FR2644463A1 - - Google Patents

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Publication number
FR2644463A1
FR2644463A1 FR8903557A FR8903557A FR2644463A1 FR 2644463 A1 FR2644463 A1 FR 2644463A1 FR 8903557 A FR8903557 A FR 8903557A FR 8903557 A FR8903557 A FR 8903557A FR 2644463 A1 FR2644463 A1 FR 2644463A1
Authority
FR
France
Prior art keywords
protein
polypeptide
male
hybrid
hiv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8903557A
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Original Assignee
Institut Pasteur de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur de Lille filed Critical Institut Pasteur de Lille
Priority to FR8903557A priority Critical patent/FR2644463A1/fr
Priority to PCT/FR1990/000182 priority patent/WO1990011360A1/fr
Priority to EP19900905557 priority patent/EP0426787A1/fr
Priority to JP50532590A priority patent/JPH03504729A/ja
Publication of FR2644463A1 publication Critical patent/FR2644463A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FR8903557A 1989-03-17 1989-03-17 Withdrawn FR2644463A1 (fi)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR8903557A FR2644463A1 (fi) 1989-03-17 1989-03-17
PCT/FR1990/000182 WO1990011360A1 (fr) 1989-03-17 1990-03-16 POLYPEPTIDE DE FUSION ENTRE UNE AFFINE DU MALTOSE (MalE) ET UN FRAGMENT DE CD4 NEUTRALISANT LES VIRUS HIV.
EP19900905557 EP0426787A1 (fr) 1989-03-17 1990-03-16 POLYPEPTIDE DE FUSION ENTRE UNE AFFINE DU MALTOSE (MalE) ET UN FRAGMENT DE CD4 NEUTRALISANT LES VIRUS HIV.
JP50532590A JPH03504729A (ja) 1989-03-17 1990-03-16 マルトースに対して親和性のある物質（ＭａｌＥ）と、ＨＩＶウイルスに対する中和特性を有するＣＤ４タンパク質フラグメントとの融合によって生じた融合ＣＤ４ポリペプチド

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8903557A FR2644463A1 (fi) 1989-03-17 1989-03-17

Publications (1)

Publication Number Publication Date
FR2644463A1 true FR2644463A1 (fi) 1990-09-21

Family

ID=9379821

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8903557A Withdrawn FR2644463A1 (fi) 1989-03-17 1989-03-17

Country Status (4)

Country Link
EP (1) EP0426787A1 (fi)
JP (1) JPH03504729A (fi)
FR (1) FR2644463A1 (fi)
WO (1) WO1990011360A1 (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5851828A (en) 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US7049136B2 (en) 1991-03-07 2006-05-23 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US6004811A (en) 1991-03-07 1999-12-21 The Massachussetts General Hospital Redirection of cellular immunity by protein tyrosine kinase chimeras
US5843728A (en) * 1991-03-07 1998-12-01 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US5912170A (en) * 1991-03-07 1999-06-15 The General Hospital Corporation Redirection of cellular immunity by protein-tyrosine kinase chimeras
US6753162B1 (en) 1991-03-07 2004-06-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0299810A1 (fr) * 1987-05-18 1989-01-18 Institut Pasteur Procédé de préparation de polypeptides par ADN recombinant

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0299810A1 (fr) * 1987-05-18 1989-01-18 Institut Pasteur Procédé de préparation de polypeptides par ADN recombinant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
COMPTES RENDUS DE L'ACADEMIE DES SCIENCES DE PARIS, vol. 308, no. 14, série III, 6 avril 1989, pages 401-406, Académie des Sciences; J.-M. CLEMENT et al.: "Propriétés neutralisantes pour le virus HIV d'une protéine hybride Ma1E-CD4 exprimée chez E. coli et purifiable en une étape" *
GENE, vol. 74, no. 2, 30 décembre 1988, pages 365-373, Elsevier Science Publishers B.V. (Biomedical Division), Amsterdam, NL; C.V. MAINA et al.: "An Escherichia coli vector to express and purify foreign proteins by fusion and separation from maltose-binding protein" *
NATURE, vol. 335, no. 6188, 22 septembre 1988, pages 369-372, Londres, GB; Y.K. CHAUDHARY et al.: "Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein" *

Also Published As

Publication number Publication date
JPH03504729A (ja) 1991-10-17
WO1990011360A1 (fr) 1990-10-04
EP0426787A1 (fr) 1991-05-15

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Legal Events

Date Code Title Description
ER Errata listed in the french official journal (bopi)

Free format text: 38/90

ST Notification of lapse