FR2704395A1 - Nutritional supplement which can be taken by mouth, intended for improving mental activity - Google Patents

Nutritional supplement which can be taken by mouth, intended for improving mental activity Download PDF

Info

Publication number
FR2704395A1
FR2704395A1 FR9305319A FR9305319A FR2704395A1 FR 2704395 A1 FR2704395 A1 FR 2704395A1 FR 9305319 A FR9305319 A FR 9305319A FR 9305319 A FR9305319 A FR 9305319A FR 2704395 A1 FR2704395 A1 FR 2704395A1
Authority
FR
France
Prior art keywords
vitamin
intended
nutritional supplement
methionine
choline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR9305319A
Other languages
French (fr)
Other versions
FR2704395B1 (en
Inventor
Curtay Jean-Paul
Boiron Christian
Abecassis Jacky
Baume Bernard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boiron SA
Original Assignee
Boiron SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boiron SA filed Critical Boiron SA
Priority to FR9305319A priority Critical patent/FR2704395B1/en
Publication of FR2704395A1 publication Critical patent/FR2704395A1/en
Application granted granted Critical
Publication of FR2704395B1 publication Critical patent/FR2704395B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • A61K38/063Glutathione
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/175Amino acids
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

Nutritional supplement which can be taken by mouth, intended for improving mental activity, in particular memory and concentration, which contains tyrosine, at least one choline salt, a combination of B vitamins, methionine and an excipient.

Description

COMPLEMENT NUTRITIONNEL ABSORBABLE PER-OS DESTINE A
AMELIORER L'ACTIVISTE CEREBRALE.
PER-OS ABSORBABLE NUTRITIONAL SUPPLEMENT FOR A
IMPROVE THE BRAIN ACTIVIST.

L'invention vise un complément nutritionnel absorbable per-os destiné à améliorer l'activité cérébrale, notamment la concentration et la mémorisation. The invention relates to an absorbable per-bone nutritional supplement intended to improve brain activity, in particular concentration and memorization.

Dans une forme de réalisation pratique, ce complément nutritionnel absorbable est utilisé pour compenser les carences alimentaires et optimiser le fonctionnement intellectuel. In a practical embodiment, this absorbable nutritional supplement is used to compensate for nutritional deficiencies and optimize intellectual functioning.

Par "complément nutritionnel", on désigne un ensemble absorbable formant une supplémentation en micronutriments, complétant l'alimentation quotidienne, qui permet à la fois d'agir sur un symptôme et en même temps de renforcer l'organisme. By "nutritional supplement" is meant an absorbable whole forming a micronutrient supplementation, supplementing the daily diet, which allows both to act on a symptom and at the same time to strengthen the organism.

Comme on le sait, les déficiences alimentaires, notamment en oligoéléments, en vitamines, en acides aminés ou en acides gras polyinsaturés, se traduisent souvent par des fatigues physiques ou par une sensation d'inconfort (baisses de la forme intellectuelle et morale), pouvant parfois malheureusement aboutir à des troubles fonctionnels ou des maladies spécifiques. As we know, dietary deficiencies, especially in trace elements, vitamins, amino acids or polyunsaturated fatty acids, often result in physical fatigue or a feeling of discomfort (reduced intellectual and moral form), which can sometimes unfortunately lead to functional disorders or specific diseases.

L'invention vise à pallier ces inconvénients. Elle concerne un complément nutritionnel absorbable per-os, qui améliore efficacement l'activité cérébrale en rééquilibrant l'ensemble de l'organisme.  The invention aims to overcome these drawbacks. It relates to an absorbable per-bone nutritional supplement, which effectively improves brain activity by rebalancing the entire body.

Ce complément se caractérise en ce qu'il contient de la tyrosine, au moins un sel de la choline, une association de vitamines B, de la méthionine et un excipient. This supplement is characterized in that it contains tyrosine, at least one salt of choline, a combination of B vitamins, methionine and an excipient.

Comme on le sait:
- la tyrosine est un amino-acide aromatique, dont la fonction -NH2 est bloquée par amidification, notamment acétyle ou propionyle; c'est à partir de cet acide aminé qu'est synthétisée la noradrénaline, neurotransmetteur impliqué dans le phénomène de la concentration;
- la choline est la molécule à partir de laquelle est synthétisée l'acétylcholine, neurotransmetteur impliqué dans le phénomène de mémorisation ; ce composé est présent dans la lécithine de soja, notamment sous forme de phosphatidylcholine;
- la méthionine est un amino-acide aliphatique soufré, qui contribue à la synthèse de l'acétylcholine;
- les vitamines B, notamment BI, B6 , B9 et B12 comme la
L-méthionine, optimisent la transformation de la L-tyrosine et de la choline, respectivement en noradrénaline et en acétylcholine.
As we know:
- Tyrosine is an aromatic amino acid, the -NH2 function of which is blocked by amidification, in particular acetyl or propionyl; it is from this amino acid that norepinephrine, the neurotransmitter involved in the phenomenon of concentration, is synthesized;
- choline is the molecule from which acetylcholine, the neurotransmitter involved in the memorization phenomenon, is synthesized; this compound is present in soy lecithin, in particular in the form of phosphatidylcholine;
- methionine is a sulfur-containing aliphatic amino acid, which contributes to the synthesis of acetylcholine;
- vitamins B, in particular BI, B6, B9 and B12 such as
L-methionine, optimize the transformation of L-tyrosine and choline, respectively into norepinephrine and acetylcholine.

Avantageusement, en pratique
- la tyrosine et la méthionine sont sous forme L;
- la source de choline est issue du citrate de choline et de la lécithine de soja;
- l'association de vitamines B comprend dans l'ordre pondéral décroissant: de la vitamine B6, B1, B9 et B12;
- l'excipient comprend du dextrose, de la cellulose et du stéarate de magnésium (agent liant et lubrifiant).
Advantageously, in practice
- tyrosine and methionine are in L form;
- the source of choline comes from choline citrate and soy lecithin;
- the association of vitamins B comprises in decreasing weight order: vitamin B6, B1, B9 and B12;
- the excipient includes dextrose, cellulose and magnesium stearate (binding and lubricating agent).

En d'autres termes, l'invention vise une association, qui non seulement optimise la transformation, respectivement de la L-tyrosine en noradrénaline et de la choline en acétylcholine, mais également optimise les propriétés neurotransmettrices de la noradrénaline et de l'acétylcholine, et ce dans les meilleures conditions possibles. In other words, the invention relates to a combination which not only optimizes the transformation, respectively of L-tyrosine into noradrenaline and choline into acetylcholine, but also optimizes the neurotransmitter properties of noradrenaline and acetylcholine, and this in the best possible conditions.

Dans une forme de réalisation pratique, le complément nutritionnel conforme à l'invention contient en poids en pour cent:
- 40 % de citrate de choline
- 5 % d'une lécithine de soja contenant de 30 à 35 % de phosphatidylcholine;
-18 % de L tyrosine;
-10 % de L méthionine L méthionine;
- 0,1 % de vitamine B6;
- 0,07 % de vitamine B1;
- 0,01 % de vitamine B9;
- 0,00005 % de vitamine B12;
- 26,82 % d'excipient, par exemple:
. 19 % de dextrose;
.5,82% de cellulose;
. 2 % de stéarate de magnésium.
In a practical embodiment, the nutritional supplement according to the invention contains by weight in percent:
- 40% choline citrate
- 5% of a soy lecithin containing from 30 to 35% of phosphatidylcholine;
-18% L tyrosine;
-10% of L methionine L methionine;
- 0.1% vitamin B6;
- 0.07% vitamin B1;
- 0.01% vitamin B9;
- 0.00005% vitamin B12;
- 26.82% of excipient, for example:
. 19% dextrose;
5.82% cellulose;
. 2% magnesium stearate.

Pour garantir l'intégrité des différents composés, on effectue avantageusement la formulation de la manière suivante. Dans un premier temps, on granule en phase humide les excipients et les principaux composés. Puis, dans un deuxième temps, on mélange en phase sèche les vitamines et les principes actifs fragiles. To guarantee the integrity of the various compounds, the formulation is advantageously carried out in the following manner. Initially, the excipients and the main compounds are granulated in the wet phase. Then, in a second step, vitamins and fragile active ingredients are mixed in the dry phase.

Le complément nutritionnel conforme à l'invention se présente sous forme sèche, notamment sous forme de granules, de gélules, de poudre, et avantageusement de comprimés, etc
Cette préparation peut facilement être absorbée lorsque les fonctions intellectuelles, telles que la concentration et la mémoire sont particulièrement sollicitées, notamment pour faire face à une augmentation particulière de la demande, comme c'est parfois le cas chez les étudiants ou les adultes. Elle permet également de relancer essentiellement le fonctionnement des neurones chez les personnes qui observent parfois un manque de concentration et une baisse des capacités de mémorisation.
The nutritional supplement according to the invention is in dry form, in particular in the form of granules, capsules, powder, and advantageously tablets, etc.
This preparation can easily be absorbed when intellectual functions, such as concentration and memory are particularly stressed, in particular to cope with a particular increase in demand, as is sometimes the case in students or adults. It also essentially boosts the functioning of neurons in people who sometimes observe a lack of concentration and a decline in memory capacity.

Ce complément nutritionnel, sous la forme de comprimés de 500 mg, peut être avalé à raison de quatre comprimés le matin à jeun pendant deux à trois mois, à renouveler suivant les besoins.  This nutritional supplement, in the form of 500 mg tablets, can be swallowed at the rate of four tablets in the morning on an empty stomach for two to three months, to be renewed as needed.

Claims (6)

REVENDICATIONS 1/ Elément nutritionnel absorbable per-os, destiné à améliorer l'activité cérébrale, notamment la mémoire et la concentration, caractérisé en ce qu'il contient de la tyrosine, au moins un sel de choline, une association de vitamines B, de la méthionine et un excipient. 1 / Absorbable nutritional element per-bone, intended to improve brain activity, in particular memory and concentration, characterized in that it contains tyrosine, at least one choline salt, a combination of B vitamins, methionine and an excipient. 2/ Complément selon la revendication 1, caractérisé en ce que la choline est issue du citrate de choline et de la lécithine de soja. 2 / Supplement according to claim 1, characterized in that the choline is derived from choline citrate and soy lecithin. 3/ Complément selon la revendication 1, caractérisé en ce que la tyrosine et la méthionine sont sous forme L. 3 / Supplement according to claim 1, characterized in that the tyrosine and methionine are in L form. 4/ Complément selon la revendication 1, caractérisé en ce que l'association de vitamines B comprend dans l'ordre pondéral décroissant de la vitamine B6, BI, B9 et B12. 4 / Supplement according to claim 1, characterized in that the combination of B vitamins comprises in decreasing weight order of vitamin B6, BI, B9 and B12. 5/ Complément selon la revendication 1, caractérisé en ce que l'excipient comprend du dextrose, de la cellulose et du stéarate de magnésium. 5 / A supplement according to claim 1, characterized in that the excipient comprises dextrose, cellulose and magnesium stearate. 6/ Complément nutritionnel absorbable per-os, destiné à améliorer l'activité cérébrale selon l'une des revendications 1 à 5, caractérisé en ce qu'il contient en poids: 6 / nutritional supplement absorbable per-bone, intended to improve the cerebral activity according to one of claims 1 to 5, characterized in that it contains by weight: - 40 % de citrate de choline ; - 40% choline citrate; - 5 % d'une lécithine de soja; - 5% of a soy lecithin; -18 % de L tyrosine; -18% L tyrosine; -10 % de L méthionine; -10% L methionine; - 0,1 % de vitamine B6; - 0.07 % de vitamine B1; - 0,01 % de vitamine B9; - 0,00005 % de vitamine B12; - 26,82 % d'excipient.  - 0.1% vitamin B6; - 0.07% vitamin B1; - 0.01% vitamin B9; - 0.00005% vitamin B12; - 26.82% of excipient.
FR9305319A 1993-04-29 1993-04-29 Oral absorbable nutritional supplement intended to improve brain activity. Expired - Fee Related FR2704395B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR9305319A FR2704395B1 (en) 1993-04-29 1993-04-29 Oral absorbable nutritional supplement intended to improve brain activity.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9305319A FR2704395B1 (en) 1993-04-29 1993-04-29 Oral absorbable nutritional supplement intended to improve brain activity.

Publications (2)

Publication Number Publication Date
FR2704395A1 true FR2704395A1 (en) 1994-11-04
FR2704395B1 FR2704395B1 (en) 1995-06-02

Family

ID=9446746

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9305319A Expired - Fee Related FR2704395B1 (en) 1993-04-29 1993-04-29 Oral absorbable nutritional supplement intended to improve brain activity.

Country Status (1)

Country Link
FR (1) FR2704395B1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19731432A1 (en) * 1997-07-22 1999-02-04 Phoenix Lab Pharmazeutische Pr Use of choline citrate to treat CNS disorders
WO2008067640A1 (en) * 2006-12-06 2008-06-12 H3 Formulations Ltd. Composition for promoting cognitive attributes

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB992956A (en) * 1960-06-02 1965-05-26 Gustave Marie Joseph Boucher Pharmaceutical preparations containing pyrrolidone carboxylic acid and salts and esters thereof
US4837219A (en) * 1987-11-05 1989-06-06 Jeffrey Hutterer Medication for Alzheimer's disease
JPH02212421A (en) * 1989-02-10 1990-08-23 Masaki Imagawa Remedy for dementia
JPH02265457A (en) * 1989-04-04 1990-10-30 Nikken Food Kk Auxiliary food of brain nutrition
JPH0494669A (en) * 1990-08-08 1992-03-26 Q P Corp Composition for healthy brain

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB992956A (en) * 1960-06-02 1965-05-26 Gustave Marie Joseph Boucher Pharmaceutical preparations containing pyrrolidone carboxylic acid and salts and esters thereof
US4837219A (en) * 1987-11-05 1989-06-06 Jeffrey Hutterer Medication for Alzheimer's disease
JPH02212421A (en) * 1989-02-10 1990-08-23 Masaki Imagawa Remedy for dementia
JPH02265457A (en) * 1989-04-04 1990-10-30 Nikken Food Kk Auxiliary food of brain nutrition
JPH0494669A (en) * 1990-08-08 1992-03-26 Q P Corp Composition for healthy brain

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 9040, Derwent World Patents Index; AN 90-301255 *
DATABASE WPI Week 9049, Derwent World Patents Index; AN 90-366299 *
DATABASE WPI Week 9219, Derwent World Patents Index; AN 92-156043 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19731432A1 (en) * 1997-07-22 1999-02-04 Phoenix Lab Pharmazeutische Pr Use of choline citrate to treat CNS disorders
DE19731432C2 (en) * 1997-07-22 1999-07-15 Phoenix Lab Pharmazeutische Pr Use of choline citrate
WO2008067640A1 (en) * 2006-12-06 2008-06-12 H3 Formulations Ltd. Composition for promoting cognitive attributes

Also Published As

Publication number Publication date
FR2704395B1 (en) 1995-06-02

Similar Documents

Publication Publication Date Title
US5911992A (en) Method for controlling weight with hypericum perforatum and garcinia cambogia
RU2152216C1 (en) Composition containing dietetic additives (versions)
EP0007691B1 (en) Compositions for use in decreasing appetite for calories as carbohydrates
US20020155163A1 (en) Integrated multi-vitamin and mineral combination
WO2002032234A1 (en) Anti-stress composition designed to be mainly incorporated in nutritional carriers
EA015422B1 (en) Combination preparation for improving sperm quality
KR20010071467A (en) Composition comprising a carnitine and glutathione, useful to increase the absorption of glutathione and synergize its effects
US6218420B1 (en) Compositions based on aminoacids
US6447818B1 (en) Compositions containing compounds with adrenergic activity and vegetable extracts of Crataegus and gingko biloba for the treatment of overweight and obesity
JP2001518484A (en) Composition for suppressing withdrawal symptoms and craving for alcohol in alcoholics and for preventing abuse of alcohol in healthy people
MXPA06001706A (en) Multivitamin syrup for children or young adults.
FR2704395A1 (en) Nutritional supplement which can be taken by mouth, intended for improving mental activity
FR2704393A1 (en) Nutritional supplement which can be taken orally to optimise growth and maintain robustness of bones
WO1995005146A1 (en) Composition against hair loss and brittle nails
FR2704392A1 (en) Nutritional supplement which can be taken orally to improve and optimise individuals' levels of physical and mental activity
EP0349143B1 (en) Use of phytic acid or its salts for the prevention or treatment of hepatic diseases
CA3113821A1 (en) Leucine-enriched ketogenic formulations
FR2737849A1 (en) Orally administered food supplement for adults of over forty
FR2886154A1 (en) COMPOSITION FOR DELAYING THE DEVELOPMENT OF ALZHEIMER'S DISEASE
WO2022013581A1 (en) Nutritional supplement, suitable for oral administration, comprising dihydromyricetin, choline and one or more vitamins with antioxidant activity, for use in the maintenance of normal liver function
FR2704391A1 (en) Nutritional supplement which can be taken orally to facilitate adaptation to daily stress
Wilcken An Introduction to Nutritional Treatment in Inborn Errors of Metabolism-Different Disorders, Different Approaches
JPS61192264A (en) Food
Dickerson Some adverse effects of drugs on nutrition
KR100309715B1 (en) Composition having function for preventing toxicity and hangover of alcohol by activation of citric acid cycle

Legal Events

Date Code Title Description
ST Notification of lapse