb> lSP)
<tb> Alcohol <SEP> cetylstearyl alcohol <SEP> (C16 / C18 <SEP> - <SEP> 30170) <SEP> oxyethylenated <SEP> with <SEP> 33 <SEP> moles
<tb> oxide <SEP> of ethylene <SEP> 1,2 <SEP> 9 <SEP>
<tb><SEP> Mixture of <SEP> 2-ethylhexanoate <SEP> of <SEP> Cetostearyl <SEP> / <SEP> Myristate
<SEQ ID> ISPRO <SEP> (90110) <SEP> 4 <SEP> g <SEP>
<tb> Oil <SEP> of <SEP> silicone <SEP> (Silbione <SEP> Oil <SEP> 70 <SEP> 047 <SEP> V300 <SEP> from <SEP> Rhône <SEP> Poulenc
<tb> Silicones) <SEP> 1.5 <SEP> 9 <SEP>
<tb> Alcohol <SEP> cetyl <SEP> pure <SEP> bidistilled <SEP> 1.5 <SEP> 9 <SEP>
<tb> Alcohol <SEP> stearyl alcohol <SEP> 19
<tb> Oil <SEP> of <SEP> Vaseline <SEP> 15 <SEP> g <SEP>
<tb> 3 - [(2-ethylhexyl) oxy] -1,2-propanediol <SEP> (Sensiva <SEP> SC <SEP> 50 <SEP> from <SEP> Schulke <SEP>& BR <
<tb> Mayr <SEP> GmbH) <SEP> (active <SEP> 1) <SEP> x <SEP> g
<tb> Polyol <SEP> in <SEP> C2-C6 <SEP> (active <SEP> 2) <SEP> y <SEP> g <SEP>
<tb> Demineralized <SEP> water <SEP> qsp <SEP> 100 <SEP> g <SEP>
<Tb>
The antimicrobial activity of these formulas was evaluated on 4 microorganisms ::
Escherichia coli (gram-bacterium), Pseudomonas aeruginosa (gram-bacterium),
Streptococcus faecalis (Gram + bacterium), Candida albicans (yeast), using a test adapted from the European Pharmacopoeia (1991 - Efficacy of antimicrobial protection).
A l'instant initial To, le taux d'inocolum (nombre de germes par gramme de produit) est d'environ 106.At the initial time To, the rate of inoculum (number of germs per gram of product) is about 106.
Après 48 heures de contact, on a effectué une nouvelle lecture du nombre de germes (T,). On a déterminé l'activité microbicide de chaque formule en calculant la différence entre To et T, du nombre de germes restant. Cette différence (ou décontamination) est exprimée en Log.After 48 hours of contact, the number of germs (T 1) was read again. The microbicidal activity of each formula was determined by calculating the difference between To and T of the number of germs remaining. This difference (or decontamination) is expressed in Log.
On a réuni les résultats obtenus (selon la nature et les quantités d'actifs) dans les tableaux (I) (II) et (III) ci-dessous.The results obtained (according to the nature and quantities of assets) were combined in Tables (I) (II) and (III) below.
Dans ces tableaux, I'activité microbicide a été codée de la façon suivante: - Augmentation du nombre de germes. - . .... - - Pas d'augmentation notable du nombre de germes et
décontamination (D) partielle (D < 1Log) ... . ... O - Décontamination (D) partielle (1 Log < D < 3Log)... ..In these tables, the microbicidal activity was coded as follows: - Increase in the number of germs. -. .... - - No noticeable increase in the number of germs and
partial decontamination (D) (D <1Log) .... ... O - Partial decontamination (D) (1 Log <D <3Log) ... ..
- Décontamination (D) substantielle (D > 3Log) - + ++ -Décontamination totale... ... +++
Tableau (I)
- Substantial decontamination (D) (D> 3Log) - + ++ - Total decontamination ... ... +++
Table (I)
<tb> <SEP> Microorganismes <SEP> Escherichia <SEP> coli <SEP> Pseudomonas <SEP> Sreptococcus <SEP> Candida
<tb> Crèmes <SEP> aeruginosa <SEP> faecalis <SEP> albicans
<tb> <SEP> crème <SEP> sans <SEP> actif <SEP> O <SEP> <SEP> - <SEP> - <SEP> - <SEP>
<tb> <SEP> crème <SEP> + <SEP> 14% <SEP> glycérine <SEP> O <SEP> O <SEP> - <SEP>
<tb> <SEP> crème <SEP> + <SEP> 1% <SEP> SensivaSC50 <SEP> +++ <SEP> + <SEP> + <SEP> O
<tb> <SEP> crème <SEP> + <SEP> 1% <SEP> SensivaSC50 <SEP> + <SEP> +++ <SEP> +++ <SEP> ++ <SEP>
<tb> <SEP> 14% <SEP> glycérine
<tb>
Tableau (II)
<tb><SEP> Microorganisms <SEP> Escherichia <SEP> coli <SEP> Pseudomonas <SEP> Sreptococcus <SEP> Candida
<tb> Creams <SEP> aeruginosa <SEP> faecalis <SEP> albicans
<tb><SEP> cream <SEP> without <SEP> active <SEP> O <SEP><SEP> - <SEP> - <SEP> - <SEP>
<tb><SEP> cream <SEP> + <SEP> 14% <SEP> glycerin <SEP> O <SEP> O <SEP> - <SEP>
<tb><SEP> cream <SEP> + <SEP> 1% <SEP> SensivaSC50 <SEP> +++ <SEP> + <SEP> + <SEP> O
<tb><SEP> cream <SEP> + <SEP> 1% <SEP> SensivaSC50 <SEP> + <SEP> +++ <SEP> +++ <SEP> ++ <SEP>
<tb><SEP> 14% <SEP> Glycerin
<Tb>
Table (II)
<tb> <SEP> Microorganismes <SEP> Escherichia <SEP> coli <SEP> Pseudomonas <SEP> Sreptococcus
<tb> Crèmes <SEP> aeruginosa <SEP> faecalis
<tb> <SEP> crème <SEP> sans <SEP> actif <SEP> O <SEP> - <SEP> - <SEP> - <SEP>
<tb> <SEP> crème <SEP> + <SEP> 14% <SEP> propylèneglycol <SEP> + <SEP> + <SEP> - <SEP>
<tb> <SEP> crème <SEP> + <SEP> 1% <SEP> SensivaSC5O <SEP> +++ <SEP> + <SEP> + <SEP> O
<tb> <SEP> crème <SEP> + <SEP> 1% <SEP> SensivaSC5O <SEP> + <SEP> +++ <SEP> ++ <SEP> +++
<tb> <SEP> 14% <SEP> propylèneglycol
<tb>
Tableau (III)
<tb><SEP> Microorganisms <SEP> Escherichia <SEP> coli <SEP> Pseudomonas <SEP> Sreptococcus
<tb> Creams <SEP> aeruginosa <SEP> faecalis
<tb><SEP> cream <SEP> without <SEP> active <SEP> O <SEP> - <SEP> - <SEP> - <SEP>
<tb><SEP> cream <SEP> + <SEP> 14% <SEP> propylene glycol <SEP> + <SEP> + <SEP> - <SEP>
<tb><SEP> cream <SEP> + <SEP> 1% <SEP> SensivaSC5O <SEP> +++ <SEP> + <SEP> + <SEP> O
<tb><SEP> cream <SEP> + <SEP> 1% <SEP> SensivaSC5O <SEP> + <SEP> +++ <SEP> ++ <SEP> +++
<tb><SEP> 14% <SEP> Propylene Glycol
<Tb>
Table (III)
<tb> <SEP> Microorganismes <SEP> Escherichia <SEP> coli <SEP> Pseudomonas <SEP> Sreptococcus <SEP> Candida
<tb> Crèmes <SEP> aeruginosa <SEP> taecalis <SEP> albicans
<tb> <SEP> crème <SEP> sans <SEP> actif <SEP> O <SEP> - <SEP> - <SEP>
<tb> <SEP> crème <SEP> + <SEP> 14% <SEP> butylèneglycol <SEP> + <SEP> + <SEP> O <SEP> O <SEP>
<tb> <SEP> crème <SEP> + <SEP> 1% <SEP> SensivaSC50 <SEP> +++ <SEP> + <SEP> + <SEP> O
<tb> <SEP> crème <SEP> + <SEP> 1% <SEP> SensivaSC5O <SEP> +
<tb> <SEP> 14% <SEP> butylèneglycol
<tb>
Ces résultats démontrent que, dans les conditions du test, les crèmes ne renfermant que de la glycérine, du propylèneglycol ou du butylèneglycol, n'ont au plus, qu'une très faible activité de décontamination microbienne, et que lorsqu'elles renferment ces mêmes polyols cette fois associés à de faibles quantités de Sensiva SC50, leur activité de décontamination est totale, dans la plupart des cas, et revèle une action synergique. <tb><SEP> Microorganisms <SEP> Escherichia <SEP> coli <SEP> Pseudomonas <SEP> Sreptococcus <SEP> Candida
<tb> Creams <SEP> aeruginosa <SEP> taecalis <SEP> albicans
<tb><SEP> cream <SEP> without <SEP> active <SEP> O <SEP> - <SEP> - <SEP>
<tb><SEP> cream <SEP> + <SEP> 14% <SEP> butyleneglycol <SEP> + <SEP> + <SEP> O <SEP> O <SEP>
<tb><SEP> cream <SEP> + <SEP> 1% <SEP> SensivaSC50 <SEP> +++ <SEP> + <SEP> + <SEP> O
<tb><SEP> cream <SEP> + <SEP> 1% <SEP> SensivaSC5O <SEP> +
<tb><SEP> 14% <SEP> Butylene Glycol
<Tb>
These results demonstrate that, under the conditions of the test, the creams containing only glycerin, propylene glycol or butylene glycol, have at most only a very low microbial decontamination activity, and that when they contain these same polyols this time associated with small amounts of Sensiva SC50, their decontamination activity is total, in most cases, and reveals a synergistic action.
Claims (15)
Priority Applications (1)
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FR9502134A FR2729050A1 (en) | 1995-02-23 | 1995-02-23 | Synergistic compsn. with microbicidal properties |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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FR9502134A FR2729050A1 (en) | 1995-02-23 | 1995-02-23 | Synergistic compsn. with microbicidal properties |
Publications (1)
Publication Number | Publication Date |
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FR2729050A1 true FR2729050A1 (en) | 1996-07-12 |
Family
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FR9502134A Pending FR2729050A1 (en) | 1995-02-23 | 1995-02-23 | Synergistic compsn. with microbicidal properties |
Country Status (1)
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