FR2662939A1 - Anti-inflammatory gel and process for producing it - Google Patents

Abstract

A non-fatty anti-inflammatory gel is prepared by bringing a mixture of dermatophilic excipient to 90 DEG C as well as purified water to which sodium methyl parabenzoate is added, and mixing at this temperature one part by weight of the first with 2.75 parts by weight of the second, allowing this product to cool to 60 DEG C and adding at this temperature 6 % by weight of a mixture of essential oils having an analgesic and antiseptic effect; and allowing the whole to cool, skimming off the surface to expose the clear gel.

Description

 The present invention relates to an anti-inflammatory pharmaceutical substance of the gel type intended to be applied locally to the area of the body to be treated and to its manufacturing process.

 Certain painful affections of muscular and / or articular origins (sprains, strains, muscle breakdowns or tears, torticollis) can be alleviated by the application of active ingredients in the form of essential oils having anti-neuralgic and antispasmodic properties.

 These oils often have in addition sanitizing and healing properties.

 We therefore thought of associating a certain number of these oils to group their properties into a single product capable of acting on muscle or joint pain and / or on a wound or burn, having found that in many cases the wound was often accompanied of this kind of pain.

 Furthermore, the mode of action of such a substance also leads to using it for muscle heating before a sporting effort.

 It is in this spirit that the invention was developed. That is to say, to manufacture a substance which contains essential oils having effects in the three areas (analgesic, aseptic, heating3 and having a pleasant appearance in the form of a non-greasy transparent gel.

For this purpose therefore, the invention firstly relates to a pharmaceutical substance for skin application which comprises, for one liter
- 60 to 80 grams of essential oils comprising five constituents: cajeput, peppermint, lavender, eucalyptus, rosemary in equal parts,
- About 250 grams of excipients comprising three constituents: a fatty alcohol polyglycol ether for 62% by weight, an oleic acid decylester for 36.5% by weight and a 2-octyl-dodecanol for the rest,
- purified water as a supplement.

 The choice of these five essential oils was chosen for their aseptic, analgesic and anti-neuralgic properties which are well known, in order to produce an anti-inflammatory product.

 Preferably, the purified water is added with sodium methyl para-oxybenzoate in an amount of 2.2 per thousand by weight.

 Finally, the substance also contains a dye of the orange-yellow methyl type in sufficient quantity.

A second object of the present invention consists of a process for the preparation of the above substance in the form of a non-fatty anti-inflammatory gel. This process includes the following phases
- bring the mixture of excipient in the liquid state to the temperature of 900C,
- heat the purified water to 900C,
- incorporate the excipient at this temperature in the water, avoiding the formation of air bubbles,
- allow the mixture to cool to 600C,
- incorporate the mixture of oils brought to 600C in the preceding mixture and
- skim the resulting mixture during its cooling before setting the gel.

 To perfect the clarity of the gel, the process comprises an additional phase of reheating the final mixture followed by additional skimming.

It will be recalled that the essence of cajeput, which is an abundant tree in the Philippines, in Malaysia, in
Moluccas and the Celebes Islands essentially includes the following constituents: Cineol (60 to 75%), Left Pinene, Terpineol and Aldehydes. Its properties make it a general antiseptic, a neuralgic and an antispasmodic for external use.

Peppermint (or English mint) has the following essential constituents
Menthol (30 to 70%), terpene, mint, phellandrene, limonene, acetone (menthone) and tannin.

 In addition to its analgesic and antispetic properties, this product, for external use, is a parasiticide.

 Lavender is used externally for wounds of all kinds and burns, as is the essence of Eucalyptus which has a bactericidal power.

 Rosemary has similar components and is indicated for external use as healing and resolving wounds, burns, rheumatism and muscle pain.

 As an indication, it will be reported that 250 milliliters of the substance according to the invention comprise 3.07 g of each essential oil.

With regard to the excipients, we have chosen a) EUMULGIN B1, trade name of a polyglycolether of alcohols
saturated fat type lanette O which appears under the
form of a white or slightly yellow mass. It's about
a non-ionic emulsifier specially indicated for
emulsify oils, mineral waxes, hydro
carbides, solvents, vegetable oils and fats
animal.

b) CETIOL V, trade name of an oleic acid decylester
is a slightly yellowish oily liquid akin to
with skin fats and very dermatophilic. This is
a stable product over time. Its miscibility with
many fatty substances make it an interesting vehicle
for many liposoluble active products.

c) EUTANOL G, trade name of a 2-octyl-dodecanol, product
condensation of predominantly saturated fatty alcohols
decyl alcohol produced by Guerbet reaction.

This very dermatophilic product penetrates well into the
skin and is an excellent solvent for products
liposoluble active ingredients. It is stable and can be easily
fragrant.

In the 250 ml of the final product above, there will be an excipient comprising 38.5 g of EUMULGIN, 22.68 g of
CETIOL V and 1.01 g EUTANOL G.

 These constituents will be supplemented with 171.36 g of purified water added with 0.38 g of sodium methyl para-oxybenzoate.

 The process according to the invention as described above is necessary for obtaining a clear gel.

Indeed, a simple mixture of the constituents at any temperature leads only to an opaque mass rejecting essential oils.

 Combining the oils with the excipient-water mixture at 600C gives a creamy appearance to the resulting product.

 It has also been found that bringing the oils to a temperature above 60 ° C causes them to deteriorate.

It is also quite necessary to "let cool" the product from 6O0C rather than forcing the cooling which causes the appearance of suspended particles making the gel opaque. On the other hand, natural cooling causes these slowly forming particles to group on the surface in the form of a cream which it is easy to separate from the clear gel.

 This clarity is improved by reheating followed by gentle cooling of the final substance, with additional creaming.

Claims (5)

 1. Pharmaceutical substance for skin application characterized in that it comprises for one liter  - 60 to 80 grams of essential oils comprising five constituents: cajeput, peppermint, lavender, eucalyptus, rosemary, at a rate of 12.28 grams each,  - approximately 250 grams of excipients comprising three constituents: a polyglycolether of fatty alcohol for 62% by weight, a decylester of oleic acid for 36.5% by weight and a 2-octyl-dodecanol for the rest,  - purified water as a supplement.  2. Substance according to claim 1 characterized in that the purified water is added with sodium methyl paraoxybenzoate in an amount of 2.2 per thousand by weight.  3. Substance according to claim 1 or claim 2 characterized in that it comprises a dye of the orange yellow methyl type.  4. Method for preparing the pharmaceutical substance according to claim 1, characterized in that it comprises the following phases  - bring the mixture of excipient in the liquid state to the temperature of 900C,  - heat the purified water to 90 C,  - incorporate the excipient at this temperature in the water, avoiding the formation of air bubbles  - allow the mixture to cool to 600C,  - incorporate the mixture of oils brought to 600C (possibly supplemented with dye) in the preceding mixture and,  - skim the resulting mixture during its cooling before setting the gel.  5. Method according to claim 4 characterized in that it consists in slightly reheating the final mixture and in performing an additional skimming.