FR2686250A1 - Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques. - Google Patents
Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques. Download PDFInfo
- Publication number
- FR2686250A1 FR2686250A1 FR9200411A FR9200411A FR2686250A1 FR 2686250 A1 FR2686250 A1 FR 2686250A1 FR 9200411 A FR9200411 A FR 9200411A FR 9200411 A FR9200411 A FR 9200411A FR 2686250 A1 FR2686250 A1 FR 2686250A1
- Authority
- FR
- France
- Prior art keywords
- microcapsules
- atelocollagen
- composition according
- collagen
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003094 microcapsule Substances 0.000 title claims abstract description 50
- 108010035532 Collagen Proteins 0.000 title claims abstract description 37
- 102000008186 Collagen Human genes 0.000 title claims abstract description 37
- 229920001436 collagen Polymers 0.000 title claims abstract description 37
- 239000000725 suspension Substances 0.000 title claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 5
- 239000007972 injectable composition Substances 0.000 title description 4
- 239000000203 mixture Substances 0.000 claims abstract description 57
- 108010045569 atelocollagen Proteins 0.000 claims abstract description 49
- 239000000463 material Substances 0.000 claims abstract description 25
- 150000004676 glycans Chemical class 0.000 claims abstract description 21
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 21
- 239000005017 polysaccharide Substances 0.000 claims abstract description 21
- 238000011049 filling Methods 0.000 claims abstract description 16
- 239000013543 active substance Substances 0.000 claims abstract description 15
- 229920002683 Glycosaminoglycan Polymers 0.000 claims abstract description 12
- 239000000243 solution Substances 0.000 claims description 50
- 239000000126 substance Substances 0.000 claims description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- 238000011282 treatment Methods 0.000 claims description 14
- 238000004132 cross linking Methods 0.000 claims description 13
- 229940094517 chondroitin 4-sulfate Drugs 0.000 claims description 12
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 11
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 11
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims description 10
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- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
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- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims 1
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- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 3
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
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- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/044—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9200411A FR2686250A1 (fr) | 1992-01-16 | 1992-01-16 | Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques. |
| JP5512202A JPH07503001A (ja) | 1992-01-16 | 1993-01-14 | コラーゲンマイクロカプセル含有注射可能組成物 |
| ES93904081T ES2090969T3 (es) | 1992-01-16 | 1993-01-14 | Composicion inyectable que contiene microcapsulas de colageno. |
| EP93904081A EP0621776B1 (fr) | 1992-01-16 | 1993-01-14 | Composition injectable contenant des microcapsules de collagene |
| DE69302262T DE69302262T2 (de) | 1992-01-16 | 1993-01-14 | Kollagenmikrokapseln enthaltende injezierbare zusammensetzung |
| PCT/FR1993/000035 WO1993013755A1 (fr) | 1992-01-16 | 1993-01-14 | Composition injectable contenant des microcapsules de collagene |
| CA002127885A CA2127885A1 (en) | 1992-01-16 | 1993-01-14 | Injectable compositions containing collagen microcapsules |
| AT93904081T ATE136773T1 (de) | 1992-01-16 | 1993-01-14 | Kollagenmikrokapseln enthaltende injezierbare zusammensetzung |
| US08/594,479 US5658593A (en) | 1992-01-16 | 1996-01-31 | Injectable compositions containing collagen microcapsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9200411A FR2686250A1 (fr) | 1992-01-16 | 1992-01-16 | Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2686250A1 true FR2686250A1 (fr) | 1993-07-23 |
| FR2686250B1 FR2686250B1 (enExample) | 1994-04-22 |
Family
ID=9425684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9200411A Granted FR2686250A1 (fr) | 1992-01-16 | 1992-01-16 | Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0621776B1 (enExample) |
| JP (1) | JPH07503001A (enExample) |
| AT (1) | ATE136773T1 (enExample) |
| CA (1) | CA2127885A1 (enExample) |
| DE (1) | DE69302262T2 (enExample) |
| ES (1) | ES2090969T3 (enExample) |
| FR (1) | FR2686250A1 (enExample) |
| WO (1) | WO1993013755A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0742818A4 (en) * | 1994-01-13 | 2002-01-09 | Rogosin Inst | MACRO-ENCAPSULATED SECRETORY CELLS |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5691423A (en) * | 1992-08-24 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-bound nitric oxide-nucleophile adducts |
| US5916790A (en) * | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
| FR2733427B1 (fr) * | 1995-04-25 | 2001-05-25 | W K Et Associes | Compositions biphasiques injectables renfermant de l'acide hyaluronique, notamment utiles en chirurgies reparatrice et esthetique |
| FR2733426B1 (fr) * | 1995-04-25 | 1997-07-18 | Debacker Yves | Dispositif medical pour le comblement des deformations du volume de la peau telles que rides et cicatrices par injection de 2 formes physico-chimiques differentes d'un polymere biologique |
| US5879712A (en) * | 1995-06-07 | 1999-03-09 | Sri International | Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced |
| DE19530249A1 (de) * | 1995-08-17 | 1997-02-20 | Resorba Chirurgisches Nahtmate | Brustimplantat |
| FR2764514B1 (fr) | 1997-06-13 | 1999-09-03 | Biopharmex Holding Sa | Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique |
| GB2345638A (en) * | 1998-09-11 | 2000-07-19 | Tissue Science Lab Limited | Injectable collagen compositions |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0196197A2 (en) * | 1985-03-22 | 1986-10-01 | COLLAGEN CORPORATION (a Delaware corporation) | Collagen implant material and method of preparing it |
| EP0230647A2 (en) * | 1985-12-27 | 1987-08-05 | Sumitomo Pharmaceuticals Company, Limited | Method for producing a sustained release formulation |
| EP0381543A1 (en) * | 1989-01-31 | 1990-08-08 | Coletica | Use of solutions of atelocollagen and polyholosides, for example glycosaminoglycans, for the manufacture of microcapsules, microcapsules produced in this way, processes for the manufacture of such microcapsules and cosmetic, pharmaceutical or food compositions in which they are present |
| EP0397542A1 (en) * | 1988-12-02 | 1990-11-14 | Coletica | Stabilization process for hydrated lamellar phases |
-
1992
- 1992-01-16 FR FR9200411A patent/FR2686250A1/fr active Granted
-
1993
- 1993-01-14 ES ES93904081T patent/ES2090969T3/es not_active Expired - Lifetime
- 1993-01-14 WO PCT/FR1993/000035 patent/WO1993013755A1/fr not_active Ceased
- 1993-01-14 AT AT93904081T patent/ATE136773T1/de not_active IP Right Cessation
- 1993-01-14 EP EP93904081A patent/EP0621776B1/fr not_active Expired - Lifetime
- 1993-01-14 JP JP5512202A patent/JPH07503001A/ja active Pending
- 1993-01-14 CA CA002127885A patent/CA2127885A1/en not_active Abandoned
- 1993-01-14 DE DE69302262T patent/DE69302262T2/de not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0196197A2 (en) * | 1985-03-22 | 1986-10-01 | COLLAGEN CORPORATION (a Delaware corporation) | Collagen implant material and method of preparing it |
| EP0230647A2 (en) * | 1985-12-27 | 1987-08-05 | Sumitomo Pharmaceuticals Company, Limited | Method for producing a sustained release formulation |
| EP0397542A1 (en) * | 1988-12-02 | 1990-11-14 | Coletica | Stabilization process for hydrated lamellar phases |
| EP0381543A1 (en) * | 1989-01-31 | 1990-08-08 | Coletica | Use of solutions of atelocollagen and polyholosides, for example glycosaminoglycans, for the manufacture of microcapsules, microcapsules produced in this way, processes for the manufacture of such microcapsules and cosmetic, pharmaceutical or food compositions in which they are present |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0742818A4 (en) * | 1994-01-13 | 2002-01-09 | Rogosin Inst | MACRO-ENCAPSULATED SECRETORY CELLS |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2127885A1 (en) | 1993-07-22 |
| DE69302262T2 (de) | 1996-09-19 |
| ATE136773T1 (de) | 1996-05-15 |
| ES2090969T3 (es) | 1996-10-16 |
| JPH07503001A (ja) | 1995-03-30 |
| FR2686250B1 (enExample) | 1994-04-22 |
| WO1993013755A1 (fr) | 1993-07-22 |
| EP0621776B1 (fr) | 1996-04-17 |
| EP0621776A1 (fr) | 1994-11-02 |
| DE69302262D1 (de) | 1996-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CD | Change of name or company name |