FR2706772A1 - Prevention and treatment of septic syndrome with an immunosuppressant, in particular cyclosporin. - Google Patents
Prevention and treatment of septic syndrome with an immunosuppressant, in particular cyclosporin. Download PDFInfo
- Publication number
- FR2706772A1 FR2706772A1 FR9307559A FR9307559A FR2706772A1 FR 2706772 A1 FR2706772 A1 FR 2706772A1 FR 9307559 A FR9307559 A FR 9307559A FR 9307559 A FR9307559 A FR 9307559A FR 2706772 A1 FR2706772 A1 FR 2706772A1
- Authority
- FR
- France
- Prior art keywords
- sep
- ciclosporin
- immunosuppressant
- treatment
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003018 immunosuppressive agent Substances 0.000 title claims abstract description 23
- 229960003444 immunosuppressant agent Drugs 0.000 title claims abstract description 18
- 208000011580 syndromic disease Diseases 0.000 title claims abstract description 18
- 230000001861 immunosuppressant effect Effects 0.000 title claims abstract description 16
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims description 45
- 229930105110 Cyclosporin A Natural products 0.000 title claims description 23
- 229960001265 ciclosporin Drugs 0.000 title claims description 23
- 108010036949 Cyclosporine Proteins 0.000 title claims description 22
- 238000011282 treatment Methods 0.000 title claims description 18
- 230000002265 prevention Effects 0.000 title claims description 15
- 229930182912 cyclosporin Natural products 0.000 title description 3
- 239000003814 drug Substances 0.000 claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- 206010040070 Septic Shock Diseases 0.000 claims description 22
- 230000036303 septic shock Effects 0.000 claims description 17
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
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- 108010063738 Interleukins Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 108010093965 Polymyxin B Proteins 0.000 description 1
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
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- 230000016571 aggressive behavior Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
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- 239000003125 aqueous solvent Substances 0.000 description 1
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- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- FCFNRCROJUBPLU-UHFFFAOYSA-N compound M126 Natural products CC(C)C1NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC(=O)C(C(C)C)NC(=O)C(C)OC(=O)C(C(C)C)NC(=O)C(C(C)C)OC1=O FCFNRCROJUBPLU-UHFFFAOYSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 150000001923 cyclic compounds Chemical class 0.000 description 1
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- 230000008034 disappearance Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000002635 electroconvulsive therapy Methods 0.000 description 1
- 231100000655 enterotoxin Toxicity 0.000 description 1
- 239000002095 exotoxin Substances 0.000 description 1
- 231100000776 exotoxin Toxicity 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000001951 hemoperfusion Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000002650 immunosuppressive therapy Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
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- 239000007972 injectable composition Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 229940047122 interleukins Drugs 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
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- 231100000053 low toxicity Toxicity 0.000 description 1
- 229940041033 macrolides Drugs 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
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- 238000010172 mouse model Methods 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229940046781 other immunosuppressants in atc Drugs 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 229920000024 polymyxin B Polymers 0.000 description 1
- 229960005266 polymyxin b Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
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- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
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- 238000012552 review Methods 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 206010040560 shock Diseases 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
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- 239000003848 thrombocyte activating factor antagonist Substances 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- FCFNRCROJUBPLU-DNDCDFAISA-N valinomycin Chemical compound CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC1=O FCFNRCROJUBPLU-DNDCDFAISA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9307559A FR2706772A1 (en) | 1993-06-22 | 1993-06-22 | Prevention and treatment of septic syndrome with an immunosuppressant, in particular cyclosporin. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9307559A FR2706772A1 (en) | 1993-06-22 | 1993-06-22 | Prevention and treatment of septic syndrome with an immunosuppressant, in particular cyclosporin. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2706772A1 true FR2706772A1 (en) | 1994-12-30 |
| FR2706772B1 FR2706772B1 (enrdf_load_stackoverflow) | 1995-09-01 |
Family
ID=9448412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9307559A Granted FR2706772A1 (en) | 1993-06-22 | 1993-06-22 | Prevention and treatment of septic syndrome with an immunosuppressant, in particular cyclosporin. |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2706772A1 (enrdf_load_stackoverflow) |
Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998052594A1 (en) * | 1997-05-19 | 1998-11-26 | Vladimir Petrovich Zavialov | Compositions for enhancing immunosuppressants' pharmaceutical activities |
| US6013253A (en) * | 1997-08-15 | 2000-01-11 | Amgen, Inc. | Treatment of multiple sclerosis using consensus interferon and IL-1 receptor antagonist |
| US6159460A (en) * | 1988-05-27 | 2000-12-12 | Amgen Inc. | Method for treating interleukin-1 mediated diseases |
| US6733753B2 (en) | 1997-02-10 | 2004-05-11 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| US6844315B2 (en) * | 1998-05-20 | 2005-01-18 | Erasmus Universiteit Rotterdam | Immunoregulator |
| US6921751B1 (en) | 1998-05-20 | 2005-07-26 | Erasmus Universiteit Rotterdam | Immunoregulator |
| US7175679B2 (en) | 2001-03-29 | 2007-02-13 | Biotempt B.V. | Oligopeptide treatment of NF-κB mediated inflammation |
| US7358330B2 (en) | 2001-03-29 | 2008-04-15 | Biotempt B.V. | Immunoregulatory compositions |
| WO2008054603A2 (en) | 2006-10-02 | 2008-05-08 | Amgen Inc. | Il-17 receptor a antigen binding proteins |
| EP2002846A2 (en) | 1996-12-06 | 2008-12-17 | Amgen Inc. | Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases |
| US7501391B2 (en) | 2001-12-21 | 2009-03-10 | Biotempt B.V. | Treatment of transplant survival |
| US7517529B2 (en) | 2003-04-08 | 2009-04-14 | Biotempt B.V. | Treatment of type I diabetes |
| US7524820B1 (en) | 2001-10-04 | 2009-04-28 | Biotempt B.V. | Compounds of therapeutic value in the treatment of multiple sclerosis and other diseases wherein foamy cells are involved in the disease etiology |
| EP2087908A1 (en) | 2001-06-26 | 2009-08-12 | Amgen, Inc. | Antibodies to opgl |
| US7576174B2 (en) | 2000-03-29 | 2009-08-18 | Biotempt B.V. | Compositions capable of reducing elevated blood urea concentration |
| EP2213685A1 (en) | 2002-09-06 | 2010-08-04 | Amgen Inc. | Therapeutic anti-IL-1R1 monoclonal antibody |
| WO2011046958A1 (en) | 2009-10-12 | 2011-04-21 | Amgen Inc. | Use of il-17 receptor a antigen binding proteins |
| EP2366715A2 (en) | 2005-11-14 | 2011-09-21 | Amgen Inc. | Rankl Antibody-PTH/PTHRP Chimeric Molecules |
| US8106098B2 (en) | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| USRE43279E1 (en) | 2000-03-29 | 2012-03-27 | Biotemp B.V. | Compositions capable of reducing elevated blood urea concentration |
| WO2013016220A1 (en) | 2011-07-22 | 2013-01-31 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
| WO2015191783A2 (en) | 2014-06-10 | 2015-12-17 | Abbvie Inc. | Biomarkers for inflammatory disease and methods of using same |
| US10041044B2 (en) | 2016-07-29 | 2018-08-07 | Trustees Of Boston University | Age-associated clonal hematopoiesis accelerates cardio-metabolic disease development |
| WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7560433B2 (en) | 2001-12-21 | 2009-07-14 | Biotempt B.V. | Treatment of multiple sclerosis (MS) |
| AU2003299971A1 (en) | 2002-12-30 | 2004-07-29 | Amgen Inc. | Combination therapy with co-stimulatory factors |
| EP1904086A2 (en) | 2005-07-05 | 2008-04-02 | Biotempt B.V. | Treatment of tumors |
| EP1864692A1 (en) | 2006-06-07 | 2007-12-12 | Biotempt B.V. | Use of peptides for the control of radiation injury |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001475A1 (fr) * | 1990-07-18 | 1992-02-06 | Vacsyn France, S.A. | Compositions a base de principes actifs de medicaments hydrophobes solubilisables dans un solvant aqueux |
| WO1992017193A1 (fr) * | 1991-03-27 | 1992-10-15 | Institut Pasteur | Medicament contenant un agent inhibant in vivo l'apoptose pathologique et applications |
-
1993
- 1993-06-22 FR FR9307559A patent/FR2706772A1/fr active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001475A1 (fr) * | 1990-07-18 | 1992-02-06 | Vacsyn France, S.A. | Compositions a base de principes actifs de medicaments hydrophobes solubilisables dans un solvant aqueux |
| WO1992017193A1 (fr) * | 1991-03-27 | 1992-10-15 | Institut Pasteur | Medicament contenant un agent inhibant in vivo l'apoptose pathologique et applications |
Non-Patent Citations (2)
| Title |
|---|
| DANIEL G. REMICK ET AL.: "CYCLOSPORINE A INHIBITS TNF PRODUCTION WITHOUT DECREASING TNF MRNA LEVELS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 161, no. 2, 15 June 1989 (1989-06-15), DULUTH, MINNESOTA US, pages 551 - 555 * |
| DUNG T. NGUYEN ET AL.: "CYCLOSPORIN A MODULATION OF TUMOR NECROSIS FACTOR GENE EXPRESSION AND EFFECTS IN VITRO AND IN VIVO", JOURNAL OF IMMUNOLOGY, vol. 144, no. 10, 15 May 1990 (1990-05-15), BALTIMORE US, pages 3822 - 3828 * |
Cited By (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6159460A (en) * | 1988-05-27 | 2000-12-12 | Amgen Inc. | Method for treating interleukin-1 mediated diseases |
| EP2002846A2 (en) | 1996-12-06 | 2008-12-17 | Amgen Inc. | Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases |
| US6733753B2 (en) | 1997-02-10 | 2004-05-11 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| WO1998052594A1 (en) * | 1997-05-19 | 1998-11-26 | Vladimir Petrovich Zavialov | Compositions for enhancing immunosuppressants' pharmaceutical activities |
| US6013253A (en) * | 1997-08-15 | 2000-01-11 | Amgen, Inc. | Treatment of multiple sclerosis using consensus interferon and IL-1 receptor antagonist |
| US6844315B2 (en) * | 1998-05-20 | 2005-01-18 | Erasmus Universiteit Rotterdam | Immunoregulator |
| US6921751B1 (en) | 1998-05-20 | 2005-07-26 | Erasmus Universiteit Rotterdam | Immunoregulator |
| US8106098B2 (en) | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| US7576174B2 (en) | 2000-03-29 | 2009-08-18 | Biotempt B.V. | Compositions capable of reducing elevated blood urea concentration |
| USRE43279E1 (en) | 2000-03-29 | 2012-03-27 | Biotemp B.V. | Compositions capable of reducing elevated blood urea concentration |
| US7358330B2 (en) | 2001-03-29 | 2008-04-15 | Biotempt B.V. | Immunoregulatory compositions |
| US7175679B2 (en) | 2001-03-29 | 2007-02-13 | Biotempt B.V. | Oligopeptide treatment of NF-κB mediated inflammation |
| EP2087908A1 (en) | 2001-06-26 | 2009-08-12 | Amgen, Inc. | Antibodies to opgl |
| EP3492100A1 (en) | 2001-06-26 | 2019-06-05 | Amgen Inc. | Antibodies to opgl |
| US7524820B1 (en) | 2001-10-04 | 2009-04-28 | Biotempt B.V. | Compounds of therapeutic value in the treatment of multiple sclerosis and other diseases wherein foamy cells are involved in the disease etiology |
| US7501391B2 (en) | 2001-12-21 | 2009-03-10 | Biotempt B.V. | Treatment of transplant survival |
| EP2213685A1 (en) | 2002-09-06 | 2010-08-04 | Amgen Inc. | Therapeutic anti-IL-1R1 monoclonal antibody |
| EP2277543A1 (en) | 2002-09-06 | 2011-01-26 | Amgen, Inc | Therapeutic anti-IL-1R1 monoclonal antibody |
| EP3020414A1 (en) | 2002-09-06 | 2016-05-18 | Amgen, Inc | Therapeutic anti-il-1r1 monoclonal antibody |
| US7517529B2 (en) | 2003-04-08 | 2009-04-14 | Biotempt B.V. | Treatment of type I diabetes |
| EP2816060A1 (en) | 2005-11-14 | 2014-12-24 | Amgen Inc. | Rankl antibody-PTH/PTHRP chimeric molecules |
| EP2366715A2 (en) | 2005-11-14 | 2011-09-21 | Amgen Inc. | Rankl Antibody-PTH/PTHRP Chimeric Molecules |
| WO2008054603A2 (en) | 2006-10-02 | 2008-05-08 | Amgen Inc. | Il-17 receptor a antigen binding proteins |
| EP3165539A1 (en) | 2006-10-02 | 2017-05-10 | Kirin-Amgen, Inc. | Il-17 receptor a antigen binding proteins |
| WO2011046958A1 (en) | 2009-10-12 | 2011-04-21 | Amgen Inc. | Use of il-17 receptor a antigen binding proteins |
| WO2013016220A1 (en) | 2011-07-22 | 2013-01-31 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
| WO2015191783A2 (en) | 2014-06-10 | 2015-12-17 | Abbvie Inc. | Biomarkers for inflammatory disease and methods of using same |
| US10041044B2 (en) | 2016-07-29 | 2018-08-07 | Trustees Of Boston University | Age-associated clonal hematopoiesis accelerates cardio-metabolic disease development |
| WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
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|---|---|
| FR2706772B1 (enrdf_load_stackoverflow) | 1995-09-01 |
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