FR2727116B1 - Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation - Google Patents

Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation

Info

Publication number
FR2727116B1
FR2727116B1 FR9413955A FR9413955A FR2727116B1 FR 2727116 B1 FR2727116 B1 FR 2727116B1 FR 9413955 A FR9413955 A FR 9413955A FR 9413955 A FR9413955 A FR 9413955A FR 2727116 B1 FR2727116 B1 FR 2727116B1
Authority
FR
France
Prior art keywords
peptides
domain
binding
preparation
sequences coding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9413955A
Other languages
English (en)
Other versions
FR2727116A1 (fr
Inventor
Bruno Tocque
Marc Duchesne
Didier Faucher
Fabienne Parker
Fabien Schweighoffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to FR9413955A priority Critical patent/FR2727116B1/fr
Priority to IL11602695A priority patent/IL116026A/xx
Priority to ZA959882A priority patent/ZA959882B/xx
Priority to BR9510067A priority patent/BR9510067A/pt
Priority to ES95941126T priority patent/ES2248800T3/es
Priority to HU9702079A priority patent/HU221410B1/hu
Priority to DE69534471T priority patent/DE69534471T2/de
Priority to MX9703364A priority patent/MX9703364A/es
Priority to DK95941126T priority patent/DK0793721T3/da
Priority to CA002204438A priority patent/CA2204438A1/fr
Priority to US08/836,791 priority patent/US5886150A/en
Priority to JP8516632A priority patent/JPH10509044A/ja
Priority to AU42636/96A priority patent/AU713937B2/en
Priority to EP95941126A priority patent/EP0793721B1/fr
Priority to SK629-97A priority patent/SK287034B6/sk
Priority to AT95941126T priority patent/ATE305037T1/de
Priority to PCT/FR1995/001539 priority patent/WO1996016169A1/fr
Priority to CZ19971545A priority patent/CZ292538B6/cs
Publication of FR2727116A1 publication Critical patent/FR2727116A1/fr
Application granted granted Critical
Publication of FR2727116B1 publication Critical patent/FR2727116B1/fr
Priority to FI972170A priority patent/FI972170A0/fi
Priority to NO972313A priority patent/NO972313D0/no
Priority to JP2005309422A priority patent/JP2006122049A/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C07K14/4706—Guanosine triphosphatase activating protein, GAP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR9413955A 1994-11-22 1994-11-22 Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation Expired - Fee Related FR2727116B1 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR9413955A FR2727116B1 (fr) 1994-11-22 1994-11-22 Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation
IL11602695A IL116026A (en) 1994-11-22 1995-11-16 Peptides capable of linking to the sh3 domain of gap, nucleotide sequences encoding the same, their preparation and uses
ZA959882A ZA959882B (en) 1994-11-22 1995-11-21 Novel polypeptides nucleotide sequences encoding these peptides their preparation and use
SK629-97A SK287034B6 (sk) 1994-11-22 1995-11-22 Peptidy schopné väzby s oblasťou SH3 proteínu GAP, nukleotidové sekvencie kódujúce tieto peptidy a spôsob ich prípravy a použitie
HU9702079A HU221410B1 (en) 1994-11-22 1995-11-22 Polypeptides capable of binding to the gap protein sh3 domain, nucleotide sequences coding thereof, preparation and use thereof
DE69534471T DE69534471T2 (de) 1994-11-22 1995-11-22 Peptide, die fähig sind die sh3-domäne des gap-proteins zu binden, ihre kodierende dns, ihre zubereitung und verwendung
MX9703364A MX9703364A (es) 1994-11-22 1995-11-22 Peptidos capaces de unirse al dominio sh3 de la proteina gap, secuencias nucleotidicas que codifican para estos peptidos, su preparacion y su uso.
DK95941126T DK0793721T3 (da) 1994-11-22 1995-11-22 Peptider, der er i stand til at binde sig til GAP-proteinets SH3-domæne, nukleotidsekvenser, der koder derfor, fremstilling og anvendelse deraf
CA002204438A CA2204438A1 (fr) 1994-11-22 1995-11-22 Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation
US08/836,791 US5886150A (en) 1994-11-22 1995-11-22 Peptides capable of binding to the GAP protein SH3 domain, nucleotide sequences coding therefor, and preparation and use thereof
BR9510067A BR9510067A (pt) 1994-11-22 1995-11-22 Peptídio capaz de interagir com o domínio sh3 da proteína gap anticorpo ou fragmento de anticorpo dirigido contra um polipeptídeo sequência nucleotídica codificando para um polipeptídio ácido nucléico anti-sentido capaz de inibir ao menos parcialmente a produção de polipeptídeos sua utilização composição farmacêutica e utilização de um anticorpo ou fragmento de anticorpo
AU42636/96A AU713937B2 (en) 1994-11-22 1995-11-22 Peptides capable of binding to the gap protein sh3 domain, nucleotide sequences coding therefor, and preparation and use thereof
EP95941126A EP0793721B1 (fr) 1994-11-22 1995-11-22 Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation
ES95941126T ES2248800T3 (es) 1994-11-22 1995-11-22 Peptidos capaces de unirse al dominio sh3 de la proteina gap, secuencias nucleotidicas codificadoras para estos peptidos, su preparacion y su utilizacion.
AT95941126T ATE305037T1 (de) 1994-11-22 1995-11-22 Peptide, die fähig sind die sh3-domäne des gap- proteins zu binden, ihre kodierende dns, ihre zubereitung und verwendung
PCT/FR1995/001539 WO1996016169A1 (fr) 1994-11-22 1995-11-22 Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation
CZ19971545A CZ292538B6 (cs) 1994-11-22 1995-11-22 Polypeptid schopný interakce s doménou SH3 proteinu GAP, protilátka řízená proti tomuto polypeptidu, nukleotidová sekvence kódující tento polypeptid, farmaceutická kompozice obsahující tento polypeptid a použití této protilátky, tohoto polypeptidu a této nukleotidové sekvence
JP8516632A JPH10509044A (ja) 1994-11-22 1995-11-22 Ｇａｐタンパク質ｓｈ３ドメインに結合可能なペプチド、それをコードするヌクレオチド配列ならびにその製造法および使用
FI972170A FI972170A0 (fi) 1994-11-22 1997-05-21 Peptidejä, jotka kykenevät sitoutumaan GAP-proteiinin SH3-domeeniin, näitä peptidejä koodittavia nukleotidisekvenssejä, niiden valmistus ja käyttö
NO972313A NO972313D0 (no) 1994-11-22 1997-05-21 Peptider som er i stand til å binde til GAP-protein-SH3-området, nukleotid-sekvenser som koder for dette samt fremstilling og bruk derav
JP2005309422A JP2006122049A (ja) 1994-11-22 2005-10-25 Ｇａｐタンパク質ｓｈ３ドメインに結合可能なペプチド、それをコードするヌクレオチド配列ならびにその製造法および使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9413955A FR2727116B1 (fr) 1994-11-22 1994-11-22 Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation

Publications (2)

Publication Number Publication Date
FR2727116A1 FR2727116A1 (fr) 1996-05-24
FR2727116B1 true FR2727116B1 (fr) 1996-12-20

Family

ID=9469021

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9413955A Expired - Fee Related FR2727116B1 (fr) 1994-11-22 1994-11-22 Peptides capables de se lier au domaine sh3 de la proteine gap, sequences nucleotidiques codant pour ces peptides, leur preparation et utilisation

Country Status (2)

Country Link
FR (1) FR2727116B1 (fr)
ZA (1) ZA959882B (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05500506A (ja) * 1989-08-21 1993-02-04 カイロン　コーポレイション Ｇｔｐアーゼ活性化タンパク質（ｇａｐ）からのペプチドおよびその診断および治療学的使用
EP0496162A3 (en) * 1990-12-24 1993-09-01 Merck & Co. Inc. Peptide inhibitors of ras-gap interaction
FR2694296B1 (fr) * 1992-07-30 1994-09-02 Rhone Poulenc Rorer Sa Peptides inhibant l'activité des protéines ras, préparation et utilisation.
EP0679185A1 (fr) * 1993-01-15 1995-11-02 Schering Corporation Proteins gap associees aux ras

Also Published As

Publication number Publication date
FR2727116A1 (fr) 1996-05-24
ZA959882B (en) 1996-01-01

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Effective date: 20110801