FR2712888B1 - Use of alpha-D-alkylglucopyranosides and esters thereof for the preparation of prodrugs capable of crossing the blood-brain barrier, prodrugs obtained and precursors thereof. - Google Patents

Use of alpha-D-alkylglucopyranosides and esters thereof for the preparation of prodrugs capable of crossing the blood-brain barrier, prodrugs obtained and precursors thereof.

Info

Publication number
FR2712888B1
FR2712888B1 FR9313994A FR9313994A FR2712888B1 FR 2712888 B1 FR2712888 B1 FR 2712888B1 FR 9313994 A FR9313994 A FR 9313994A FR 9313994 A FR9313994 A FR 9313994A FR 2712888 B1 FR2712888 B1 FR 2712888B1
Authority
FR
France
Prior art keywords
prodrugs
alkylglucopyranosides
precursors
crossing
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9313994A
Other languages
French (fr)
Other versions
FR2712888A1 (en
Inventor
Jean Franck Pierre Louis Fabre
Francois Marie Bernard Paul
Pierre Frederic Emmanue Monsan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioeurope
Original Assignee
Bioeurope
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioeurope filed Critical Bioeurope
Priority to FR9313994A priority Critical patent/FR2712888B1/en
Priority to PCT/FR1994/001363 priority patent/WO1995014705A1/en
Publication of FR2712888A1 publication Critical patent/FR2712888A1/en
Application granted granted Critical
Publication of FR2712888B1 publication Critical patent/FR2712888B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9313994A 1993-11-23 1993-11-23 Use of alpha-D-alkylglucopyranosides and esters thereof for the preparation of prodrugs capable of crossing the blood-brain barrier, prodrugs obtained and precursors thereof. Expired - Fee Related FR2712888B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR9313994A FR2712888B1 (en) 1993-11-23 1993-11-23 Use of alpha-D-alkylglucopyranosides and esters thereof for the preparation of prodrugs capable of crossing the blood-brain barrier, prodrugs obtained and precursors thereof.
PCT/FR1994/001363 WO1995014705A1 (en) 1993-11-23 1994-11-22 USE OF α-D-ALKYLGLUCOPYRANOSIDES AND ESTERS THEREOF IN THE PREPARATION OF PRODRUGS CAPABLE OF CROSSING THE BLOOD-BRAIN BARRIER, PRODRUGS AND THEIR PRECURSORS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9313994A FR2712888B1 (en) 1993-11-23 1993-11-23 Use of alpha-D-alkylglucopyranosides and esters thereof for the preparation of prodrugs capable of crossing the blood-brain barrier, prodrugs obtained and precursors thereof.

Publications (2)

Publication Number Publication Date
FR2712888A1 FR2712888A1 (en) 1995-06-02
FR2712888B1 true FR2712888B1 (en) 1996-02-09

Family

ID=9453140

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9313994A Expired - Fee Related FR2712888B1 (en) 1993-11-23 1993-11-23 Use of alpha-D-alkylglucopyranosides and esters thereof for the preparation of prodrugs capable of crossing the blood-brain barrier, prodrugs obtained and precursors thereof.

Country Status (2)

Country Link
FR (1) FR2712888B1 (en)
WO (1) WO1995014705A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19524515A1 (en) * 1995-07-05 1997-01-09 Deutsches Krebsforsch Saccharide conjugates
FR2768630B1 (en) * 1997-09-22 2000-08-04 Ulice Sa USE OF ALKYL MONOGLUCOSIDES AS MOLECULAR VECTORS
PT915088E (en) 1997-10-31 2003-01-31 Hoffmann La Roche D-PROLINA DERIVATIVES
JP5328183B2 (en) * 2008-03-17 2013-10-30 国立大学法人 長崎大学 Method for producing glucoside ester derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034083A (en) * 1975-11-03 1977-07-05 The Procter & Gamble Company Compositions for inhibiting absorption of cholesterol
US4939174A (en) * 1988-02-26 1990-07-03 Shashoua Victor E Appetite suppression with dopamine-fatty acid conjugates
EP0413307A1 (en) * 1989-08-15 1991-02-20 Lion Corporation Process for producing saccharide fatty acid monoesters
FR2676058B1 (en) * 1991-04-30 1994-02-25 Hoechst Lab GLYCOSYLATED PRODUCTS, THEIR PREPARATION PROCESS AND THEIR USE IN THE TREATMENT OF CANCERS.
JPH0543428A (en) * 1991-08-13 1993-02-23 Lion Corp Cosmetic

Also Published As

Publication number Publication date
FR2712888A1 (en) 1995-06-02
WO1995014705A1 (en) 1995-06-01

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20090731