FR2649605A1 - Corneal implant - Google Patents

Corneal implant Download PDF

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Publication number
FR2649605A1
FR2649605A1 FR8909478A FR8909478A FR2649605A1 FR 2649605 A1 FR2649605 A1 FR 2649605A1 FR 8909478 A FR8909478 A FR 8909478A FR 8909478 A FR8909478 A FR 8909478A FR 2649605 A1 FR2649605 A1 FR 2649605A1
Authority
FR
France
Prior art keywords
lens
support
corneal implant
cornea
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8909478A
Other languages
French (fr)
Other versions
FR2649605B1 (en
Inventor
Jean-Marc Legeais
Gilles Renard
Maurice Anton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
France Chirurgie Instrumentation (FCI) SAS
Original Assignee
France Chirurgie Instrumentation (FCI) SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by France Chirurgie Instrumentation (FCI) SAS filed Critical France Chirurgie Instrumentation (FCI) SAS
Priority to FR8909478A priority Critical patent/FR2649605B1/en
Publication of FR2649605A1 publication Critical patent/FR2649605A1/en
Application granted granted Critical
Publication of FR2649605B1 publication Critical patent/FR2649605B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/15—Implant having one or more holes, e.g. for nutrient transport, for facilitating handling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Abstract

Corneal implant comprising a central lens of transparent amorphous material and a peripheral support made integral with the lens. According to the invention, the support 3 of the lens 2 consists of a material which can be colonised by the conjunctival tissue CT, such as expanded PTFE. Applications: replacement of the opacified corneal tissue.

Description

IMPLANT CORNEEN
La présente invention a pour objet une kérato-prothèse, implant cornéen destiné être implanté lorsque la cornée, normalement transparente se vascularise et, s'opacifie à la suite d'une maladie telle qu'un herpès ou d'un accident tel qu'une projection d'acide, par exemple.CORNEAN IMPLANT
The present invention relates to a kerato-prosthesis, corneal implant intended to be implanted when the normally transparent cornea is vascularized and becomes cloudy following a disease such as herpes or an accident such as splashing of acid, for example.

L'implantation d'une prothèse est nécessaire chaque fois qu'il est impossible de réaliser une greffe sur le patient considéré.The implantation of a prosthesis is necessary whenever it is impossible to perform a transplant on the patient in question.

L'implantation d'une prothèse est une opération qui a été proposée depuis très longtemps. Malheureusement, le tissu malade à une tendance naturelle à rejeter les produits artificiels, de sorte que de telles implantations se soldent généralement par un échec au bout d'un temps plus ou moins Iog. The implantation of a prosthesis is an operation which has been proposed for a very long time. Unfortunately, the diseased tissue has a natural tendency to reject artificial products, so that such implantations generally end in failure after a time more or less Iog.

Dans le processus de vision, la cornée se comporte comme une lentille convergente dont la puissance est de 45 dioptries environ. Aussi, les implants qui ont été proposés sont généralement constitués d'une lentille en PMMA (Polyméthylmétacrylate) qui est un corps complètement inerte vis-à-vis de l'environnement biologique. Cette lentille doit être incluse dans un support assurant la liaison entre la cornée et la lentille et le problème qui est résolu par la présente invention est celui de la fixation du support sur la cornée.In the vision process, the cornea behaves like a converging lens whose power is around 45 diopters. Also, the implants which have been proposed generally consist of a PMMA (Polymethylmetacrylate) lens which is a body completely inert with respect to the biological environment. This lens must be included in a support ensuring the connection between the cornea and the lens and the problem which is solved by the present invention is that of the fixing of the support on the cornea.

Selon la présente invention, la prothèse cornéenne comprenant une lentille centrale de matériau amorphe transparent et un support périphérique solidarisé avec la lentille est caractérisée en ce que, le support est constitué par un matériau colonisable par les tissus conjonctifs. According to the present invention, the corneal prosthesis comprising a central lens of transparent amorphous material and a peripheral support secured to the lens is characterized in that, the support consists of a material that can be colonized by the connective tissues.

D'une manière générale, lorsque la cornée est atteinte de maladie, le tissu conjonctif se développe de manière à rejeter le corps étranger. La présente invention se propose d'utiliser ce phénomène pour assurer la fixation de la prothèse sur la cornée. Generally, when the cornea is affected by disease, the connective tissue develops so as to reject the foreign body. The present invention proposes to use this phenomenon to ensure the fixation of the prosthesis on the cornea.

Selon une autre caractéristique de l'invention, le support est constitué par un "morceau ou pièce " de PTFE (polytétrafluoroéthylène) expansé. A partir du Téflon (marque déposée), il est possible d'opérer une transformation pour donner une structure microporeuse dont les espaces nodaux sont d'environ 20 microns, et communiquent les uns avec les autres pour constituer un vaste réseau tridimensionnel. La colonisation tissulaire se fait par pénétration des cellules conzonctives à l'intérieur du matériau pour augmenter la colision entre cornée récéptive et la prothèse.According to another characteristic of the invention, the support consists of a "piece or piece" of expanded PTFE (polytetrafluoroethylene). From Teflon (registered trademark), it is possible to carry out a transformation to give a microporous structure whose nodal spaces are about 20 microns, and communicate with each other to constitute a vast three-dimensional network. Tissue colonization is done by penetration of the conzunctive cells inside the material to increase the colonization between the receptive cornea and the prosthesis.

Selon encore une autre caractéristique de l'invention, la lentille et le support sont solidarisés par sertissage. A cet effet, la membrane de polytétrafluoroéthylène expansé est emcrisonnée entre la lentille et une bague par exemple en titane. Les dimensions de la bague sont légèrement inférieures aux dimensions de la lentille, cette dernière présentant à sa partie supérieure une lèvre périphérique venant s'appliquer contre une partie correspondante formée dans la lentille.According to yet another characteristic of the invention, the lens and the support are secured by crimping. To this end, the expanded polytetrafluoroethylene membrane is trapped between the lens and a ring, for example made of titanium. The dimensions of the ring are slightly smaller than the dimensions of the lens, the latter having at its upper part a peripheral lip which comes to bear against a corresponding part formed in the lens.

La liaison mécanique ainsi réalisée, s'est révélée très solide.The mechanical connection thus produced, proved to be very solid.

D'autres caractéristiques et avantages de l'invention apparaîtront au cours de la description qui va suivre d'un mode particulier de réalisation, donné uniquement à titre d'exemple non 1 imitatif, en regard des figures qui représentent un implant cornéen monté sur un globe oculaire. Other characteristics and advantages of the invention will appear during the following description of a particular embodiment, given solely by way of non-imitative example 1, with reference to the figures which represent a corneal implant mounted on a eye-ball.

Sur la figure 1, un implant cornéen monté sur un globe oculaire ; on distingue la cornée C, recouverte par le tissu conjcnctif TC. A l'intérieur de la cornée a été réalisée une ouverture O dans laquelle est inclus l'implant cornéen désigné d'une manière générale par la référence 1.In Figure 1, a corneal implant mounted on an eyeball; there is a cornea C, covered by the connective tissue TC. Inside the cornea was made an opening O in which is included the corneal implant generally designated by the reference 1.

La figure 2 une vue de la bague de sertissage pour obtenir une fixation convenable entre le support 3 et la lentille 2, cette dernière comprend un bord 5 contre lequel vient s'appuyer la surface inférieure d'une collerette formée c-ans la bague 4.Figure 2 a view of the crimping ring to obtain a suitable fixing between the support 3 and the lens 2, the latter comprises an edge 5 against which abuts the lower surface of a flange formed c-ans the ring 4 .

la figure 3 une vue de la lentille. Ccmme indiqué précédemment, l'implant cornéen comprend une lent montée sur un support 3 microporeux l'ensemble étant verrouillé par une bague 4 Corne cela apparat sur la figure 2, la bague 4 comprend, dans son alésage interne, des dents 7 qui, lors du sertisage, viennent s'insérer dans la surface externe 8 de la lentille 2.La bague peut ainsi p pincer le support microporeux 3 er.re les collerettes ô et 5, le bord de la pièce est inséré soit sur la surface de la cornée C soit à l'intérieur de celle-ci. Bien entendu, le support 3 est suture sur la cornée C, et ocmme représenté sur la f figure le tissu conjonctif T@se dévelope de manière à pénétrer à l'intérieur du support 3 pour le coloniser et assurer une bonne fixation entre la cornée C d'une part, et l'implant I d'autre part.Figure 3 a view of the lens. Ccmme indicated previously, the corneal implant includes a slow mounted on a support 3 microporous the whole being locked by a ring 4 Horn that appears on figure 2, the ring 4 includes, in its internal bore, teeth 7 which, during crimping, are inserted into the outer surface 8 of the lens 2.The ring can thus pinch the microporous support 3 er. the flanges ô and 5, the edge of the part is inserted either on the surface of the cornea C either inside of it. Of course, the support 3 is sutured on the cornea C, and ocmme represented in the f figure the connective tissue T @ develops so as to penetrate inside the support 3 to colonize it and ensure a good fixation between the cornea C on the one hand, and implant I on the other.

1 va de soi que de nombreuses variantes peuvent être introduites, notamment par substitution de moyens techniquement équivalents sans pour autant sortir du cadre de l'invention.  1 goes without saying that many variants can be introduced, in particular by substitution of technically equivalent means without departing from the scope of the invention.

Claims (2)

REVENDICATIONS 4. Implant corneen comprenant une lentille de -matériau amorphe et un support, caractérisé er. ce que le support (3) est constitué par un matériau souple colonisable par les tissus conjonctifs.CLAIMS 4. Corneal implant comprising a lens of amorphous material and a support, characterized er. that the support (3) consists of a flexible material that can be colonized by the connective tissues. 2. Implant cornée selon la revendication 1, caractérisée e2. Corneal implant according to claim 1, characterized e ce que le support (3, est constitué par du that the support (3, consists of polytétrafluoroétylène expansé. expanded polytetrafluoroetylene. implant cornéen selon l'une des revendications 1 ou 2 corneal implant according to one of claims 1 or 2 caractérisé, e ce que le support (3) est emprisonné entre characterized, that the support (3) is trapped between la lentille (2) et une bague (4). the lens (2) and a ring (4). 4. Implant cornéen selon la revendication 3, caractérisé e4. Corneal implant according to claim 3, characterized e ce que la bague (4, est sertie sur ra lentille (2) par that the ring (4, is crimped onto the lens (2) by pénétration de dents (7) de la bague (4) dans la penetration of teeth (7) of the ring (4) in the surface (8, ce la lentille.  surface (8, this lens.
FR8909478A 1989-07-13 1989-07-13 CORNEAN IMPLANT Expired - Fee Related FR2649605B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8909478A FR2649605B1 (en) 1989-07-13 1989-07-13 CORNEAN IMPLANT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8909478A FR2649605B1 (en) 1989-07-13 1989-07-13 CORNEAN IMPLANT

Publications (2)

Publication Number Publication Date
FR2649605A1 true FR2649605A1 (en) 1991-01-18
FR2649605B1 FR2649605B1 (en) 1995-07-21

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FR8909478A Expired - Fee Related FR2649605B1 (en) 1989-07-13 1989-07-13 CORNEAN IMPLANT

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Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018065A1 (en) * 1991-04-10 1992-10-29 F.C.I. (France Chirurgie Instrumentation) Support for a partially extracorporeal prosthesis
FR2687564A1 (en) * 1992-02-26 1993-08-27 France Chirurgie Instr Assembly device for a keratoprosthesis
US5300116A (en) * 1992-08-05 1994-04-05 Lions Eye Institute Of Western Australia Keratoprosthesis
EP0670701A1 (en) * 1992-11-19 1995-09-13 PY, Daniel Intraocular prosthesis
US6106552A (en) * 1996-01-30 2000-08-22 Corneal Industrie Corneal prosthesis device having anterior and posterior annular skirts
US6391055B1 (en) * 1996-11-13 2002-05-21 Menicon Co., Ltd. Artificial cornea
US6423093B1 (en) 1999-09-14 2002-07-23 The Lions Eye Institute Of Western Australia Incorporated Method of insertion of keratoprostheses
WO2008127653A3 (en) * 2007-04-13 2008-12-04 Gore Enterprise Holdings Inc Artificial cornea
US20150216651A1 (en) * 2012-09-05 2015-08-06 University Of Miami Novel keratoprosthesis, and system and method of corneal repair using same
US9603704B2 (en) 2013-03-13 2017-03-28 Acufocus, Inc. In situ adjustable optical mask
US9844919B2 (en) 2013-03-14 2017-12-19 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
US9848979B2 (en) 2011-12-02 2017-12-26 Acufocus, Inc. Ocular mask having selective spectral transmission
US9943403B2 (en) 2014-11-19 2018-04-17 Acufocus, Inc. Fracturable mask for treating presbyopia
US10004593B2 (en) 2009-08-13 2018-06-26 Acufocus, Inc. Intraocular lens with elastic mask
US10449036B2 (en) 2009-08-13 2019-10-22 Acufocus, Inc. Masked intraocular implants and lenses
US10687935B2 (en) 2015-10-05 2020-06-23 Acufocus, Inc. Methods of molding intraocular lenses
US10869752B2 (en) 2003-05-28 2020-12-22 Acufocus, Inc. Mask for increasing depth of focus
CN112584795A (en) * 2018-06-14 2021-03-30 W.L.戈尔及同仁股份有限公司 Artificial cornea
US11364110B2 (en) 2018-05-09 2022-06-21 Acufocus, Inc. Intraocular implant with removable optic
US11464625B2 (en) 2015-11-24 2022-10-11 Acufocus, Inc. Toric small aperture intraocular lens with extended depth of focus

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6554424B1 (en) 1999-03-01 2003-04-29 Boston Innovative Optices, Inc. System and method for increasing the depth of focus of the human eye
US20050046794A1 (en) 2003-06-17 2005-03-03 Silvestrini Thomas A. Method and apparatus for aligning a mask with the visual axis of an eye
US7976577B2 (en) 2005-04-14 2011-07-12 Acufocus, Inc. Corneal optic formed of degradation resistant polymer
BR112012008079A2 (en) 2009-08-13 2016-03-01 Acufocus Inc corneal graft with nutrient transport structures
USD656526S1 (en) 2009-11-10 2012-03-27 Acufocus, Inc. Ocular mask

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3945054A (en) * 1973-03-04 1976-03-23 Svyatoslav Nikolaevich Fedorov Through corneal prosthesis and method of installing same
WO1982001644A1 (en) * 1980-11-17 1982-05-27 Robert L Kaster Anastomotic fitting
FR2608041A1 (en) * 1986-12-15 1988-06-17 Pintucci Stefano KERATO-PROSTHESIS INTENDED TO BE IMPLANTED IN THE CORNEA AND METHOD FOR MANUFACTURING THE SAME
WO1989000032A1 (en) * 1987-07-07 1989-01-12 Caldwell Delmar R Intraocular prostheses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3945054A (en) * 1973-03-04 1976-03-23 Svyatoslav Nikolaevich Fedorov Through corneal prosthesis and method of installing same
WO1982001644A1 (en) * 1980-11-17 1982-05-27 Robert L Kaster Anastomotic fitting
FR2608041A1 (en) * 1986-12-15 1988-06-17 Pintucci Stefano KERATO-PROSTHESIS INTENDED TO BE IMPLANTED IN THE CORNEA AND METHOD FOR MANUFACTURING THE SAME
WO1989000032A1 (en) * 1987-07-07 1989-01-12 Caldwell Delmar R Intraocular prostheses

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018065A1 (en) * 1991-04-10 1992-10-29 F.C.I. (France Chirurgie Instrumentation) Support for a partially extracorporeal prosthesis
FR2687564A1 (en) * 1992-02-26 1993-08-27 France Chirurgie Instr Assembly device for a keratoprosthesis
US5300116A (en) * 1992-08-05 1994-04-05 Lions Eye Institute Of Western Australia Keratoprosthesis
US5458819A (en) * 1992-08-05 1995-10-17 Lions Eye Institute Of Western Australia, Incorporated Method of producing a keratoprosthesis
EP0670701A1 (en) * 1992-11-19 1995-09-13 PY, Daniel Intraocular prosthesis
EP0670701A4 (en) * 1992-11-19 1996-06-26 Py Daniel C Intraocular prosthesis.
US6106552A (en) * 1996-01-30 2000-08-22 Corneal Industrie Corneal prosthesis device having anterior and posterior annular skirts
US6391055B1 (en) * 1996-11-13 2002-05-21 Menicon Co., Ltd. Artificial cornea
US6423093B1 (en) 1999-09-14 2002-07-23 The Lions Eye Institute Of Western Australia Incorporated Method of insertion of keratoprostheses
US10869752B2 (en) 2003-05-28 2020-12-22 Acufocus, Inc. Mask for increasing depth of focus
WO2008127653A3 (en) * 2007-04-13 2008-12-04 Gore Enterprise Holdings Inc Artificial cornea
US10004593B2 (en) 2009-08-13 2018-06-26 Acufocus, Inc. Intraocular lens with elastic mask
US11357617B2 (en) 2009-08-13 2022-06-14 Acufocus, Inc. Method of implanting and forming masked intraocular implants and lenses
US11311371B2 (en) 2009-08-13 2022-04-26 Acufocus, Inc. Intraocular lens with elastic mask
US10548717B2 (en) 2009-08-13 2020-02-04 Acufocus, Inc. Intraocular lens with elastic mask
US10449036B2 (en) 2009-08-13 2019-10-22 Acufocus, Inc. Masked intraocular implants and lenses
US10342656B2 (en) 2011-12-02 2019-07-09 Acufocus, Inc. Ocular mask having selective spectral transmission
US9848979B2 (en) 2011-12-02 2017-12-26 Acufocus, Inc. Ocular mask having selective spectral transmission
US10765508B2 (en) 2011-12-02 2020-09-08 AcFocus, Inc. Ocular mask having selective spectral transmission
US20150216651A1 (en) * 2012-09-05 2015-08-06 University Of Miami Novel keratoprosthesis, and system and method of corneal repair using same
US9974646B2 (en) * 2012-09-05 2018-05-22 University Of Miami Keratoprosthesis, and system and method of corneal repair using same
US9603704B2 (en) 2013-03-13 2017-03-28 Acufocus, Inc. In situ adjustable optical mask
US10350058B2 (en) 2013-03-13 2019-07-16 Acufocus, Inc. In situ adjustable optical mask
US11771552B2 (en) 2013-03-13 2023-10-03 Acufocus, Inc. In situ adjustable optical mask
US10939995B2 (en) 2013-03-13 2021-03-09 Acufocus, Inc. In situ adjustable optical mask
US10583619B2 (en) 2013-03-14 2020-03-10 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
US9844919B2 (en) 2013-03-14 2017-12-19 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
US10183453B2 (en) 2013-03-14 2019-01-22 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
US9943403B2 (en) 2014-11-19 2018-04-17 Acufocus, Inc. Fracturable mask for treating presbyopia
US10687935B2 (en) 2015-10-05 2020-06-23 Acufocus, Inc. Methods of molding intraocular lenses
US11690707B2 (en) 2015-10-05 2023-07-04 Acufocus, Inc. Methods of molding intraocular lenses
US11464625B2 (en) 2015-11-24 2022-10-11 Acufocus, Inc. Toric small aperture intraocular lens with extended depth of focus
US11364110B2 (en) 2018-05-09 2022-06-21 Acufocus, Inc. Intraocular implant with removable optic
CN112584795A (en) * 2018-06-14 2021-03-30 W.L.戈尔及同仁股份有限公司 Artificial cornea
US20210244528A1 (en) * 2018-06-14 2021-08-12 W. L. Gore & Associates, Inc. Artificial cornea

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